Essentials for starting a pediatric clinical study (1): Pharmacokinetics in children

Journal of Toxicological Sciences

Volumn 34, Issue 2 SPEC. ISS., 2009, Pages

  Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Drug disposition; Drug interactions; Drug metabolism; Interindividual difference; Pharmacokinetics

Indexed keywords

CARBAMAZEPINE; CYTOCHROME P450 3A7; DIGOXIN; GENTAMICIN; GLUCURONIC ACID; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B7; PARACETAMOL; PHENOBARBITAL; PHENYTOIN; PLASMA PROTEIN; SULFATE; THEOPHYLLINE; VANCOMYCIN; WARFARIN;

BIRTH; BODY WEIGHT; CHILD DEVELOPMENT; CLINICAL STUDY; CONFERENCE PAPER; CONJUGATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; GASTROINTESTINAL TRACT; GESTATIONAL AGE; GLOMERULUS FILTRATION RATE; HUMAN; INTESTINE ABSORPTION; LIVER BLOOD FLOW; LIVER WEIGHT; PEDIATRICS; PH MEASUREMENT; PHARMACOKINETICS; PROTEIN BINDING; PROTEIN BLOOD LEVEL; STOMACH ABSORPTION; STOMACH EMPTYING; STOMACH JUICE; STOMACH PH; URINARY EXCRETION;

EID: 67651160651     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.SP307     Document Type: Conference Paper

References (13)

1. Heimann, G. (1980): Enteral absoiption and bioavailability in children in relation to age. Eur. J. Clin. Pharmacol., 18, 43-50.
2. Iisalo, E., Dahl, M. and Sundqvist, H. (1973): Serum digoxin in adults and children. Int. J. Clin. Pharmacol., 7, 219-222.
3. Klotz, U., Avant, G.R., Hoyumpa, A., Schenker, S. and Wilkinson, G.R. (1975): The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J. Clin. Invest., 55, 347-359.
4. Koukouritaki, S.B., Simpson, P., Yeung, C.K., Rettie, A.E. and Hines, R.N. (2002): Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression. Pediatr. Res., 51, 236-243.
5. Koukouritaki, S.B., Manro, J.R., Marsh, S.A., Stevens, J.C., Rettie, A.E., McCarver, D.G. and Hines, R.N. (2004): Developmental expression of human hepatic CYP2C9 and CYP2C19. J. Pharmacol. Exp. Ther., 308, 965-974.
6. Mirochnick, M., Capparelli, E. and Connor, J. (1999): Pharmacokinetics of zidovudine in infants: A population analysis across studies. Clin. Pharmacol. Ther., 66, 16-24.
7. Schmitt, M., Blackman, D.J., Middleton, G.W., Cockcroft, J.R. and Frenneaux, M.P. (2002): Assessment of venous capacitance. Radionuclide plethysmography: methodology and research applications. Br. J. Clin. Pharmacol., 54, 565-576.
8. Sonnier, M. and Cresteil, T. (1998): Delayed ontogenesis of CYP1A2 in the human liver. Eur. J. Biochem., 251, 893-898.
9. Stevens, J.C., Hines, R.N., Gu, C., Koukouritaki, S.B., Manro, J.R., Tandler, P.J. and Zaya, M.J. (2003): Developmental expression of the major human hepatic CYP3A enzymes. J. Pharmacol. Exp. Ther., 307, 573-582.
10. Takahashi, H., Ishikawa, S., Nomoto, S., Nishigaki, Y., Ando, F., Kashima, T., Kimura, S., Kanamori, M. and Echizen, H. (2000): Developmental changes in pharmacokinetics and pharmacodynamics of warfarin enantiomers in Japanese children. Clin. Phrmacol. Ther., 68, 541-555.
11. Treluyer, J.M., Jacqz-Aigrain, E., Alvarez, F. and Cresteil, T. (1991): Expression of CYP2D6 in developing human liver. Eur. J. Biochem., 202, 583-588.
12. Treluyer, J.M., Gueret, G., Cheron, G., Sonnier, M. and Cresteil, T. (1997): Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility. Pharmacogenetics, 7, 441-452. (Pubitemid 27517572)
13. Yukawa, E. (2007): Approach to individualized pharmacotherapy -Analysis of population pharmacokinetic parameters-. TDM Research, 24, 8-16.