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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 11, 2012, Pages 3786-3790

Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors

(9) Rew, Yosup a Degraffenreid, Michael a He, Xiao a Jaen, Juan C a,b McMinn, Dustin L a Sun, Daqing a Tu, Hua a Ursu, Stefania a Powers, Jay P a,b

a AMGEN INC (United States)

b ChemoCentryx Inc (United States)

Author keywords

11 Hydroxysteroid dehydrogenase type 1 (11 HSD1) inhibitor; Benzenesulfonanilide

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ORGANOLEAD COMPOUND; OXIDOREDUCTASE INHIBITOR; PIPERAZINE DERIVATIVE; SULFONAMIDE; SULFUR ACID DERIVATIVE;

ARTICLE; DRUG SCREENING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANILIDES; ANILINE COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; MOLECULAR CONFORMATION; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRANSFECTION;

EID: 84861188548 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.04.005 Document Type: Article

Times cited : (7)

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