Retroviral cyclin enhances cyclin-dependent kinase-8 activity

Journal of Virology

Volumn 86, Issue 10, 2012, Pages 5742-5751

  Rovnak, Joel ^a   Brewster, Connie D ^a   Quackenbush, Sandra L ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 8; CYCLINE; HISTONE H3; PHOSPHOPROTEIN PHOSPHATASE 2A; VIRUS ENZYME;

ANTIBODY AFFINITY; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REGULATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; SARCOMA VIRUS; SUICIDE SUBSTRATE; WALLEYE DERMAL SARCOMA VIRUS;

CYCLIN-DEPENDENT KINASE 8; CYCLINS; EPSILONRETROVIRUS; HUMANS; PROTEIN BINDING; PROTEIN PHOSPHATASE 2; RETROVIRIDAE INFECTIONS; UP-REGULATION; VIRAL PROTEINS;

WALLEYE DERMAL SARCOMA VIRUS;

EID: 84861325132     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.07006-11     Document Type: Article

References (60)

1. Akoulitchev S, Chuikov S, Reinberg D. 2000. TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature 407:102-106.
2. Alarcon C, et al. 2009. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 139:757-769.
3. Ammosova T, et al. 2011. Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. PLoS One 6:1-13.
4. Aragon E, et al. 2011. A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 25:1275-1288.
5. Bex F, McDowall A, Burny A, Gaynor R. 1997. The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kB proteins. J. Virol. 71:3484 -3497.
6. Bowser PR, Wolfe MJ, Forney JL, Wooster GA. 1988. Seasonal prevalence of skin tumors from walleye (Stizostedion vitreum) from Oneida Lake, New York. J. Wildlife Dis. 24:292-298.
7. Bowser PR, Wooster GA. 1991. Regression of dermal sarcoma in adult walleyes (Stizostedion vitreum). J. Aquat. Anim. Health 3:147-150.
8. Bowser PR, Wooster GA, Quackenbush SL, Casey RN, Casey JW. 1996. Comparison of fall and spring tumors as inocula for experimental transmission of walleye dermal sarcoma. J. Aquat. Anim. Health 8:78-81.
9. Brewster C, Birkenheuer C, Vogt M, Quackenbush S, Rovnak J. 2011. The retroviral cyclin of walleye dermal sarcoma virus binds cyclindependent kinases 3 and 8. Virology 409:299 -307.
10. Chen W, et al. 2004. Identification of specific PP2A complexes involved in human cell transformation. Cancer Cell 5:127-136.
11. Conaway RC, Conaway JW. 2011. Function and regulation of the Mediator complex. Curr. Opin. Genet. Dev. 21:225-230.
12. Dignam JD, Lebovitz RM, Roeder RG. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
13. Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM. 2010. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat. Struct. Mol. Biol. 17:194 -201.
14. Dow EC, Liu H, Rice AP. 2010. T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes. J. Cell. Physiol. 224:84 -93.
15. Eichhorn P, Creyghton M, Bernards R. 2009. Protein phosphatase 2A regulatory subunits and cancer. Biochim. Biophys. Acta 1795:1-15.
16. Firestein R, et al. 2008. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 455:547-551.
17. Galbraith M, Donner A, Espinosa J. 2010. CDK8: a positive regulator of transcription. Transcription 1:4 -12.
18. Gigena M, Ito A, Nojima H, Rogers T. 2005. A B56 regulatory subunit of protein phosphatase 2A localizes to nuclear speckles in cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol. 289:H285-H294.
19. Gold MO, Rice AP. 1998. Targeting of CDK8 to a promoter-proximal RNA element demonstrates catalysis-dependent activation of gene expression. Nucleic Acids Res. 26:3784 -3788.
20. Gold MO, Tassan JP, Nigg EA, Rice AP, Herrmann CH. 1996. Viral transactivators E1A and VP16 interact with a large complex that is associated with CTD kinase activity and contains CDK8. Nucleic Acids Res. 24:3771-3777.
21. Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D. 1999. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 96:99 -110.
22. Herrmann CH, Mancini MA. 2001. The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions. J. Cell Sci. 114:1491-1503.
23. Hoeppner S, Baumli S, Cramer P. 2005. Structure of the mediator subunit cyclin C and its implications for CDK8 function. J. Mol. Biol. 350:833- 842.
24. Ishihara H, et al. 1989. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem. Biophys. Res. Commun. 159:871- 877.
25. Kapoor A, et al. 2010. The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature 468:1105-1109.
26. Knuesel MT, Meyer KD, Bernecky C, Taatjes DJ. 2009. The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev. 23:439-451.
27. Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ. 2009. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Mol. Cell. Biol. 29: 650-661.
28. Kremmer E, Ohst K, Kiefer J, Brewis N, Walter G. 1997. Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells. Mol. Cell. Biol. 17:1692-1701.
29. LaPierre LA, Casey JW, Holzschu DL. 1998. Walleye retroviruses associated with skin tumors and hyperplasias encode cyclin D homologs. J. Virol. 72:8765- 8771.
30. Martin ES, et al. 2007. Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res. 67:10736 -10743.
31. Martineau D, Bowser PR, Renshaw PR, Casey JW. 1992. Molecular characterization of a unique retrovirus associated with a fish tumor. J. Virol. 66:596 -599.
32. Martineau D, Renshaw R, Williams JR, Casey JW, Bowser PR. 1991. A large unintegrated retrovirus DNA species present in a dermal tumor of walleye Stizostedion vitreum. Dis. Aquat. Organisms 10:153-158.
33. Meyer KD, et al. 2008. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J. 27: 1447-1457.
34. Morris EJ, et al. 2008. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature 455:552-556.
35. Ohata N, et al. 2006. Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma. Int. J. Mol. Med. 18:1153-1158.
36. Oppermann F, et al. 2009. Large-scale proteomics analysis of the human kinome. Mol. Cell Proteomics 8:1751-1764.
37. Pallas DC, et al. 1990. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell 60:167-176.
38. Pallas DC, et al. 1992. The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens. J. Virol. 66:886-893.
39. Quackenbush SL, Holzschu DL, Bowser PR, Casey JW. 1997. Transcriptional analysis of walleye dermal sarcoma virus (WDSV). Virology 237: 107-112.
40. Quackenbush SL, Linton A, Brewster CD, Rovnak J. 2009. Walleye dermal sarcoma virus rv-cyclin inhibits NF-κB-dependent transcription. Virology 386:55- 60.
41. Rickert P, Corden JL, Lees E. 1999. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases. Oncogene 18:1093-1102.
42. Rickert P, Seghezzi W, Shanahan F, Cho H, Lees E. 1996. Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II. Oncogene 12:2631-2640.
43. Rovnak J, Casey JW, Quackenbush SL. 2001. Intracellular targeting of walleye dermal sarcoma virus Orf A (rv-cyclin). Virology 280:31- 40.
44. Rovnak J, Casey RN, Brewster CD, Casey JW, Quackenbush SL. 2007. Establishment of productively infected walleye dermal sarcoma explant cells J. Gen. Virol. 88:2583-2589.
45. Rovnak J, Hronek BW, Ryan SO, Cai S, Quackenbush SL. 2005. An activation domain within the walleye dermal sarcoma virus retroviral cyclin protein is essential for inhibition of the viral promoter. Virology 342:240-251.
46. Rovnak J, Quackenbush SL. 2002. Walleye dermal sarcoma virus cyclin interacts with components of the Mediator complex and the RNA polymerase II holoenzyme. J. Virol. 76:8031- 8039.
47. Rovnak J, Quackenbush SL. 2006. Walleye dermal sarcoma virus retroviral cyclin directly contacts TAF9. J. Virol. 80:12041-12048.
48. Ruediger R, Hentz M, Fait J, Mumby M, Walter G. 1994. Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. J. Virol. 68:123-129.
49. Sablina A, Hector M, Colpaert N, Hahn W. 2010. Identification of PP2A complexes and pathways involved in cell transformation. Cancer Res. 70: 10474-10484.
50. Schneider E, et al. 2011. The structure of CDK8/CycC implicates specificity in the CDK/Cyclin family and reveals interaction with a deep-pocket binder. J. Mol. Biol. 412:251-266.
51. Semmes OJ, Jeang K-T. 1996. Localization of human T-cell leukemia virus type 1 Tax to subnuclear compartments that overlap with interchromatin speckles. J. Virol. 70:6347- 6357.
52. Sontag E, et al. 1993. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the Map kinase pathway and induces cell proliferation. Cell 75:887- 897.
53. Stevens JL, Cantin GT, Wang G, Shevchenko A, Berk AJ. 2002. Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science 296:755-758.
54. Tsafrir D, et al. 2006. Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer Res. 66:2129 -2137.
55. Ulug ET, Cartwright AJ, Coutneidge SA. 1992. Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase. J. Virol. 66:1458 -1467.
56. Wang Y, et al. 2008. Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop. J. Biol. Chem. 283:33578 -33584.
57. Xu W, Ji JY. 2011. Dysregulation of CDK8 and Cyclin C in tumorigenesis. J. Genet. Genomics 38:439-452.
58. Yamamoto T, MacDonald RD, Gillespie DC, Kelly RK. 1976. Viruses associated with lymphocystis and dermal sarcoma of walleye (Stizostedion vitreum vitreum). J. Fish Res. Board Canada 33:2408 -2419.
59. Yang J, Phiel C. 2010. Functions of B56-containing PP2As in major developmental and cancer signaling pathways. Life Sci. 87:659-666.
60. Zhang Z, Martineau D. 1999. Walleye dermal sarcoma virus: OrfA N-terminal end inhibits the activity of a reporter gene directed by eukaryotic promoters and has a negative effect on the growth of fish and mammalian cells. J. Virol. 73:8884-8889.