Design, synthesis and biological evaluation of potent NAD +-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 11, 2012, Pages 3693-3698

  Gu, Wenxin ^a   Wang, Tiansheng ^a   Maltais, Francois ^a   Ledford, Brian ^a   Kennedy, Joseph ^a   Wei, Yunyi ^a   Gross, Christian H ^a   Parsons, Jonathan ^a   Duncan, Leonard ^a   Ryan Arends, S J ^a   Moody, Cameron ^a   Perola, Emanuele ^a   Green, Jeremy ^a   Charifson, Paul S ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

Aminoalkoxypyrimidine carboxamide; Antibacterial; Crystal structures; MIC; NAD+ DNA ligase

Indexed keywords

2 6 AMINOALKOXYPYRIMIDINE CARBOXYAMIDE; AMIDE; ANTIINFECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RIBOSE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; SUBSTITUTION REACTION;

AMIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DNA LIGASES; DRUG DESIGN; ENTEROCOCCUS FAECALIS; ENZYME INHIBITORS; HUMANS; MICROBIAL SENSITIVITY TESTS; NAD; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 84861183874     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.037     Document Type: Article

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