-
1
-
-
27744603884
-
Dose-dependent effects of folic acid on blood concentrations of homocysteine: A meta-analysis of the randomized trials
-
HOMOCYSTEINE Lowering Trialists? Collaboration
-
Homocysteine Lowering Trialists? Collaboration (2005) Dose-dependent effects of folic acid on blood concentrations of homocysteine: A meta-analysis of the randomized trials. Am J Clin Nutr 82, 806-812.
-
(2005)
Am. J. Clin. Nutr.
, vol.82
, pp. 806-812
-
-
-
2
-
-
19344377753
-
Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: A dose-finding trial
-
Eussen SJ, de Groot LC, Clarke R et al. (2005) Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: A dose-finding trial. Arch Intern Med 165, 1167-1172.
-
(2005)
Arch. Intern. Med.
, vol.165
, pp. 1167-1172
-
-
Eussen, S.J.1
De Groot, L.C.2
Clarke, R.3
-
3
-
-
0035076561
-
Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete
-
McKinley MC, McNulty H, McPartlin J et al. (2001) Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr 73, 759-764.
-
(2001)
Am. J. Clin. Nutr.
, vol.73
, pp. 759-764
-
-
McKinley, M.C.1
McNulty, H.2
McPartlin, J.3
-
4
-
-
33644863502
-
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-
-
McNulty H, Dowey le RC, Strain JJ et al. (2006) Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-
-
(2006)
Circulation
, vol.113
, pp. 74-80
-
-
McNulty, H.1
Dowey Le, R.C.2
Strain, J.J.3
-
5
-
-
17644408031
-
B-vitamins, homocysteine metabolism and CVD
-
Strain JJ, Dowey L, Ward M et al. (2004) B-vitamins, homocysteine metabolism and CVD. Proc Nutr Soc 63, 597-603.
-
(2004)
Proc. Nutr. Soc.
, vol.63
, pp. 597-603
-
-
Strain, J.J.1
Dowey, L.2
Ward, M.3
-
6
-
-
0037164104
-
Homocysteine and risk of ischemic heart disease and stroke
-
The Homocysteine Studies Collaboration
-
The Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke. JAMA 288, 2015-2022.
-
(2002)
JAMA
, vol.288
, pp. 2015-2022
-
-
-
7
-
-
0037164375
-
Homocysteine and cardiovascular disease: Evidence on causality from a metaanalysis
-
Wald DS, Law M & Morris JK (2002) Homocysteine and cardiovascular disease: Evidence on causality from a metaanalysis. BMJ 325, 1202-1208.
-
(2002)
BMJ
, vol.325
, pp. 1202-1208
-
-
Wald, D.S.1
Law, M.2
Morris, J.K.3
-
8
-
-
33645743547
-
Improvement in stroke mortality in Canada and the United States 1990 to 2002
-
Yang Q, Botto LD, Erickson JD et al. (2006) Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation 113, 1335-1343.
-
(2006)
Circulation
, vol.113
, pp. 1335-1343
-
-
Yang, Q.1
Botto, L.D.2
Erickson, J.D.3
-
9
-
-
1342309318
-
Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial
-
Toole JF, Malinow MR, Chambless LE et al. (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 291, 565-575.
-
(2004)
JAMA
, vol.291
, pp. 565-575
-
-
Toole, J.F.1
Malinow, M.R.2
Chambless, L.E.3
-
10
-
-
33645753544
-
Homocysteine lowering with folic acid and B vitamins in vascular disease
-
Lonn E, Yusuf S, Arnold MJ et al. (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 354, 1567-1577.
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1567-1577
-
-
Lonn, E.1
Yusuf, S.2
Arnold, M.J.3
-
11
-
-
33645796222
-
Homocysteine lowering and cardiovascular events after acute myocardial infarction
-
Bønaa KH, Njølstad I, Ueland PM et al. (2006) Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 354, 1578-1588.
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1578-1588
-
-
Bønaa, K.H.1
Njølstad, I.2
Ueland, P.M.3
-
12
-
-
49949101867
-
Mortality and cardiovascular events in patients treated with homocysteinelowering B vitamins after coronary angiography: A randomized controlled trial
-
Ebbing M, Bleie Ø, Ueland PM et al. (2008) Mortality and cardiovascular events in patients treated with homocysteinelowering B vitamins after coronary angiography: A randomized controlled trial. JAMA 300, 795-804.
-
(2008)
JAMA
, vol.300
, pp. 795-804
-
-
Ebbing, M.1
Bleie, Ø.2
Ueland, P.M.3
-
13
-
-
43049176549
-
Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease
-
Albert CM, Cook NR, Gaziano JM et al. (2008) Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease. A randomized trial. JAMA 299, 2027-2036.
-
(2008)
A randomized trial. JAMA
, vol.299
, pp. 2027-2036
-
-
Albert, C.M.1
Cook, N.R.2
Gaziano, J.M.3
-
14
-
-
77953867844
-
Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors
-
Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group
-
Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group (2010) Effects of homocysteine- lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors. JAMA 303, 2486-2494.
-
(2010)
JAMA
, vol.303
, pp. 2486-2494
-
-
-
15
-
-
77955656519
-
B vitamins in patients with recent transient ischaemic attack or stroke in the vitamins to prevent stroke (vitatops) trial: A randomised, double-blind, parallel, placebo-controlled trial
-
VITATOPS Trial Study Group
-
VITATOPS Trial Study Group (2010) B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: A randomised, double-blind, parallel, placebo-controlled trial. Lancet Neurol 9, 855-865.
-
(2010)
Lancet Neurol..
, vol.9
, pp. 855-865
-
-
-
16
-
-
31344459617
-
Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials
-
B-Vitamin Treatment Trialists? Collaboration
-
B-Vitamin Treatment Trialists? Collaboration (2006) Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials. Am Heart J 151, 282-287.
-
(2006)
Am. Heart J.
, vol.151
, pp. 282-287
-
-
-
17
-
-
65249094749
-
Homcysteinelowering therapy and stroke risk, severity, and disability: Additional findings from the HOPE 2 trial
-
Saposnik G, Ray JG, Sheridan P et al. (2009) Homcysteinelowering therapy and stroke risk, severity, and disability: Additional findings from the HOPE 2 trial. Stroke 40, 1365-1372.
-
(2009)
Stroke
, vol.40
, pp. 1365-1372
-
-
Saposnik, G.1
Ray, J.G.2
Sheridan, P.3
-
18
-
-
34249730020
-
Efficacy of folic acid supplementation in stroke prevention: A meta-analysis
-
Wang X, Qin X, Demirtas H et al. (2007) Efficacy of folic acid supplementation in stroke prevention: A meta-analysis. Lancet 369, 1876-1882.
-
(2007)
Lancet
, vol.369
, pp. 1876-1882
-
-
Wang, X.1
Qin, X.2
Demirtas, H.3
-
19
-
-
77953133802
-
Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: A meta-analysis
-
Lee M, Hong KS, Chang SC et al. (2010) Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: A meta-analysis. Stroke 41, 1205-1212.
-
(2010)
Stroke
, vol.41
, pp. 1205-1212
-
-
Lee, M.1
Hong, K.S.2
Chang, S.C.3
-
20
-
-
0029049553
-
A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
-
Frosst P, Blom HJ, Milos R et al. (1995) A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 10, 111-113.
-
(1995)
Nat. Genet.
, vol.10
, pp. 111-113
-
-
Frosst, P.1
Blom, H.J.2
Milos, R.3
-
21
-
-
0030027668
-
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
-
Jacques PF, Bostom AG, Williams RR et al. (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93, 7-9.
-
(1996)
Circulation
, vol.93
, pp. 7-9
-
-
Jacques, P.F.1
Bostom, A.G.2
Williams, R.R.3
-
22
-
-
0041326346
-
Geographical and ethnic variation of the 677C!T allele of 5, 10 methylenetetrahydrofolate reductase (MTHFR): Findings from over 7000 newborns from 16 areas world wide
-
Wilcken B, Bamforth F, Li Z et al. (2003) Geographical and ethnic variation of the 677C!T allele of 5, 10 methylenetetrahydrofolate reductase (MTHFR): Findings from over 7000 newborns from 16 areas world wide. J Med Genet 40, 619-625.
-
(2003)
J. Med. Genet.
, vol.40
, pp. 619-625
-
-
Wilcken, B.1
Bamforth, F.2
Li, Z.3
-
23
-
-
0037163849
-
MTHFR C677T polymorphism and risk of coronary heart disease: A metaanalysis
-
Klerk M, Verhoef P, Clarke R et al. (2002) MTHFR C677T polymorphism and risk of coronary heart disease: A metaanalysis. JAMA 288, 2023-2031.
-
(2002)
JAMA
, vol.288
, pp. 2023-2031
-
-
Klerk, M.1
Verhoef, P.2
Clarke, R.3
-
24
-
-
27744471516
-
Meta-analysis of the MTHFR 677C!T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventative potential of folate
-
Lewis SJ, Ebrahim S & Davey-Smith G (2005) Meta-analysis of the MTHFR 677C!T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventative potential of folate. Br Med J 331, 1053-1059.
-
(2005)
Br. Med. J.
, vol.331
, pp. 1053-1059
-
-
Lewis, S.J.1
Ebrahim, S.2
Davey-Smith, G.3
-
25
-
-
80051695692
-
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: A meta-analysis of genetic studies and randomised trials
-
Holmes MV, Newcombe P, Hubacek JA et al. (2011) Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: A meta-analysis of genetic studies and randomised trials. Lancet 378, 584-594.
-
(2011)
Lancet
, vol.378
, pp. 584-594
-
-
Holmes, M.V.1
Newcombe, P.2
Hubacek, J.A.3
-
26
-
-
33644967742
-
A longitudinal study of hypertension risk factors and their relation to cardiovascular disease: The strong heart study
-
Wang W, Lee ET, Fabsitz RR et al. (2006) A longitudinal study of hypertension risk factors and their relation to cardiovascular disease: The Strong Heart Study. Hypertension 47, 403-409.
-
(2006)
Hypertension
, vol.47
, pp. 403-409
-
-
Wang, W.1
Lee, E.T.2
Fabsitz, R.R.3
-
27
-
-
0035922695
-
Cardiovascular protection and BP reduction: A meta-Analysis
-
Staessen JA, Wang JG & Thijs L (2001) Cardiovascular protection and BP reduction: A meta-analysis. Lancet 358, 1305-1315.
-
(2001)
Lancet
, vol.358
, pp. 1305-1315
-
-
Staessen, J.A.1
Wang, J.G.2
Thijs, L.3
-
28
-
-
77949656345
-
The MTHFR C677T polymorphism B-vitamins and blood pressure
-
Wilson CP, McNulty H, Scott JM et al. (2010) The MTHFR C677T polymorphism, B-vitamins and blood pressure. Proc Nutr Soc 69, 156-165.
-
(2010)
Proc. Nutr. Soc.
, vol.69
, pp. 156-165
-
-
Wilson, C.P.1
McNulty, H.2
Scott, J.M.3
-
29
-
-
77149145514
-
Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the C677T polymorphism in MTHFR
-
Horigan G, McNulty H, Ward M et al. (2010) Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the C677T polymorphism in MTHFR. J Hypertens 28, 478-486.
-
(2010)
J. Hypertens.
, vol.28
, pp. 478-486
-
-
Horigan, G.1
McNulty, H.2
Ward, M.3
-
30
-
-
0035909980
-
Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase
-
Yamada K, Chen Z, Rozen R et al. (2001) Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proc Natl Acad Sci USA 98, 14853-14858.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14853-14858
-
-
Yamada, K.1
Chen, Z.2
Rozen, R.3
-
31
-
-
66549090409
-
MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis
-
Antoniades C, Shirodaria C, Leeson P et al. (2009) MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis. Circulation 119, 2507-2515.
-
(2009)
Circulation
, vol.119
, pp. 2507-2515
-
-
Antoniades, C.1
Shirodaria, C.2
Leeson, P.3
-
32
-
-
46649114158
-
Intake and status of folate and related B-vitamins: Considerations and challenges in achieving optimal status
-
McNulty H & Scott JM (2008) Intake and status of folate and related B-vitamins: Considerations and challenges in achieving optimal status. Br J Nutr 99, S48-S54.
-
(2008)
Br. J. Nutr.
, vol.99
-
-
McNulty, H.1
Scott, J.M.2
-
33
-
-
36248993031
-
Impact of a voluntary food fortification policy on folate, related B-vitamin status and homocysteine in healthy adults
-
Hoey L, McNulty H, Askin N et al. (2007) Impact of a voluntary food fortification policy on folate, related B-vitamin status and homocysteine in healthy adults. Am J Clin Nutr 86, 1405-1413.
-
(2007)
Am. J. Clin. Nutr.
, vol.86
, pp. 1405-1413
-
-
Hoey, L.1
McNulty, H.2
Askin, N.3
-
34
-
-
79957511968
-
Women?s compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defects
-
McNulty B, Pentieva K, Marshall B et al. (2011) Women?s compliance with current folic acid recommendations and achievement of optimal vitamin status for preventing neural tube defects. Hum Reprod 26, 1530-1536.
-
(2011)
Hum. Reprod.
, vol.26
, pp. 1530-1536
-
-
McNulty, B.1
Pentieva, K.2
Marshall, B.3
-
35
-
-
33749685522
-
Vitamin B12, folic acid, and the nervous system
-
Reynolds E (2006) Vitamin B12, folic acid, and the nervous system. Lancet Neurol 5, 949-960.
-
(2006)
Lancet Neurol.
, vol.5
, pp. 949-960
-
-
Reynolds, E.1
-
36
-
-
33846102164
-
Folate and vitamin B12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification
-
Morris MS, Jacques PF, Rosenberg IH et al. (2007) Folate and vitamin B12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 85, 193-200.
-
(2007)
Am. J. Clin. Nutr.
, vol.85
, pp. 193-200
-
-
Morris, M.S.1
Jacques, P.F.2
Rosenberg, I.H.3
-
37
-
-
0033007272
-
Folate and carcinogenesis: Evidence, mechanisms, and implications
-
Kim Y-I (1999) Folate and carcinogenesis: Evidence, mechanisms, and implications. J Nutr Biochem 10, 66-88.
-
(1999)
J. Nutr. Biochem.
, vol.10
, pp. 66-88
-
-
Kim, Y.-I.1
-
38
-
-
34547884338
-
High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort
-
Ericson U, Sonestedt E, Gullberg B et al. (2007) High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort. Am J Clin Nutr 86, 434-443.
-
(2007)
Am. J. Clin. Nutr.
, vol.86
, pp. 434-443
-
-
Ericson, U.1
Sonestedt, E.2
Gullberg, B.3
-
39
-
-
80053188657
-
Pre- and postfortification intake of folate and risk of colorectal cancer in a large prospective cohort study in the United States
-
Gibson TM, Weinstein SJ, Pfeiffer RM et al. (2011) Pre- and postfortification intake of folate and risk of colorectal cancer in a large prospective cohort study in the United States. Am J Clin Nutr 94, 1053-1062.
-
(2011)
Am. J. Clin. Nutr.
, vol.94
, pp. 1053-1062
-
-
Gibson, T.M.1
Weinstein, S.J.2
Pfeiffer, R.M.3
-
40
-
-
34249979299
-
Folic acid for the prevention of colorectal adenomas: A randomized clinical trial
-
Cole BF, Baron JA, Sandler RS et al. (2007) Folic acid for the prevention of colorectal adenomas: A randomized clinical trial. JAMA 297, 2351-2359.
-
(2007)
JAMA
, vol.297
, pp. 2351-2359
-
-
Cole, B.F.1
Baron, J.A.2
Sandler, R.S.3
-
41
-
-
64949110935
-
Folic acid and risk of prostate cancer: Results from a randomized clinical trial
-
Figueiredo JC, Grau MV, Haile RW et al. (2009) Folic acid and risk of prostate cancer: Results from a randomized clinical trial. J Natl Cancer Inst 101, 432-435.
-
(2009)
J. Natl. Cancer Inst.
, vol.101
, pp. 432-435
-
-
Figueiredo, J.C.1
Grau, M.V.2
Haile, R.W.3
-
42
-
-
71749111560
-
Cancer incidence and mortality after treatment with folic acid and vitamin B12
-
Ebbing M, Bønaa KH, Nygård O et al. (2009) Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 302, 2119-2126.
-
(2009)
JAMA
, vol.302
, pp. 2119-2126
-
-
Ebbing, M.1
Bønaa, K.H.2
Nygård, O.3
-
43
-
-
80053217556
-
Folate consumption and cancer risk: A confirmation and some reassurance, but we?re not out of the woods quite yet
-
Mason JB (2011) Folate consumption and cancer risk: A confirmation and some reassurance, but we?re not out of the woods quite yet. Am J Clin Nutr 94, 965-966.
-
(2011)
Am. J. Clin. Nutr.
, vol.94
, pp. 965-966
-
-
Mason, J.B.1
-
44
-
-
78651295457
-
A dose-finding trial of the effect of long-term folic acid intervention: Implications for food fortification policy
-
Tighe P, Ward M, McNulty H et al. (2011) A dose-finding trial of the effect of long-term folic acid intervention: Implications for food fortification policy. Am J Clin Nutr 93, 11-18.
-
(2011)
Am. J. Clin. Nutr.
, vol.93
, pp. 11-18
-
-
Tighe, P.1
Ward, M.2
McNulty, H.3
-
45
-
-
0033547813
-
Homocyst( e)ine, diet, and cardiovascular diseases: A statement for healthcare professionals from the Nutrition Committee
-
American Heart Association
-
Malinow MR, Bostom AG & Krauss RM (1999) Homocyst( e)ine, diet, and cardiovascular diseases: A statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 99, 178-182.
-
(1999)
Circulation
, vol.99
, pp. 178-182
-
-
Malinow, M.R.1
Bostom, A.G.2
Krauss, R.M.3
-
46
-
-
66849106748
-
Studies of biomarker responses to intervention with vitamin B-12: A systematic review of randomized controlled trials
-
Hoey L, Strain JJ & McNulty H (2009) Studies of biomarker responses to intervention with vitamin B-12: A systematic review of randomized controlled trials. Am J Clin Nutr 89, Suppl., 1981S-1996S.
-
(2009)
Am. J. Clin. Nutr.
, vol.89 SUPPL.
-
-
Hoey, L.1
Strain, J.J.2
McNulty, H.3
-
47
-
-
0038474037
-
Screening for vitamin B-12 and folate deficiency in older persons
-
Clarke R, Refsum H, Birks J et al. (2003) Screening for vitamin B-12 and folate deficiency in older persons. Am J Clin Nutr 77, 1241-1247.
-
(2003)
Am. J. Clin. Nutr.
, vol.77
, pp. 1241-1247
-
-
Clarke, R.1
Refsum, H.2
Birks, J.3
-
48
-
-
0030771355
-
Cobalamin, the stomach, and aging
-
Carmel R (1997) Cobalamin, the stomach, and aging. Am J Clin Nutr 66, 750-759.
-
(1997)
Am. J. Clin. Nutr.
, vol.66
, pp. 750-759
-
-
Carmel, R.1
-
49
-
-
0003788033
-
-
Institute of Medicine, Panel on Folate, Other B Vitamins, and Choline Washington, DC: National Academy Press
-
Institute of Medicine, Panel on Folate, Other B Vitamins, and Choline (1998) Dietary Reference Intake; Thiamine, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press.
-
(1998)
Dietary Reference Intake; Thiamine Riboflavin Niacin Vitamin B6 Folate Vitamin B12 Pantothenic Acid Biotin and Choline
-
-
-
50
-
-
3242694851
-
-
The National Diet and Nutrition Survey: Adults Aged 19 to 64 Years.Vol. 4: Nutritional Status (Anthropometry and Blood Analytes): The Stationery Office
-
Ruston D, Hoare J, Henderson L et al. (2004) The National Diet and Nutrition Survey: Adults Aged 19 to 64 Years. Vol. 4: Nutritional Status (Anthropometry and Blood Analytes), Blood Pressure and Physical Activity. London: The Stationery Office.
-
(2004)
Blood Pressure and Physical Activity
-
-
Ruston, D.1
Hoare, J.2
Henderson, L.3
|