Renal proximal tubule angiotensin AT1A receptors regulate blood pressure

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 301, Issue 4, 2011, Pages

  Li, Huiping ^a   Weatherford, Eric T ^a   Davis, Deborah R ^a   Keen, Henry L ^a   Grobe, Justin L ^a   Daugherty, Alan ^b   Cassis, Lisa A ^c   Allen, Andrew M ^d   Sigmund, Curt D ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Angiotensin II; Kidney

Indexed keywords

ANDROGEN; ANGIOTENSIN 1A RECEPTOR; CRE RECOMBINASE; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; FEMALE; GENE OVEREXPRESSION; HYPERTENSION; HYPOTENSION; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIGNAL TRANSDUCTION; SODIUM TRANSPORT; TRANSGENIC MOUSE;

ANDROGENS; ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; FEMALE; INTEGRASES; KIDNEY TUBULES, PROXIMAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, ANIMAL; RECEPTOR, ANGIOTENSIN, TYPE 1; SIGNAL TRANSDUCTION;

EID: 80053655134     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00124.2011     Document Type: Article

References (39)

1. Allen AM, Dosanjh JK, Erac M, Dassanayake S, Hannan RD, Thomas WG. Expression of constitutively active angiotensin receptors in the rostral ventrolateral medulla increases blood pressure. Hypertension 47: 1054-1061, 2006.
2. Auger-Messier M, Arguin G, Chaloux B, Leduc R, Escher E, Guillemette G. Down-regulation of inositol 1,4,5-trisphosphate receptor in cells stably expressing the constitutively active angiotensin II N111GAT(1) receptor. Mol Endocrinol 18: 2967-2980, 2004.
3. Auger-Messier M, Clement M, Lanctot PM, Leclerc PC, Leduc R, Escher E, Guillemette G. The constitutively active N111G-AT1 receptor for angiotensin II maintains a high affinity conformation despite being uncoupled from its cognate G protein Gq/11. Endocrinology 144: 5277-5284, 2003.
4. Bartke A. Increased sensitivity of seminal vesicles to testosterone in a mouse strain with low plasma testosterone levels. J Endocrinol 60: 145-148, 1974.
5. Bianco RA, Keen HL, Lavoie JL, Sigmund CD. Untraditional methods for targeting the kidney in transgenic mice. Am J Physiol Renal Physiol 285: F1027-F1033, 2003.
6. Billet S, Bardin S, Tacine R, Clauser E, Conchon S. The AT1A receptor "gain-of-function" mutant N111S/delta329 is both constitutively active and hyperreactive to angiotensin II. Am J Physiol Endocrinol Metab 290: E840-E848, 2006.
7. Billet S, Bardin S, Verp S, Baudrie V, Michaud A, Conchon S, Muffat-Joly M, Escoubet B, Souil E, Hamard G, Bernstein KE, Gasc JM, Elghozi JL, Corvol P, Clauser E. Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice. J Clin Invest 117: 1914-1925, 2007.
8. Boer WH, Braam B, Fransen R, Boer P, Koomans HA. Effects of reduced renal perfusion pressure and acute volume expansion on proximal tubule and whole kidney angiotensin II content in the rat. Kidney Int 51: 44-49, 1997.
9. Brouillette J, Rivard K, Lizotte E, Fiset C. Sex and strain differences in adult mouse cardiac repolarization: importance of androgens. Cardiovasc Res 65: 148-157, 2005.
10. Cervenka L, Wang CT, Mitchell KD, Navar LG. Proximal tubular angiotensin II levels and renal functional responses to AT1 receptor blockade in nonclipped kidneys of Goldblatt hypertensive rats. Hypertension 33: 102-107, 1999.
11. Crowley SD, Gurley SB, Oliverio MI, Pazmino AK, Griffiths R, Flannery PJ, Spurney RF, Kim HS, Smithies O, Le TH, Coffman TM. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest 115: 1092-1099, 2005.
12. Daugherty A, Rateri DL, Lu H, Inagami T, Cassis LA. Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation 110: 3849-3857, 2004.
13. Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD. Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol Genomics 1: 3-9, 1999.
14. Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, Sigmund CD. The kidney androgen-regulated protein (KAP) promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem 272: 28142-28148, 1997.
15. Ding Y, Sigmund CD. Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. Am J Physiol Renal Physiol 280: F54-F60, 2001.
16. Groblewski T, Maigret B, Larguier R, Lombard C, Bonnafous JC, Marie J. Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation. J Biol Chem 272: 1822-1826, 1997.
17. Gurley SB, Riquier-Brison AD, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab 13: 469-475, 2011.
18. Hall JE. Control of sodium excretion by angiotensin II: intrarenal mechanisms and blood pressure regulation. Am J Physiol Regul Integr Comp Physiol 250: R960-R972, 1986.
19. Harris PJ, Young JA. Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney. Pflügers Arch 367: 295-297, 1977.
20. Harrison-Bernard LM, Navar LG, Ho MM, Vinson GP, el-Dahr SS. Immunohistochemical localization of ANG II AT1 receptor in adult rat kidney using a monoclonal antibody. Am J Physiol Renal Physiol 273: F170-F177, 1997.
21. Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 59: 251-287, 2007.
22. Kobori H, Ozawa Y, Satou R, Katsurada A, Miyata K, Ohashi N, Hase N, Suzaki Y, Sigmund CD, Navar LG. Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice. Am J Physiol Renal Physiol 293: F938-F945, 2007.
23. Lavoie JL, Lake-Bruse KD, Sigmund CD. Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. Am J Physiol Renal Physiol 286: F965-F971, 2004.
24. Lavoie JL, Liu X, Bianco RA, Beltz TG, Johnson AK, Sigmund CD. Evidence supporting a functional role for intracellular renin in the brain. Hypertension 47: 461-466, 2006.
25. Le TH, Kim HS, Allen AM, Spurney RF, Smithies O, Coffman TM. Physiological impact of increased expression of the AT1 angiotensin receptor. Hypertension 42: 507-514, 2003.
26. Le TH, Oliverio MI, Kim HS, Salzler H, Dash RC, Howell DN, Smithies O, Bronson S, Coffman TM. A GT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. Physiol Genomics 18: 290-298, 2004.
27. Li H, Zhou X, Davis DR, Xu D, Sigmund CD. An androgen-inducible proximal tubule-specific Cre recombinase transgenic model. Am J Physiol Renal Physiol 294: F1481-F1486, 2008.
28. Li S, Nagothu KK, Desai V, Lee T, Branham W, Moland C, Megyesi JK, Crew MD, Portilla D. Transgenic expression of proximal tubule peroxisome proliferator-activated receptor- in mice confers protection during acute kidney injury. Kidney Int 76: 1049-1062, 2009.
29. Li Z, Iwai M, Wu L, Shiuchi T, Jinno T, Cui TX, Horiuchi M. Role of AT2 receptor in the brain in regulation of blood pressure and water intake. Am J Physiol Heart Circ Physiol 284: H116-H121, 2003.
30. Miserey-Lenkei S, Parnot C, Bardin S, Corvol P, Clauser E. Constitutive internalization of constitutively active agiotensin II AT1A receptor mutants is blocked by inverse agonists. J Biol Chem 277: 5891-5901, 2002.
31. Navar LG, Imig JD, Wang CT. Intrarenal production of angiotensin II. Sem Nephrol 17: 412-422, 1997.
32. Navar LG, Lewis L, Hymel A, Braam B, Mitchell KD. Tubular fluid concentrations and kidney contents of angiotensins I and II in anesthetized rats. J Am Soc Nephrol 5: 1153-1158, 1994.
33. Ouali R, Berthelon MC, Begeot M, Saez JM. Angiotensin II receptor subtypes AT1 and AT2 are down-regulated by angiotensin II through AT1 receptor by different mechanisms. Endocrinology 138: 725-733, 1997.
34. Rankin EB, Tomaszewski JE, Haase VH. Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res 66: 2576-2583, 2006.
35. Rateri DL, Moorleghen JJ, Balakrishnan A, Owens AP, III, Howatt DA, Subramanian V, Poduri A, Charnigo R, Cassis LA, Daugherty A. Endothelial cell-specific deficiency of ANG II type 1a receptors attenuates ANG II-induced ascending aortic aneurysms in LDL receptor-/- mice. Circ Res 108: 574-581, 2011.
36. Redding KM, Chen BL, Singh A, Re RN, Navar LG, Seth DM, Sigmund CD, Tang WW, Cook JL. Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. Am J Physiol Heart Circ Physiol 298: H1807-H1818, 2010.
37. Sachetelli S, Liu Q, Zhang SL, Liu F, Hsieh TJ, Brezniceanu ML, Guo DF, Filep JG, Ingelfinger JR, Sigmund CD, Hamet P, Chan JS. RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney Int 69: 1016-1023, 2006.
38. Song K, Allen AM, Paxinos G, Mendelsohn FAO. Mapping of angiotensin II receptor subtype heterogeneity in rat brain. J Comp Neurol 316: 467-484, 1992.
39. Wang X, Armando I, Upadhyay K, Pascua A, Jose PA. The regulation of proximal tubular salt transport in hypertension: an update. Curr Opin Nephrol Hypertens 18: 412-420, 2009.