메뉴 건너뛰기




Volumn 14, Issue 3, 2012, Pages 211-218

Sortilin as a regulator of lipoprotein metabolism

Author keywords

Atherosclerotic cardiovascular disease; Genome wide association study; Lipid metabolism; Low density lipoprotein cholesterol; Sort1

Indexed keywords

APOLIPOPROTEIN B; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SORTILIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

EID: 84861233637     PISSN: 15233804     EISSN: 15346242     Source Type: Journal    
DOI: 10.1007/s11883-012-0248-x     Document Type: Article
Times cited : (46)

References (30)
  • 1
    • 77649091020 scopus 로고    scopus 로고
    • Executive summary: Heart disease and stroke statistics-2010 update: A report from the American Heart Association
    • Lloyd-Jones D, et al. Executive summary: heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation. 2010;121:948-54.
    • (2010) Circulation. , vol.121 , pp. 948-954
    • Lloyd-Jones, D.1
  • 2
    • 0034648768 scopus 로고    scopus 로고
    • Atherosclerosis
    • Lusis AJ. Atherosclerosis. Nature. 2000;407:233-41.
    • (2000) Nature. , vol.407 , pp. 233-241
    • Lusis, A.J.1
  • 3
    • 67651111687 scopus 로고    scopus 로고
    • Lipid treatment assessment project 2: A multinational survey to evaluate the proportion of patients achieving lowdensity lipoprotein cholesterol goals
    • Waters DD, et al. Lipid treatment assessment project 2: a multinational survey to evaluate the proportion of patients achieving lowdensity lipoprotein cholesterol goals. Circulation. 2009;120:28-34.
    • (2009) Circulation. , vol.120 , pp. 28-34
    • Waters, D.D.1
  • 7
    • 58149163149 scopus 로고    scopus 로고
    • Common variants at 30 loci contribute to polygenic dyslipidemia
    • Kathiresan S, et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009;41:56-65. This is a genome-wide association study in European populations identifying 10 novel genetic determinants of lipid traits.
    • (2009) Nat Genet. , vol.41 , pp. 56-65
    • Kathiresan, S.1
  • 8
    • 77955505564 scopus 로고    scopus 로고
    • Biological, clinical and population relevance of 95 loci for blood lipids
    • Teslovich TM, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466;707-13. This is the largest genome-wide association study for lipid traits, and it identified 95 total loci associated with lipid traits, including 59 novel loci. Many of these loci were replicated in non-European populations as well. This study named the SORT1 locus as a genome-wide significant determinant of LDL-C levels and cardiovascular disease risk in European and non-European populations with the lowest P-value in the human genome for LDL-C.
    • (2010) Nature. , vol.466 , pp. 707-713
    • Teslovich, T.M.1
  • 10
    • 79953204259 scopus 로고    scopus 로고
    • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
    • Schunkert H, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011;43:333-8. This large-scale genome-wide association study for cardiovascular disease with 135,000 individuals of European descent identified 13 novel loci for CAD.
    • (2011) Nat Genet. , vol.43 , pp. 333-338
    • Schunkert, H.1
  • 11
    • 79751532388 scopus 로고    scopus 로고
    • Genetic risk score and risk of myocardial infarction in Hispanics
    • Qi L, et al. Genetic risk score and risk of myocardial infarction in Hispanics. Circulation. 2011;123;374-80.
    • (2011) Circulation. , vol.123 , pp. 374-380
    • Qi, L.1
  • 12
    • 81055145752 scopus 로고    scopus 로고
    • Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population
    • Zhou L, et al. Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population. PLoS One. 2011;6:e27481.
    • (2011) PLoS One. , vol.6
    • Zhou, L.1
  • 13
    • 70749096913 scopus 로고    scopus 로고
    • Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    • Kathiresan S, et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet. 2009;41:334-41. This is a genome-wide association study of cardiovascular disease and early-onset myocardial infarction.
    • (2009) Nat Genet. , vol.41 , pp. 334-341
    • Kathiresan, S.1
  • 14
    • 58149214774 scopus 로고    scopus 로고
    • Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication
    • Chasman DI, et al. Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication. Circ Cardiovasc Genet. 2008;1:21-30.
    • (2008) Circ Cardiovasc Genet. , vol.1 , pp. 21-30
    • Chasman, D.I.1
  • 15
    • 73649141739 scopus 로고    scopus 로고
    • Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease
    • Linsel-Nitschke P, et al. Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease. Atherosclerosis. 2010;208:183-9. This is the first mechanistic study associating elevated Sort1 expression with increased LDL uptake.
    • (2010) Atherosclerosis. , vol.208 , pp. 183-189
    • Linsel-Nitschke, P.1
  • 16
    • 67449128717 scopus 로고    scopus 로고
    • Large scale replication analysis of loci associated with lipid concentrations in a Japanese population
    • Nakayama K, et al. Large scale replication analysis of loci associated with lipid concentrations in a Japanese population. J Med Genet. 2009;46:370-4.
    • (2009) J Med Genet. , vol.46 , pp. 370-374
    • Nakayama, K.1
  • 17
    • 77955499945 scopus 로고    scopus 로고
    • From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
    • Musunuru K, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 2010;466:714-9. This study identified the causal SNP at the 1p13 locus that confers the expression changes seen with the minor allele and in vivo proof of principles studies showing that Sort1 overexpression reduces plasma cholesterol and VLDL secretion, whereas Sort1 knockdown increases plasma cholesterol and VLDL secretion.
    • (2010) Nature. , vol.466 , pp. 714-719
    • Musunuru, K.1
  • 18
    • 78049425343 scopus 로고    scopus 로고
    • Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica
    • Gupta R, et al. Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica. Hum Genet. 2010;128:557-61.
    • (2010) Hum Genet. , vol.128 , pp. 557-561
    • Gupta, R.1
  • 19
    • 77949320494 scopus 로고    scopus 로고
    • Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III
    • Keebler ME, et al. Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III. Circ Cardiovasc Genet. 2009;2:238-43.
    • (2009) Circ Cardiovasc Genet. , vol.2 , pp. 238-243
    • Keebler, M.E.1
  • 22
    • 78449286213 scopus 로고    scopus 로고
    • Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin
    • Hu F, et al. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron. 2010;68:654-67. This study shows that SORT1 mediates the lysosomal degradation of progranulin and shows a functional relationship between sortilin and frontotemporal dementia.
    • (2010) Neuron. , vol.68 , pp. 654-667
    • Hu, F.1
  • 23
    • 0036434311 scopus 로고    scopus 로고
    • Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line
    • DOI 10.1016/S0006-291X(02)02564-0, PII S0006291X02025640
    • Navarro V, Vincent JP, Mazella J. Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line. Biochem Biophys Res Commun. 2002;298:760-4. (Pubitemid 35356805)
    • (2002) Biochemical and Biophysical Research Communications , vol.298 , Issue.5 , pp. 760-764
    • Navarro, V.1    Vincent, J.-P.2    Mazella, J.3
  • 24
    • 80051940841 scopus 로고    scopus 로고
    • Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation
    • Evans SF, et al. Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. J Biol Chem. 2011;286:29556-67.
    • (2011) J Biol Chem. , vol.286 , pp. 29556-29567
    • Evans, S.F.1
  • 26
    • 0035933822 scopus 로고    scopus 로고
    • Activation and functional characterization of the mosaic receptor SorLA/LR11
    • Jacobsen L, et al. Activation and functional characterization of the mosaic receptor SorLA/LR11. J Biol Chem. 2001;276:22788-96.
    • (2001) J Biol Chem. , vol.276 , pp. 22788-22796
    • Jacobsen, L.1
  • 27
    • 54449087031 scopus 로고    scopus 로고
    • Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families
    • Nilsson SK, et al. Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families. J Biol Chem. 2008;283:25920-7.
    • (2008) J Biol Chem. , vol.283 , pp. 25920-25927
    • Nilsson, S.K.1
  • 28
    • 77956327982 scopus 로고    scopus 로고
    • Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export
    • Kjolby M, et al. Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab. 2010;12:213-23. This is a mechanistic studies using a SORT-/- mouse that suggest that Sort1 deficiency is associated with reduced plasma cholesterol and reduced VLDL secretion.
    • (2010) Cell Metab. , vol.12 , pp. 213-223
    • Kjolby, M.1
  • 29
    • 84860593304 scopus 로고    scopus 로고
    • Activation of ER stress and mTORC1 supresses hepatic sortilin-1 levels in obese mice
    • Apr 2 [Epub ahead of print]
    • Ai D, Baez JM, Jiang H, Conlon D, Hernandez-Ono A, Frank-Kamenetsky M, Milstein S, et al. Activation of ER stress and mTORC1 supresses hepatic sortilin-1 levels in obese mice. J Clin Investi. 2012; Apr 2 [Epub ahead of print]. This is a study showing that Sort1 expression is regulated by ER stress and mTOR signaling and demonstrating that elevated Sort1 expression is associated with reductions in VLDL/apoB secretion whereas reduced Sort1 expression is associated with increased VLDL/apoB secretion.
    • (2012) J Clin Investi.
    • Ai, D.1    Baez, J.M.2    Jiang, H.3    Conlon, D.4    Hernandez-Ono, A.5    Frank-Kamenetsky, M.6    Milstein, S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.