Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status

Free Radical Biology and Medicine

Volumn 52, Issue 10, 2012, Pages 2082-2090

  Ladurner, Angela ^a   Schmitt, Christoph A ^b   Schachner, Daniel ^a   Atanasov, Atanas G ^a   Werner, Ernst R ^c   Dirsch, Verena M ^a   Heiss, Elke H ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

AMP activated kinase; Ascorbate; Endothelial NO synthase activity; Endothelial NO synthase phosphorylation; Free radicals; Protein phosphatase 2A

Indexed keywords

ARGININE; ASCORBIC ACID; CITRULLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE; SMALL INTERFERING RNA; TETRAHYDROBIOPTERIN;

ARTICLE; ASSAY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VIVO STUDY; PRIORITY JOURNAL; VASODILATATION;

AMP-ACTIVATED PROTEIN KINASES; ASCORBIC ACID; BIOPTERIN; CELL LINE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RNA INTERFERENCE; RNA, SMALL INTERFERING; VASODILATION;

EID: 84861042304     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.03.022     Document Type: Article

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