Immunogenicity and protective efficacy of a novel recombinant BCG strain overexpressing antigens Ag85A and Ag85B

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Wang, Chun ^a   Fu, Ruiling ^a   Chen, Zhenhua ^a   Tan, Kun ^a   Chen, Lingxia ^a   Teng, Xindong ^a   Lu, Jia ^a   Shi, Chunwei ^a   Fan, Xionglin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AG85A PROTEIN; AG85B PROTEIN; BACTERIAL ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G; MYCOBACTERIUM VACCINE; RECOMBINANT BACILLUS CALMETTE GUERIN; UNCLASSIFIED DRUG; ACYLTRANSFERASE; ANTIGEN 85A, MYCOBACTERIUM TUBERCULOSIS; ANTIGEN 85B, MYCOBACTERIUM TUBERCULOSIS; BACTERIAL PROTEIN; BACTERIUM ANTIBODY; BCG VACCINE; EPITOPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENE OVEREXPRESSION; IMMUNOGENICITY; LUNG; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TUBERCULOSIS; VACCINATION; ACTIVE IMMUNIZATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM;

ACYLTRANSFERASES; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BCG VACCINE; HUMANS; IMMUNITY, ACTIVE; IMMUNODOMINANT EPITOPES; INTERFERON-GAMMA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; VACCINATION;

EID: 84861038873     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/563838     Document Type: Article

References (39)

1. Andersen P., Doherty T. M., The success and failure of BCGimplications for a novel tuberculosis vaccine Nature Reviews Microbiology 2005 3 8 656 662 (Pubitemid 41052152)
2. Horwitz M. A., Harth G., Dillon B. J., Maslesa-Galic S., Recombinant bacillus Calmette-Guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity againts tuberculosis than conventional BCG vaccines in a highly susceptible animal model Proceedings of the National Academy of Sciences of the United States of America 2000 97 25 13853 13858
3. Horwitz M. A., Harth G., Dillon B. J., Maslea-Gali S., Extraordinarily few organisms of a live recombinant BCG vaccine against tuberculosis induce maximal cell-mediated and protective immunity Vaccine 2006 24 4 443 451 (Pubitemid 41832547)
4. Horwitz M. A., Harth G., Dillon B. J., Maslea-Gali S., A novel live recombinant mycobacterial vaccine against bovine tuberculosis more potent than BCG Vaccine 2006 24 10 1593 1600 (Pubitemid 43238235)
5. Horwitz M. A., Harth G., A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis Infection and Immunity 2003 71 4 1672 1679 (Pubitemid 36368696)
6. Sugawara I., Li Z., Sun L., Udagawa T., Taniyama T., Recombinant BCG Tokyo (Ag85A) protects cynomolgus monkeys (Macaca fascicularis) infected with H37Rv Mycobacterium tuberculosis Tuberculosis 2007 87 6 518 525 (Pubitemid 47589038)
7. Sugawara I., Udagawa T., Taniyama T., Protective efficacy of recombinant (Ag85A) BCG Tokyo with Ag85A peptide boosting against Mycobacterium tuberculosis -infected guinea pigs in comparison with that of DNA vaccine encoding Ag85A Tuberculosis 2007 87 2 94 101 (Pubitemid 46217256)
8. Sugawara I., Sun L., Mizuno S., Taniyama T., Protective efficacy of recombinant BCG Tokyo (Ag85A) in rhesus monkeys (Macaca mulatta) infected intratracheally with H37Rv Mycobacterium tuberculosis Tuberculosis 2009 89 1 62 67
9. Jain R., Dey B., Dhar N., Rao V., Singh R., Gupta U. D., Katoch V. M., Ramanathan V. D., Tyagi A. K., Enhanced and enduring protection against tuberculosis by recombinant BCG-Ag85C and its association with modulation of cytokine profile in lung PLoS One 2008 3 12
10. Pym A. S., Brodin P., Majlessi L., Brosch R., Demangel C., Williams A., Griffiths K. E., Marchal G., Leclerc C., Cole S. T., Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis Nature Medicine 2003 9 5 533 539 (Pubitemid 36597098)
11. Fan X. L., Yu T. H., Gao Q., Yao W., Immunological properties of recombinant Mycobacterium bovis bacillus Calmette-Guérin strain expressing fusion protein IL-2-ESAT-6 Acta Biochimica et Biophysica Sinica 2006 38 10 683 690 (Pubitemid 44657212)
12. Wang L. M., Shi C. H., Fan X. L., Xue Y., Bai Y. L., Xu Z. K., Expression and immunogenicity of recombinant Mycobacterium bovis Bacillus Calmette-Guérin strains secreting the antigen ESAT-6 from Mycobacterium tuberculosis in mice Chinese Medical Journal 2007 120 14 1220 1225 (Pubitemid 47232904)
13. Dey B., Jain R., Khera A., Rao V., Dhar N., Gupta U. D., Katoch V. M., Ramanathan V. D., Tyagi A. K., Boosting with a DNA vaccine expressing ESAT-6 (DNAE6) obliterates the protection imparted by recombinant BCG (rBCGE6) against aerosol Mycobacterium tuberculosis infection in guinea pigs Vaccine 2009 28 1 63 70
14. Shi C., Chen L., Chen Z., Zhang Y., Zhou Z., Lu J., Fu R., Wang C., Fang Z., Fan X., Enhanced protection against tuberculosis by vaccination with recombinant BCG over-expressing HspX protein Vaccine 2010 28 32 5237 5244
15. Mir F. A., Kaufmann S. H. E., Eddine A. N., A multicistronic DNA vaccine induces significant protection against tuberculosis in mice and offers flexibility in the expressed antigen repertoire Clinical and Vaccine Immunology 2009 16 10 1467 1475
16. Derrick S. C., Yang A. L., Morris S. L., A polyvalent DNA vaccine expressing an ESAT6-Ag85B fusion protein protects mice against a primary infection with Mycobacterium tuberculosis and boosts BCG-induced protective immunity Vaccine 2004 23 6 780 788 (Pubitemid 39473176)
17. Skeiky Y. A. W., Alderson M. R., Ovendale P. J., Guderian J. A., Brandt L., Dillon D. C., Campos-Neto A., Lobet Y., Dalemans W., Orme I. M., Reed S. G., Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein Journal of Immunology 2004 172 12 7618 7628 (Pubitemid 38747626)
18. Lu J., Cai C., Wang C., Zhou Z., Zhang Y., Cao T., Shi C., Chen Z., Chen L., Fan X., Immunogenicity and protective efficacy against murine tuberculosis of a prime-boost regimen with BCG and a DNA vaccine expressing ESAT-6 and Ag85A fusion protein Clinical and Developmental Immunology 2011 2011 10
19. Yuan W., Dong N., Zhang L., Immunogenicity and protective efficacy of a tuberculosis DNA vaccine expressing a fusion protein of Ag85B-Esat6-HspX in mice Vaccine 2012 30 14 2490 2497
20. Qie Y. Q., Wang J. L., Zhu B. D., Xu Y., Wang Q. Z., Chen J. Z., Wang H. H., Evaluation of a new recombinant BCG which contains mycobacterial antigen ag85B-mpt64190-198-mtb8.4 in C57/BL6 mice Scandinavian Journal of Immunology 2008 67 2 133 139
21. Wang J. L., Qie Y. Q., Zhu B. D., Zhang H. M., Xu Y., Wang Q. Z., Chen J. Z., Liu W., Wang H. H., Evaluation of a recombinant BCG expressing antigen Ag85B and PPE protein Rv3425 from DNA segment RD11 of Mycobacterium tuberculosis in C57BL/6 mice Medical Microbiology and Immunology 2009 198 1 5 11
22. Qie Y. Q., Wang J. L., Liu W., Shen H., Chen J. Z., Zhu B. D., Xu Y., Zhang X. L., Wang H. H., More vaccine efficacy studies on the recombinant bacille calmette-guerin co-expressing Ag85B, Mpt64190-198 and Mtb8.4 Scandinavian Journal of Immunology 2009 69 4 342 350
23. Shen H., Wang C., Yang E., Xu Y., Liu W., Yan J., Wang F., Wang H., Novel recombinant BCG coexpressing Ag85B, ESAT-6 and mouse TNF- induces significantly enhanced cellular immune and antibody responses in C57BL/6 mice Microbiology and Immunology 2010 54 8 435 441
24. Xu Y., Zhu B., Wang Q., Chen J., Qie Y., Wang J., Wang H., Wang B., Wang H., Recombinant BCG coexpressing Ag85B, ESAT-6 and mouse-IFN- confers effective protection against Mycobacterium tuberculosis in C57BL/6 mice FEMS Immunology and Medical Microbiology 2007 51 3 480 487 (Pubitemid 350076157)
25. Xu Y., Liu W., Shen H., Yan J., Yang E., Wang H., Recombinant Mycobacterium bovis BCG expressing chimaeric protein of Ag85B and ESAT-6 enhances immunostimulatory activity of human macrophages Microbes and Infection 2010 12 8-9 683 689
26. Fan X., Gao Q., Fu R., Differential immunogenicity and protective efficacy of DNA vaccines expressing proteins of Mycobacterium tuberculosis in a mouse model Microbiological Research 2009 164 4 374 382
27. Fine P. E. M., Variation in protection by BCG: implications of and for heterologous immunity Lancet 1995 346 8986 1339 1345
28. Andersen P., Tuberculosis vaccinesan update Nature Reviews Microbiology 2007 5 7 484 487
29. Dennehy M., Williamson A. L., Factors influencing the immune response to foreign antigen expressed in recombinant BCG vaccines Vaccine 2005 23 10 1209 1224 (Pubitemid 40126524)
30. Post F. A., Manca C., Neyrolles O., Ryffel B., Young D. B., Kaplan G., Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits Mycobacterium smegmatis -induced cytokine production by human macrophages in vitro Infection and Immunity 2001 69 3 1433 1439 (Pubitemid 32187591)
31. Rao V., Dhar N., Shakila H., Singh R., Khera A., Jain R., Naseema M., Paramasivan C. N., Narayanan P. R., Ramanathan V. D., Tyagi A. K., Increased expression of Mycobacterium tuberculosis 19 kDa lipoprotein obliterates the protective efficacy of BCG by polarizing host immune responses to the Th2 subtype Scandinavian Journal of Immunology 2005 61 5 410 417 (Pubitemid 40695011)
32. Hovav A. H., Mullerad J., Davidovitch L., Fishman Y., Bigi F., Cataldi A., Bercovier H., The Mycobacterium tuberculosis recombinant 27-kilodalton lipoprotein induces a strong Th1-type immune response deleterious to protection Infection and Immunity 2003 71 6 3146 3154 (Pubitemid 36637537)
33. Tanghe A., Denis O., Lambrecht B., Motte V., Van Den Berg T., Huygen K., Tuberculosis DNA vaccine encoding Ag85A is immunogenic and protective when administered by intramuscular needle injection but not by epidermal gene gun bombardment Infection and Immunity 2000 68 7 3854 3860 (Pubitemid 30434532)
34. Bao L., Chen W., Zhang H., Wang X., Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis bacillus Calmette-Guérin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosis Infection and Immunity 2003 71 4 1656 1661 (Pubitemid 36368694)
35. Pym A. S., Brodin P., Majlessi L., Brosch R., Demangel C., Williams A., Griffiths K. E., Marchal G., Leclerc C., Cole S. T., Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis Nature Medicine 2003 9 5 533 539 (Pubitemid 36597098)
36. Belisle J. T., Vissa V. D., Sievert T., Takayama K., Brennan P. J., Besra G. S., Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis Science 1997 276 5317 1420 1422 (Pubitemid 27235411)
37. Flynn J. L., Chan J., Triebold K. J., Dalton D. K., Stewart T. A., Bloom B. R., An essential role for interferon in resistance to Mycobacterium tuberculosis infection Journal of Experimental Medicine 1993 178 6 2249 2254 (Pubitemid 23344886)
38. Barker L. F., Brennan M. J., Rosenstein P. K., Sadoff J. C., Tuberculosis vaccine research: the impact of immunology Current Opinion in Immunology 2009 21 3 331 338
39. Dheda K., Schwander S. K., Zhu B., Van Zyl-Smit R. N., Zhang Y., The immunology of tuberculosis: from bench to bedside Respirology 2010 15 3 433 450