Reduced cell death by inosine pretreatment after photochemically induced cerebral ischemia in adult rats

Progress in Natural Science

Volumn 18, Issue 12, 2008, Pages 1513-1518

  Wu, Zhongliang ^a   Liu, Fei ^a   Wang, Yazhou ^a   Jiao, Xiying ^a   Shi, Ming ^a   Zhao, Qingbo ^a   Ju, Gong ^a   You, Siwei ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cell death; Cerebral infarction; Inosine; Photothrombosis; Rat

Indexed keywords

RATS;

CELL/B.E; CEREBRAL INFARCTION; CEREBRAL ISCHEMIA; FOCAL CEREBRAL ISCHEMIAS; INOSINE; INTRAPERITONEAL INJECTIONS; NISSL STAINING; PHOTOTHROMBOSE; PRE-TREATMENTS; PROTECTIVE EFFECTS;

CELL DEATH;

EID: 57949087772     PISSN: 10020071     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnsc.2008.03.032     Document Type: Article

References (22)

1. B.K. Siesjo Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment J Neurosurg 77 3 1992 337 354
2. A. Kharlamov T. Uz J.Y. Joo Pharmacological characterization of apoptotic cell death in a model of photothrombotic brain injury in rats Brain Res 734 1–2 1996 1 9
3. S. Isenmann G. Stoll M. Schroeter Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat Brain Pathol 8 1 1998 49 62
4. M.D. Linnik P. Zahos M.D. Geschwind Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia Stroke 26 9 1995 1670 1674
5. A.R. Fernando D.M. Armstrong J.R. Griffiths Inosine in experimental acute renal failure Lancet 1 7959 1976 555 557
6. S.E. Haun J.E. Segeleon V.L. Trapp Inosine mediates the protective effect of adenosine in rat astrocyte cultures subjected to combined glucose–oxygen deprivation J Neurochem 67 5 1996 2051 2059
7. M.S. Jurkowitz M.L. Litsky M.J. Browning Adenosine, inosine, and guanosine protect glial cells during glucose deprivation and mitochondrial inhibition: correlation between protection and ATP preservation J Neurochem 71 2 1998 535 548
8. M.L. Litsky C.M. Hohl J.H. Lucas Inosine and guanosine preserve neuronal and glial cell viability in mouse spinal cord cultures during chemical hypoxia Brain Res 821 2 1999 426 432
9. H. Shen G.J. Chen B.K. Harvey Inosine reduces ischemic brain injury in rats Stroke 36 3 2005 654 659
10. G. Hsiao K.H. Lin Y. Chang Protective mechanisms of inosine in platelet activation and cerebral ischemic damage Arterioscler Thromb Vasc Biol 25 2005 1998 2004
11. M. Shi S.W. You J.H. Meng Direct protection of inosine on PC12 cells against zinc-induced injury Neuroreport 13 4 2002 477 479
12. P.J. Marangos E. Trams R.L. Clark-Rosenberg The benzodiazepines and inosine antagonize caffeine-induced seizures Psychopharmacology (Berl) 75 2 1981 175 178
13. W.D. Dietrich R. Busto B.D. Watson Photochemically induced cerebral infarction. II: Edema and blood–brain barrier disruption Acta Neuropathol (Berl) 72 4 1987 326 334
14. B. Grasl-Kraupp B. Ruttkay-Nedecky H. Koudelka In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note Hepatology 21 5 1995 1465 1468
15. A. Heron H. Pollard F. Dessi Regional variability in DNA fragmentation after global ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain J Neurochem 61 5 1993 1973 1976
16. T. Iwai A. Hara M. Niwa Temporal profile of nuclear DNA fragmentation in situ in gerbil hippocampus following transient forebrain ischemia Brain Res 671 2 1995 305 308
17. G. Torregrosa M.D. Barbera M. Orti Temporospatial expression of HSP72 and c-JUN, and DNA fragmentation in goat hippocampus after global cerebral ischemia Hippocampus 11 2 2001 146 156
18. E. Candelario-Jalil N.H. Mhadu S.M. Al Dalain Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils Neurosci Res 41 2 2001 233 241
19. D.C. Hooper S. Spitsin R.B. Kean Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis Proc Natl Acad Sci USA 95 2 1998 675 680
20. Z.F. Yu A.J. Bruce-Keller Y. Goodman Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo J Neurosci Res 53 3 1998 613 625
21. F.C. Barone B. Arvin R.F. White Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury Stroke 28 6 1997 1233 1244
22. G. Hasko D.G. Kuhel Z.H. Nemeth Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock J Immunol 164 2 2000 1013 1019