Association of variants in innate immune genes with asthma and eczema

Pediatric Allergy and Immunology

Volumn 23, Issue 4, 2012, Pages 315-323

  Sharma, Sunita ^a,b   Poon, Audrey ^a,b   Himes, Blanca E ^a,b   Lasky Su, Jessica ^a,b   Sordillo, Joanne E ^a   Belanger, Kathleen ^c   Milton, Donald K ^d   Bracken, Michael B ^c   Triche, Elizabeth W ^e   Leaderer, Brian P ^c   Gold, Diane R ^a,b   Litonjua, Augusto A ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

^e BROWN UNIVERSITY   (United States)

Author keywords

Asthma; Bayesian network; Eczema; Genetic association; Innate immunity

Indexed keywords

B7 ANTIGEN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; GAMMA INTERFERON; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; PROTEIN MD 2; STAT4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

5' UNTRANSLATED REGION; ARTICLE; ASTHMA; BAYES THEOREM; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ECZEMA; EXON; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC SELECTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; IMMUNE RESPONSE GENE; INNATE IMMUNITY; INTRON; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALIDITY; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

ALGORITHMS; ASTHMA; BAYES THEOREM; CHILD, PRESCHOOL; ECZEMA; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY, INNATE; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84861334467     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2011.01243.x     Document Type: Article

References (30)

1. Asher MI, Montefort S, Bjorksten B, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006: 368: 733-43.
2. Weiss ST. Environmental risk factors in childhood asthma. Clin Exp Allergy 1998: 28 (Suppl 5): 29-34; discussion 50-1.
3. Larsen FS, Holm NV, Henningsen K. Atopic dermatitis. A genetic-epidemiologic study in a population-based twin sample. J Am Acad Dermatol 1986: 15: 487-94.
4. Celedon JC, Milton DK, Ramsey CD, et al. Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood. J Allergy Clin Immunol 2007: 120: 144-9.
5. Gehring U, Strikwold M, Schram-Bijkerk D, et al. Asthma and allergic symptoms in relation to house dust endotoxin: Phase Two of the International Study on Asthma and Allergies in Childhood (ISAAC II). Clin Exp Allergy 2008: 38: 1911-20.
6. Genuneit J, Cantelmo JL, Weinmayr G, et al. A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2. Clin Exp Allergy 2009: 39: 1875-88.
7. Raby BA, Klimecki WT, Laprise C, et al. Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Respir Crit Care Med 2002: 166: 1449-56.
8. Smit LA, Siroux V, Bouzigon E, et al. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med 2009: 179: 363-8.
9. Litonjua AA, Belanger K, Celedon JC, et al. Polymorphisms in the 5′ region of the CD14 gene are associated with eczema in young children. J Allergy Clin Immunol 2005: 115: 1056-62.
10. Gold DR, Burge HA, Carey V, Milton DK, Platts-Mills T, Weiss ST. Predictors of repeated wheeze in the first year of life: the relative roles of cockroach, birth weight, acute lower respiratory illness, and maternal smoking. Am J Respir Crit Care Med 1999: 160: 227-36.
11. Leaderer BP, Belanger K, Triche E, et al. Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density. Environ Health Perspect 2002: 110: 419-25.
12. Devlin B, Roeder K. Genomic control for association studies. Biometrics 1999: 55: 997-1004.
13. Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH. Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia. Nat Genet 2005: 37: 435-40.
14. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988: 44: 837-45.
15. Gustafsson D, Sjoberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis - a prospective follow-up to 7years of age. Allergy 2000: 55: 240-5.
16. Morar N, Willis-Owen SA, Moffatt MF, Cookson WO. The genetics of atopic dermatitis. J Allergy Clin Immunol 2006: 118: 24-34; quiz 35-6.
17. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006: 24: 179-89.
18. Schmidt-Weber CB, Blaser K. Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation. Curr Opin Immunol 2004: 16: 709-16.
19. Sharma S, Raby BA, Hunninghake GM, et al. Variants in TGFB1, dust mite exposure, and disease severity in children with asthma. Am J Respir Crit Care Med 2009: 179: 356-62.
20. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM. Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997: 88: 553-60.
21. Levy H, Raby BA, Lake S, et al. Association of defensin beta-1 gene polymorphisms with asthma. J Allergy Clin Immunol 2005: 115: 252-8.
22. Cao Y, Liao M, Huang X, Mo Z, Gao F. Meta-analysis of genome-wide linkage studies of atopic dermatitis. Dermatitis 2009: 20: 193-9.
23. Muzio M, Ni J, Feng P, Dixit VM. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997: 278: 1612-5.
24. Stamm LM, Satoskar AA, Ghosh SK, David JR, Satoskar AR. STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis. Eur J Immunol 1999: 29: 2524-9.
25. Reijmerink NE, Bottema RW, Kerkhof M, et al. TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy. Allergy 2010: 65: 199-207.
26. Fritz DK, Kerr C, Fattouh R, et al. A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis Is STAT6 independent. J Immunol 2011: 186: 1107-18.
27. Sharma S, Murphy AJ, Soto-Quiros ME, et al. Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness. Eur Respir J 2009: 33: 1287-94.
28. Fesenkova VI, Kurchenko AI, Castellani ML, et al. Expression of co-stimulatory molecules on Langerhans cells in lesional epidermis of human atopic dermatitis. Immunopharmacol Immunotoxicol 2007: 29: 487-98.
29. Daley D, Lemire M, Akhabir L, et al. Analyses of associations with asthma in four asthma population samples from Canada and Australia. Hum Genet 2009: 125: 445-59.
30. Zhang G, Candelaria P, Makela JM, et al. Disparity of innate immunity-related gene effects on asthma and allergy on Karelia. Pediatr Allergy Immunol 2011: 22: 621-30.