The protective effects of inosine against chemical hypoxia on cultured rat oligodendrocytes

Cellular and Molecular Neurobiology

Volumn 31, Issue 8, 2011, Pages 1171-1186

  Ma, Quan Rui ^a   Yang, Hao ^a   Zhao, Xiang Hui ^a   Zhang, Yu Kai ^a   Yao, An Hui ^a   Cheng, Peng ^a   Xie, Ya Bin ^a   Zhao, Hai Kang ^a   Ju, Gong ^a   Kuang, Fang ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Chemical hypoxia; Immature oligodendrocyte; Inosine; Mature oligodendrocyte; Rat

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; 3 NITROTYROSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A3 RECEPTOR; CASPASE 3; INOSINE; MYELIN; ROTENONE; ADENOSINE TRIPHOSPHATE; INSECTICIDE;

ANIMAL CELL CULTURE; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATPASE ACTIVITY ASSAY; CELL DEATH; CELL DIFFERENTIATION; CELL HYPOXIA; CELL MATURATION; CELL MEMBRANE; CELL PROTECTION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DEMYELINATION; IMMUNOCOMPETENT CELL; IMMUNOCYTOCHEMISTRY; MTT ASSAY; NERVE CELL LESION; NEWBORN; NICK END LABELING; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; ANOXIA; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; METABOLISM; OLIGODENDROGLIA;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANOXIA; CELL SURVIVAL; CELLS, CULTURED; IN SITU NICK-END LABELING; INOSINE; INSECTICIDES; OLIGODENDROGLIA; RATS; ROTENONE;

EID: 84860875851     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-011-9719-9     Document Type: Article

References (61)

1. Back SA, Craig A, Luo NL, Ren J, Akundi RS, Ribeiro I, Rivkees SA (2006) Protective effects of caffeine on chronic hypoxia-induced perinatal white matter injury. Ann Neurol 60(6):696-705
2. Barankiewicz J, Cohen A (1985) Purine nucleotide metabolism in resident and activated rat macrophages in vitro. Eur J Immunol 15(6):627-631
3. Baud O, Greene AE, Li J, Wang H, Volpe JJ, Rosenberg PA (2004a) Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes. J Neurosci 24(7):1531-1540
4. Baud O, Haynes RF, Wang H, Folkerth RD, Li J, Volpe JJ, Rosenberg PA (2004b) Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury. Eur J Neurosci 20(1):29-40
5. Becker D, Sadowsky CL, McDonald JW (2003) Restoring function after spinal cord injury. Neurologist 9(1):1-15
6. Benowitz LI, Goldberg DE, Madsen JR, Soni D, Irwin N (1999) Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury. Proc Natl Acad Sci USA 96(23):13486-13490
7. Benowitz LI, Goldberg DE, Irwin N (2002) Inosine stimulates axon growth in vitro and in the adult CNS. Prog Brain Res 137: 389-399
8. Blight AR (1983) Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling. Neuroscience 10(2):521-543
9. Bradl M, Lassmann H (2010) Oligodendrocytes: biology and pathology. Acta Neuropathol 119(1):37-53
10. Brana C, Benham C, Sundstrom L (2002) A method for characterising cell death in vitro by combining propidium iodide staining with immunohistochemistry. Brain Res Protoc 10:109-114
11. Bunge MB, Bunge RP, Ris H (1961) Ultrastructural study of remyelination in an experimental lesion in adult cat spinal cord. J Biophys Biochem Cytol 10:67-94
12. Bunge RP, Puckett WR, Becerra JL, Marcillo A, Quencer RM (1993) Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination. Adv Neurol 59:75-89
13. Butts BD, Houde C, Mehmet H (2008) Maturation dependent sensitivity of oligodendrocyte lineage cells to apoptosis implications for normal development and disease. Cell Death Differ 15(7):1178-1186
14. Chen Y, Balasubramaniyan V, Peng J, Hurlock EC, Tallquist M, Li J, Lu QR (2007) Isolation and culture of rat and mouse oligodendrocyte. Nat Protoc 2(5):1044-1051
15. Deng YH, Kuang SJ, Hei MY, Tian L (2006) Effects of inosine on neuronal apoptosis and the expression of cytochrome C mRNA following hypoxic-ischemic brain damage in neonatal rats. Zhongguo Dang Dai Er Ke Za Zhi 8(4):266-271
16. Fernandes-Alnemri T, Litwack G, Alnemri ES (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem 269(49):30761-30764
17. Gomez G, Sitkovsky MV (2003) Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo. Blood 102(13):4472-4478
18. Hasko G, Kuhel DG, Nemeth ZH, Mabley JG, Stachlewitz RF, Virag L, Lohinai Z, Southan GJ, Salzman AL, Szabo C (2000) Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol 164(2):1013-1019
19. Hou B, You SW, Wu MM, Kuang F, Liu HL, Jiao XY, Ju G (2004) Neuroprotective effect of inosine on axotomized retinal ganglion cells in adult Rats. Invest Ophth Vis Sci 45(2):662-667
20. Huang J, Hao L, Xiong N, Cao X, Liang Z, Sun S, Wang T (2009) Involvement of glyceraldehyde-3-phosphate dehydrogenase in rotenone-induced cell apoptosis: relevance to protein misfolding and aggregation. Brain Res 1279:1-8
21. Irwin N, Li YM, O'Toole JE, Benowitz LI (2006) Mst3b, a purinesensitive Ste20-like protein kinase, regulates axon outgrowth. Proc Natl Acad Sci USA 103(48):18320-18325
22. Itoh Y, Takaoka R, Ohira M, Abe T, Tanahashi N, Suzuki N (2006) Reactive oxygen species generated by mitochondrial injury in human brain microvessel endothelial cells. Clin Hemorheol Microcirc 34(1-2):163-168
23. Jeong JI, Lee YW, Kim YK (2003) Chemical hypoxia-induced cell death in human glioma cells: role of reactive oxygen species, ATP depletion, mitochondrial damage and Ca2+. Neurochem Res 28(8):1201-1211
24. Jin X, Shepherd RK, Duling BR, Linden J (1997) Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation. J Clin Invest 100(11):2849-2857
25. Jurkowitz MS, Litsky ML, Browning MJ, Hohl CM (1998) Adenosine, inosine, and guanosine protect glia cells during glucose deprivation and mitochondrial inhibition: correlation between protection and ATP preservation. J Neurochem 71(2):535-548
26. Kim YK, Lee SK, Ha MS, Woo JS, Jung JS (2002) Differential role of reactive oxygen species in chemical hypoxia-induced cell injury in opossum kidney cells and rabbit renal cortical slices. Exp Nephrol 10(4):275-284
27. Kong T, Westerman KA, Faigle M, Eltzschig HK, Colgan SP (2006) HIF-dependent induction of adenosine A2B receptor in hypoxia. Faseb J 20(13):2242-2250
28. Levine JM, Reynolds R, Fawcett JW (2001) The oligodendrocyte precursor cell in health and disease. Trends Neurosci 24(1): 39-47
29. Liaudet L, Mabley JG, Pacher P, Virag L, Soriano FG, Marton A, Hasko G, Deitch EA, Szabo C (2002) Inosine exerts a broad range of anti-inflammatory effects in a murine model of acute lung injury. Ann Surg 235(4):568-578
30. Litsky ML, Hohl CM, Lucas JH, Jurkowitz MS (1999) Inosine and guanosine preserve neuronal and glial cell viability in mouse spinal cord cultures during chemical hypoxia. Brain Res 821(2): 426-432
31. Liu XZ, Xu XM, Hu R, Du C, Zhang SX, McDonald JW, Dong HX, Wu YJ, Fan GS, Jacquin MF, Hsu CY, Choi DW (1997) Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci 17(14):5395-5406
32. Liu F, You SW, Yao LP, Liu HL, Jiao XY, Shi M, Zhao QB, Ju G (2006) Secondary degeneration reduced by inosine after spinal cord injury in rats. Spinal Cord 44(7):421-426
33. Mann CM, Kwon BK (2010) An update on the pathophysiology of acute spinal cord injury. Semin Spine Surg 19:272-279
34. Marton A, Pacher P, Murthy KG, Nemeth ZH, Hasko G, Szabo C (2001) Anti-inflammatory effects of inosine in human monocytes, neutrophils and epithelial cells in vitro. Int J Mol Med 8(6):617-621
35. Mayer SA, Lignelli A, Fink ME, Kessler DB, Thomas CE, Swarup R, Van Heertum RL (1998) Perilesional blood flow and edema formation in acute intracerebral hemorrhage: a SPECT study. Stroke 29(9):1791-1798
36. McDonald JW, Belegu V (2006) Demyelination and remyelination after spinal cord injury. J Neurotrauma 23(3-4):345-359
37. Melani A, Cipriani S, Vannucchi MG, Nosi D, Donati C, Bruni P, Giovannini MG, Pedata F (2009) Selective adenosine A2a receptor antagonism reduces JNK activation in oligodendrocytes after cerebral ischaemia. Brain 132(Pt 6):1480-1495
38. Moriyama K, Sitkovsky MV (2010) Adenosine A2A receptor is involved in cell surface expression of A2B receptor. J Biol Chem 285(50):39271-39288
39. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65(1-2):55-63
40. Pastorino JG, Snyder JW, Serroni A, Hoek JB, Farber JL (1993) Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J Biol Chem 268(19):13791-13798
41. Pei W, Liou AK, Chen J (2003) Two caspase-mediated apoptotic pathways induced by rotenone toxicity in cortical neuronal cells. Faseb J 17(3):520-522
42. Pendlebury ST, Lee MA, Blamire AM, Styles P, Matthews PM (2000) Correlating magnetic resonance imaging markers of axonal injury and demyelination in motor impairment secondary to stroke and multiple sclerosis. Magn Reson Imaging 18(4):369-378
43. Radad K, Rausch WD, Gille G (2006) Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration. Neurochem Int 49(4): 379-386
44. Schoenfeld R, Wong A, Silva J, Li M, Itoh A, Horiuchi M, Itoh T, Pleasure D, Cortopassi G (2010) Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiation. Mitochondrion 10(2):143-150
45. Shen H, Chen GJ, Harvey BK, Bickford PC, Wang Y (2005) Inosine reduces ischemic brain injury in rats. Stroke 36(3):654-659
46. Shen XF, Zhao Y, Zhang YK, Jia LY, Ju G (2009) A modified ferric tannate method for visualizing a blood vessel and its usage in the study of spinal cord injury. Spinal Cord 47(12):852-856
47. Shi M, You SW, Meng JH, Ju G (2002) Direct protection of inosine on PC12 cells against zinc-induced injury. Neuroreport 13(4): 477-479
48. Silva JM, Wong A, Carelli V, Cortopassi GA (2009) Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia. Neurobiol Dis 34(2):357-365
49. Spitsin S, Koprowski H (2008) Role of uric acid in multiple sclerosis. Curr Top Microbiol Immunol 318:325-342
50. Spitsin S, Hooper DC, Leist T, Streletz LJ, Mikheeva T, Koprowskil H (2001) Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease. Mult Scler 7(5):313-319
51. Spitsin S, Markowitz CE, Zimmerman V, Koprowski H, Hooper DC (2010) Modulation of serum uric acid levels by inosine in patients with multiple sclerosis does not affect blood pressure. J Hum Hypertens 24(5):359-362
52. Szabo G, Stumpf N, Radovits T, Sonnenberg K, Gero D, Hagl S, Szabo C, Bahrle S (2006) Effects of inosine on reperfusion injury after heart transplantation. Eur J Cardiothorac Surg 30(1):96-102
53. Tator CH, Fehlings MG (1991) Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75(1):15-26
54. Tator CH, Koyanagi I (1997) Vascular mechanisms in the pathophysiology of human spinal cord injury. J Neurosurg 86(3): 483-492
55. Waxman SG (1989) Demyelination in spinal cord injury. J Neurol Sci 91(1-2):1-14
56. Waxman SG (1992) Demyelination in spinal cord injury and multiple sclerosis: what can we do to enhance functional recovery? J Neurotrauma 9(Suppl 1):S105-S117
57. Whitmarsh TE (2009) The treatment of multiple sclerosis with inosine. J Altern Complement Med 15(6):609
58. Wu MM, You SW, Hou B, Jiao XY, Li YY, Ju G (2003) Effects of inosine on axonal regeneration of axotomized retinal ganglion cells in adult rats. Neurosci Lett 341:84-86
59. Wu ZL, Liu F, Wang YZ, Jiao XY, Shi M, Zhao QB, Ju G, You SW (2008) Reduced cell death by inosine pretreatment after photochemically induced cerebral ischemia in adult rats. Prog Nat Sci 18:1513-1518
60. Yitzhaki S, Hochhauser E, Porat E, Shainberg A (2007) Uridine-5'- triphosphate (UTP) maintains cardiac mitochondrial function following chemical and hypoxic stress. J Mol Cell Cardiol 43(5):653-662
61. Zai L, Ferrari C, Subbaiah S, Havton LA, Coppola G, Strittmatter S, Irwin N, Geschwind D, Benowitz LI, Irwin N, Geschwind D, Benowitz LI (2009) Inosine alters gene expression and axonal projections in neurons contralateral to a cortical infarct and improves skilled use of the impaired limb. J Neurosci 29(25): 8187-8197