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Volumn 23, Issue 2, 2012, Pages 145-152

Interferon regulatory factor 1 regulation of oligodendrocyte injury and inflammatory demyelination

Author keywords

Caspase 1; central nervous system (CNS) inflammation; demyelination; glial cells; interferon regulatory factor 1; IRF 1; multiple sclerosis; oligodendrocytes

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN P35; STAT1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

EID: 84861087063     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/revneuro-2011-068     Document Type: Review
Times cited : (20)

References (56)
  • 2
    • 0034651029 scopus 로고    scopus 로고
    • Major histocompatibility complex heavy chain accumulation in the endoplasmic reticulum of oligodendrocytes results in myelin abnormalities
    • Baerwald, K., Corbin, J., and Popko, B. (2000). Major histocompatibility complex heavy chain accumulation in the endoplasmic reticulum of oligodendrocytes results in myelin abnormalities. J. Neurosci. Res. 15 , 160-169.
    • (2000) J. Neurosci. Res. , vol.15 , pp. 160-169
    • Baerwald, K.1    Corbin, J.2    Popko, B.3
  • 3
    • 33646903671 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 expression protects oligodendrocytes from the deleterious effects of interferon-β
    • Balabanov, R., Stand, K., Kemper, A., Lee, J., and Popko, B. (2006). Suppressor of cytokine signaling 1 expression protects oligodendrocytes from the deleterious effects of interferon-β. J. Neurosci. 26 , 5143-5152.
    • (2006) J. Neurosci. , vol.26 , pp. 5143-5152
    • Balabanov, R.1    Stand, K.2    Kemper, A.3    Lee, J.4    Popko, B.5
  • 4
    • 33847223756 scopus 로고    scopus 로고
    • Interferon-β-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis
    • Balabanov, R., Strand, K., Goswami, R., McMahon, E., Begolka, W., Miller, S., and Popko, B. (2007). Interferon-β-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis. J. Neurosci. 27 , 2013-2024.
    • (2007) J. Neurosci. , vol.27 , pp. 2013-2024
    • Balabanov, R.1    Strand, K.2    Goswami, R.3    McMahon, E.4    Begolka, W.5    Miller, S.6    Popko, B.7
  • 5
    • 1642281535 scopus 로고    scopus 로고
    • Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
    • Barnett, M. and Prineas, J. (2004). Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann. Neurol. 55 , 458-468.
    • (2004) Ann. Neurol. , vol.55 , pp. 458-468
    • Barnett, M.1    Prineas, J.2
  • 6
    • 58449083290 scopus 로고    scopus 로고
    • Pyroptosis: Host cell death and inflammation
    • Bergsbaken, T., Fink, L., and Cookson, T. (2009). Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 7 , 99-109.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 99-109
    • Bergsbaken, T.1    Fink, L.2    Cookson, T.3
  • 7
    • 24344507725 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 (irf-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis
    • Bouker, K., Skaar, T., Riggis, R., Harburger, D., Fernandez, D., Zwart, A., Wand, A., and Clark, R. (2005). Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis. Carcinogenesis 26 , 1527-1535.
    • (2005) Carcinogenesis , vol.26 , pp. 1527-1535
    • Bouker, K.1    Skaar, T.2    Riggis, R.3    Harburger, D.4    Fernandez, D.5    Zwart, A.6    Wand, A.7    Clark, R.8
  • 8
    • 0038689234 scopus 로고    scopus 로고
    • Protection from autoimmune brain inflammation in mice lacking ifnregulatory factor-1 is associated with th2-type cytokines
    • Buch, T., Uthoff-Hachenberg, C., and Waisman, A. (2003). Protection from autoimmune brain inflammation in mice lacking IFNregulatory factor-1 is associated with Th2-type cytokines. Int. Immunol. 15 , 855-856.
    • (2003) Int. Immunol. , vol.15 , pp. 855-856
    • Buch, T.1    Uthoff-Hachenberg, C.2    Waisman, A.3
  • 10
    • 0032516799 scopus 로고    scopus 로고
    • Cytokine gene expression in cells derived from csf of multiple sclerosis patients
    • Calabresi, P., Tranquill, L., McFarland, H., and Cowan, E. (1998). Cytokine gene expression in cells derived from CSF of multiple sclerosis patients. J. Neuroimmunol. 89 , 198-205.
    • (1998) J. Neuroimmunol. , vol.89 , pp. 198-205
    • Calabresi, P.1    Tranquill, L.2    McFarland, H.3    Cowan, E.4
  • 11
    • 27844562681 scopus 로고    scopus 로고
    • Interferongamma inhibits cell cycle exit in differentiating oligodendrocyte progenitor cells
    • Chew, L., King, W., Kennedy, A., and Gallo, V. (2005). Interferongamma inhibits cell cycle exit in differentiating oligodendrocyte progenitor cells. Glia 52 , 127-143.
    • (2005) Glia , vol.52 , pp. 127-143
    • Chew, L.1    King, W.2    Kennedy, A.3    Gallo, V.4
  • 12
    • 0030135421 scopus 로고    scopus 로고
    • Targeted cns expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development
    • Corbin, J., Kelly, D., Rath, E., Baerwald, K., Suzuki, K., and Popko, B. (1996). Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development. Mol. Cell. Neurosci. 7 , 354-370.
    • (1996) Mol. Cell. Neurosci. , vol.7 , pp. 354-370
    • Corbin, J.1    Kelly, D.2    Rath, E.3    Baerwald, K.4    Suzuki, K.5    Popko, B.6
  • 13
    • 0036341053 scopus 로고    scopus 로고
    • Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of stat1
    • Feng, X., Petraglia, A., Chen, M., Byskosh, P., Boos, M., and Reder, A. (2002). Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1. J. Neuroimmunol. 129 , 205-215.
    • (2002) J. Neuroimmunol. , vol.129 , pp. 205-215
    • Feng, X.1    Petraglia, A.2    Chen, M.3    Byskosh, P.4    Boos, M.5    Reder, A.6
  • 14
    • 16244362671 scopus 로고    scopus 로고
    • Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells
    • Fink, L. and Cookson, T. (2005). Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect. Immun. 73 , 1907-1916.
    • (2005) Infect. Immun. , vol.73 , pp. 1907-1916
    • Fink, L.1    Cookson, T.2
  • 16
    • 0034800712 scopus 로고    scopus 로고
    • Upregulation of transcription factors controlling mhc expression in multiple sclerosis lesions
    • Gobin, S., Mantagne, L., Van Zutphen, M., Van Der Valk, P., Van Den Elsen, P., and De Groot, C. (2001). Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions. Glia 36 , 68-77.
    • (2001) Glia , vol.36 , pp. 68-77
    • Gobin, S.1    Mantagne, L.2    Van Zutphen, M.3    Van Der Valk, P.4    Van Den Elsen, P.5    De Groot, C.6
  • 17
    • 2142662186 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Hafler, D. (2004). Multiple sclerosis. J. Clin. Invest. 113 , 778-794.
    • (2004) J. Clin. Invest. , Issue.113 , pp. 778-794
    • Hafler, D.1
  • 18
    • 0022348063 scopus 로고
    • Lymphocytes from multiple sclerosis produce elevated levels of βinterferon in vitro
    • Hirsch, R., Panitch, H., and Johnson, K. (1985). Lymphocytes from multiple sclerosis produce elevated levels of βinterferon in vitro . J. Clin. Immunol. 5 , 386-389.
    • (1985) J. Clin. Immunol. , vol.5 , pp. 386-389
    • Hirsch, R.1    Panitch, H.2    Johnson, K.3
  • 19
    • 0034142394 scopus 로고    scopus 로고
    • Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination
    • Hisahara, S., Araki, T., Sugiyama, F., Yagami, K., Suzuki, M., Abe, K., Yamamura, K., Miyazaki, J., Momoi, T., Satura, T., et al. (2000). Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination. EMBO J. 19 , 341-348.
    • (2000) EMBO J. , vol.19 , pp. 341-348
    • Hisahara, S.1    Araki, T.2    Sugiyama, F.3    Yagami, K.4    Suzuki, M.5    Abe, K.6    Yamamura, K.7    Miyazaki, J.8    Momoi, T.9    Satura, T.10
  • 21
    • 33746017378 scopus 로고    scopus 로고
    • Mek-erk signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells
    • Horiuchi, M., Itoh, A., Pleasure, D., and Itoh, T. (2006). MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells. J. Biol. Chem. 281 , 2095-2106.
    • (2006) J. Biol. Chem. , vol.281 , pp. 2095-2106
    • Horiuchi, M.1    Itoh, A.2    Pleasure, D.3    Itoh, T.4
  • 22
    • 78751644948 scopus 로고    scopus 로고
    • Cooperative contribution of interferon regulatory factor 1 (IRF-1) and IRF-8 to interferon-β-medicated cytotoxic effect on oligodendrocyte progenitor cells
    • Horiuchi, M., Itoh, A., Pleasure, D., Ozato, K., and Itoh, T. (2011). Cooperative contribution of interferon regulatory factor 1 (IRF-1) and IRF-8 to interferon-β-medicated cytotoxic effect on oligodendrocyte progenitor cells. J. Neuroinflamm. 8 , 8.
    • (2011) J. Neuroinflamm. , Issue.8 , pp. 8
    • Horiuchi, M.1    Itoh, A.2    Pleasure, D.3    Ozato, K.4    Itoh, T.5
  • 25
    • 0035975262 scopus 로고    scopus 로고
    • Active mri lesion appearance in ms patients is preceded by fluctuations in circulating t-helper 1 and 2 cells
    • Killestein, J., Rep, M., Barkof, F., Roos, M., Adler, H., van Lier, R., and Polman, C. (2001). Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells. J. Neuroimmunol. 118 , 286-294.
    • (2001) J. Neuroimmunol. , vol.118 , pp. 286-294
    • Killestein, J.1    Rep, M.2    Barkof, F.3    Roos, M.4    Adler, H.5    Van Lier, R.6    Polman, C.7
  • 26
    • 23844506444 scopus 로고    scopus 로고
    • Multiple sclerosis pathology: Evaluation of pathogenic concepts
    • Lassmann, H. (2005). Multiple sclerosis pathology: evaluation of pathogenic concepts. Brain. Pathol. 15 , 217-222.
    • (2005) Brain. Pathol. , vol.15 , pp. 217-222
    • Lassmann, H.1
  • 27
    • 22344435167 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma
    • Lin, W., Harding, H., Ron, D., and Popko, B. (2005). Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. J. Cell. Biol. 169 , 603-612.
    • (2005) J. Cell. Biol. , vol.169 , pp. 603-612
    • Lin, W.1    Harding, H.2    Ron, D.3    Popko, B.4
  • 28
    • 0036281689 scopus 로고    scopus 로고
    • Cntf is a major protective factor in demyelinating cns disease: A neuroprotective cytokine as modulator in neuroinflammation
    • Linker, R., Maüer, M., Gaupp, S., Martini, R., Holtmann, L., Giess, R., Rieckmann, P., Lassmann, H., Toyka, K., Sendtner, M., et al. (2002). CNTF is a major protective factor in demyelinating CNS disease: a neuroprotective cytokine as modulator in neuroinflammation. Nat. Med. 8 , 620-624.
    • (2002) Nat. Med. , Issue.8 , pp. 620-624
    • Linker, R.1    Maüer, M.2    Gaupp, S.3    Martini, R.4    Holtmann, L.5    Giess, R.6    Rieckmann, P.7    Lassmann, H.8    Toyka, K.9    Sendtner, M.10
  • 29
    • 13444283466 scopus 로고    scopus 로고
    • Roles of interferon-regulatory factors in t-helper-cell differentiation
    • Lohoff, M. and Mak, T. (2005). Roles of interferon-regulatory factors in T-helper-cell differentiation. Nat. Rev. Immunol. 5 , 125-135.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 125-135
    • Lohoff, M.1    Mak, T.2
  • 30
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti, C., Brück, W., Parisi, J., Scheitauer, B., Rodriguez, M., and Lassmann, H. (2000). Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann. Neurol. 47 , 707-717.
    • (2000) Ann. Neurol. , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3    Scheitauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 31
    • 42249109064 scopus 로고    scopus 로고
    • Unexpected regulatory roles of tlr4 and tlr9 in experimental autoimmune encephalomyelitis
    • Marta, T., Anderson, A., Isaksson, M., Kä mpe, O., and Lobell, A. (2008). Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis. Eur. J. Immunol. 38 , 565-575.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 565-575
    • Marta, T.1    Anderson, A.2    Isaksson, M.3    Kämpe, O.4    Lobell, A.5
  • 32
    • 77952239855 scopus 로고    scopus 로고
    • Stem cell transplantation in multiple sclerosis: Current status and future prospects
    • Stem Cells in Multiple Sclerosis (STEMS) Consensus Group (
    • Martino, G., Franklin, R., Van Evercooren, A., Kerr, D., Stem Cells in Multiple Sclerosis (STEMS) Consensus Group (2010). Stem cell transplantation in multiple sclerosis: current status and future prospects. Nat. Rev. Neurol. 6 , 247-255.
    • (2010) Nat. Rev. Neurol. , Issue.6 , pp. 247-255
    • Martino, G.1    Franklin, R.2    Van Evercooren, A.3    Kerr, D.4
  • 35
    • 34948888764 scopus 로고    scopus 로고
    • Lingo-1 antagonist promotes spinal cord remyelination and axonal integrity in mog-induced experimental autoimmune encephalomyelitis
    • Mi, S., Hu, B., Hahm, K., Luo, Y., Kam Hui, ES., Yuan, Q., Wong, W., Wang, L., Su, H., Chu, T., et al. (2007). LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat. Med. 13 , 1228-1233.
    • (2007) Nat. Med. , vol.13 , pp. 1228-1233
    • Mi, S.1    Hu, B.2    Hahm, K.3    Luo, Y.4    Kam Hui, E.S.5    Yuan, Q.6    Wong, W.7    Wang, L.8    Su, H.9    Chu, T.10
  • 36
    • 0037094037 scopus 로고    scopus 로고
    • Caspase 1 expression in multiple sclerosis plaques and cultured glial cells
    • Ming, X., Li, W., Maeda, Y., Cook, S., Chapin, J., Husar, W., and Dowling, P. (2002). Caspase 1 expression in multiple sclerosis plaques and cultured glial cells. J. Neurol. Sci. 197 , 9-18.
    • (2002) J. Neurol. Sci. , vol.197 , pp. 9-18
    • Ming, X.1    Li, W.2    Maeda, Y.3    Cook, S.4    Chapin, J.5    Husar, W.6    Dowling, P.7
  • 37
    • 0142043832 scopus 로고    scopus 로고
    • Interferon βresponses to myelin peptides in multiple sclerosis correlate with new clinical measure of disease progression
    • Moldovan, I., Rudick, R., Cotleur, A., Born, S., Lee, J., Karafa, M., and Pelfrey, C. (2003). Interferon βresponses to myelin peptides in multiple sclerosis correlate with new clinical measure of disease progression. J. Neuroimmunol. 141 , 132-140.
    • (2003) J. Neuroimmunol. , vol.141 , pp. 132-140
    • Moldovan, I.1    Rudick, R.2    Cotleur, A.3    Born, S.4    Lee, J.5    Karafa, M.6    Pelfrey, C.7
  • 39
    • 0023126661 scopus 로고
    • Exacerbations of multiple sclerosis in patients treated with βinterferon
    • Panitch, N., Hirsch, R., Haley, A., and Johnson, K. (1987). Exacerbations of multiple sclerosis in patients treated with βinterferon. Lancet 1 , 893-895.
    • (1987) Lancet , vol.1 , pp. 893-895
    • Panitch, N.1    Hirsch, R.2    Haley, A.3    Johnson, K.4
  • 40
    • 0034069944 scopus 로고    scopus 로고
    • Interferon-βmodulates human oligodendrocyte susceptibility to fas-mediated injury
    • Pouly, S., Becher, B., Blain, M., and Antel, J. (2000). Interferon-βmodulates human oligodendrocyte susceptibility to Fas-mediated injury. J. Neuropathol. Exp. Neurol. 59 , 280-286.
    • (2000) J. Neuropathol. Exp. Neurol. , vol.59 , pp. 280-286
    • Pouly, S.1    Becher, B.2    Blain, M.3    Antel, J.4
  • 41
    • 77954564014 scopus 로고    scopus 로고
    • Central nervous system expression of interferon regulatory factor 1 regulates experimental autoimmune encephalomyelitis
    • Ren, Z., Wang, Y., Tao, D., Liebenson, D., Liggett, T., Goswami, R., Stefoski, D., and Balabanov, R. (2010). Central nervous system expression of interferon regulatory factor 1 regulates experimental autoimmune encephalomyelitis. J. Neuroimmune Pharmacol. 5 , 260-265.
    • (2010) J. Neuroimmune Pharmacol. , vol.5 , pp. 260-265
    • Ren, Z.1    Wang, Y.2    Tao, D.3    Liebenson, D.4    Liggett, T.5    Goswami, R.6    Stefoski, D.7    Balabanov, R.8
  • 43
    • 79958279017 scopus 로고    scopus 로고
    • Overexpression of the dominant negative form of interferon regulatory factor 1 in oligodendrocytes protects against experimental autoimmune encephalomyelitis
    • Ren, Z., Wang, Y., Tao, D., Liebenson, D., Liggett, T., Goswami, R., Stefoski, D., and Balabanov, R. (2011b). Overexpression of the dominant negative form of interferon regulatory factor 1 in oligodendrocytes protects against experimental autoimmune encephalomyelitis. J. Neurosci. 83 , 8329-8341.
    • (2011) J. Neurosci. , vol.83 , pp. 8329-8341
    • Ren, Z.1    Wang, Y.2    Tao, D.3    Liebenson, D.4    Liggett, T.5    Goswami, R.6    Stefoski, D.7    Balabanov, R.8
  • 45
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    • Steinman, L. (1996). Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 185 , 299-302.
    • (1996) Cell , vol.185 , pp. 299-302
    • Steinman, L.1
  • 46
    • 0034748269 scopus 로고    scopus 로고
    • Blockade of gamma interferon might be benefi-cial in ms
    • Steinman, L. (2001). Blockade of gamma interferon might be benefi-cial in MS. Mult. Scler. 7 , 275-276.
    • (2001) Mult. Scler. , vol.7 , pp. 275-276
    • Steinman, L.1
  • 47
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • Steinman, L. and Zamvil, S. (2006). How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann. Neurol. 60 , 12-21.
    • (2006) Ann. Neurol. , vol.60 , pp. 12-21
    • Steinman, L.1    Zamvil, S.2
  • 48
    • 33847197231 scopus 로고
    • Experimental allergic encephalomyelitis
    • Swanborg, R. (1988). Experimental allergic encephalomyelitis. Methods Enzymol. 140 , 1132-1138.
    • (1988) Methods Enzymol. , vol.140 , pp. 1132-1138
    • Swanborg, R.1
  • 49
    • 0031048823 scopus 로고    scopus 로고
    • Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1
    • Tada, Y., Ho, A., Matsuyma, T., and Mak, T. (1997). Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1. J. Exp. Med. 185 , 231-238.
    • (1997) J. Exp. Med. , vol.185 , pp. 231-238
    • Tada, Y.1    Ho, A.2    Matsuyma, T.3    Mak, T.4
  • 50
    • 79955753777 scopus 로고    scopus 로고
    • Oligodendrocyte progenitors reversibly exit the cell cycle and give rise to astrocytes in response to interferon-β
    • Tanner, D., Cherry, J., and Mayer-Pröschel, M. (2011). Oligodendrocyte progenitors reversibly exit the cell cycle and give rise to astrocytes in response to interferon-β. J. Neurosci. 31 , 6235-6246.
    • (2011) J. Neurosci. , vol.31 , pp. 6235-6246
    • Tanner, D.1    Cherry, J.2    Mayer-Pröschel, M.3
  • 51
    • 0028971386 scopus 로고
    • Expression of interferon-gamma receptor on murine oligodendrocytes and its regulation by cytokines and mitogens
    • Torres, C., Aranguez, I., and Rubino, N. (1995). Expression of interferon-gamma receptor on murine oligodendrocytes and its regulation by cytokines and mitogens. Immunology 86 , 250-255.
    • (1995) Immunology , vol.86 , pp. 250-255
    • Torres, C.1    Aranguez, I.2    Rubino, N.3
  • 52
    • 0037090253 scopus 로고    scopus 로고
    • De novo cns processing of myelin antigen is required for the initiation of eae
    • Tompkins, S., Padilla, M., Dal Canto, J., Ting, J., Van Kaer, L., and Miller, S. (2002). De novo CNS processing of myelin antigen is required for the initiation of EAE. J. Immunol. 168 , 4173-4183.
    • (2002) J. Immunol. , vol.168 , pp. 4173-4183
    • Tompkins, S.1    Padilla, M.2    Dal Canto, J.3    Ting, J.4    Van Kaer, L.5    Miller, S.6
  • 53
    • 0026059873 scopus 로고
    • Regulation of mhc molecules on mbp positive oligodendrocytes in mice by ifn-βand tnf-β
    • Turnley, A., Miller, J., and Bartlett, P. (1991). Regulation of MHC molecules on MBP positive oligodendrocytes in mice by IFN-βand TNF-β. Neurosci. Lett. 123 , 45-48.
    • (1991) Neurosci. Lett. , vol.123 , pp. 45-48
    • Turnley, A.1    Miller, J.2    Bartlett, P.3
  • 54
    • 0029410743 scopus 로고    scopus 로고
    • Interferon-β-induced oligodendrocyte cell death: Implications for the pathogenesis of multiple sclerosis
    • Vartanian, T., Li, Y., Zhao, M., and Stefansson, K. (1996). Interferon-β-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol. Med. 1 , 732-743.
    • (1996) Mol. Med. , vol.1 , pp. 732-743
    • Vartanian, T.1    Li, Y.2    Zhao, M.3    Stefansson, K.4
  • 55
    • 73149097207 scopus 로고    scopus 로고
    • Stat1/irf-1 signaling pathway mediates the injurious effect of interferon-gamma on oligodendrocyte progenitor cells
    • Wang, Y., Ren, Z., Tao, D., Tilwalli, S., Goswami, R., and Balabanov, R. (2010). STAT1/IRF-1 signaling pathway mediates the injurious effect of interferon-gamma on oligodendrocyte progenitor cells. Glia 58 , 195-209.
    • (2010) Glia , vol.58 , pp. 195-209
    • Wang, Y.1    Ren, Z.2    Tao, D.3    Tilwalli, S.4    Goswami, R.5    Balabanov, R.6
  • 56
    • 37549070224 scopus 로고    scopus 로고
    • Normal-appearing white matter in multiple sclerosis is a subtle balance between inflammation and neuroprotection
    • Zeis, T., Graumann, U., Reynolds, R., and Schaeren-Wiemers, N. (2008). Normal-appearing white matter in multiple sclerosis is a subtle balance between inflammation and neuroprotection. Brain 131 , 288-303.
    • (2008) Brain , vol.131 , pp. 288-303
    • Zeis, T.1    Graumann, U.2    Reynolds, R.3    Schaeren-Wiemers, N.4


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