A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Li, Lin wei ^a   Li, Yuan yuan ^b   Li, Xiao yan ^a   Zhang, Chun Peng ^b   Zhou, Yun ^a   Lu, Shih Hsin ^b  

^a HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b CANCER HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BROXURIDINE; PROTEIN P21; TRANSMEMBRANE PROTEASE SERINE 11A; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN ECRG4; UNCLASSIFIED DRUG; C2ORF40 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ECRG 1 PROTEIN, HUMAN; ECRG-1 PROTEIN, HUMAN; MEMBRANE PROTEIN; SERINE PROTEINASE; TUMOR PROTEIN;

ARTICLE; BINDING AFFINITY; CANCER CELL; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TUMOR SUPPRESSOR GENE; UPREGULATION; BINDING COMPETITION; CELL CYCLE; ESOPHAGUS TUMOR; FLOW CYTOMETRY; GENETICS; METABOLISM; PATHOLOGY; PROTEIN BINDING; TUMOR CELL LINE; WESTERN BLOTTING;

BINDING, COMPETITIVE; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ESOPHAGEAL NEOPLASMS; FLOW CYTOMETRY; G1 PHASE; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; NEOPLASM PROTEINS; PROTEIN BINDING; SERINE PROTEASES; TRANSFECTION;

EID: 79551529132     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-52     Document Type: Article

References (30)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005, 55:74-108. 10.3322/canjclin.55.2.74, 15761078.
2. Holmes RS, Vaughan TL. Epidemiology and pathogenesis of esophageal cancer. Semin Radiat Oncol 2007, 17:2-9. 10.1016/j.semradonc.2006.09.003, 17185192.
3. Luo A, Kong J, Hu G, Liew CC, Xiong M, Wang X, Ji J, Wang T, Zhi H, Wu M, Liu Z. Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. Oncogene 2004, 23:1291-1299. 10.1038/sj.onc.1207218, 14647409.
4. Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, Sugano S, Nakamura Y, Inazawa J. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. Cancer Res 2000, 60:4735-4739.
5. Bi MX, Han WD, Lu SX. Using lab on-line to clone and identify the esophageal cancer related gene 4. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2001, 33:257-261.
6. Su T, Liu H, Lu S. Cloning and identification of cDNA fragments related to human esophageal cancer. Chin J Oncol 1998, 20:254-257.
7. Yue CM, Deng DJ, Bi MX, Guo LP, Lu SH. Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma. World J Gastroenterol 2003, 9:1174-1178.
8. Mori Y, Ishiguro H, Kuwabara Y, Kimura M, Mitsui A, Kurehara H, Mori R, Tomoda K, Ogawa R, Katada T, Harata K, Fujii Y. Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Oncol Rep 2007, 18:981-985.
9. Li LW, Yu XY, Yang Y, Zhanag CP, Guo LP, Lu SH. Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo. Int J Cancer 2009, 125:1505-1513. 10.1002/ijc.24513, 19521989.
10. Li LW, Zhang CP, Li XY, Lu SH, Zhou Y. The candidate tumor suppressor gene ECR4 inhibits cancer cells migration and invasion in esophageal carcinoma. J Exp Clin Cancer Res 2010, 29:133. 10.1186/1756-9966-29-133, 2958930, 20937111.
11. Vanaja DK, Ehrich M, Van den Boom D, Cheville JC, Karnes RJ, Tindall DJ, Cantor CR, Young CY. Hypermethylation of genes for diagnosis and risk stratification of prostate cancer. Cancer Invest 2009, 27:549-560. 10.1080/07357900802620794, 2693083, 19229700.
12. Götze S, Feldhaus V, Traska T, Wolter M, Reifenberger G, Tannapfel A, Kuhnen C, Martin D, Mu{double acute}ller O, Sievers S. ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma. BMC Cancer 2009, 9:447. 2804712, 20017917.
13. Li W, Liu XR, Zhang B, Qi DX, Zhang LH, Jin YH, Yang HF. Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion. J Exp Clin Cancer Res 2010, 29:89. 10.1186/1756-9966-29-89, 2913949, 20598162.
14. Han Y, Wei F, Xu X, Cai Y, Chen B, Wang J, Xia S, Hu H, Huang X, Han Y, Wu M, Wang M. Establishment and comparative genomic hybridization analysis of human esophageal carcinomas cell line EC9706. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2002, 19:455-457.
15. Huang G, Hu Z, Li M, Cui Y, Li Y, Guo L, Jiang W, Lu SH. ECRG2 inhibits cancer cell migration, invasion and metastasis through the down-regulation of uPA/plasmin activity. Carcinogenesis 2007, 28:2274-2281. 10.1093/carcin/bgm140, 17602171.
16. Steck E, Breit S, Breusch SJ, Axt M, Richter W. Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. Biochem Biophys Res Commun 2002, 299:109-115. 10.1016/S0006-291X(02)02585-8, 12435396.
17. Huh YH, Ryu JH, Shin S, Lee DU, Yang S, Oh KS, Chun CH, Choi JK, Song WK, Chun JS. Esophageal cancer related gene 4 (ECRG4) is a marker of articular chondrocyte differentiation and cartilage destruction. Gene 2009, 448:7-15. 10.1016/j.gene.2009.08.015, 19735703.
18. Woo JM, Park SJ, Kang HI, Kim BG, Shim SB, Jee SW, Lee SH, Sin JS, Bae CJ, Jang MK, Cho C, Hwang DY, Kim CK. Characterization of changes in global gene expression in the brain of neuron-specific enolase/human Tau23 transgenic mice in response to overexpression of Tau protein. Int J Mol Med 2010, 25:667-675.
19. Kujuro Y, Suzuki N, Kondo T. Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells. Proc Natl Acad Sci USA 2010, 107:8259-8264. 10.1073/pnas.0911446107, 2889548, 20404145.
20. Li YY, Zhang XM, Huang G, Miao XP, Guo LP, Lin DX, Lu SX. Identification of a novel polymorphism Arg290Gln of esophageal cancer related gene 1 (ECRG1) and it related risk to esophageal squamous cell carcinoma. Carcinogenesis 2006, 27:798-802. 10.1093/carcin/bgi258, 16267096.
21. Bachmann K, Shahmiri S, Kaifi J, Schurr P, Mann O, Rawnaq T, Block S, Kalinin V, Izbicki JR, Strate T. Polymorphism Arg290Arg in esophageal-cancer-related gene 1 (ECRG1) is a prognostic factor for survival in esophageal cancer. J Gastrointest Surg 2009, 13:181-187. 10.1007/s11605-008-0766-6, 19052822.
22. Blessmann M, Pohlenz P, Atac A, Kaifi JT, Eulenburg C, Kalinin V, Merkert P, Smeets R, Heiland M, Blake F, Schmelzle R, Izbicki JR. Single nucleotide polymorphism in esophageal cancer related gene 1: an analysis in resected oral squamous cell carcinoma patients. Int J Oral Maxillofac Surg 2009, 38:779-784. 10.1016/j.ijom.2009.02.021, 19394797.
23. Wang YY, Tang HJ, Lu SX. Expression in E.coli of protein encoded by human esophageal cancer related gene-1. Chin J Oncol 2000, 22:198-200.
24. Wang YY, Wang JB, Liu HL, Tang HJ, Guo LP, Lu SX. ECRG1, a novel esophageal gene, cloned and identified from human esophagus and its inhibition effect on tumors. Carcinogenesis 2008, 29:157-160.
25. Wang JB, Fan Y, Guo LP, Lu SX. Search for interacting proteins of esophageal cancer related gene-1 encoded protein through the yeast two-hybrid system. Chin J Oncol 2002, 24:219-221.
26. Zhao NX, Wang JB, Cui YP, Guo LP, Lu SX. Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1. J Cell Biochem 2004, 92:65-76. 10.1002/jcb.20025, 15095404.
27. Zhao NX, Huang G, Guo LP, Lu SX. ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells. Exp Biol Med 2006, 231:84-90.
28. Lu SH. Alterations of oncogenes and tumor suppressor genes in esophageal cancer in China. Mutat Res 2000, 462:343-353. 10.1016/S1383-5742(00)00023-5, 10767644.
29. Whitson JM, Noonan EJ, Pookot D, Place RF, Dahiya R. Double stranded-RNA-mediated activation of P21 gene induced apoptosis and cell cycle arrest in renal cell carcinoma. Int J Cancer 2009, 125:446-452. 10.1002/ijc.24370, 19384944.
30. Liu F, Li X, Wang C, Cai X, Du Z, Xu H, Li F. Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1. Int J Cancer 2009, 125:2511-2519. 10.1002/ijc.24588, 19610058.