Efficient and improved synthesis of Telmisartan

Beilstein Journal of Organic Chemistry

Volumn 6, Issue , 2010, Pages

  Kumar, A Sanjeev ^a   Ghosh, Samir ^a   Mehta, G N ^a  

^a SARDAR VALLABHBHAI NATIONAL INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Antihypertensive drug; Oxazoline hydrolysis; Suzuki coupling; Telmisartan

Indexed keywords

EID: 77950963866     PISSN: 18605397     EISSN: 18605397     Source Type: Journal    
DOI: 10.3762/bjoc.6.25     Document Type: Article

References (13)

1. Battershill, A. J.; Scott, L. J. Drugs 2006, 66, 51-83.
2. Hauel, N.; Narr, B.; Ries, U.; van Meel, J. C. A.; Wienen, W.; Entzeroth, M. Benzimidazoles useful as angiotensin-11 antagonists. U.S. Patent 5,591,762, Jan 7, 1997
3. Wexler, R. R.; Greenlee, W. J.; Irvin, J. D.; Goldberg, M. R.; Prendergast, K.; Smith, R. D.; Timmermans, P. B. M. W. M. J. Med. Chem. 1996, 39, 625-656. doi:10.1021/jm9504722
4. http://www.rxlist.com/cgi/generic2/telmisartan.htm.
5. Ries, U. J.; Mihm, G.; Narr, B.; Hasselbach, K. M.; Wittneben, H.; Entzeroth, M.; van Meel, J. C. A.; Wienen, W.; Hauel, N. H. J. Med. Chem. 1993, 36, 4040-4051. doi:10.1021/jm00077a007
6. Reddy, K. S.; Srinivasan, N.; Reddy, C. R.; Kolla, N.; Anjaneyulu, Y.; Venkatraman, S.; Bhattacharya, A.; Mathad, V. T. Org. Process Res. Dev. 2007, 11, 81-85. doi:10.1021/op060200g
7. Carini, D. J.; Duncia, J. V.; Aldrich, P. E.; Chiu, A. T.; Johnson, A. L; Pierce, M. E.; Price, W. A.; Santella, J. B., III; Wells, G. J.; Wexler, R. R.; Wong, P. C; Yoo, S.-E.; Timmermans, P. B. W. M. J. Med. Chem. 1991, 34, 2525-2547. doi:10.1021/jm00112a031
8. Kohler, B.; Langer, M.; Mosandl, T. Catalyzed Coupling of Aryl magnesium halides and Bromo aryl carbon Acidic Compounds to the Production of Biphenyl Carboxlic Acid. Ger. Pat. Appl. DE19632643C1, Jan 22, 1998.
9. Amatore, C; Jutand, A.; Negri, S. J. Organomet. Chem. 1990, 390, 389-398. doi:10.1016/0022-328X(90)85107-A
10. Sharp, M. J.; Snieckus, V. Tetrahedron Lett. 1985, 26, 5997-6000. doi:10.1016/S0040-4039(00)95108-6
11. Copar, A.; Antoncic, L; Antoncic, M. T. A Synthesis of 4-Bromo-methyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethyl biphenyl and Its Use in Preparation of Angiotensin II Antagonists. Int. Pat. Appl. WO 2006/103068A1, 2006.
12. Reuman, M.; Meyers, A. I. Tetrahedron 1985, 41, 837-860. doi:10.1016/S0040-4020(01)96401-4
13. Goossen, L. J.; Knaubar, T. J. Org. Chem. 2008, 73, 8631-8634. doi:10.1021/jo801937h