Applications of differential scanning calorimetry for thermal stability analysis of proteins: Qualification of DSC

Journal of Pharmaceutical Sciences

Volumn 101, Issue 3, 2012, Pages 955-964

  Wen, Jie ^a   Arthur, Kelly ^a   Chemmalil, Letha ^a   Muzammil, Salman ^b   Gabrielson, John ^a   Jiang, Yijia ^a  

^a AMGEN INC   (United States)

^b CENTOCOR INC   (United States)

Author keywords

Biotechnology; Calorimetry (DSC); Method qualification; Protein structure; Proteins; Thermal analysis

Indexed keywords

CYTOKINE; GLOBULAR PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; PROTEIN;

ACCURACY; ARTICLE; CALIBRATION; CALORIMETER; CONFORMATIONAL TRANSITION; DIFFERENTIAL SCANNING CALORIMETRY; PH; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; STRUCTURE ANALYSIS; THERMOSTABILITY; TRANSITION TEMPERATURE;

EID: 84855884280     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22820     Document Type: Article

References (22)

1. Cooper A, Nutley MA, Wadood A. 2000. Differential scanning microcalorimetry. In Protein-ligand interactions: Hydrodynamics and calorimetry; Harding SE, Chowdhry BZ, Eds. Oxford, New York: Oxford University Press, pp 287-318.
2. Privalov PL. 1979. Stability of proteins: Small globular proteins. In Advances in protein chemistry; Anfinsen CB, Edsall JT, Richards FM, Eds. Vol. 33. New York: Academic Press, pp 167-241.
3. Privalov PL. 1982. Stability of proteins: Proteins which do not present a single cooperative system. In Advances in protein chemistry; Anfinsen CB, Edsall JT, Richards FM, Eds. Vol. 35. New York: Academic Press, pp 1-101.
4. Remmele RL, Nightlinger NS, Srinivasan S, Gombotz, WR. 1998. Interleukin-1 receptor (IL-1R) liquid formulation development using differential scanning calorimetry. Pharm Res 15:200-208.
5. Wen J, Jiang Y, Narhi L, Hymes K, Gong K. 2007. Correlation between thermal stability and protein stability. In Proceedings of the 2007 Current Trends in Microcalorimetry Conference; Reese E, Spotts S, Eds. Northampton, Massachusetts: MicroCal LLC, pp 93-108.
6. Wen J, Jiang Y, Narhi L. 2007. Applications of DSC for antibodies and Fc-conjugated proteins. Am Pharm Rev 10:10-15.
7. Wen J, Jiang Y, Narhi L. 2008. Effect of carbohydrate on thermal stability of antibodies. Am Pharm Rev 11:98-104.
8. Hahn R, Schlegel R, Jungbauer A. 2003. Comparison of protein A affinity sorbents. J Chromatogr B 790:35-51.
9. Zhou JX, Tressel T, Hong T, Li F, Yang X, Lee B. (2007) Optimization of antibody processing: Upstream and downstream in advances in large scale biomanufacturing and scale-up production, Chapter 20. 2nd ed. ASM Press (American Society for Microbiology) and BioPlan Associates, Rockville, Maryland.
10. MicroCal VP-Capillary DSC system user's manual. Northampton, Massachusetts: MicroCal LLC. 2005.
11. MicroCal VP-DSC MicroCalorimeter user's manual. Northampton, Massachusetts: MicroCal LLC. 2005.
12. MicroCal DSC Data Analysis in Origin, version 7.0. Northampton, Massachusetts: MicroCal LLC. 2004.
13. TA Instruments Q Series Manuals. New Castle, Delaware: TA Instruments. 2006.
14. Cover, TM, Hart PE. 1967. Nearest neighbor pattern classification. IEEE Trans Inf Theory 13:21-27.
15. Thermo OMNIC software manual. Waltham, Massachusetts: Thermo Fisher Scientific Inc.
16. Welfle K, Misselwitz R, Hausdorf G, Hohne W, Welfle H. 1999. Conformation, pH-induced conformational changes, and thermal unfolding of anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab and Fc fragments. Biochim Biophys Acta 1431:120-131.
17. Tischenko VM, Abramov VM, Zav'yalov VP. 1998. Investigation of the cooperative structure of Fc fragments from myeloma immunoglobulin G. Biochemistry 37:5576-5581.
18. Vermeer AW, Norde W, van Amerongen A. 2000. The unfolding/denaturation of immunogammaglobulin of isotype 2b and its F(ab) and F(c) fragments. Biophys J 79:2150-2154.
19. Vermeer AW, Norde W. 2000. The thermal stability of immunoglobulin: Unfolding and aggregation of a multi-domain protein. Biophys J 78:394-404.
20. Garber E, Demarest SJ. 2007. A broad range of Fab stabilities within a host of therapeutic IgGs. Biochem Biophys Res Commun 355:751-757.
21. Jefferis R, Lund J, Pound J. 1998. IgG-Fc mediated effector functions: Molecular definition of interaction sites for effector ligands and the role of glycosylation. Immunol Rev 163:50-76.
22. Mimura Y, Church S, Ghirlando R, Ashton PR, Dong S, Goodall M, Lund J, Jefferis R. 2000. The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc. Mol Immunol 37:697-706.