Cell surface localization and release of the candidate tumor suppressor Ecrg4 from polymorphonuclear cells and monocytes activate macrophages

Journal of Leukocyte Biology

Volumn 91, Issue 5, 2012, Pages 773-781

  Baird, Andrew ^a   Coimbra, Raul ^a   Dang, Xitong ^a   Lopez, Nicole ^a   Lee, Jisook ^a   Krzyzaniak, Michael ^a   Winfield, Robert ^a   Potenza, Bruce ^a   Eliceiri, Brian P ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECRG4 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOTINYLATION; BURN; CASE REPORT; CELL LYSATE; CELL SUBPOPULATION; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA METHYLATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; INFLAMMATION; LEUKOCYTE; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MONOCYTE; NEUTROPHIL; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN SECRETION; TUMOR SUPPRESSOR GENE;

ANIMALS; BALB 3T3 CELLS; BLOTTING, WESTERN; BURNS; CASE-CONTROL STUDIES; CELLS, CULTURED; DNA METHYLATION; FLOW CYTOMETRY; GENES, TUMOR SUPPRESSOR; HUMANS; LEUKOCYTES; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MICE; MONOCYTES; NEOPLASM PROTEINS; NEUTROPHILS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84860891094     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1011503     Document Type: Article

References (42)

1. Han, J., Ulevitch, R. J. (2005) Limiting inflammatory responses during activation of innate immunity. Nat. Immunol. 6, 1198-1205.
2. Liew, F. Y., Xu, D., Brint, E. K., O'Neill, L. A. (2005) Negative regulation of Toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5, 446-458.
3. Gonzalez, A., Podvin, S., Lin, S-Y., Miller, M., Botfield, H., Leadbeater, W., Roberton, A., Dang, X., Knowling, S., Cardenas-Galindo, E., Donahue, J. E., Stopa, E. G., Johanson, C. E., Coimbra, R., Eliceiri, B. P., Baird, A. (2011) Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeosta-sis and neuroprogenitor cell response to CNS injury. Fluids Barriers CNS 8, 6.
4. Gotze, S., Feldhaus, V., Traska, T., Wolter, M., Reifenberger, G., Tannap-fel, A., Kuhnen, C., Martin, D., Muller, O., Sievers, S. (2009) ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorec-tal carcinoma and glioma. BMC Cancer 9, 447.
5. Huh, Y. H., Ryu, J. H., Shin, S., Lee, D. U., Yang, S., Oh, K. S., Chun, C. H., Choi, J. K., Song, W. K., Chun, J. S. (2009) Esophageal cancer related gene 4 (ECRG4) is a marker of articular chondrocyte differentiation and cartilage destruction. Gene 448, 7-15.
6. Kujuro, Y., Suzuki, N., Kondo, T. (2010) Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells. Proc. Natl. Acad. Sci. USA 107, 8259-8264.
7. Li, L., Li, Y., Li, X., Zhang, C., Zhou, Y., Lu, S. (2011) A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma. BMC Cancer 11, 52.
8. Li, L., Yang, Y., Li, X., Zhou, Y., Lu, S. (2011) Cloning and expression of soluble recombinant human esophageal cancer related gene 4 protein and its inhibitory effect on tumor growth in vitro and in vivo in esopha-geal carcinoma. Cancer Sci. 102, 1245.
9. Li, L. W., Yu, X. Y., Yang, Y., Zhang, C. P., Guo, L. P., Lu, S. H. (2009) Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo. Int. J. Cancer 125, 1505-1513.
10. Li, W., Liu, X., Zhang, B., Qi, D., Zhang, L., Jin, Y., Yang, H. (2010) Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion. J. Exp. Clin. Cancer Res. 29, 89.
11. Tadross, J. A., Patterson, M., Suzuki, K., Beale, K. E., Boughton, C. K., Smith, K. L., Moore, S., Ghatei, M. A., Bloom, S. R. (2010) Augurin stimulates the hypothalamo-pituitary-adrenal axis via the release of corticotro-phin-releasing factor in rats. Br. J. Pharmacol. 159, 1663-1671.
12. Yue, C. M., Deng, D. J., Bi, M. X., Guo, L. P., Lu, S. H. (2003) Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG Island hypermethylation in human esophageal squamous cell carcinoma. World J. Gastroenterol. 9, 1174-1178.
13. Podvin, S., Gonzalez, A. M., Miller, M. C., Dang, X., Botfield, H., Donahue, J. E., Kurabi, A., Boissaud-Cooke, M., Rossi, R., Leadbeater, W. E., Johanson, C. E., Coimbra, R., Stopa, E. G., Eliceiri, B. P., Baird, A. (2011) Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury. PLoS One 6, e24609.
14. Lee, E. Y., Muller, W. J. (2010) Oncogenes and tumor suppressor genes. Cold Spring Harb. Perspect. Biol. 2, a003236.
15. Clark, H. F., Gurney, A. L., Abaya, E., Baker, K., Baldwin, D., Brush, J., Chen, J., Chow, B., Chui, C., Crowley, C., et al. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 13, 2265-2270.
16. Mirabeau, O., Perlas, E., Severini, C., Audero, E., Gascuel, O., Possenti, R., Birney, E., Rosenthal, N., Gross, C. (2007) Identification of novel pep-tide hormones in the human proteome by hidden Markov model screening. Genome Res. 17, 320-327.
17. Ozawa, A., Lick, A. N., Lindberg, I. (2011) Processing of proaugurin is required to suppress proliferation of tumor cell lines. Mol. Endocrinol. 25, 776-784.
18. Lazure, C., Seidah, N. G., Pelaprat, D., Chretien, M. (1983) Proteases and posttranslational processing of prohormones: a review. Can. J. Biochem. Cell Biol. 61, 501-515.
19. Lowry, P. J. (1984) Pro-opiocortin: the multiple adrenal hormone precursor. Review. Biosci. Rep. 4, 467- 482.
20. Mori, Y., Ishiguro, H., Kuwabara, Y., Kimura, M., Mitsui, A., Kurehara, H., Mori, R., Tomoda, K., Ogawa, R., Katada, T., Harata, K., Fujii, Y. (2007) Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Oncol. Rep. 18, 981-985.
21. Nishikawa, M., Drmanac, R. T., Lobal, I., Tang, Y. T., Lee, J., Stache-Crain, B. (2008) Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and DNA coding for the same. In United States Patent Trade Office (USPTO, ed.), Nuvelo, San Carlos, CA, USA.
22. Trudel, C, Faure-Desire, V., Florkiewicz, R. Z., Baird, A. (2000) Translocation of FGF2 to the cell surface without release into conditioned media. J. Cell. Physiol. 185, 260-268.
23. Xiao, W., Mindrinos, M. N., Seok, J., Cuschieri, J., Cuenca, A. G., Gao, H., Hayden, D. L., Hennessy, L., Moore, E. E., Minei, J. P., et al. (2011) A genomic storm in critically injured humans. J. Exp. Med. 208, 2581-2590.
24. Chen, L. W., Huang, H. L., Lee, I. T., Hsu, C. M., Lu, P.J. (2006) Thermal injury-induced priming effect of neutrophil is TNF-a and P38 dependent. Shock 26, 69-76.
25. Howard, T. H., Meyer, W. H. (1984) Chemotactic peptide modulation of actin assembly and locomotion in neutrophils. J. Cell Biol. 98, 1265-1271.
26. Kutsuna, H., Suzuki, K, Kamata, N., Kato, T., Hato, F., Mizuno, K, Ko-bayashi, H., Ishii, M., Kitagawa, S. (2004) Actin reorganization and morphological changes in human neutrophils stimulated by TNF, GM-CSF, and G-CSF: the role of MAP kinases. Am. J. Physiol. Cell. Physiol. 286, C55-C64.
27. Fernandez-Segura, E., Garcia, J. M., Santos, J. L., Campos, A. (1995) Shape, F-actin, and surface morphology changes during chemotactic pep-tide-induced polarity in human neutrophils. Anat. Rec. 241, 519-528.
28. Cavaillon, J. M, Adrie, C, Fitting, C, Adib-Conquy, M. (2005) Repro-gramming of circulatory cells in sepsis and SIRS.J. Endotoxin. Res. 11, 311-320.
29. Cavaillon, J. M., Annane, D. (2006) Compartmentalization of the inflammatory response in sepsis and SIRS. J. Endotoxin. Res. 12, 151-170.
30. Dahiya, P. (2009) Burns as a model of SIRS. Front. Biosci. 14, 4962-4967.
31. Desai, K. H., Tan, C. S., Leek, J. T., Maier, R V., Tompkins, R G., Storey, J. D. (2011) Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study. PLoS Med. 8, e1001093.
32. Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K, Rossi, D., Greaves, D. R, Zlotnik, A, Schall, T.J. (1997) A new class of membrane-bound chemokine with a CX3C motif. Nature 385, 640-644.
33. Decoster, E., Vanhaesebroeck, B., Vandenabeele, P., Grooten, J., Fiers, W. (1995) Generation and biological characterization of membrane-bound, uncleavable murine tumor necrosis factor. J. Biol. Chem. 270, 18473-18478.
34. Ludwig, A, Weber, C. (2007) Transmembrane chemokines: versatile "special agents" in vascular inflammation. Thromb. Haemost. 97, 694-703.
35. Santos, D. O., Lorre, K, de Boer, M., Van Heuverswyn, H. (1999) Shedding of soluble receptor for tumor necrosis factor a induced by M. leprae or LPS from human mononuclear cells. Nihon Hansenbyo Gakkai Zasshi 68, 185-193.
36. Douvdevani, A, Einbinder, T., Yulzari, R, Rogachov, B., Chaimovitz, C. (1996) TNF-receptors on human peritoneal mesothelial cells: regulation of receptor levels and shedding by IL-1 α and TNF α. Kidney Int. 50, 219-228.
37. Vanaja, D. K, Ehrich, M., Van den Boom, D., Cheville, J. C, Karnes, R J., Tindall, D. J., Cantor, C. R, Young, C. Y (2009) Hypermethylation of genes for diagnosis and risk stratification of prostate cancer. Cancer Invest. 27, 549-560.
38. Pillay, J., Ramakers, B. P., Kamp, V M., Loi, A. L., Lam, S. W., Hietbrink, F., Leenen, L. P., Tool, A. T., Pickkers, P., Koenderman, L. (2010) Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia. J. Leukoc. Biol. 88, 211-220.
39. Kopydlowski, K. M., Salkowski, C. A, Cody, M. J., van Rooijen, N., Major, J., Hamilton, T. A, Vogel, S. N. (1999) Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo. J. Immunol. 163, 1537-1544.
40. Lederer, J. A., Brownstein, B. H., Lopez, M. C, Macmillan, S., Delisle, A. J., Macconmara, M. P., Choudhry, M. A, Xiao, W., Lekousi, S., Cobb, J. P., Baker, H. V., Mannick, J. A., Chaudry, I. H., Inflammation and the Host Response to Injury Collaborative Research Program Participants (2008) Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiol. Genomics 32, 299-310.
41. Farrah, T., Deutsch, E. W., Omenn, G. S., Campbell, D. S., Sun, Z., Bletz, J. A, Mallick, P., Katz, J. E., Malmstrom, J., Ossola, R, Watts, J. D., Lin, B., Zhang, H., Moritz, R L., Aebersold, R (2011) A high-confidence human plasma proteome reference set with estimated concentrations in PeptideAtlas. Mol. Cell. Proteomics 10, M110.006353.
42. Steck, E., Breit, S., Breusch, S. J., Axt, M., Richter, W. (2002) Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chiti-nase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. Biochem. Biophys. Res. Commun. 299, 109-115.