Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating

Journal of Biological Chemistry

Volumn 287, Issue 21, 2012, Pages 17232-17240

  Ćelić, Andjelka S ^a,b   Petri, Edward T ^a,b   Benbow, Jennifer ^a   Hodsdon, Michael E ^a   Ehrlich, Barbara E ^a   Boggon, Titus J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NOVI SAD   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ULTRACENTRIFUGATION; AUTOSOMAL DOMINANTS; C-TERMINAL TAIL; CHANNEL GATING; CHANNEL PORE; CONFORMATIONAL CHANGE; CYTOPLASMIC DOMAINS; CYTOPLASMIC TAIL; DOMINANT NEGATIVE; EF-HAND; INTER-ATOMIC DISTANCES; KIDNEY CELLS; MOLECULAR BASIS; OVER-EXPRESSION; POLYCYSTIC KIDNEY DISEASE; RADIUS OF GYRATION; SINGLE-CHANNEL; SMALL ANGLE X-RAY SCATTERING; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

CENTRIFUGATION; DIMERS; LIPID BILAYERS; X RAY SCATTERING;

CALCIUM;

CALCIUM; POLYCYSTIN 2;

ARTICLE; CALCIUM BINDING; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; LIPID BILAYER; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

CALCIUM; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; ION CHANNEL GATING; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; TRPP CATION CHANNELS;

EID: 84861217550     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.354613     Document Type: Article

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