Improvac does not modify the expression and activities of the major drug metabolizing enzymes cytochrome P450 3A and 2C in pigs

Vaccine

Volumn 30, Issue 24, 2012, Pages 3515-3518

  Tomankova, Jana ^a,d   Rasmussen, Martin Krøyer ^b   Andersson, Kristina ^c   Ekstrand, Bo ^b   Zamaratskaia, Galia ^c  

^a UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^b AARHUS UNIVERSITY   (Denmark)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^d Department of Meat Hygiene and Technology   (Czech Republic)

Author keywords

7 benzyloxyquinoline; CAR; Immunocastration; PXR; Tolbutamide, 7 benzyloxy 4 trifluoromethylcoumarin

Indexed keywords

7 BENZYLOXY 4 TRIFLUOROMETHYLCOUMARIN; 7 BENZYLOXYQUINOLINE; CONSTITUTIVE ANDROSTANE RECEPTOR; COUMARIN DERIVATIVE; CYTOCHROME P450 2C; CYTOCHROME P450 3A; IMPROVAC; MESSENGER RNA; PREGNANE X RECEPTOR; QUINOLINE DERIVATIVE; TOLBUTAMIDE; UNCLASSIFIED DRUG; VACCINE;

ANIMAL EXPERIMENT; ARTICLE; CASTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; CASTRATION; COUMARINS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION; LIVER; MALE; QUINOLINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SWINE; TOLBUTAMIDE; VACCINES, CONTRACEPTIVE;

EID: 84861006247     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.03.072     Document Type: Article

References (19)

1. Zamaratskaia G., Squires E.J. Biochemical, nutritional and genetic effects on boar taint in entire male pigs. Animal 2009, 3(11):1508-1521.
2. Rydhmer L., Lundström K., Andersson K. Immunocastration reduces aggressive and sexual behavior in male pigs. Animal 2010, 4(6):965-972.
3. Zamaratskaia G., Zlabek V., Chen G., Madej A. Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration. Animal 2009, 3(8):1124-1132.
4. Brunius C., Rasmussen M., Ekstrand B., Lacoutiere H., Andersson K., Zamaratskaia G. Expression and activities of hepatic cytochrome P450 (CYP1A, CYP2A and CYP2E1) in entire and castrated male pigs. Animal 2012, 6:271-277.
5. Puccinelli E., Gervasi P.G., Longo V. Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model. Current Drug Metabolism 2011, 12:507-525.
6. Rasmussen M.K., Zamaratskaia G., Ekstrand B. In vitro cytochrome P450 2E1 and 2A activities in the presence of testicular steroids. Reproduction in Domestic Animals 2011, 46:149-154.
7. Achour B., Barber J., Rostami-Hodjegan A. Cytochrome p450 pig liver pie: determination of individual cytochrome p450 isoform contents in microsomes from two pig livers using liquid chromatography in conjunction with mass spectroscopy. Drug Metabolism Disposition 2011, 39:2130-2134.
8. ®-effects on boar taint, hormones and reproductive organs. Vaccine 2011, 29(51):9514-9520.
9. ®-effects on performance and behaviour of male pigs. Animal 2012, 6(1):87-95.
10. Doran E., Whittington F.M., Wood J.D., McGivan J.D. Characterization of androstenone metabolism in pig liver microsomes. Chemico-Biological Interactions 2004, 147:141-149.
11. Rasmussen M.K., Ekstrand B., Zamaratskaia G. Comparison of cytochrome P450 concentrations and metabolic activities in porcine hepatic microsomes prepared with two different methods. Toxicology In Vitro 2011, 25:343-346.
12. Yamazaki H., Inoue K., Turvy C.G., Guengerich F.P., Shimada T. Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome P450 enzymes. Drug Metabolism Disposition 1997, 25:168-174.
13. Zlabek V, Zamaratskaia G. Comparison of three fluorescent CYP3A substrates in two vertebrate models, pig and Atlantic salmon. Animal; in press; http://dx.doi.org/10.1017/S1751731111002096.
14. Zamaratskaia G, Zlabek V, Ropstad E, Andresen Ø. Association of porcine liver cytochrome P450 3A (CYP3A) and 2C (CYP2C) activity with testicular steroid levels. Reproduction of domestic animals; in press; http://dx.doi.org/10.1111/j.1439-0531.2012.01986.x.
15. Rasmussen M.K., Zamaratskaia G., Ekstrand B. Gender-related differences in cytochrome P450 in porcine microsomes-implication for activity, expression and inhibition by testicular steroids. Reproduction in Domestic Animals 2011, 46:616-623.
16. Nannelli A., Rossignolo F., Tolando R., Rossato P., Pellegatti M., Longo V., et al. Expression and distribution of CYP3A genes, CYP2B22, and MDR1, MRP1, MRP2, LRP efflux transporters in brain of control and rifampicin-treated pigs. Molecular and Cellular Biochemistry 2010, 337:133-143.
17. Young J.F., Christensen L.P., Theil P.K., Oksbjerg N. The polyacetylenes falcarinol and falcarindiol affect stress responses in myotube cultures in a biphasic manner. Dose-Response 2008, 6:239-251.
18. Theil P.K., Sørensen I.L., Therkildsen M., Oksbjerg N. Changes in proteolytic enzyme mRNAs relevant for meat quality during myogenesis of primary porcine satellite cells. Meat Science 2006, 73:335-343.
19. Skaanild M.T., Friis C. Is cytochrome P450 CYP2D activity present in pig liver?. Pharmacology & Toxicology 2002, 91:198-203.