메뉴 건너뛰기




Volumn 8, Issue 3, 2012, Pages 183-190

Telmisartan in the management of diabetic nephropathy: A contemporary view

Author keywords

AT 1receptor blockade; Diabetic nephropathy; PPAR partial agonism; Renoprotection; Telmisartan

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; C REACTIVE PROTEIN; ENALAPRIL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SUPEROXIDE DISMUTASE; TELMISARTAN;

EID: 84861159160     PISSN: 15733998     EISSN: 18756417     Source Type: Journal    
DOI: 10.2174/157339912800563972     Document Type: Review
Times cited : (24)

References (82)
  • 1
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimated for the year 2000 and projection of 2030
    • Wild S, Roqlic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimated for the year 2000 and projection of 2030. Diabetes Care 2004; 27: 1047-53.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roqlic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 2
    • 2442719209 scopus 로고    scopus 로고
    • Chronic complications and risk factors in patients with type 1 diabetes mellitus-retrospective analysis
    • Kozek E, Górska A, Fross K, Marcinowska A, Citkowska A, Sieradzki J. Chronic complications and risk factors in patients with type 1 diabetes mellitus-retrospective analysis. Przegl Lek 2003; 60: 773-7.
    • (2003) Przegl Lek , vol.60 , pp. 773-777
    • Kozek, E.1    Górska, A.2    Fross, K.3    Marcinowska, A.4    Citkowska, A.5    Sieradzki, J.6
  • 3
    • 67349117682 scopus 로고    scopus 로고
    • Recent advances in pharmacotherapy for diabetic nephropathy: Current perspectives and future directions
    • Balakumar P, Arora MK, Ganti SS, Reddy J, Singh M. Recent advances in pharmacotherapy for diabetic nephropathy: current perspectives and future directions. Pharmacol Res 2009; 60: 24-32.
    • (2009) Pharmacol Res , vol.60 , pp. 24-32
    • Balakumar, P.1    Arora, M.K.2    Ganti, S.S.3    Reddy, J.4    Singh, M.5
  • 4
    • 55249114365 scopus 로고    scopus 로고
    • Diabetic Nephropathy: Important pathophysiologic mechanisms
    • Soldatos G, Cooper ME. Diabetic Nephropathy: important pathophysiologic mechanisms. Diabetic Res Clin Pract 2008; 82: S75-9.
    • (2008) Diabetic Res Clin Pract , vol.82
    • Soldatos, G.1    Cooper, M.E.2
  • 6
    • 34250361947 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of proteinuria in diabetic nephropathy
    • Wolf G, Ziyadeh FN. Cellular and molecular mechanisms of proteinuria in diabetic nephropathy. Nephron Physiol 2007; 106: 26-31.
    • (2007) Nephron Physiol , vol.106 , pp. 26-31
    • Wolf, G.1    Ziyadeh, F.N.2
  • 7
    • 37549035027 scopus 로고    scopus 로고
    • Diabetic nephropathy: Mechanisms of renal disease progression
    • Kanwar YS, Wada J, Sun L, et al. Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med (Maywood) 2008; 233: 4-11.
    • (2008) Exp Biol Med (Maywood) , vol.233 , pp. 4-11
    • Kanwar, Y.S.1    Wada, J.2    Sun, L.3
  • 9
    • 78649362445 scopus 로고    scopus 로고
    • Cardiovascular and renal pathologic implications of prorenin, renin, and the (pro)renin receptor: Promising young players from the old renin-angiotensin-aldosterone system
    • Balakumar P, Jagadeesh G. Cardiovascular and renal pathologic implications of prorenin, renin, and the (pro)renin receptor: promising young players from the old renin-angiotensin-aldosterone system. J Cardiovasc Pharmacol 2010; 56: 570-9.
    • (2010) J Cardiovasc Pharmacol , vol.56 , pp. 570-579
    • Balakumar, P.1    Jagadeesh, G.2
  • 10
    • 2442680120 scopus 로고    scopus 로고
    • Proteinuria, a target for renoprotection in patient with type 2 diabetic nephropathy: Lessons from RENAAL
    • de Zeeuw D, Remuzzi G, Parving HH, et al. Proteinuria, a target for renoprotection in patient with type 2 diabetic nephropathy: lessons from RENAAL. Kidney Int 2004; 65: 2309-20.
    • (2004) Kidney Int , vol.65 , pp. 2309-2320
    • de Zeeuw, D.1    Remuzzi, G.2    Parving, H.H.3
  • 11
    • 74249096576 scopus 로고    scopus 로고
    • Pathogenesis of diabetic nephropathy: Involvement of multifaceted signalling mechanism
    • Balakumar P, Arora MK, Reddy J, Anand-Srivastava MB. Pathogenesis of diabetic nephropathy: involvement of multifaceted signalling mechanism. J Cardiovasc Pharmacol 2009; 54: 129-38.
    • (2009) J Cardiovasc Pharmacol , vol.54 , pp. 129-138
    • Balakumar, P.1    Arora, M.K.2    Reddy, J.3    Anand-Srivastava, M.B.4
  • 12
    • 73349120559 scopus 로고    scopus 로고
    • Do resident renal mast cells play a role in the pathogenesis of diabetic nephropathy?
    • Balakumar P, Reddy J, Singh M. Do resident renal mast cells play a role in the pathogenesis of diabetic nephropathy? Mol Cell Biochem 2009; 330: 187-92.
    • (2009) Mol Cell Biochem , vol.330 , pp. 187-192
    • Balakumar, P.1    Reddy, J.2    Singh, M.3
  • 13
    • 80052269271 scopus 로고    scopus 로고
    • Does microvascular disease predict macrovascular events in type 2 diabetes?
    • Rosenson RS, Fioretto P, Dodson PM. Does microvascular disease predict macrovascular events in type 2 diabetes? Atherosclerosis 2011; 218: 13-8.
    • (2011) Atherosclerosis , vol.218 , pp. 13-18
    • Rosenson, R.S.1    Fioretto, P.2    Dodson, P.M.3
  • 15
    • 77955058990 scopus 로고    scopus 로고
    • Renin angiotensin aldosterone system (RAAS) inhibitors in the prevention of early renal disease in diabetes
    • Gnudi L, Goldsmith D. Renin angiotensin aldosterone system (RAAS) inhibitors in the prevention of early renal disease in diabetes. F1000 Med Rep 2010; 2. pii: 18.
    • (2010) F1000 Med Rep , vol.2
    • Gnudi, L.1    Goldsmith, D.2
  • 17
    • 77954503845 scopus 로고    scopus 로고
    • Diabetes, cardiovascular risk and nephropathy
    • Hahr AJ, Molitch ME. Diabetes, cardiovascular risk and nephropathy. Cardiol Clin 2010; 28: 467-75.
    • (2010) Cardiol Clin , vol.28 , pp. 467-475
    • Hahr, A.J.1    Molitch, M.E.2
  • 18
    • 79958719334 scopus 로고    scopus 로고
    • The role of angiotensin receptor blockers in diabetic nephropathy
    • Sharma AM, Weir MR. The role of angiotensin receptor blockers in diabetic nephropathy. Postgrad Med 2011; 123: 109-21.
    • (2011) Postgrad Med , vol.123 , pp. 109-121
    • Sharma, A.M.1    Weir, M.R.2
  • 19
    • 8544251308 scopus 로고    scopus 로고
    • Telmisartan - killing two birds with one stone
    • Doggrell SA. Telmisartan - killing two birds with one stone. Expert Opin Pharmacother 2004; 5: 2397-400.
    • (2004) Expert Opin Pharmacother , vol.5 , pp. 2397-2400
    • Doggrell, S.A.1
  • 20
    • 79952654623 scopus 로고    scopus 로고
    • Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1-7) mas receptor expression associated with its PPAR-γ agonist action
    • Lakshmanan AP, Watanabe K, Thandavarayan RA, et al. Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1-7) mas receptor expression associated with its PPAR-γ agonist action. Free Radic Res 2011; 45: 575-84.
    • (2011) Free Radic Res , vol.5 , pp. 75-84
    • Lakshmanan, A.P.1    Watanabe, K.2    Thandavarayan, R.A.3
  • 22
    • 24944463413 scopus 로고    scopus 로고
    • Angiotensin-receptor blocking agent and peroxisome proliferator-activated receptor-gamma system
    • Tuck ML. Angiotensin-receptor blocking agent and peroxisome proliferator-activated receptor-gamma system. Curr Hypertens Rep 2005; 7: 240-3.
    • (2005) Curr Hypertens Rep , vol.7 , pp. 240-243
    • Tuck, M.L.1
  • 23
    • 77955477023 scopus 로고    scopus 로고
    • Telmisartan ameliorates hyperglycemia and metabolic profile in non obese Cohen-Rosenthal diabetic hypertensive rats via peroxisome proliferator activated receptor-gamma activation
    • Younis F, Stern N, Limor R, Oron Y Zanqen S, Rosenthal T. Telmisartan ameliorates hyperglycemia and metabolic profile in non obese Cohen-Rosenthal diabetic hypertensive rats via peroxisome proliferator activated receptor-gamma activation. Metabolism 2010; 59: 1200-9.
    • (2010) Metabolism , vol.59 , pp. 1200-1209
    • Younis, F.1    Stern, N.2    Limor, R.3    Oron, Y.4    Zanqen, S.5    Rosenthal, T.6
  • 24
    • 1542547460 scopus 로고    scopus 로고
    • Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
    • Benson SC, Pershadsingh HA, Ho CI, et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension 2004; 43: 993-1002.
    • (2004) Hypertension , vol.43 , pp. 993-1002
    • Benson, S.C.1    Pershadsingh, H.A.2    Ho, C.I.3
  • 25
    • 74949135696 scopus 로고    scopus 로고
    • Telmisartan: A different angiotensin II receptor blocker protecting a different population?
    • Burnier M. Telmisartan: a different angiotensin II receptor blocker protecting a different population? J Int Med Res 2009; 37: 1662-79.
    • (2009) J Int Med Res , vol.37 , pp. 1662-1679
    • Burnier, M.1
  • 26
    • 73549106828 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor-alpha-induced interleukin-6 expression by telmisartan through cross-talk of peroxisome proliferator-activated receptorgamma with nuclear factor kappaB and CCAAT/enhancer-binding protein-beta
    • Tian Q, Miyazaki R, Ichiki T, et al. Inhibition of tumor necrosis factor-alpha-induced interleukin-6 expression by telmisartan through cross-talk of peroxisome proliferator-activated receptorgamma with nuclear factor kappaB and CCAAT/enhancer-binding protein-beta. Hypertension 2009; 53:798-804.
    • (2009) Hypertension , vol.53 , pp. 798-804
    • Tian, Q.1    Miyazaki, R.2    Ichiki, T.3
  • 27
    • 0035295819 scopus 로고    scopus 로고
    • Comparative antihypertensive and renoprotective effect of telmisartan and lisinopril after long term treatment in hypertensive diabetic rats
    • Wienen W, Richard S, Champeroux P, Audeval-Gerard C. Comparative antihypertensive and renoprotective effect of telmisartan and lisinopril after long term treatment in hypertensive diabetic rats. J Renin Angiotensin Aldosterone Syst 2001; 2:31-6.
    • (2001) J Renin Angiotensin Aldosterone Syst , vol.2 , pp. 31-36
    • Wienen, W.1    Richard, S.2    Champeroux, P.3    Audeval-Gerard, C.4
  • 28
    • 48949118159 scopus 로고    scopus 로고
    • Telmisartan is more effective than losartan in reducing proteinuria in patients with diabetic nephropathy
    • AMADEO Study Investigators
    • Bakris G, Burgess E, Weir M, Davidai G, Koval S; AMADEO Study Investigators. Telmisartan is more effective than losartan in reducing proteinuria in patients with diabetic nephropathy. Kidney Int 2008; 74: 364-9.
    • (2008) Kidney Int , vol.74 , pp. 364-369
    • Bakris, G.1    Burgess, E.2    Weir, M.3    Davidai, G.4    Koval, S.5
  • 29
    • 79959372114 scopus 로고    scopus 로고
    • Telmisartan provides better renal protection than valsartan in a rat model of metabolic syndrome
    • Khan AH, Imig JD. Telmisartan provides better renal protection than valsartan in a rat model of metabolic syndrome. Am J Hypertens 2011; 24: 816-21.
    • (2011) Am J Hypertens , vol.24 , pp. 816-821
    • Khan, A.H.1    Imig, J.D.2
  • 30
    • 79952670636 scopus 로고    scopus 로고
    • Clinical effectiveness of telmisartan alone or in combination therapy for controlling blood pressure and vascular risk in the elderly
    • Jugdutt BI. Clinical effectiveness of telmisartan alone or in combination therapy for controlling blood pressure and vascular risk in the elderly. Clin Interv Aging 2010; 5: 403-16.
    • (2010) Clin Interv Aging , vol.5 , pp. 403-416
    • Jugdutt, B.I.1
  • 31
    • 34347333419 scopus 로고    scopus 로고
    • PPAR ligands: Are they potential agent for cardiovascular disorders?
    • Balakumar P, Rose M, Singh M. PPAR ligands: are they potential agent for cardiovascular disorders? Pharmacology 2007; 80: 1-10.
    • (2007) Pharmacology , vol.80 , pp. 1-10
    • Balakumar, P.1    Rose, M.2    Singh, M.3
  • 33
    • 0027218706 scopus 로고
    • Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277
    • Wienen W, Hauel N, Van Meel JC, Narr B, Ries U, Entzeroth M. Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Br J Pharmacol 1993; 110: 245-52.
    • (1993) Br J Pharmacol , vol.110 , pp. 245-252
    • Wienen, W.1    Hauel, N.2    van Meel, J.C.3    Narr, B.4    Ries, U.5    Entzeroth, M.6
  • 34
    • 0033220662 scopus 로고    scopus 로고
    • Pharmacological properties of angiotensin II receptor antagonists
    • Timmermans PB. Pharmacological properties of angiotensin II receptor antagonists. Can J Cardiol 1999; 15: 26F-8F.
    • (1999) Can J Cardiol , vol.15
    • Timmermans, P.B.1
  • 35
    • 0035070563 scopus 로고    scopus 로고
    • The comparative pharmacology of angiotensin II receptor antagonists
    • Burnier M, Maillard M. The comparative pharmacology of angiotensin II receptor antagonists. Blood Press Suppl 2001; 1: 6-11.
    • (2001) Blood Press Suppl , vol.1 , pp. 6-11
    • Burnier, M.1    Maillard, M.2
  • 37
    • 78650882616 scopus 로고    scopus 로고
    • Unique "delta lock" structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor
    • Ohno K, Amano Y, Kakuta H, et al. Unique "delta lock" structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor. Biochem Biophys Res Commun 2011; 404: 434-7.
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 434-437
    • Ohno, K.1    Amano, Y.2    Kakuta, H.3
  • 38
    • 0033840660 scopus 로고    scopus 로고
    • Pharmacokinetics of orally and intravenously administered telmisartan in healthy young and elderly volunteers and in hypertensive patients
    • Stangier J, Su CA, Roth W. Pharmacokinetics of orally and intravenously administered telmisartan in healthy young and elderly volunteers and in hypertensive patients. J Int Med Res 2000; 28: 149-67.
    • (2000) J Int Med Res , vol.28 , pp. 149-167
    • Stangier, J.1    Su, C.A.2    Roth, W.3
  • 40
    • 0033749163 scopus 로고    scopus 로고
    • Pharmacokinetics of singledose telmisartan 120 mg given during and between hemodialysis in subjects with severe renal insufficiency: Comparison with healthy volunteers
    • Stangier J, Su CA, Brickl R, Franke H. Pharmacokinetics of singledose telmisartan 120 mg given during and between hemodialysis in subjects with severe renal insufficiency: Comparison with healthy volunteers. J Clin Pharmacol 2000; 40: 1365-72.
    • (2000) J Clin Pharmacol , vol.40 , pp. 1365-1372
    • Stangier, J.1    Su, C.A.2    Brickl, R.3    Franke, H.4
  • 41
    • 85009545147 scopus 로고    scopus 로고
    • Population pharmacokinetics of an angiotensin II receptor antagonist, telmisartan, in healthy volunteers and hypertensive patients
    • Tatami S, Sarashina A, Yamamura N, Igarashi T, Tanigawara Y. Population pharmacokinetics of an angiotensin II receptor antagonist, telmisartan, in healthy volunteers and hypertensive patients. Drug Metab Pharmacokinet 2003; 18: 203-11.
    • (2003) Drug Metab Pharmacokinet , vol.18 , pp. 203-211
    • Tatami, S.1    Sarashina, A.2    Yamamura, N.3    Igarashi, T.4    Tanigawara, Y.5
  • 42
    • 25844490022 scopus 로고    scopus 로고
    • Significance of angiotensin II receptor blocker lipophilicities and their protective effect against vascular remodeling
    • Takai S, Kirimura K, Jin D, et al. Significance of angiotensin II receptor blocker lipophilicities and their protective effect against vascular remodeling. Hypertens Res 2005; 28: 593-600.
    • (2005) Hypertens Res , vol.28 , pp. 593-600
    • Takai, S.1    Kirimura, K.2    Jin, D.3
  • 43
  • 44
    • 0036720461 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of the activity of telmisartan: An insurmountable angiotensin II receptor antagonist
    • Maillard MP, Perregaux C, Centeno C, et al. In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist. J Pharmacol Exp Ther 2002; 302: 1089-95.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 1089-1095
    • Maillard, M.P.1    Perregaux, C.2    Centeno, C.3
  • 46
    • 31444437343 scopus 로고    scopus 로고
    • Telmisartan: A review of its use in the management of hypertension
    • Battershill AJ, Scott LJ. Telmisartan: a review of its use in the management of hypertension. Drugs 2006; 66: 51-83.
    • (2006) Drugs , vol.66 , pp. 51-83
    • Battershill, A.J.1    Scott, L.J.2
  • 47
    • 2442451618 scopus 로고    scopus 로고
    • Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
    • Schupp M, Janke J, Clasen R, Unger T, Kintscher U. Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation 2004; 109: 2054-7.
    • (2004) Circulation , vol.109 , pp. 2054-2057
    • Schupp, M.1    Janke, J.2    Clasen, R.3    Unger, T.4    Kintscher, U.5
  • 48
    • 33748947293 scopus 로고    scopus 로고
    • Telmisartan downregulates angiotensin II type 1 receptorthrough activation of peroxisome proliferator- activated receptor gamma
    • Imayama I, Ichiki T, Inanaga K, et al. Telmisartan downregulates angiotensin II type 1 receptorthrough activation of peroxisome proliferator- activated receptor gamma. Cardiovasc Res 2006; 72: 184-90.
    • (2006) Cardiovasc Res , vol.72 , pp. 184-190
    • Imayama, I.1    Ichiki, T.2    Inanaga, K.3
  • 49
    • 33644672013 scopus 로고    scopus 로고
    • Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity
    • Schupp M, Clemenz M, Gineste R, et al. Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity. Diabetes 2005; 54: 3442-52.
    • (2005) Diabetes , vol.54 , pp. 3442-3452
    • Schupp, M.1    Clemenz, M.2    Gineste, R.3
  • 50
    • 0034951366 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease
    • Guan Y, Breyer MD. Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int 2001; 60: 14-30.
    • (2001) Kidney Int , vol.60 , pp. 14-30
    • Guan, Y.1    Breyer, M.D.2
  • 51
    • 33645470403 scopus 로고    scopus 로고
    • Preventing renal complications in type 2 diabetes: Results of the diabetics exposed to telmisartan and enalapril trial
    • Barnett A. Preventing renal complications in type 2 diabetes: results of the diabetics exposed to telmisartan and enalapril trial. J Am Soc Nephrol 2006; 17: S132-5.
    • (2006) J Am Soc Nephrol , vol.17
    • Barnett, A.1
  • 52
    • 51649094297 scopus 로고    scopus 로고
    • Effects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose intolerance
    • Makita S, Abiko A, Naganuma Y, Moriai Y, Nakamura M. Effects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose intolerance. Metabolism 2008; 57: 1473-8.
    • (2008) Metabolism , vol.57 , pp. 1473-1478
    • Makita, S.1    Abiko, A.2    Naganuma, Y.3    Moriai, Y.4    Nakamura, M.5
  • 53
    • 34547884217 scopus 로고    scopus 로고
    • Telmisartan, an angiotensin II type 1 receptor blocker, inhibits advanced glycation end-product (AGE)-induced monocyte chemoattractant protein-1 expression in mesangial cells through downregulation of receptor for AGEs via peroxisome proliferator-activated receptor-gamma activation
    • Matsui T, Yamagishi S, Ueda S, et al. Telmisartan, an angiotensin II type 1 receptor blocker, inhibits advanced glycation end-product (AGE)-induced monocyte chemoattractant protein-1 expression in mesangial cells through downregulation of receptor for AGEs via peroxisome proliferator-activated receptor-gamma activation. J Int Med Res 2007; 35: 482-9.
    • (2007) J Int Med Res , vol.35 , pp. 482-489
    • Matsui, T.1    Yamagishi, S.2    Ueda, S.3
  • 54
    • 42549146445 scopus 로고    scopus 로고
    • Oxidative stress and advanced glycation in diabetic nephropathy
    • Coughlan MT, Mibus AL, Forbes JM. Oxidative stress and advanced glycation in diabetic nephropathy. Ann N Y Acad Sci 2008; 1126: 190-3.
    • (2008) Ann N Y Acad Sci , vol.1126 , pp. 190-193
    • Coughlan, M.T.1    Mibus, A.L.2    Forbes, J.M.3
  • 55
    • 33750913676 scopus 로고    scopus 로고
    • Telmisartan inhibits AGE-induced C-reactive protein production through downregulation of the receptor for AGE via peroxisome proliferator-activated receptor-gamma activation
    • Yoshida T, Yamagishi S, Nakamura K, et al. Telmisartan inhibits AGE-induced C-reactive protein production through downregulation of the receptor for AGE via peroxisome proliferator-activated receptor-gamma activation. Diabetologia 2006; 49: 3094-9.
    • (2006) Diabetologia , vol.49 , pp. 3094-3099
    • Yoshida, T.1    Yamagishi, S.2    Nakamura, K.3
  • 56
    • 51449089179 scopus 로고    scopus 로고
    • Telmisartan inhibits advanced glycation end products (AGEs)- elicited endothelial cell injury by suppressing AGE receptor (RAGE) expression via peroxisome proliferator-activated receptorgamma activation
    • Yamagishi S, Matsui T, Nakamura K, Takeuchi M, Inoue H. Telmisartan inhibits advanced glycation end products (AGEs)- elicited endothelial cell injury by suppressing AGE receptor (RAGE) expression via peroxisome proliferator-activated receptorgamma activation. Protein Pept Lett 2008; 15: 850-3.
    • (2008) Protein Pept Lett , vol.15 , pp. 850-853
    • Yamagishi, S.1    Matsui, T.2    Nakamura, K.3    Takeuchi, M.4    Inoue, H.5
  • 58
    • 58049134293 scopus 로고    scopus 로고
    • Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat
    • Balakumar P, Chakkarwar VA, Singh M. Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat. Mol Cell Biochem 2009; 320: 149-62.
    • (2009) Mol Cell Biochem , vol.320 , pp. 149-162
    • Balakumar, P.1    Chakkarwar, V.A.2    Singh, M.3
  • 59
    • 78650522881 scopus 로고    scopus 로고
    • Endothelial dysfunction as a potential contributor in diabetic nephropathy
    • Nakagawa T, Tanabe K, Croker BP, et al. Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nat Rev Nephrol 2011; 7: 36-44.
    • (2011) Nat Rev Nephrol , vol.7 , pp. 36-44
    • Nakagawa, T.1    Tanabe, K.2    Croker, B.P.3
  • 60
    • 48449093231 scopus 로고    scopus 로고
    • AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats
    • Wenzel P, Schulz E, Oelze M, et al. AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats. Free Radic Biol Med 2008; 45: 619-26.
    • (2008) Free Radic Biol Med , vol.45 , pp. 619-626
    • Wenzel, P.1    Schulz, E.2    Oelze, M.3
  • 61
    • 82955188102 scopus 로고    scopus 로고
    • Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy
    • Fujita H, Sakamoto T, Komatsu K, et al. Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy. Hypertens Res 2011; 34: 1302-8.
    • (2011) Hypertens Res , vol.34 , pp. 1302-1308
    • Fujita, H.1    Sakamoto, T.2    Komatsu, K.3
  • 62
    • 23944456367 scopus 로고    scopus 로고
    • Effect of telmisartan on blood pressure control and kidney function in hypertensive, proteinuric patients with chronic kidney disease
    • For the Czech Group for the Study of Glomerulonephritis
    • Rysavá R, Tesar V, Merta M; for the Czech Group for the Study of Glomerulonephritis. Effect of telmisartan on blood pressure control and kidney function in hypertensive, proteinuric patients with chronic kidney disease. Blood Press Monit 2005; 10: 207-13.
    • (2005) Blood Press Monit , vol.10 , pp. 207-213
    • Rysavá, R.1    Tesar, V.2    Merta, M.3
  • 63
    • 33847729477 scopus 로고    scopus 로고
    • Potential protective effects of telmisartan on renal function deterioration
    • Remuzzi A, Remuzzi G. Potential protective effects of telmisartan on renal function deterioration. J Renin Angiotensin Aldosterone Syst 2006; 7: 185-91.
    • (2006) J Renin Angiotensin Aldosterone Syst , vol.7 , pp. 185-191
    • Remuzzi, A.1    Remuzzi, G.2
  • 64
    • 29444440258 scopus 로고    scopus 로고
    • The telmisartan renoprotective study from incipient nephropathy to overt nephropathy-- rationale, study design, treatment plan and baseline characteristics of the incipient to overt: Angiotensin II receptor blocker, telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATION) Study
    • Makino H, Haneda M, Babazono T, et al. The telmisartan renoprotective study from incipient nephropathy to overt nephropathy-- rationale, study design, treatment plan and baseline characteristics of the incipient to overt: angiotensin II receptor blocker, telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATION) Study. J Int Med Res 2005; 33: 677-86.
    • (2005) J Int Med Res , vol.33 , pp. 677-686
    • Makino, H.1    Haneda, M.2    Babazono, T.3
  • 65
    • 44649162402 scopus 로고    scopus 로고
    • Microalbuminuria reduction with telmisartan in normotensive and hypertensive Japanese patients with type 2 diabetes: A post-hoc analysis of The Incipient to Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATION) study
    • Makino H, Haneda M, Babazono T, et al. Microalbuminuria reduction with telmisartan in normotensive and hypertensive Japanese patients with type 2 diabetes: a post-hoc analysis of The Incipient to Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATION) study. Hypertens Res 2008; 31: 657-64.
    • (2008) Hypertens Res , vol.31 , pp. 657-664
    • Makino, H.1    Haneda, M.2    Babazono, T.3
  • 66
    • 52649110647 scopus 로고    scopus 로고
    • Antiproteinuric effects of angiotensin receptor blockers: Telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy
    • VIVALDI investigators
    • Galle J, Schwedhelm E, Pinnetti S, Böger RH, Wanner C, VIVALDI investigators. Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy. Nephrol Dial Transplant 2008; 23: 3174-83.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3174-3183
    • Galle, J.1    Schwedhelm, E.2    Pinnetti, S.3    Böger, R.H.4    Wanner, C.5
  • 67
    • 79953678422 scopus 로고    scopus 로고
    • Review of the AMADEO study: Reducing proteinuria in patients with diabetic nephropathy with telmisartan versus losartan. Commentary
    • Toth PP. Review of the AMADEO study: reducing proteinuria in patients with diabetic nephropathy with telmisartan versus losartan. Commentary. Postgrad Med 2010; 122: 165-8.
    • (2010) Postgrad Med , vol.122 , pp. 165-168
    • Toth, P.P.1
  • 68
    • 71049155309 scopus 로고    scopus 로고
    • Effects of angiotensin II type 1 receptor blocker on ambulatory blood pressure variability in hypertensive patients with overt diabetic nephropathy
    • Masuda S, Tamura K, Wakui H, et al. Effects of angiotensin II type 1 receptor blocker on ambulatory blood pressure variability in hypertensive patients with overt diabetic nephropathy. Hypertens Res 2009; 32: 950-5.
    • (2009) Hypertens Res , vol.32 , pp. 950-955
    • Masuda, S.1    Tamura, K.2    Wakui, H.3
  • 69
    • 67349188030 scopus 로고    scopus 로고
    • Emerging role of PPAR ligands in the management of diabetic nephropathy
    • Balakumar P, Arora MK, Singh M. Emerging role of PPAR ligands in the management of diabetic nephropathy. Pharmacol Res 2009; 60: 170-3.
    • (2009) Pharmacol Res , vol.60 , pp. 170-173
    • Balakumar, P.1    Arora, M.K.2    Singh, M.3
  • 70
    • 56949105387 scopus 로고    scopus 로고
    • Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats
    • Ko GJ, Kang YS, Han SY, et al. Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Nephrol Dial Transplant 2008; 23: 2750-60.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 2750-2760
    • Ko, G.J.1    Kang, Y.S.2    Han, S.Y.3
  • 71
    • 34147213227 scopus 로고    scopus 로고
    • Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation
    • Ohga S, Shikata K, Yozai K, et al. Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation. Am J Physiol Renal Physiol 2007; 292: F1141-50.
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Ohga, S.1    Shikata, K.2    Yozai, K.3
  • 72
    • 77952674092 scopus 로고    scopus 로고
    • The low dose combination of fenofibrate and rosiglitazone halts the progression of diabetesinduced experimental nephropathy
    • Arora MK, Reddy K, Balakumar P. The low dose combination of fenofibrate and rosiglitazone halts the progression of diabetesinduced experimental nephropathy. Eur J Pharmacol 2010; 636: 137-44.
    • (2010) Eur J Pharmacol , vol.636 , pp. 137-144
    • Arora, M.K.1    Reddy, K.2    Balakumar, P.3
  • 73
    • 77956124593 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor-γ agonist rosiglitazone prevents albuminuria but not glomerulosclerosis in experimental diabetes
    • Setti G, Hayward A, Dessapt C, et al. Peroxisome proliferatoractivated receptor-γ agonist rosiglitazone prevents albuminuria but not glomerulosclerosis in experimental diabetes. Am J Nephrol 2010; 32: 393-402.
    • (2010) Am J Nephrol , vol.32 , pp. 393-402
    • Setti, G.1    Hayward, A.2    Dessapt, C.3
  • 74
    • 21344466513 scopus 로고    scopus 로고
    • Rosiglitazone improves glomerular hyperfiltration, renal endothelial dysfunction, and microalbuminuria of incipient diabetic nephropathy in patients
    • Pistrosch F, Herbrig K, Kindel B, Passauer J, Fischer S, Gross P. Rosiglitazone improves glomerular hyperfiltration, renal endothelial dysfunction, and microalbuminuria of incipient diabetic nephropathy in patients. Diabetes 2005; 54: 2206-11.
    • (2005) Diabetes , vol.54 , pp. 2206-2211
    • Pistrosch, F.1    Herbrig, K.2    Kindel, B.3    Passauer, J.4    Fischer, S.5    Gross, P.6
  • 75
    • 70449707755 scopus 로고    scopus 로고
    • Long-term effects of rosiglitazone on the progressive decline in renal function in patients with type 2 diabetes
    • Kim MK, Ko SH, Baek KH, et al. Long-term effects of rosiglitazone on the progressive decline in renal function in patients with type 2 diabetes. Korean J Intern Med 2009; 24: 227-32.
    • (2009) Korean J Intern Med , vol.24 , pp. 227-232
    • Kim, M.K.1    Ko, S.H.2    Baek, K.H.3
  • 76
    • 68449093090 scopus 로고    scopus 로고
    • Rosiglitazone enhances glucose uptake in glomerular podocytes using the glucose transporter GLUT1
    • Lennon R, Welsh GI, Singh A, et al. Rosiglitazone enhances glucose uptake in glomerular podocytes using the glucose transporter GLUT1. Diabetologia 2009; 52: 1944-52.
    • (2009) Diabetologia , vol.52 , pp. 1944-1952
    • Lennon, R.1    Welsh, G.I.2    Singh, A.3
  • 77
    • 83755220049 scopus 로고    scopus 로고
    • Interplay between statins and PPARs in improving cardiovascular outcomes: A double-edged sword?
    • Balakumar P, Mahadevan N. Interplay between statins and PPARs in improving cardiovascular outcomes: A double-edged sword? Br J Pharmacol 2012; 165: 373-9.
    • (2012) Br J Pharmacol , vol.165 , pp. 373-379
    • Balakumar, P.1    Mahadevan, N.2
  • 78
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007; 356: 2457-71.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 79
    • 49149087718 scopus 로고    scopus 로고
    • Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): A multicentre, randomised, double-blind, controlled trial
    • ONTARGET investigators
    • Mann JF, Schmieder RE, McQueen M, et al. ONTARGET investigators. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 2008; 372: 547-53.
    • (2008) Lancet , vol.372 , pp. 547-553
    • Mann, J.F.1    Schmieder, R.E.2    McQueen, M.3
  • 80
    • 67650070753 scopus 로고    scopus 로고
    • TRANSCEND (Telmisartan Randomised Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease) Investigators Effect of telmisartan on renal outcomes: A randomized trial
    • Mann JF, Schmieder RE, Dyal L, et al. TRANSCEND (Telmisartan Randomised Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease) Investigators Effect of telmisartan on renal outcomes: a randomized trial. Ann Intern Med 2009; 151: 1-10, W1-2.
    • (2009) Ann Intern Med , vol.151 , pp. 1-10
    • Mann, J.F.1    Schmieder, R.E.2    Dyal, L.3
  • 81
    • 67650160474 scopus 로고    scopus 로고
    • ONTARGET, TRANSCEND and PROFESS--clarifying, confusing or misleading?
    • Oparil S, Kjeldsen SE, Hedner T, Narkiewicz K. ONTARGET, TRANSCEND and PROFESS--clarifying, confusing or misleading? Blood Press 2009; 18: 4-6.
    • (2009) Blood Press , vol.18 , pp. 4-6
    • Oparil, S.1    Kjeldsen, S.E.2    Hedner, T.3    Narkiewicz, K.4
  • 82
    • 7444237666 scopus 로고    scopus 로고
    • Diabetics Exposed to Telmisartan and Enalapril Study Group. Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy
    • Barnett AH, Bain SC, Bouter P, et al. Diabetics Exposed to Telmisartan and Enalapril Study Group. Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy. N Engl J Med 2004; 351: 1952-61.
    • (2004) N Engl J Med , vol.351 , pp. 1952-1961
    • Barnett, A.H.1    Bain, S.C.2    Bouter, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.