Dietary salt modulates the sodium chloride cotransporter expression likely through an aldosterone-mediated WNK4-ERK1/2 signaling pathway

Pflugers Archiv European Journal of Physiology

Volumn 463, Issue 3, 2012, Pages 477-485

  Lai, Lingyun ^a   Feng, Xiuyan ^b   Liu, Defeng ^a   Chen, Jing ^a   Zhang, Yiqian ^b   Niu, Bowen ^b   Gu, Yong ^a   Cai, Hui ^b,c  

^a FUDAN UNIVERSITY   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Aldosterone; Dietary salt; ERK1 2; Sodium chloride cotransporter; WNK4

Indexed keywords

ALDOSTERONE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE WNK4; SODIUM CHLORIDE COTRANSPORTER; PRKWNK4 PROTEIN, RAT; PROTEIN SERINE THREONINE KINASE; WNK4 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; GENETIC TRANSFECTION; HORMONAL REGULATION; HUMAN; HUMAN CELL; KIDNEY FUNCTION; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALT INTAKE; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL STRAIN HEK293; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PSEUDOHYPOALDOSTERONISM; RAT;

ALDOSTERONE; ANIMALS; HEK293 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; PROTEIN-SERINE-THREONINE KINASES; PSEUDOHYPOALDOSTERONISM; RATS; RNA, MESSENGER; SODIUM CHLORIDE SYMPORTERS; SODIUM CHLORIDE, DIETARY;

EID: 84861208182     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-1062-y     Document Type: Article

References (32)

1. Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB (2006) WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney Int 69:2162-2170
2. Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, Uchida S (2008) Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int 74:1403-1409
3. Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'shaughnessy KM (2006) Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved. Am J Physiol Renal Physiol 291:F1369-F1376
4. Kahle KT, Wilson FH, Lalioti M, Toka H, Qin H, Lifton RP (2004) WNK kinases: molecular regulators of integrated epithelial ion transport. Curr Opin Nephrol Hypertens 13:557-562
5. Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP (2003) WNK4 regulates the balance between renal NaCl reabsorption and K+secretion. Nat Genet 35:372-376
6. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA (1998) The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95:14552-14557
7. Ko B, Joshi LM, Cooke LL, Vazquez N, Musch MW, Hebert SC, Gamba G, Hoover RS (2007) Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKCindependent pathway. Proc Natl Acad Sci USA 104:20120-20125
8. Lazrak A, Liu Z, Huang CL (2006) Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci USA 103:1615-1620
9. Masilamani S, Kim GH, Mitchell C, Wade JB, Knepper MA (1999) Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest 104:R19-R23
10. Masilamani S, Wang X, Kim GH, Brooks H, Nielsen J, Nielsen S, Nakamura K, Stokes JB, Knepper MA (2002) Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction. Am J Physiol Renal Physiol 283:F648-F657
11. McCormick JA, Yang CL, Ellison DH (2008) WNK kinases and renal sodium transport in health and disease: an integrated view. Hypertension 51:588-596
12. Moniz S, Verissimo F, Matos P, Brazao R, Silva E, Kotelevets L, Chastre E, Gespach C, Jordan P (2007) Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. Oncogene 26:6071-6081
13. O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW (2006) Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. J Am Soc Nephrol 17:2402-2413
14. Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanovic S, Jovanovic A, O'shaughnessy KM, Alessi DR (2010) Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med 2:63-75
15. Richardson C, Alessi DR (2008) The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. J Cell Sci 121:3293-3304
16. Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR (2008) Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci 121:675-684
17. Rozansky DJ, Cornwall T, Subramanya AR, Rogers S, Yang YF, David LL, Zhu X, Yang CL, Ellison DH (2009) Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. J Clin Invest 119:2601-2612
18. San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G (2009) Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci USA 106:4384-4389
19. Sandberg MB, Maunsbach AB, McDonough AA (2006) Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet. Am J Physiol Renal Physiol 291: F503-F508
20. Shaharabany M, Holtzman EJ, Mayan H, Hirschberg K, Seger R, Farfel Z (2008) Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF. FEBS J 275:1631-1642
21. Subramanya AR, Liu J, Ellison DH, Wade JB, Welling PA (2009) WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction. J Biol Chem 284:18471-18480
22. Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR (2004) WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. Biochem J 378:257-268
23. Vitari AC, Deak M, Morrice NA, Alessi DR (2005) The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 391:17-24
24. Welling PA, Chang YP, Delpire E, Wade JB (2010) Multigene kinase network, kidney transport, and salt in essential hypertension. Kidney Int 77:1063-1069
25. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP (2001) Human hypertension caused by mutations in WNK kinases. Science 293:1107-1112
26. Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP (2003) Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci USA 100:680-684
27. Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH (2000) WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem 275:16795-16801
28. Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH (2004) WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem 279:7826-7831
29. Yang CL, Angell J, Mitchell R, Ellison DH (2003) WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 111:1039-1045
30. Yang LE, Sandberg MB, Can AD, Pihakaski-Maunsbach K, McDonough AA (2008) Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status. Am J Physiol Renal Physiol 295:F1003-F1016
31. Yang CL, Zhu X, Wang Z, Subramanya AR, Ellison DH (2005) Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. J Clin Invest 115:1379-1387
32. Zhou B, Zhuang J, Gu D,Wang H, Cebotaru L, Guggino WB, Cai H (2010) WNK4 enhances the degradation of NCC through a sortilinmediated lysosomal pathway. J Am Soc Nephrol 21:82-92