Asthmatic airway smooth muscle CXCL10 production: Mitogen-activated protein kinase JNK involvement

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 10, 2012, Pages

  Alrashdan, Yazan A ^a   Alkhouri, Hatem ^a   Chen, Emily ^a   Lalor, Daniel J ^a   Poniris, Maree ^a,b   Henness, Sheridan ^a   Brightling, Christopher E ^c   Burgess, Janette K ^a,b   Armour, Carol L ^a   Ammit, Alaina J ^a   Hughes, J Margaret ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

ERK; IFN inducible protein 10; mRNA levels and stability; NK B; p38

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

AIRWAY; ARTICLE; ASTHMA; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GROWTH DISORDER; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MAST CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE;

ASTHMA; CELL MOVEMENT; CHEMOKINE CXCL10; GENE EXPRESSION; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; MAP KINASE KINASE 4; MAST CELLS; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RESPIRATORY SYSTEM; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84861175829     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00232.2011     Document Type: Article

References (32)

1. Amin K, Janson C, Boman G, Venge P. The extracellular deposition of mast cell products is increased in hypertrophic airway smooth muscles in allergic asthma but not in non-allergic asthma. Allergy 60: 1241-1247, 2005.
2. Baraket M, Oliver BG, Burgess JK, Dibas S, Black JL, Lim S. Relationship between alveolar macrophage derived GM-CSF, IL-1β0, airway hyperresponsiveness and exhaled nitric oxide in asthmatic volunteers. Proc Am Thorac Soc 3: A485, 2006.
3. Begueret H, Berger P, Vernejoux JM, Dubuisson L, Marthan R, Tunon-de-Lara JM. Inflammation of bronchial smooth muscle in allergic asthma. Thorax 62: 8-15, 2007.
4. Bochner B, Hudson S, Xiao H, Liu MC. Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions. J Allergy Clin Immunol 112: 930-934, 2003.
5. Brightling CE, Ammit A, Kaur D, Black JL, Wardlaw AJ, Hughes JM, Bradding P. The chemokine CXCL10 (IP-10) mediates mast cell migration into the asthmatic airway smooth muscle bundle. Am J Respir Crit Care Med 171: 1103-1108, 2005.
6. Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. Mast cell infiltration of airway smooth muscle in asthma. N Engl J Med 346: 1699-1705, 2002.
7. Carroll NG, Muyavdzic S, James AL. Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 19: 879-885, 2002.
8. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
9. Clarke DL, Clifford RL, Jindarat S, Proud D, Pang L, Belvisi M, Knox AJ. TNF-αand IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB and the transcriptional coactivator CREB-binding protein. J Biol Chem 285: 29101-29110, 2010.
10. Delgado M. Inhibition of interferon (IFN)γ-induced Jak-STAT1 activation in microglia by vasoactive intestinal peptide. J Biol Chem 278: 27620-27629, 2003.
11. Fukakusa M, Bergeron C, Tulic MK, Fiset MO, Al Dewachi O, Laviolette M, Hamid Q, Chakir J. Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-g-inducible protein expression in asthmatic airway mucosa. J Allergy Clin Immunol 115: 280-286, 2005.
12. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. NHLBI/WHO Workshop Report. Publication No 02-3659. Bethesda, MD: National Institutes of Health, National Health, Lung and Blood Institute, 2003.
13. Hardaker EL, Bacon AM, Carlson K, Roshak AK, Foley JJ, Schmidt DB, Buckley PT, Comegys M, Panettieri RA, Sarau HM, Belmonte KE. Regulation of TNF-α-and IFN-γ-induced CXCL10 expression. FASEB J 18: 191-193, 2004.
14. Issa R, Xie S, Lee KY, Stanbridge RD, Bhavsar P, Sukkar MB, Chung KF. GRO-αregulation in airway smooth muscle by IL-1β and TNF-α:Role of NF-κB and MAP kinases. Am J Physiol Lung Cell Mol Physiol 291: L66-L74, 2006.
15. John AE, Zhu YM, Brightling CE, Pang L, Knox AJ. Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter. J Immunol 183: 4682-4692, 2009.
16. John M, Hirst SJ, Jose PJ, Robichaud A, Berkman N, Witt C, Twort CH, Barnes PJ, Chung KF. Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids. J Immunol 158: 1841-1847, 1997.
17. Johnson PRA, Roth M, Tamm M, Hughes JM, Ge Q, King G, Burgess JK, Black JL. Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 164: 474-477, 2001.
18. Ko FW, Diba C, Roth M, McKay K, Johnson PR, Salome C, King GG. A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with mucus hypersecretion. Chest 127: 1919-1927, 2005.
19. Lalor DJ, Truong B, Henness S, Blake AE, Ge Q, Ammit AJ, Armour CL, Hughes JM. Mechanisms of serum potentiation of GM-CSF production by human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 287: L1007-L1016, 2004.
20. Medoff BD, Sauty A, Tager AM, Maclean JA, Smith RN, Mathew A, Dufour JH, Luster AD. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol 168: 5278-5286, 2002.
21. Miotto D, Christodoulopoulos P, Olivenstein R, Taha R, Cameron L, Tsicopoulos A, Tonnel AB, Fahy O, Lafitte JJ, Luster AD, Wallaert B, Mapp CE, Hamid Q. Expression of IFN-(gamma)-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in T(H)1-and T(H)2-mediated lung diseases. J Allergy Clin Immunol 107: 664-670, 2001.
22. Pilette C, Francis JN, Till SJ, Durham SR. CCR4 ligands are upregulated in the airways of atopic asthmatics after segmental allergen challenge. Eur Respir J 23: 876-884, 2004.
23. Seidel P, Merfort I, Hughes JM, Oliver BG, Tamm M, Roth M. Dimethylfumarate inhibits NF-κB function at multiple levels to limit airway smooth muscle cell cytokine secretion. Am J Physiol Lung Cell Mol Physiol 297: L326-L339, 2009.
24. Seidel P, Merfort I, Tamm M, Roth M. Inhibition of NF-κB and AP-1 by dimethylfumarate correlates with down-regulated IL-6 secretion and proliferation in human lung fibroblasts. Swiss Med Wkly 140: w13132, 2010.
25. Seidel P, Roth M, Ge Q, Merfort I, S'ng CT, Ammit A. I B-glutathionylation and reduced histone H3 phosphorylation inhibit eotaxin and RANTES. Eur Respir J 38: 1444-1452, 2011.
26. Shen Q, Zhang R, Bhat NR. MAP kinase regulation of CXCL10/CXCL10 chemokine gene expression in microglial cells. Brain Res 1086: 9-16, 2006.
27. Spurrell JC, Wiehler S, Zaheer RS, Sanders SP, Proud D. Human airway epithelial cells produce CXCL10 (CXCL10) in vitro and in vivo upon rhinovirus infection. Am J Physiol Lung Cell Mol Physiol 289: L85-L95, 2005.
28. Sukkar MB, Issa R, Xie S, Olymanns U, Newton R, Chung KF. Fractalkine/CX3CL1 production by human airway smooth muscle cells: induction by IFN-γ and TNF-alpha; and regulation by TGF-β and corticosteroids. Am J Physiol Lung Cell Mol Physiol 287: L1230-L1240, 2004.
29. Tan X, Khalil N, Tesarik C, Vanapalli K, Yaputra V, Alkhouri V, Oliver BGG, Armour CL, Hughes JM. Th1 cytokine-induced syndecan-4 shedding by airway smooth muscle cells is dependent on mitogen-activated protein kinases. Am J Physiol Lung Cell Mol Physiol. First published January 20, 2012; doi: 10.1152/ajplung.00167.2011.
30. Tliba O, Cidlowski JA, Amrani Y. CD38 expression is insensitive to steroid action in cells treated with tumour necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform. Mol Pharmacol 69: 588-596, 2006.
31. Vandermeeren M, Janssens S, Wouters H, Borghmans I, Borgers M, Beyaert R, Geysen J. Dimethylfumarate is an inhibitor of cytokineinduced nuclear translocation of NF-kappa B1, but not RelA in normal human dermal fibroblast cells. J Invest Dermatol 116: 124-130, 2001.
32. Wuyts WA, Vanaudenaerde BM, Dupont LJ, Demedts MG, Verleden GM. Involvement of p38 MAPK, JNK, p42/44 ERK and NF-kappaB in IL-1βbeta-induced chemokine release in human airway smooth muscle cells. Respir Med 97: 811-817, 2003.