Systematic evaluation of the root cause of non-linearity in liquid chromatography/tandem mass spectrometry bioanalytical assays and strategy to predict and extend the linear standard curve range

Rapid Communications in Mass Spectrometry

Volumn 26, Issue 12, 2012, Pages 1465-1474

  Yuan, Long ^a   Zhang, Duxi ^a,b   Jemal, Mohammed ^a   Aubry, Anne Francoise ^a  

^a BRISTOL MYERS SQUIBB RESEARCH AND DEVELOPMENT   (United States)

^b Research and Development ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; CURVE FITTING; LIQUID CHROMATOGRAPHY;

A-STABLE; BIOANALYTICAL ASSAYS; LINEAR RANGE; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; NONLINEAR BEHAVIOURS; ORDERS OF MAGNITUDE; QUADRATIC REGRESSION; ROOT CAUSE; SELECTIVE REACTION MONITORING; STABLE ISOTOPE LABELED INTERNAL STANDARDS;

MASS SPECTROMETRY;

EID: 84861313206     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.6252     Document Type: Article

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