Synergistic interactions between the NS3 hel and E proteins contribute to the virulence of dengue virus type 1

PLoS Neglected Tropical Diseases

Volumn 6, Issue 4, 2012, Pages

  de Borba, Luana ^a   Strottmann, Daisy M ^a   de Noronha, Lucia ^b   Mason, Peter W ^c,d   Duarte dos Santos, Claudia N ^a  

^a INSTITUTO CARLOS CHAGAS   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

^c University of Texas Medical Branch School of Medicine   (United States)

^d NOVARTIS VACCINES AND DIAGNOSTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NONSTRUCTURAL PROTEIN 3; VIRUS ENVELOPE PROTEIN; E PROTEIN TH SMAN, DENGUE VIRUS; MUTANT PROTEIN; NS3 PROTEIN, FLAVIVIRUS; RNA HELICASE; SERINE PROTEINASE; VIRULENCE FACTOR; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DENGUE VIRUS 1; FLOW CYTOMETRY; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MORTALITY; MOSQUITO; MOUSE; NEWBORN; NONHUMAN; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SYNTHESIS; SEQUENCE ANALYSIS; VIRUS LOAD; VIRUS REPLICATION; VIRUS VIRULENCE; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; DENGUE VIRUS; DISEASE MODEL; GENETICS; METABOLISM; MOLECULAR GENETICS; PATHOGENICITY; REVERSE GENETICS; SURVIVAL; VIRULENCE;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, NEWBORN; CELL LINE; CULICIDAE; DENGUE VIRUS; DISEASE MODELS, ANIMAL; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; REVERSE GENETICS; RNA HELICASES; SERINE ENDOPEPTIDASES; SURVIVAL ANALYSIS; VIRAL ENVELOPE PROTEINS; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE; VIRULENCE FACTORS; VIRUS REPLICATION;

EID: 84861206961     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001624     Document Type: Article

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