Cross-reacting antibodies enhance dengue virus infection in humans

Science

Volumn 328, Issue 5979, 2010, Pages 745-748

  Dejnirattisai, Wanwisa ^a   Jumnainsong, Amonrat ^a   Onsirisakul, Naruthai ^a,b   Fitton, Patricia ^a   Vasanawathana, Sirijitt ^c   Limpitikul, Wannee ^d   Puttikhunt, Chunya ^e   Edwards, Carolyn ^a   Duangchinda, Thaneeya ^e   Supasa, Sunpetchuda ^f   Chawansuntati, Kriangkrai ^a   Malasit, Prida ^e,f   Mongkolsapaya, Juthathip ^a,f   Screaton, Gavin ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MAHIDOL UNIVERSITY   (Thailand)

^c KHON KAEN HOSPITAL   (Thailand)

^d Songkhla Hospital   (Thailand)

^e NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^f MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

CROSS REACTING ANTIBODY; DENGUE VACCINE; FC RECEPTOR; HUMAN MONOCLONAL ANTIBODY; MEMBRANE PROTEIN; PROTEIN PRECURSOR;

ANTIBODY; DENGUE FEVER; DISEASE RESISTANCE; DISEASE SPREAD; VACCINE; VIRUS;

ANTIBODY BLOOD LEVEL; ANTIBODY DEPENDENT ENHANCEMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DENGUE; DENGUE VIRUS; DISEASE SEVERITY; DRUG DESIGN; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SEROTYPE; SURFACE PROPERTY;

AEDES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIBODY-DEPENDENT ENHANCEMENT; ANTIGENS, VIRAL; CELL LINE; CROSS REACTIONS; DENGUE; DENGUE VACCINES; DENGUE VIRUS; ENCEPHALITIS VIRUS, JAPANESE; HUMANS; IMMUNE EVASION; MONOCYTES; RECEPTORS, FC; SEROTYPING; U937 CELLS; VIRAL ENVELOPE PROTEINS; VIRAL MATRIX PROTEINS; VIRUS REPLICATION;

DENGUE VIRUS; DENGUE VIRUS GROUP;

EID: 77952180847     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1185181     Document Type: Article

References (17)

1. World Health Organization, Fact sheet no.117 (2008); available at www.who.int/mediacentre/factsheets/fs117/en/
2. M. G. Guzman et al., Am. J. Epidemiol. 152, 793, discussion 804 (2000).
3. N. Sangkawibha et al., Am. J. Epidemiol. 120, 653 (1984).
4. S. B. Halstead, E. J. O'Rourke, J. Exp. Med. 146, 201 (1977).
5. M. S. Diamond, T. C. Pierson, D. H. Fremont, Immunol. Rev. 225, 212 (2008).
6. Y. Modis, S. Ogata, D. Clements, S. C. Harrison, Nature 427, 313 (2004).
7. L. Li et al., Science 319, 1830 (2008).
8. E. Traggiai et al., Nat. Med. 10, 871 (2004).
9. C.-Y. Lai et al., J. Virol. 82, 6631 (2008).
10. K.-J.. Huang et al., J. Immunol, 176, 2825 (2006).
11. F. Guirakhoo, F. X. Heinz, C. W. Mandl, H. Holzmann, C. Kunz, ;. Gen. Virol. 72, 1323 (1991).
12. I. M. Yu et al., Science 319, 1834 (2008).
13. I. A. Zybert, H. van der Ende-Metselaar, J. Wilschut, J. M. Smit, J. Gen. Virol. 89, 3047 (2008).
14. J. Junjhon et al., J. Virol. 82, 10776 (2008).
15. M. V. Cherrier et al., EMBO J. 28, 3269 (2009).
16. S. S. Whitehead, J. E. Blaney, A. P. Durbin, B. R. Murphy, Nat Rev. Microbiol. 5, 518 (2007).
17. We thank W. Supanchaimat, V. Jarupoonphol, S. Jinathongthai, K. Sriruksa, P. Wongsilarat, T. Suphachaiyakit, K. Ratarpa, Y. Sutvigit, and the staff of Khon Kaen and Songkhla hospitals for sample collection; L. Damrikarnlerd, P. Suriyapol, C. Komoltri, S. Udompunturak, N. Tangthawomchaikul, A. Jairangsri, K. Sae-Jang, and S. Supajitkasem for data and clinical database management and statistical analysis; N. Sittisombut and P. Keelapang from Chiang Mai University for sharing knowledge; and C. P. Simmons and B. Wills from the Oxford University Clinical Research Unit, Ho Chi Minh City for samples. This work was supported by the Medical Research Council, UK; the Wellcome Trust, UK; the National Institute for Health Research Biomedical Research Centre funding scheme; the Thailand Tropical Disease Research Program T2; and the Thailand National Centre for Genetic Engineering and Biotechnology.