The structural basis of DKK-mediated inhibition of Wnt/LRP signaling

Science Signaling

Volumn 5, Issue 224, 2012, Pages

  Bao, Ju ^a   Zheng, Jie J ^a   Wu, Dianqing ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DICKKOPF 1 PROTEIN; EPIDERMAL GROWTH FACTOR; FRIZZLED PROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; WNT3A PROTEIN; WNT9B PROTEIN; DKK1 PROTEIN, HUMAN; LRP5 PROTEIN, HUMAN; LRP6 PROTEIN, HUMAN; SIGNAL PEPTIDE; WNT PROTEIN;

AMINO TERMINAL SEQUENCE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; BONE MASS; CRYSTAL STRUCTURE; DEGENERATIVE DISEASE; DIMERIZATION; GLUCOSE METABOLISM; HOMEOSTASIS; HUMAN; LIGAND BINDING; LIPID METABOLISM; MUTAGENESIS; NEOPLASM; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW; STEM CELL; WNT SIGNALING PATHWAY; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION;

HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MODELS, MOLECULAR; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84861165397     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003028     Document Type: Review

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