Quantitative determination of glycopyrrolate in human plasma by liquid chromatography-electrospray ionization mass spectrometry: The use of a volatile ion-pairing agent during both liquid-liquid extraction and liquid chromatography

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 876, Issue 1, 2008, Pages 24-30

  Storme, M L ^a   t'Kindt, R S ^a   Goeteyn, W ^a   Reyntjens, K ^b   Van Bocxlaer, J F ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Glycopyrrolate; LC MS MS; Pharmacokinetics

Indexed keywords

ACIDS; AMINES; AMMONIUM COMPOUNDS; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; CONCENTRATION (PROCESS); ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ION CHROMATOGRAPHY; IONIZATION OF LIQUIDS; IONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PLASMA (HUMAN); PLASMAS; QUANTUM THEORY; SOLVENT EXTRACTION; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

ABSOLUTE QUANTIFICATIONS; BIOANALYTICAL METHOD VALIDATIONS; CALIBRATION FUNCTIONS; CONCENTRATION RANGES; ELECTROSPRAY IONIZATION MASS SPECTROMETRIES; EXTRACTION PROCEDURES; GLYCOPYRROLATE; HUMAN PLASMA SAMPLES; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS/MS; LIQUID EXTRACTIONS; MATRIX EFFECTS; PLASMA SAMPLES; PROCESS EFFICIENCIES; QUANTITATIVE DETERMINATIONS; QUANTITATIVE TOOLS; QUATERNARY AMMONIUMS; RELATIVE STANDARD DEVIATIONS; RETENTION TIMES; TOF MASS SPECTROMETRIES;

EXTRACTION;

BUTYRIC ACID DERIVATIVE; GLYCOPYRRONIUM BROMIDE; MEPENZOLATE; PERFLUOROBUTYRIC ACID; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CALIBRATION; CASE REPORT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; ION PAIR EXTRACTION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; STANDARD; TIME OF FLIGHT MASS SPECTROMETRY;

CHEMICAL FRACTIONATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLYCOPYRROLATE; HUMANS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 56249087920     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.10.013     Document Type: Article

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