Neuropharmacological specificity of brain structures involved in soman-induced seizures

NeuroToxicology

Volumn 33, Issue 3, 2012, Pages 463-468

  Skovira, Jacob W ^a   Shih, Tsung Ming ^a   McDonough, John H ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Anticonvulsant; Brain areas; Midazolam; MK 801; Nerve agents; Rats; Scopolamine; Seizures; Soman

Indexed keywords

DIZOCILPINE; MIDAZOLAM; SCOPOLAMINE; SOMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG INDUCED DISEASE; DRUG SPECIFICITY; ENTORHINAL CORTEX; MALE; NEUROANATOMY; NEUROMODULATION; NEUROTOXICITY; NONHUMAN; PERIRHINAL CORTEX; PRIORITY JOURNAL; RAT; SEIZURE; STATISTICAL ANALYSIS; THALAMUS;

ANIMALS; ANTICONVULSANTS; BRAIN; BRAIN MAPPING; CHEMICAL WARFARE AGENTS; CHOLINERGIC ANTAGONISTS; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MIDAZOLAM; RATS; RATS, SPRAGUE-DAWLEY; SCOPOLAMINE HYDROBROMIDE; SEIZURES; SOMAN;

ANIMALIA; RATTUS;

EID: 84861189228     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2012.03.006     Document Type: Article

References (42)

1. Bertram E.H., Zhang D., Williamson J.M. Multiple roles of midline dorsal thalamic nuclei in induction and spread of limbic seizures. Epilepsia 2008, 49(2):256-268.
2. Bertram E.H., Mangan P.S., Zhang D., Scott C.A., Williamson J.M. The midline thalamus: alterations and a potential role in limbic epilepsy. Epilepsia 2001, 42(8):967-978.
3. Bertram E.H., Scott C. The pathological substrate of limbic epilepsy: neuronal loss in the medial dorsal thalamic nucleus as the consistent change. Epilepsia 2000, 41(Suppl. 6):S3-S8.
4. Bertram E.H., Zhang D., Mangan P., Fountain N., Rempe D. Functional anatomy of limbic epilepsy: a proposal for central synchronization of diffusely hyperexcitable network. Epilepsy Research 1998, 32:194-205.
5. Braitman D.J., Sparenborg S. MK-801 protects against seizures induced by the cholinesterase inhibitor soman. Brain Research Bulletin 1989, 23:145-148.
6. Capacio B.R., Shih T.M. Anticonvulsant actions of anticholinergic drugs in soman poisoning. Epilepsia 1991, 32(5):604-615.
7. Denoyer M., Lallement G., Collet A., Pernot-Marino I., Sereno D., Blanchet G. Influence of medial septal cholinoceptive cells on c-Fos-like proteins induced by soman. Brain Research 1992, 592:157-162.
8. Dixon W., Massey F. Introduction to statistical analysis 1983, Mcgraw-Hill, New York, p. 426-441.
9. Dorandeu F., Carpentier P., Baubichon D., Four E., Bernabé Burckhart M-F., Lallement G. Efficacy of the ketamine-atropine combination in the delayed treatment of soman-induced status epilepticus. Brain Research 2005, 1051:164-175.
10. Fukumoto S.I., Tanaka S., Tojo H., Akaike K., Takigawa M. Perirhinal cortical lesion suppresses the secondary generalization in kainic acid-induced limbic seizure. Psychiatry and Clinical Neurosciences 2002, 56:561-567.
11. Gale K. Subcortical structures and pathways involved in convulsive seizure generation. Journal of Clinical Neurophysiology 1992, 9(2):264-322.
12. Groenewegen H.J. Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography. Neuroscience 1988, 24(2):379-431.
13. Guarisco J.A., Shih T.-M., Kan R., McDonough J.H. Evaluation of delayed treatment with novel nerve agent anticonvulsants and their effects on brain neurotransmitters in a rat model. The Toxicologist 2009, 108(1):111.
14. Kelly M.E., McIntyre D.C. Perirhinal cortex involvement in limbic kindled seizures. Epilepsy Research 1996, 26:233-243.
15. Lallement G., Pernot-Marino I., Baubichon D., Burckhart M.F., Carpentier P., Blanchet G. Modulation of soman-induced neuropathology with an anticonvulsant regimen. Neuroreport 1994, 5(17):2265-2268.
16. Lallement G., Carpentier P., Collet A., Pernot-Marino I., Baubichon D., Blanchet G. Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus. Brain Research 1991, 563:234-240.
17. Löscher W., Ebert U. Basic mechanisms of seizure propagation: targets for rational drug design and rational polypharmacy. Epilepsy Research Supplement 1996, 11:17-43.
18. McDonough J.H., Clark T.R., Slone T.W., Zoeffel D., Brown K., Kim S., et al. Neural lesions in the rat and their relationship to EEG delta activity following seizures induced by nerve agent soman. Neurotoxicology 1998, 19(3):381-392.
19. McDonough J.H., Shih T.M. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neuroscience and Behavioral Reviews 1997, 21(5):559-579.
20. McDonough J.H., Dochterman L.W., Smith C.D., Shih T.M. Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment. Neurotoxicology 1995, 15(1):123-132.
21. McDonough J.H., Shih T.M. Pharmacological modulation of soman-induced seizures. Neuroscience and Behavioral Reviews 1993, 17:203-215.
22. McDonough J.H., McLeod C.G., Nipwoda M.T. Direct microinjection of soman or VX into the amygdala produces repetitive limbic convulsions and neuropathology. Brain Research 1987, 435:123-137.
23. McIntyre D.C., Gilby K.L. Mapping seizure pathways in the temporal lobe. Epilepsia 2008, 49(Suppl. 3):23-30.
24. McIntyre D.C., Kelly M.E., Armstrong J.N. Kindling in the perirhinal cortex. Brain Research 1993, 615(1):1-6.
25. Myhrer T. Identification of neuronal target areas for nerve agents and specification of receptors for pharmacological treatment. Neurotoxicology 2010, 31:629-638.
26. Myhrer T., Enger S., Aas P. Roles of perirhinal and posterior corticies in control and generation of seizures: a microinfusion study in rats exposed to soman. Neurotoxicology 2010, 31:147-153.
27. Myhrer T., Enger S., Aas P. Anticonvulsant impact of lesions in the ventrolateral forebrain of rats challenged with soman. Brain Research 2008, 1226:241-247.
28. Myhrer T., Aas P. Anticonvulsant efficacy of drugs with cholinergic and/or glutamatergic antagonism microinfused into area tempestas of rats exposed to soman. Neurochemical Research 2008, 33:348-354.
29. Myhrer T. Neuronal structures involved in the induction and propagation of seizures caused by nerve agents: implications for medical treatment. Toxicology 2007, 239:1-14.
30. Myhrer T., Enger S., Aas P. Anticonvulsant effects of damage to structures involved in seizure induction in rats exposed to soman. Neurotoxicology 2007, 28:819-828.
31. Myhrer T., Nguyen N.H.T., Enger S., Aas P. Anticonvulsant effects of GABAA modulators microinfused into area tempestas or substantia nigra in rats exposed to soman. Archives of Toxicology 2006, 80:502-507.
32. Patel S., Millan M.H., Meldrum B.S. Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats. Experimental Neurology 1988, 101:63-74.
33. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 2005, Academic Press, Harcourt Brace Jovanovich, Australia.
34. Shih T.M., Duniho S.M., McDonough J.H. Control of nerve agent-induced seizures is critical for neuroprotection and survival. Toxicology and Applied Pharmacology 2003, 188:69-80.
35. Shih T., McDonough J.H., Koplovitz I. Anticonvulsants for soman-induced seizure activity. Journal of Biomedical Science 1999, 6(2):86-96.
36. Shih T.M. Anticonvulsant effects of diazepam and MK-801 in soman poisoning. Epilepsia Research 1990, 7:105-116.
37. Shih T.M., Koviak T.A., Capacio B.R. Anticonvulsants for poisoning by the organophosphorous compound soman: pharmacological mechanisms. Neuroscience and Behavioral Reviews 1991, 15:349-362.
38. Skovira J.W., McDonough J.H., Shih T.M. Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801. Journal of Molecular Neuroscience 2010, 40(1-2):56-62.
39. Wade J.V., Samson F.E., Nelson S.R., Pazdernik T.L. Changes in extracellular amino acids during soman- and kainic acid-induced seizures. Journal of Neurochemistry 1987, 49(2):645-650.
40. 14C-2-deoxyglucose uptake and fos immunochemistry. Journal of Neuroscience 1993, 13(11):4787-4801.
41. White L.E., Price J.L. The functional anatomy of limbic status epilepticus in the rat. II. The effects of focal deactivation. The Journal of Neuroscience 1993, 13(11):4810-4830.
42. Zimmer L.A., Ennis M., el-Etri M., Shipley M.T. Anatomical localization and time course of fos expression following soman-induced seizures. Journal of Comparative Neurology 1997, 378(4):468-481.