메뉴 건너뛰기




Volumn 21, Issue 3, 2009, Pages 331-338

Tuberculosis vaccine research: the impact of immunology

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; AERAS 402; AERAS 402 VACCINE; AERAS 404; AERAS 404 VACCINE; AERAS 485; AERAS 485 VACCINE; BCG 30; BCG 30 VACCINE; BCG VACCINE; CRUCELL AD35 VACCINE; CYTOKINE; EARLY SECRETORY ANTIGENIC TARGET 6; GSK M 72; GSK M 72 VACCINE; HYBRID 1 VACCINE; HYBRID PROTEIN; HYVAC 4; IMMUNOLOGICAL ADJUVANT; LISTERIOLYSIN; MVA 85A VACCINE; MYCOBACTERIUM ANTIGEN; MYCOBACTERIUM VACCINE; PERFRINGOLYSIN; RECOMBINANT BCG VACCINE; SUBUNIT VACCINE; UNCLASSIFIED DRUG; VFM X VACCINE;

EID: 67049145538     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2009.05.017     Document Type: Review
Times cited : (58)

References (71)
  • 2
    • 33645056674 scopus 로고    scopus 로고
    • Impact of HIV infection on the epidemiology of tuberculosis in a peri-urban community in South Africa: the need for age-specific interventions
    • Lawn S.D., Bekker L.G., Middelkoop K., Myer L., and Wood R. Impact of HIV infection on the epidemiology of tuberculosis in a peri-urban community in South Africa: the need for age-specific interventions. Clin Infect Dis 42 (2006) 1040-1047
    • (2006) Clin Infect Dis , vol.42 , pp. 1040-1047
    • Lawn, S.D.1    Bekker, L.G.2    Middelkoop, K.3    Myer, L.4    Wood, R.5
  • 3
    • 0141483750 scopus 로고    scopus 로고
    • Antiretroviral drugs for tuberculosis control in the era of HIV/AIDS
    • Williams B.G., and Dye C. Antiretroviral drugs for tuberculosis control in the era of HIV/AIDS. Science 301 (2003) 1535-1537
    • (2003) Science , vol.301 , pp. 1535-1537
    • Williams, B.G.1    Dye, C.2
  • 4
    • 66449083072 scopus 로고    scopus 로고
    • Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans
    • Bruns H., Meinken C., Schauenberg P., Harter G., Kern P., Modlin R.L., Antoni C., and Stenger S. Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans. J Clin Invest 119 (2009) 1167-1177
    • (2009) J Clin Invest , vol.119 , pp. 1167-1177
    • Bruns, H.1    Meinken, C.2    Schauenberg, P.3    Harter, G.4    Kern, P.5    Modlin, R.L.6    Antoni, C.7    Stenger, S.8
  • 5
    • 55149116512 scopus 로고    scopus 로고
    • The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis
    • This review illustrates the complex role of multiple IL-12-related cytokines in the cell-mediated immune response that attempts to control Mtb in the lung. Description of the protective or detrimental roles of IL-17 and IL-23, depending on timing of action, is quite relevant to vaccine research.
    • Cooper A.M., and Khader S.A. The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis. Immunol Rev 226 (2008) 191-204. This review illustrates the complex role of multiple IL-12-related cytokines in the cell-mediated immune response that attempts to control Mtb in the lung. Description of the protective or detrimental roles of IL-17 and IL-23, depending on timing of action, is quite relevant to vaccine research.
    • (2008) Immunol Rev , vol.226 , pp. 191-204
    • Cooper, A.M.1    Khader, S.A.2
  • 6
    • 22944433876 scopus 로고    scopus 로고
    • The success and failure of BCG-implications for a novel tuberculosis vaccine
    • Andersen P., and Doherty T.M. The success and failure of BCG-implications for a novel tuberculosis vaccine. Nat Rev Microbiol 3 (2005) 656-662
    • (2005) Nat Rev Microbiol , vol.3 , pp. 656-662
    • Andersen, P.1    Doherty, T.M.2
  • 7
    • 33646822975 scopus 로고    scopus 로고
    • Advances in tuberculosis vaccine strategies
    • Skeiky Y.A., and Sadoff J.C. Advances in tuberculosis vaccine strategies. Nat Rev Microbiol 4 (2006) 469-476
    • (2006) Nat Rev Microbiol , vol.4 , pp. 469-476
    • Skeiky, Y.A.1    Sadoff, J.C.2
  • 8
    • 17644388063 scopus 로고    scopus 로고
    • Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis
    • Kaufmann S.H., and McMichael A.J. Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis. Nat Med 11 (2005) S33-44
    • (2005) Nat Med , vol.11
    • Kaufmann, S.H.1    McMichael, A.J.2
  • 9
    • 0346881216 scopus 로고    scopus 로고
    • TB vaccines at the turn of the century: insights into immunity to M. tuberculosis and modern approaches for prevention of an ancient disease
    • Lewinsohn D.M., Lewinsohn D.A., and Grotzke J.E. TB vaccines at the turn of the century: insights into immunity to M. tuberculosis and modern approaches for prevention of an ancient disease. Semin Respir Infect 18 (2003) 320-338
    • (2003) Semin Respir Infect , vol.18 , pp. 320-338
    • Lewinsohn, D.M.1    Lewinsohn, D.A.2    Grotzke, J.E.3
  • 10
    • 0035064072 scopus 로고    scopus 로고
    • Immunology of tuberculosis
    • Flynn J.L., and Chan J. Immunology of tuberculosis. Annu Rev Immunol 19 (2001) 93-129
    • (2001) Annu Rev Immunol , vol.19 , pp. 93-129
    • Flynn, J.L.1    Chan, J.2
  • 11
    • 48749119738 scopus 로고    scopus 로고
    • Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations
    • This study compares the strengths and weaknesses of various immunoassays used to measure T cell mediated responses to Mtb antigens and provides recommendations for a harmonized assay for use in human clinical trials of new TB vaccines.
    • Hanekom W.A., Dockrell H.M., Ottenhoff T.H., Doherty T.M., Fletcher H., McShane H., Weichold F.F., Hoft D.F., Parida S.K., and Fruth U.J. Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations. PLoS Med 5 (2008) e145. This study compares the strengths and weaknesses of various immunoassays used to measure T cell mediated responses to Mtb antigens and provides recommendations for a harmonized assay for use in human clinical trials of new TB vaccines.
    • (2008) PLoS Med , vol.5
    • Hanekom, W.A.1    Dockrell, H.M.2    Ottenhoff, T.H.3    Doherty, T.M.4    Fletcher, H.5    McShane, H.6    Weichold, F.F.7    Hoft, D.F.8    Parida, S.K.9    Fruth, U.J.10
  • 12
    • 33845917536 scopus 로고    scopus 로고
    • Vaccine strategies against latent tuberculosis infection
    • Andersen P. Vaccine strategies against latent tuberculosis infection. Trends Microbiol 15 (2007) 7-13
    • (2007) Trends Microbiol , vol.15 , pp. 7-13
    • Andersen, P.1
  • 15
    • 67049139724 scopus 로고    scopus 로고
    • Neutralization of TNFalpha alters inflammation in guinea pig tuberculous pleuritis
    • 10.1016/j.micinf.2009.04.015 Epub
    • Ly L.H., Jeevan A., and McMurray D.N. Neutralization of TNFalpha alters inflammation in guinea pig tuberculous pleuritis. Microbes Infect (2009) 10.1016/j.micinf.2009.04.015 Epub
    • (2009) Microbes Infect
    • Ly, L.H.1    Jeevan, A.2    McMurray, D.N.3
  • 16
    • 48849103827 scopus 로고    scopus 로고
    • Oral vaccination of guinea pigs with a Mycobacterium bovis bacillus Calmette-Guerin vaccine in a lipid matrix protects against aerosol infection with virulent M. bovis
    • Clark S., Cross M.L., Nadian A., Vipond J., Court P., Williams A., Hewinson R.G., Aldwell F.E., and Chambers M.A. Oral vaccination of guinea pigs with a Mycobacterium bovis bacillus Calmette-Guerin vaccine in a lipid matrix protects against aerosol infection with virulent M. bovis. Infect Immun 76 (2008) 3771-3776
    • (2008) Infect Immun , vol.76 , pp. 3771-3776
    • Clark, S.1    Cross, M.L.2    Nadian, A.3    Vipond, J.4    Court, P.5    Williams, A.6    Hewinson, R.G.7    Aldwell, F.E.8    Chambers, M.A.9
  • 18
    • 0030017411 scopus 로고    scopus 로고
    • Immune responses stimulated by percutaneous and intradermal bacille Calmette-Guerin
    • Kemp E.B., Belshe R.B., and Hoft D.F. Immune responses stimulated by percutaneous and intradermal bacille Calmette-Guerin. J Infect Dis 174 (1996) 113-119
    • (1996) J Infect Dis , vol.174 , pp. 113-119
    • Kemp, E.B.1    Belshe, R.B.2    Hoft, D.F.3
  • 19
    • 36248967655 scopus 로고    scopus 로고
    • Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations
    • These data from a human clinical study illustrate the effectiveness of the booster TB vaccine vectored by vaccinia, MVA85A, to induce a significant polyfunctional CD4+ T cell response specific for the Mtb antigen 85A when the vaccine is used in individuals previously immunized with a BCG vaccine.
    • Beveridge N.E., Price D.A., Casazza J.P., Pathan A.A., Sander C.R., Asher T.E., Ambrozak D.R., Precopio M.L., Scheinberg P., Alder N.C., et al. Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. Eur J Immunol 37 (2007) 3089-3100. These data from a human clinical study illustrate the effectiveness of the booster TB vaccine vectored by vaccinia, MVA85A, to induce a significant polyfunctional CD4+ T cell response specific for the Mtb antigen 85A when the vaccine is used in individuals previously immunized with a BCG vaccine.
    • (2007) Eur J Immunol , vol.37 , pp. 3089-3100
    • Beveridge, N.E.1    Price, D.A.2    Casazza, J.P.3    Pathan, A.A.4    Sander, C.R.5    Asher, T.E.6    Ambrozak, D.R.7    Precopio, M.L.8    Scheinberg, P.9    Alder, N.C.10
  • 20
    • 0028966384 scopus 로고
    • Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis
    • Sorensen A.L., Nagai S., Houen G., Andersen P., and Andersen A.B. Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis. Infect Immun 63 (1995) 1710-1717
    • (1995) Infect Immun , vol.63 , pp. 1710-1717
    • Sorensen, A.L.1    Nagai, S.2    Houen, G.3    Andersen, P.4    Andersen, A.B.5
  • 21
    • 57149092786 scopus 로고    scopus 로고
    • Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning
    • This paper describes a novel CD4+ T cell expression screening method to identify immunodominant T cell antigens in PPD+ donors. The TB antigen, Mtb9.8, was recognized by multiple individuals and then tested in animal models for TB where it was shown to be a viable new vaccine candidate.
    • Coler R.N., Dillon D.C., Skeiky Y.A., Kahn M., Orme I.M., Lobet Y., Reed S.G., and Alderson M.R. Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning. Vaccine 27 (2009) 223-233. This paper describes a novel CD4+ T cell expression screening method to identify immunodominant T cell antigens in PPD+ donors. The TB antigen, Mtb9.8, was recognized by multiple individuals and then tested in animal models for TB where it was shown to be a viable new vaccine candidate.
    • (2009) Vaccine , vol.27 , pp. 223-233
    • Coler, R.N.1    Dillon, D.C.2    Skeiky, Y.A.3    Kahn, M.4    Orme, I.M.5    Lobet, Y.6    Reed, S.G.7    Alderson, M.R.8
  • 22
    • 67049169703 scopus 로고    scopus 로고
    • T-Cell epitope mapping in Mycobacterium tuberculosis using pepmixes created by micro-scale SPOT- synthesis
    • This manuscript describes in detail the novel high-throughput system developed by the investigators for using peptide libraries to identify immunodominant antigens and T cell epitopes in subjects infected with M. tuberculosis.
    • Frieder M., and Lewinsohn D.M. T-Cell epitope mapping in Mycobacterium tuberculosis using pepmixes created by micro-scale SPOT- synthesis. Methods Mol Biol 524 (2009) 369-382. This manuscript describes in detail the novel high-throughput system developed by the investigators for using peptide libraries to identify immunodominant antigens and T cell epitopes in subjects infected with M. tuberculosis.
    • (2009) Methods Mol Biol , vol.524 , pp. 369-382
    • Frieder, M.1    Lewinsohn, D.M.2
  • 24
    • 67049127547 scopus 로고    scopus 로고
    • Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses
    • Zvi A., Ariel N., Fulkerson J., Sadoff J.C., and Shafferman A. Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses. BMC Med Genomics 1 (2008) 18
    • (2008) BMC Med Genomics , vol.1 , pp. 18
    • Zvi, A.1    Ariel, N.2    Fulkerson, J.3    Sadoff, J.C.4    Shafferman, A.5
  • 26
    • 0034610299 scopus 로고    scopus 로고
    • Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model
    • Horwitz M.A., Harth G., Dillon B.J., and Maslesa-Galic S. Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc Natl Acad Sci U S A 97 (2000) 13853-13858
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13853-13858
    • Horwitz, M.A.1    Harth, G.2    Dillon, B.J.3    Maslesa-Galic, S.4
  • 27
    • 9144267735 scopus 로고    scopus 로고
    • Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans
    • McShane H., Pathan A.A., Sander C.R., Keating S.M., Gilbert S.C., Huygen K., Fletcher H.A., and Hill A.V. Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. Nat Med 10 (2004) 1240-1244
    • (2004) Nat Med , vol.10 , pp. 1240-1244
    • McShane, H.1    Pathan, A.A.2    Sander, C.R.3    Keating, S.M.4    Gilbert, S.C.5    Huygen, K.6    Fletcher, H.A.7    Hill, A.V.8
  • 28
    • 0033966029 scopus 로고    scopus 로고
    • Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens
    • Skjot R.L., Oettinger T., Rosenkrands I., Ravn P., Brock I., Jacobsen S., and Andersen P. Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens. Infect Immun 68 (2000) 214-220
    • (2000) Infect Immun , vol.68 , pp. 214-220
    • Skjot, R.L.1    Oettinger, T.2    Rosenkrands, I.3    Ravn, P.4    Brock, I.5    Jacobsen, S.6    Andersen, P.7
  • 29
    • 0035055282 scopus 로고    scopus 로고
    • Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6
    • Weinrich Olsen A., van Pinxteren L.A., Meng Okkels L., Birk Rasmussen P., and Andersen P. Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6. Infect Immun 69 (2001) 2773-2778
    • (2001) Infect Immun , vol.69 , pp. 2773-2778
    • Weinrich Olsen, A.1    van Pinxteren, L.A.2    Meng Okkels, L.3    Birk Rasmussen, P.4    Andersen, P.5
  • 30
    • 0036568632 scopus 로고    scopus 로고
    • The PE multigene family: a 'molecular mantra' for mycobacteria
    • Brennan M.J., and Delogu G. The PE multigene family: a 'molecular mantra' for mycobacteria. Trends Microbiol 10 (2002) 246-249
    • (2002) Trends Microbiol , vol.10 , pp. 246-249
    • Brennan, M.J.1    Delogu, G.2
  • 31
    • 2942596008 scopus 로고    scopus 로고
    • Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein
    • Skeiky Y.A., Alderson M.R., Ovendale P.J., Guderian J.A., Brandt L., Dillon D.C., Campos-Neto A., Lobet Y., Dalemans W., Orme I.M., et al. Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein. J Immunol 172 (2004) 7618-7628
    • (2004) J Immunol , vol.172 , pp. 7618-7628
    • Skeiky, Y.A.1    Alderson, M.R.2    Ovendale, P.J.3    Guderian, J.A.4    Brandt, L.5    Dillon, D.C.6    Campos-Neto, A.7    Lobet, Y.8    Dalemans, W.9    Orme, I.M.10
  • 32
    • 29644432453 scopus 로고    scopus 로고
    • A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen
    • Parra M., Cadieux N., Pickett T., Dheenadhayalan V., and Brennan M.J. A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen. Infect Immun 74 (2006) 786-789
    • (2006) Infect Immun , vol.74 , pp. 786-789
    • Parra, M.1    Cadieux, N.2    Pickett, T.3    Dheenadhayalan, V.4    Brennan, M.J.5
  • 34
    • 0035849873 scopus 로고    scopus 로고
    • The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination
    • Pethe K., Alonso S., Biet F., Delogu G., Brennan M.J., Locht C., and Menozzi F.D. The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination. Nature 412 (2001) 190-194
    • (2001) Nature , vol.412 , pp. 190-194
    • Pethe, K.1    Alonso, S.2    Biet, F.3    Delogu, G.4    Brennan, M.J.5    Locht, C.6    Menozzi, F.D.7
  • 35
    • 9244251567 scopus 로고    scopus 로고
    • The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis
    • Parra M., Pickett T., Delogu G., Dheenadhayalan V., Debrie A.S., Locht C., and Brennan M.J. The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis. Infect Immun 72 (2004) 6799-6805
    • (2004) Infect Immun , vol.72 , pp. 6799-6805
    • Parra, M.1    Pickett, T.2    Delogu, G.3    Dheenadhayalan, V.4    Debrie, A.S.5    Locht, C.6    Brennan, M.J.7
  • 37
    • 34250716965 scopus 로고    scopus 로고
    • M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells
    • van der Wel N., Hava D., Houben D., Fluitsma D., van Zon M., Pierson J., Brenner M., and Peters P.J. M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell 129 (2007) 1287-1298
    • (2007) Cell , vol.129 , pp. 1287-1298
    • van der Wel, N.1    Hava, D.2    Houben, D.3    Fluitsma, D.4    van Zon, M.5    Pierson, J.6    Brenner, M.7    Peters, P.J.8
  • 39
    • 0031818673 scopus 로고    scopus 로고
    • Serum therapy for tuberculosis revisited: reappraisal of the role of antibody-mediated immunity against Mycobacterium tuberculosis
    • Glatman-Freedman A., and Casadevall A. Serum therapy for tuberculosis revisited: reappraisal of the role of antibody-mediated immunity against Mycobacterium tuberculosis. Clin Microbiol Rev 11 (1998) 514-532
    • (1998) Clin Microbiol Rev , vol.11 , pp. 514-532
    • Glatman-Freedman, A.1    Casadevall, A.2
  • 40
    • 53049090810 scopus 로고    scopus 로고
    • Mycobacterial glycoconjugates as vaccine candidates against tuberculosis
    • Kallenius G., Pawlowski A., Hamasur B., and Svenson S.B. Mycobacterial glycoconjugates as vaccine candidates against tuberculosis. Trends Microbiol 16 (2008) 456-462
    • (2008) Trends Microbiol , vol.16 , pp. 456-462
    • Kallenius, G.1    Pawlowski, A.2    Hamasur, B.3    Svenson, S.B.4
  • 41
    • 65249121913 scopus 로고    scopus 로고
    • CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination
    • Elvang T., Christensen J.P., Billeskov R., Thi Kim Thanh Hoang T., Holst P., Thomsen A.R., Andersen P., and Dietrich J. CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination. PLoS ONE 4 (2009) e5139
    • (2009) PLoS ONE , vol.4
    • Elvang, T.1    Christensen, J.P.2    Billeskov, R.3    Thi Kim Thanh Hoang, T.4    Holst, P.5    Thomsen, A.R.6    Andersen, P.7    Dietrich, J.8
  • 43
    • 34547634035 scopus 로고    scopus 로고
    • Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon
    • Radosevic K., Wieland C.W., Rodriguez A., Weverling G.J., Mintardjo R., Gillissen G., Vogels R., Skeiky Y.A., Hone D.M., Sadoff J.C., et al. Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon. Infect Immun 75 (2007) 4105-4115
    • (2007) Infect Immun , vol.75 , pp. 4105-4115
    • Radosevic, K.1    Wieland, C.W.2    Rodriguez, A.3    Weverling, G.J.4    Mintardjo, R.5    Gillissen, G.6    Vogels, R.7    Skeiky, Y.A.8    Hone, D.M.9    Sadoff, J.C.10
  • 46
    • 64049106905 scopus 로고    scopus 로고
    • MHC molecules and microbial antigen processing in phagosomes
    • Ramachandra L., Simmons D., and Harding C.V. MHC molecules and microbial antigen processing in phagosomes. Curr Opin Immunol 21 (2009) 98-104
    • (2009) Curr Opin Immunol , vol.21 , pp. 98-104
    • Ramachandra, L.1    Simmons, D.2    Harding, C.V.3
  • 47
    • 0041402773 scopus 로고    scopus 로고
    • Immune evasion by Mycobacterium tuberculosis: living with the enemy
    • Flynn J.L., and Chan J. Immune evasion by Mycobacterium tuberculosis: living with the enemy. Curr Opin Immunol 15 (2003) 450-455
    • (2003) Curr Opin Immunol , vol.15 , pp. 450-455
    • Flynn, J.L.1    Chan, J.2
  • 48
    • 52549123569 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence
    • Gan H., Lee J., Ren F., Chen M., Kornfeld H., and Remold H.G. Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence. Nat Immunol 9 (2008) 1189-1197
    • (2008) Nat Immunol , vol.9 , pp. 1189-1197
    • Gan, H.1    Lee, J.2    Ren, F.3    Chen, M.4    Kornfeld, H.5    Remold, H.G.6
  • 49
    • 22344433382 scopus 로고    scopus 로고
    • Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin
    • Grode L., Seiler P., Baumann S., Hess J., Brinkmann V., Nasser Eddine A., Mann P., Goosmann C., Bandermann S., Smith D., et al. Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin. J Clin Invest 115 (2005) 2472-2479
    • (2005) J Clin Invest , vol.115 , pp. 2472-2479
    • Grode, L.1    Seiler, P.2    Baumann, S.3    Hess, J.4    Brinkmann, V.5    Nasser Eddine, A.6    Mann, P.7    Goosmann, C.8    Bandermann, S.9    Smith, D.10
  • 50
    • 41149096579 scopus 로고    scopus 로고
    • T-cell quality in memory and protection: implications for vaccine design
    • This is a notable review highlighting the importance of measuring polyfunctional responses in T cells and the implications for both effector and memory T cell populations.
    • Seder R.A., Darrah P.A., and Roederer M. T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 8 (2008) 247-258. This is a notable review highlighting the importance of measuring polyfunctional responses in T cells and the implications for both effector and memory T cell populations.
    • (2008) Nat Rev Immunol , vol.8 , pp. 247-258
    • Seder, R.A.1    Darrah, P.A.2    Roederer, M.3
  • 51
    • 66349122656 scopus 로고    scopus 로고
    • A critical role for CD8 T cells in a nonhuman primate model of tuberculosis
    • This study in a non-human primate model of TB demonstrates that CD8+ T cell depletion of Rhesus macaques results in reduced ability of the animals to control the resulting disease after challenge with Mtb, providing evidence that CD8+ T cells play an important role in protecting against TB.
    • Chen C.Y., Huang D., Wang R.C., Shen L., Zeng G., Yao S., Shen Y., Halliday L., Fortman J., McAllister M., et al. A critical role for CD8 T cells in a nonhuman primate model of tuberculosis. PLoS Pathog 5 (2009) e1000392. This study in a non-human primate model of TB demonstrates that CD8+ T cell depletion of Rhesus macaques results in reduced ability of the animals to control the resulting disease after challenge with Mtb, providing evidence that CD8+ T cells play an important role in protecting against TB.
    • (2009) PLoS Pathog , vol.5
    • Chen, C.Y.1    Huang, D.2    Wang, R.C.3    Shen, L.4    Zeng, G.5    Yao, S.6    Shen, Y.7    Halliday, L.8    Fortman, J.9    McAllister, M.10
  • 55
    • 0027360333 scopus 로고
    • An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
    • Flynn J.L., Chan J., Triebold K.J., Dalton D.K., Stewart T.A., and Bloom B.R. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 178 (1993) 2249-2254
    • (1993) J Exp Med , vol.178 , pp. 2249-2254
    • Flynn, J.L.1    Chan, J.2    Triebold, K.J.3    Dalton, D.K.4    Stewart, T.A.5    Bloom, B.R.6
  • 56
    • 0037111049 scopus 로고    scopus 로고
    • Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity
    • Hoft D.F., Worku S., Kampmann B., Whalen C.C., Ellner J.J., Hirsch C.S., Brown R.B., Larkin R., Li Q., Yun H., et al. Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity. J Infect Dis 186 (2002) 1448-1457
    • (2002) J Infect Dis , vol.186 , pp. 1448-1457
    • Hoft, D.F.1    Worku, S.2    Kampmann, B.3    Whalen, C.C.4    Ellner, J.J.5    Hirsch, C.S.6    Brown, R.B.7    Larkin, R.8    Li, Q.9    Yun, H.10
  • 57
    • 0024634219 scopus 로고
    • The BCG story: lessons from the past and implications for the future
    • Fine P.E. The BCG story: lessons from the past and implications for the future. Rev Infect Dis 11 Suppl. 2 (1989) S353-S359
    • (1989) Rev Infect Dis , vol.11 , Issue.SUPPL. 2
    • Fine, P.E.1
  • 58
    • 20444444975 scopus 로고    scopus 로고
    • Prime-boost immunisation strategies for tuberculosis
    • McShane H., and Hill A. Prime-boost immunisation strategies for tuberculosis. Microbes Infect 7 (2005) 962-967
    • (2005) Microbes Infect , vol.7 , pp. 962-967
    • McShane, H.1    Hill, A.2
  • 59
    • 54949108635 scopus 로고    scopus 로고
    • A new recombinant bacille Calmette-Guerin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers
    • This study provides the promising results from the first human clinical trial of a new live recombinant BCG vaccine.
    • Hoft D.F., Blazevic A., Abate G., Hanekom W.A., Kaplan G., Soler J.H., Weichold F., Geiter L., Sadoff J.C., and Horwitz M.A. A new recombinant bacille Calmette-Guerin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers. J Infect Dis 198 (2008) 1491-1501. This study provides the promising results from the first human clinical trial of a new live recombinant BCG vaccine.
    • (2008) J Infect Dis , vol.198 , pp. 1491-1501
    • Hoft, D.F.1    Blazevic, A.2    Abate, G.3    Hanekom, W.A.4    Kaplan, G.5    Soler, J.H.6    Weichold, F.7    Geiter, L.8    Sadoff, J.C.9    Horwitz, M.A.10
  • 60
    • 0032574807 scopus 로고    scopus 로고
    • Mycobacterium bovis Bacille Calmette-Guerin strains secreting listeriolysin of Listeria monocytogenes
    • Hess J., Miko D., Catic A., Lehmensiek V., Russell D.G., and Kaufmann S.H. Mycobacterium bovis Bacille Calmette-Guerin strains secreting listeriolysin of Listeria monocytogenes. Proc Natl Acad Sci U S A 95 (1998) 5299-5304
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5299-5304
    • Hess, J.1    Miko, D.2    Catic, A.3    Lehmensiek, V.4    Russell, D.G.5    Kaufmann, S.H.6
  • 61
    • 56849108004 scopus 로고    scopus 로고
    • rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector
    • Magalhaes I., Sizemore D.R., Ahmed R.K., Mueller S., Wehlin L., Scanga C., Weichold F., Schirru G., Pau M.G., Goudsmit J., et al. rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector. PLoS ONE 3 (2008) e3790
    • (2008) PLoS ONE , vol.3
    • Magalhaes, I.1    Sizemore, D.R.2    Ahmed, R.K.3    Mueller, S.4    Wehlin, L.5    Scanga, C.6    Weichold, F.7    Schirru, G.8    Pau, M.G.9    Goudsmit, J.10
  • 63
    • 33646137117 scopus 로고    scopus 로고
    • Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another
    • Schnappinger D., Schoolnik G.K., and Ehrt S. Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another. Microbes Infect 8 (2006) 1132-1140
    • (2006) Microbes Infect , vol.8 , pp. 1132-1140
    • Schnappinger, D.1    Schoolnik, G.K.2    Ehrt, S.3
  • 66
    • 33747371997 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis
    • Sambandamurthy V.K., Derrick S.C., Hsu T., Chen B., Larsen M.H., Jalapathy K.V., Chen M., Kim J., Porcelli S.A., Chan J., et al. Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis. Vaccine 24 (2006) 6309-6320
    • (2006) Vaccine , vol.24 , pp. 6309-6320
    • Sambandamurthy, V.K.1    Derrick, S.C.2    Hsu, T.3    Chen, B.4    Larsen, M.H.5    Jalapathy, K.V.6    Chen, M.7    Kim, J.8    Porcelli, S.A.9    Chan, J.10
  • 67
    • 65349186494 scopus 로고    scopus 로고
    • MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques
    • This study provides evidence from a non-human primate model of TB that the new modified vaccinia vectored, MVA85A, vaccine can function as a booster for a BCG vaccine prime to improve protection against an Mtb challenge in Rhesus macaques. It is also the first study to show that a live attenuated phoP deficient Mtb vaccine is well tolerated and affords protection in a non-human primate model.
    • Verreck F.A., Vervenne R.A., Kondova I., van Kralingen K.W., Remarque E.J., Braskamp G., van der Werff N.M., Kersbergen A., Ottenhoff T.H., Heidt P.J., et al. MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques. PLoS ONE 4 (2009) e5264. This study provides evidence from a non-human primate model of TB that the new modified vaccinia vectored, MVA85A, vaccine can function as a booster for a BCG vaccine prime to improve protection against an Mtb challenge in Rhesus macaques. It is also the first study to show that a live attenuated phoP deficient Mtb vaccine is well tolerated and affords protection in a non-human primate model.
    • (2009) PLoS ONE , vol.4
    • Verreck, F.A.1    Vervenne, R.A.2    Kondova, I.3    van Kralingen, K.W.4    Remarque, E.J.5    Braskamp, G.6    van der Werff, N.M.7    Kersbergen, A.8    Ottenhoff, T.H.9    Heidt, P.J.10
  • 68
    • 0842346271 scopus 로고    scopus 로고
    • The immunological aspects of latency in tuberculosis
    • Chan J., and Flynn J. The immunological aspects of latency in tuberculosis. Clin Immunol 110 (2004) 2-12
    • (2004) Clin Immunol , vol.110 , pp. 2-12
    • Chan, J.1    Flynn, J.2
  • 70
    • 58149235337 scopus 로고    scopus 로고
    • Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant
    • Kamath A.T., Rochat A.F., Valenti M.P., Agger E.M., Lingnau K., Andersen P., Lambert P.H., and Siegrist C.A. Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant. PLoS ONE 3 (2008) e3683
    • (2008) PLoS ONE , vol.3
    • Kamath, A.T.1    Rochat, A.F.2    Valenti, M.P.3    Agger, E.M.4    Lingnau, K.5    Andersen, P.6    Lambert, P.H.7    Siegrist, C.A.8
  • 71
    • 23344440201 scopus 로고    scopus 로고
    • Enhancing the protective efficacy of Mycobacterium bovis BCG vaccination against tuberculosis by boosting with the Mycobacterium tuberculosis major secretory protein
    • Horwitz M.A., Harth G., Dillon B.J., and Maslesa-Galic S. Enhancing the protective efficacy of Mycobacterium bovis BCG vaccination against tuberculosis by boosting with the Mycobacterium tuberculosis major secretory protein. Infect Immun 73 (2005) 4676-4683
    • (2005) Infect Immun , vol.73 , pp. 4676-4683
    • Horwitz, M.A.1    Harth, G.2    Dillon, B.J.3    Maslesa-Galic, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.