A comparison of physicochemical properties of a selection of modern moisturizers: Hydrophilic index and pH

Journal of Drugs in Dermatology

Volumn 11, Issue 5, 2012, Pages 633-636

  Shi, Vivian Y ^a   Tran, Khiem ^a   Lio, Peter A ^b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID MANTLE; AVEENO; CERAVE; CETAPHIL; COSMETIC; DERMATOLOGICAL AGENT; DML; DOVE DAY LOTION; EMOLLIENT AGENT; EPICERAM; LANOLIN ALCOHOL; NEOSALUS; PETROLATUM; THERAPLEX; TIMOLOL MALEATE; TRIPLE PASTE; UNCLASSIFIED DRUG; VANICREAM; XIPAMIDE;

ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DRY SKIN; HUMIDIFIER; HYDROPHILICITY; ICHTHYOSIS VULGARIS; IRRITANT DERMATITIS; OINTMENT; PATIENT ATTITUDE; PH; PHYSICAL CHEMISTRY; PRURITUS; REHYDRATION; STRATUM CORNEUM; UNITED STATES; WATER CONTENT;

EMOLLIENTS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; SKIN; SKIN DISEASES; UNITED STATES; WATER;

EID: 84860909180     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Blank IH. Measurement of pH of the Skin Surface. Journ of Invest Dermatol. 1939;2(5):231-234.
2. Parra JL, Paye M. EEMCO guidance for the in vivo assessment of skin surface pH. Skin Pharmacol Appl Skin Physiol. 2003;16(3):188-202. (Pubitemid 36407894)
3. Schmid-Wendtner MH, Korting HC. The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol. 2006;19(6):296-302. (Pubitemid 44808083)
4. Lambers H, Piessens S, Bloem A, Pronk H, Finkel P. Natural skin surface pH is on average below 5, which is beneficial for its resident flora. Int J Cosmet Sci. 2006;28(5):359-370. (Pubitemid 44423012)
5. Elias PM. Stratum corneum defensive functions: an integrated view. J Invest Dermatol. 2005;125(2):183-200. (Pubitemid 41648149)
6. Rippke F, Schreiner V, Schwanitz HJ. The acidic milieu of the horny layer: new findings on the physiology and pathophysiology of skin pH. Am J Clin Dermatol. 2002;3(4):261-272. (Pubitemid 34615389)
7. Sparavigna A, Setaro M, Gualandri V. Cutaneous pH in children affected by atopic dermatitis and in healthy children: a multicenter study. Skin Res Technol. 1999;5(4):221-227. (Pubitemid 29504971)
8. Seidenari S, Giusti G. Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin. Acta Derm Venereol. 1995;75(6):429-433. (Pubitemid 26051887)
9. Eberlein-Konig B, Schafer T, Huss-Marp J, et al. Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children. Acta Derm Venereol. 2000;80(3):188-191.
10. Ohman H, Vahlquist A. The pH gradient over the stratum corneum differs in X-linked recessive and autosomal dominant ichthyosis: a clue to the molecular origin of the "acid skin mantle"? J Invest Dermatol. 1998;111(4):674-677. (Pubitemid 28452332)
11. Menon GK, Ghadially R, Williams ML, Elias PM. Lamellar bodies as delivery systems of hydrolytic enzymes: implications for normal and abnormal desquamation. Br J Dermatol. 1992;126(4):337-345.
12. Lynde CW. Moisturizers: what they are and how they work. Skin Therapy Lett. 2001;6(13):3-5.
13. Bikowski J, Shroot B. Multivesicular emulsion: a novel, controlled- release delivery system for topical dermatological agents. J Drugs Dermatol. 2006;5(10):942-946.
14. Anderson PC, Dinulos JG. Are the new moisturizers more effective? Curr Opin Pediatr. 2009;21(4):486-490.
15. Draelos ZD. Active agents in common skin care products. Plast Reconstr Surg. 2010;125(2):719-724.
16. Kraft JN, Lynde CW. Moisturizers: what they are and a practical approach to product selection. Skin Therapy Lett. 2005;10(5):1-8.
17. Wilhelm KP, Maibach HI. Susceptibility to irritant dermatitis induced by sodium lauryl sulfate. J Am Acad Dermatol. 1990;23(1):122-124. (Pubitemid 20219227)
18. Gfatter R, Hackl P, Braun F. Effects of soap and detergents on skin surface pH, stratum corneum hydration and fat content in infants. Dermatol. 1997;195(3):258-262. (Pubitemid 27482888)
19. Caussin J, Groenink HW, de Graaff AM, et al. Lipophilic and hydrophilic moisturizers show different actions on human skin as revealed by cryo scanning electron microscopy. Exp Dermatol. 2007;16(11):891-898. (Pubitemid 47570628)
20. Caussin J, Rozema E, Gooris GS, Wiechers JW, Pavel S, Bouwstra JA. Hydrophilic and lipophilic moisturizers have similar penetration profiles but different effects on SC water distribution in vivo. Exp Dermatol. 2009;18(11):954-961.
21. Caussin J, Gooris GS, Bouwstra JA. FTIR studies show lipophilic moisturizers to interact with stratum corneum lipids, rendering the more densely packed. Biochim Biophys Acta. 2008;1778(6):1517-1524.
22. Caussin J, Gooris GS, Groenink HW, Wiechers JW, Bouwstra JA. Interaction of lipophilic moisturizers on stratum corneum lipid domains in vitro and in vivo. Skin Pharmacol Physiol. 2007;20(4):175-186. (Pubitemid 47000421)
23. Loden M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-788. (Pubitemid 37452637)