Modulation of neuroplasticity pathways and antidepressant-like behavioural responses following the short-term (3 and 7 days) administration of the 5-HT 4 receptor agonist RS67333

International Journal of Neuropsychopharmacology

Volumn 15, Issue 5, 2012, Pages 631-643

  Pascual Brazo, Jesús ^a,b,c   Castro, Elena ^a,b,c   Díaz, Álvaro ^a,b,c   Valdizán, Elsa M ^a,b,c   Pilar Cuéllar, Fuencisla ^a,b,c   Vidal, Rebeca ^a,b,c   Treceño, Begoña ^a,b,c   Pazos, Ángel ^a,b,c  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b University of Cantabria   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

Author keywords

Adenylate cyclase; BDNF; hippocampus; neurogenesis; serotonin

Indexed keywords

1 (4 AMINO 5 CHLORO 2 METHOXYPHENYL) 3 (1 BUTYL 4 PIPERIDINYL) 1 PROPANONE; ADENYLATE CYCLASE; ANTIDEPRESSANT AGENT; BETA CATENIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; PROTEIN KINASE B; SEROTONIN 4 RECEPTOR;

ANHEDONIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; FORCED SWIMMING TEST; HIPPOCAMPUS; MALE; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; SUGAR INTAKE; UPREGULATION;

ANILINE COMPOUNDS; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MALE; NERVE TISSUE PROTEINS; NEURAL PATHWAYS; NEUROGENESIS; NEURONAL PLASTICITY; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84861022548     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145711000782     Document Type: Article

References (50)

1. Adachi M, Barrot M, Autry AE, Theobald D, et al. (2008). Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biological Psychiatry 63, 642-649. (Pubitemid 351329281)
2. Adell A, Castro E, Celada P, Bortolozzi A, et al. (2005). Strategies for producing faster acting antidepressants. Drug Discovery Today 10, 578-585. (Pubitemid 40552825)
3. Airan RD, Meltzer LA, Roy M, Gong Y, et al. (2007). High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science 317, 819-823. (Pubitemid 47257922)
4. Bessa JM, Ferreira D, Melo I, Marques F, et al. (2009). The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Molecular Psychiatry 14, 764-773.
5. Bravo JA, Diaz-Veliz G, Mora S, Ulloa JL, et al. (2009). Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection. Behavioural Pharmacology 20, 273-285.
6. Cryan JF, Valentino RJ, Lucki I (2005). Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neuroscience and Biobehavioral Reviews 29, 547-569. (Pubitemid 40755456)
7. David DJ, Samuels BA, Rainer Q, Wang JW, et al. (2009). Neurogenesis-dependent and-independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 62, 479-493.
8. De Foubert G, Carney SL, Robinson CS, Destexhe EJ, et al. (2004). Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment. Neuroscience 128, 597-604. (Pubitemid 39277429)
9. Donati RJ, Rasenick MM (2003). G protein signaling and the molecular basis of antidepressant action. Life Sciences 73, 1-17. (Pubitemid 36519215)
10. Dulawa SC, Hen R (2005). Recent advances in animal models of chronic antidepressant effects : the novelty-induced hypophagia test. Neuroscience and Biobehavioral Reviews 29, 771-783. (Pubitemid 40762599)
11. Duman RS, Monteggia LM (2006). A neurotrophic model for stress-related mood disorders. Biological Psychiatry 29, 1116-1127.
12. Encinas JM, Vaahtokari A, Enikolopov G (2006). Fluoxetine targets early progenitor cells in the adult brain. Proceedings of the National Academy of Sciences USA 103, 8233-8238. (Pubitemid 43801081)
13. Gourley SL, Taylor JR (2009). Recapitulation and reversal of a persistent depression-like syndrome in rodents. Current Protocols in Neuroscience, chapter 9 : unit 9. 32, 1-14.
14. Gourley SL, Wu FJ, Kiraly DD, Ploski JE, et al. (2008a). Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression. Biological Psychiatry 63, 353-359.
15. Gourley SL, Wu FJ, Taylor JR (2008b). Corticosterone regulates pERK1/2 map kinase in a chronic depression model. Annals of the New York Academy of Sciences 1148, 509-514.
16. Keith JR, Wu Y, Epp JR, Sutherland RJ (2007). Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology. Behavioural Pharmacology 18, 521-531. (Pubitemid 47356379)
17. Larsen MH, Hay-Schmidt A, Ronn LC, Mikkelsen JD (2008). Temporal expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat hippocampus after treatment with selective and mixed monoaminergic antidepressants. European Journal of Pharmacology 578, 114-122. (Pubitemid 350309578)
18. Lesch KP, Aulakh CS, Tolliver TJ, Hill JL, et al. (1991). Regulation of G proteins by chronic antidepressant drug treatment in rat brain : tricyclics but not clorgyline increase Go alpha subunits. European Journal of Pharmacology 207, 361-364.
19. Lesch KP, Hough CJ, Aulakh CS, Wolozin BL, et al. (1992). Fluoxetine modulates G protein alpha s, alpha q, and alpha 12 subunit mRNA expression in rat brain. European Journal of Pharmacology 227, 233-237.
20. Lucas G, Rymar VV, Du J, Mnie-Filali O, et al. (2007). Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action. Neuron 55, 712-725. (Pubitemid 47334877)
21. Madsen TM, Newton SS, Eaton ME, Russell DS, et al. (2003). Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis. Biological Psychiatry 54, 1006-1014. (Pubitemid 37415035)
22. Malberg JE, Blendy JA (2005). Antidepressant action : to the nucleus and beyond. Trends in Pharmacological Sciences 26, 631-638.
23. Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000). Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. Journal of Neuroscience 20, 9104-9110. (Pubitemid 32042912)
24. Manji HK, Bitran JA, Masana MI, Chen GA, et al. (1991). Signal transduction modulation by lithium : cell culture, cerebral microdialysis and human studies. Psychopharmacology Bulletin 27, 199-208.
25. Marcussen AB, Flagstad P, Kristjansen PEG, Johansen FF, Englund U (2008). Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats. Acta Neurol Scand 117, 94-100.
26. McGowan S, Eastwood SL, Mead A, Burnet PW, et al. (1996). Hippocampal and cortical G protein (Gs alpha, G(o) alpha and Gi2 alpha) mRNA expression after electroconvulsive shock or lithium carbonate treatment. European Journal of Pharmacology 306, 249-255. (Pubitemid 26200139)
27. Mostany R, Valdizan EM, Pazos A (2008). A role for nuclear beta-catenin in SNRI antidepressant-induced hippocampal cell proliferation. Neuropharmacology 55, 18-26.
28. Musazzi L, Cattaneo A, Tardito D, Barbon A, et al. (2009). Early raise of BDNF in hippocampus suggests induction of posttranscriptional mechanisms by antidepressants. BMC Neuroscience 10, 48.
29. Newton IG, Forbes ME, Legault C, Johnson JE, et al. (2005). Caloric restriction does not reverse aging-related changes in hippocampal BDNF. Neurobiology of Aging 26, 683-688. (Pubitemid 40228760)
30. Nibuya M, Morinobu S, Duman RS (1995). Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. Journal of Neuroscience 15, 7539-7547.
31. Nibuya M, Nestler EJ, Duman RS (1996). Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. Journal of Neuroscience 16, 2365-2372. (Pubitemid 26154346)
32. Nierenberg AA, Farabaugh AH, Alpert JE, Gordon J, et al. (2000). Timing of onset of antidepressant response with fluoxetine treatment. American Journal of Psychiatry 157, 1423-1428.
33. Peng YR, He S, Marie H, Zeng SY, et al. (2009). Coordinated changes in dendritic arborization and synaptic strength during neural circuit development. Neuron 61, 71-84.
34. Reierson GW, Mastronardi CA, Licinio J, Wong ML (2009). Chronic imipramine downregulates cyclic AMP signaling in rat hippocampus. Neuroreport 20, 307-311.
35. Rodriguez-Gaztelumendi A, Rojo ML, Pazos A, Diaz A (2009). Altered CB receptor-signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine. Journal of Neurochemistry 108, 1423-1433.
36. Santarelli L, Saxe M, Gross C, Surget A, et al. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805-809. (Pubitemid 36962615)
37. Shirayama Y, Chen AC, Nakagawa S, Russell DS, et al. (2002). Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. Journal of Neuroscience 22, 3251-3261. (Pubitemid 35379212)
38. Soumier A, Banasr M, Lortet S, Masmejean F, et al. (2009). Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus. Neuropsychopharmacology 34, 2390-2403.
39. Surget A, Saxe M, Leman S, Ibarguen-Vargas Y, et al. (2008). Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biological Psychiatry 64, 293-301.
40. Tamburella A, Micale V, Navarria A, Drago F (2009). Antidepressant properties of the 5-HT4 receptor partial agonist, SL65. 0155: behavioral and neurochemical studies in rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry 33, 1205-1210.
41. Tardito D, Musazzi L, Tiraboschi E, Mallei A, et al. (2009). Early induction of CREB activation and CREB-regulating signalling by antidepressants. International Journal of Neuropsychopharmacology 12, 1367-1381.
42. Thome J, Sakai N, Shin K, Steffen C, et al. (2000). cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. Journal of Neuroscience 20, 4030-4036. (Pubitemid 30365673)
43. Vaidya VA, Castro ME, Pei Q, Sprakes ME, et al. (2001). Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression. Neuropharmacology 40, 48-56. (Pubitemid 33779799)
44. Vidal R, Valdizan EM, Mostany R, Pazos A, et al. (2009). Long-term treatment with fluoxetine induces desensitization of 5-HT receptor-dependent signalling and functionality in rat brain. Journal of Neurochemistry 110, 1120-1127.
45. Vidal R, Valdizan EM, Vilaró MT, Pazos A, et al. (2010). Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats. British Journal of Pharmacology 161, 695-706.
46. Warner-Schmidt JL, Duman RS (2007). VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants. Proceedings of the National Academy of Sciences USA 104, 4647-4652. (Pubitemid 47186279)
47. Watts VJ (2002). Molecular mechanisms for heterologous sensitization of adenylate cyclase. Journal of Pharmacology and Experimental Therapeutics 302, 1-7. (Pubitemid 34680414)
48. Willner P, Towell A, Sampson D, Sophokleous S, et al. (1987). Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology 93, 358-364. (Pubitemid 17160661)
49. Yu X, Malenka RC (2003). Beta-catenin is critical for dendritic morphogenesis. Nature Neuroscience 6, 1169-1177.
50. Zetterstrom TS, Pei Q, Grahame-Smith DG (1998). Repeated electroconvulsive shock extends the duration of enhanced gene expression for BDNF in rat brain compared with a single administration. Brain Research. Molecular Brain Research 57, 106-110. (Pubitemid 28279566)