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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 23, 2010, Pages 7071-7075

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors

(21) Yan, Xuelei a Wang, Zhulun a Sudom, Athena a Cardozo, Mario a Degraffenreid, Michael a Di, Yongmei a Fan, Pingchen a He, Xiao a Jaen, Juan C a Labelle, Marc a Liu, Jinsong a Ma, Ji a McMinn, Dustin a Miao, Shichang a Sun, Daqing a Tang, Liang a Tu, Hua a Ursu, Stefania a Walker, Nigel a Ye, Qiuping a Powers, Jay P a more..

a AMGEN INC (United States)

Author keywords

11 HSD1; 11 HSD2; Diabetes; Diarylsulfones; Hydroxysteroid dehydrogenase; Metabolic syndrome

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; DIARYLSULFONE DERIVATIVE; ENZYME INHIBITOR; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; MONKEY; MOUSE; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; ENZYME INHIBITORS; HUMANS; PHARMACOKINETICS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

PRIMATES;

EID: 78149282518 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.09.097 Document Type: Article

Times cited : (17)

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- 1H NMR, HPLC, and MS data in full agreement with their proposed structures
- 1H NMR, HPLC, and MS data in full agreement with their proposed structures.

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