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Volumn 28, Issue 3, 2010, Pages 478-486

Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C→T polymorphism in MTHFR

Author keywords

Blood pressure; Cardiovascular disease; Methylenetetrahydrofolate reductase; Nutrition; Riboflavin

Indexed keywords

ANTIHYPERTENSIVE AGENT; PLACEBO; RIBOFLAVIN;

EID: 77149145514     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328334c126     Document Type: Article
Times cited : (92)

References (43)
  • 1
    • 0041326346 scopus 로고    scopus 로고
    • Geographical and Ethnic variation of the 677C>T allele of 5, 10 methylenetetrahydrofolate reductase (MTHFR): Findings from over 7000 newborns from 16 areas world wide
    • Wilcken B, Bamforth F, Li Z, Ritvanen A, Redlund M, Stoll C, et al. Geographical and Ethnic variation of the 677C>T allele of 5, 10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide. J Med Genet 2003; 40: 619-625.
    • (2003) J Med Genet , vol.40 , pp. 619-625
    • Wilcken, B.1    Bamforth, F.2    Li, Z.3    Ritvanen, A.4    Redlund, M.5    Stoll, C.6
  • 2
    • 0035909980 scopus 로고    scopus 로고
    • Effects of common polymorphism on the properties of recombinant human methylenetetrahydrofolate reductase
    • Yamada K, Chen Z, Rosen R, Mathews RG. Effects of common polymorphism on the properties of recombinant human methylenetetrahydrofolate reductase. Proc Natl Acad Sci USA 2001; 98:14853-14858.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14853-14858
    • Yamada, K.1    Chen, Z.2    Rosen, R.3    Mathews, R.G.4
  • 3
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10:111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 4
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93:7-9.
    • (1996) Circulation , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3    Ellison, R.C.4    Eckfeldt, J.H.5    Rosenberg, I.H.6
  • 5
    • 0033869703 scopus 로고    scopus 로고
    • Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism
    • Hustad S, Ueland PM, Vollset SE, Zhang Y, Bjorke-Monsen AL, Schneede J. Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism. Clin Chem 2000; 46:1065-1071.
    • (2000) Clin Chem , vol.46 , pp. 1065-1071
    • Hustad, S.1    Ueland, P.M.2    Vollset, S.E.3    Zhang, Y.4    Bjorke-Monsen, A.L.5    Schneede, J.6
  • 6
    • 0036076711 scopus 로고    scopus 로고
    • Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: Implications for riboflavin requirements
    • McNulty H, McKinley MC, Wilson B, Mc Partlin J, Strain JJ, Weir DG, Scott JM. Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements. Am J Clin Nutr 2002; 76:436-441.
    • (2002) Am J Clin Nutr , vol.76 , pp. 436-441
    • McNulty, H.1    McKinley, M.C.2    Wilson, B.3    Mc Partlin, J.4    Strain, J.J.5    Weir, D.G.6    Scott, J.M.7
  • 7
    • 34247589073 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductase 677!T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism
    • Hustad S, Midttun Ø, Schneede J, Vollset SE, Grotmol T, Ueland PM. The methylenetetrahydrofolate reductase 677!T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism. Am J Hum Genet 2007; 80:846-855.
    • (2007) Am J Hum Genet , vol.80 , pp. 846-855
    • Hustad, S.1    Midttun Ø2    Schneede, J.3    Vollset, S.E.4    Grotmol, T.5    Ueland, P.M.6
  • 8
    • 33644863502 scopus 로고    scopus 로고
    • Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C>T polymorphism
    • McNulty H, Dowey le RC, Strain JJ, Dunne A, Ward M, Molloy A, et al. Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C>T polymorphism. Circulation 2006; 113:74-80.
    • (2006) Circulation , vol.113 , pp. 74-80
    • McNulty, H.1    Dowey Le, R.C.2    Strain, J.J.3    Dunne, A.4    Ward, M.5    Molloy, A.6
  • 9
    • 0037164375 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis
    • Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 2002; 325:1202-1206. (Pubitemid 35398783)
    • (2002) British Medical Journal , vol.325 , Issue.7374 , pp. 1202-1206
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 10
    • 0037163849 scopus 로고    scopus 로고
    • MTHFR 677C>T polymorphism and risk ofcoronary heart disease:a meta-analysis
    • Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG. MTHFR 677C>T polymorphism and risk ofcoronary heart disease:a meta-analysis. JAMA 2002; 288:2023-2031.
    • (2002) JAMA , vol.288 , pp. 2023-2031
    • Klerk, M.1    Verhoef, P.2    Clarke, R.3    Blom, H.J.4    Kok, F.J.5    Schouten, E.G.6
  • 11
    • 27744471516 scopus 로고    scopus 로고
    • Meta-analysis of MTHFR 677C>T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventive potential of folate
    • Lewis SJ, Ebrahim S, Davey Smith G. Meta-analysis of MTHFR 677C>T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate. BMJ 2005; 331:1053-1056.
    • (2005) BMJ , vol.331 , pp. 1053-1056
    • Lewis, S.J.1    Ebrahim, S.2    Davey Smith, G.3
  • 12
    • 34249730020 scopus 로고    scopus 로고
    • Efficacy of folic acid supplementation in stroke prevention: A meta-analysis
    • Wang X, Qin X, Demirtas H, Li J, Mao G, Huo Y, et al. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 2007; 369:1876-1882.
    • (2007) Lancet , vol.369 , pp. 1876-1882
    • Wang, X.1    Qin, X.2    Demirtas, H.3    Li, J.4    Mao, G.5    Huo, Y.6
  • 13
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial
    • Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 2004; 291:565-575.
    • (2004) JAMA , vol.291 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3    Spence, J.D.4    Pettigrew, L.C.5    Howard, V.J.6
  • 14
  • 15
    • 33645753544 scopus 로고    scopus 로고
    • The Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease
    • Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, et al. The Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006; 354:1567-1577.
    • (2006) N Engl J Med , vol.354 , pp. 1567-1577
    • Lonn, E.1    Yusuf, S.2    Arnold, M.J.3    Sheridan, P.4    Pogue, J.5    Micks, M.6
  • 16
    • 0037676003 scopus 로고    scopus 로고
    • The effect of methylenetetrahydrofolate reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values
    • Rodriguez-Esparragon F, Hernandez-Perera O, Rodriguez-Perez JC, Anabitarte A, Diaz-Cremades JM, Losada A, et al. The effect of methylenetetrahydrofolate reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values. Clin Exp Hypertens 2003; 25:209-220.
    • (2003) Clin Exp Hypertens , vol.25 , pp. 209-220
    • Rodriguez-Esparragon, F.1    Hernandez-Perera, O.2    Rodriguez-Perez, J.C.3    Anabitarte, A.4    Diaz-Cremades, J.M.5    Losada, A.6
  • 17
    • 0037477386 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population
    • Inamoto N, Katsuya T, Kokubo Y, Mannami T, Asai T, Baba S, et al. Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population. Stroke 2003; 34:1628-1633.
    • (2003) Stroke , vol.34 , pp. 1628-1633
    • Inamoto, N.1    Katsuya, T.2    Kokubo, Y.3    Mannami, T.4    Asai, T.5    Baba, S.6
  • 18
    • 3042642830 scopus 로고    scopus 로고
    • The C677T polymorphism of the methylentetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor
    • Jiang S, Hsu YH, Xu X, Xing C, Niu T, Zhang Y, et al. The C677T polymorphism of the methylentetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor. Thromb Res 2004; 113:361-369.
    • (2004) Thromb Res , vol.113 , pp. 361-369
    • Jiang, S.1    Hsu, Y.H.2    Xu, X.3    Xing, C.4    Niu, T.5    Zhang, Y.6
  • 19
    • 0035058109 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase polymorphism and early organ damage in primary hypertension
    • Ravera M, Viazzi F, Berruti V, Leoncini G, Zagami P, Bezante G, et al. 5, 10-Methylenetetrahydrofolate reductase polymorphism and early organ damage in primary hypertension. Am J Hypertens 2001; 14:371-376.
    • (2001) Am J Hypertens , vol.14 , pp. 371-376
    • Ravera, M.1    Viazzi, F.2    Berruti, V.3    Leoncini, G.4    Zagami, P.5    Bezante, G.6
  • 20
    • 0031847010 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism: Relation to blood pressure and cerebrovascular disease
    • Nakata Y, Katsuya T, Takami S, Sato N, Fu Y, Ishikawa K, et al. Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease. Am J Hypertens 1998; 11:1019-1023.
    • (1998) Am J Hypertens , vol.11 , pp. 1019-1023
    • Nakata, Y.1    Katsuya, T.2    Takami, S.3    Sato, N.4    Fu, Y.5    Ishikawa, K.6
  • 21
    • 36348950227 scopus 로고    scopus 로고
    • A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension
    • Qian X, Lu Z, Tan M, Liu H, Lu D. A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension. Eur J Hum Genet 2007; 15:1239-1245.
    • (2007) Eur J Hum Genet , vol.15 , pp. 1239-1245
    • Qian, X.1    Lu, Z.2    Tan, M.3    Liu, H.4    Lu, D.5
  • 22
    • 0032918691 scopus 로고    scopus 로고
    • Fully automated measurement of total homocysteine in plasma and serum on the Abbott IMx analyzer
    • Leino A. Fully automated measurement of total homocysteine in plasma and serum on the Abbott IMx analyzer. Clin Chem 1999; 45:569-571.
    • (1999) Clin Chem , vol.45 , pp. 569-571
    • Leino, A.1
  • 23
    • 0030744634 scopus 로고    scopus 로고
    • Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method
    • Molloy AM, Scott JM. Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol 1997; 281:43-53.
    • (1997) Methods Enzymol , vol.281 , pp. 43-53
    • Molloy, A.M.1    Scott, J.M.2
  • 24
    • 0025860071 scopus 로고
    • Microbiological assay for vitamin B12 performed in 96-well microtitre plates
    • Kelleher BP, Broin SD. Microbiological assay for vitamin B12 performed in 96-well microtitre plates. J Clin Pathol 1991; 44:592-595.
    • (1991) J Clin Pathol , vol.44 , pp. 592-595
    • Kelleher, B.P.1    Broin, S.D.2
  • 25
    • 0032908213 scopus 로고    scopus 로고
    • Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over
    • Bates CJ, Pentieva KD, Prentice A, Mansoor MA, Finch S. Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over. Br J Nutr 1999; 81:191-201.
    • (1999) Br J Nutr , vol.81 , pp. 191-201
    • Bates, C.J.1    Pentieva, K.D.2    Prentice, A.3    Mansoor, M.A.4    Finch, S.5
  • 26
    • 0021071174 scopus 로고
    • The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia
    • Powers HJ, Bates CJ, Prentice AM, Lamb WH, Jepson M, Bowman H. The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia. Hum Nutr Clin Nutr 1983; 37:413-425.
    • (1983) Hum Nutr Clin Nutr , vol.37 , pp. 413-425
    • Powers, H.J.1    Bates, C.J.2    Prentice, A.M.3    Lamb, W.H.4    Jepson, M.5    Bowman, H.6
  • 28
    • 0347423198 scopus 로고    scopus 로고
    • Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report
    • Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Hypertension 2003; 42:1206-1252.
    • (2003) Hypertension , vol.42 , pp. 1206-1252
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3    Cushman, W.C.4    Green, L.A.5    Izzo Jr., J.L.6
  • 29
    • 34547841331 scopus 로고    scopus 로고
    • Hypertension: Uncontrolled and conquering the world
    • [editorial]
    • Hypertension: uncontrolled and conquering the world [editorial]. Lancet 2007; 370:539.
    • (2007) Lancet , vol.370 , pp. 539
  • 30
    • 0025234906 scopus 로고
    • Blood pressure, stroke and coronary heart disease. Part 1: Prolonged differences in blood pressure-differences in blood pressure: Prospective observational studies corrected for the regression dilution bias
    • MacMahon S, Peto R, Collins R, Godwin J, MacMahon S, Cutler J, et al. Blood pressure, stroke and coronary heart disease. Part 1: Prolonged differences in blood pressure-differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 1990; 335:765-774.
    • (1990) Lancet , vol.335 , pp. 765-774
    • MacMahon, S.1    Peto, R.2    Collins, R.3    Godwin, J.4    MacMahon, S.5    Cutler, J.6
  • 31
    • 0037079309 scopus 로고    scopus 로고
    • Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual studies for one million adults in 61 prospective studies
    • Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual studies for one million adults in 61 prospective studies. Lancet 2002; 360:1903-1913.
    • (2002) Lancet , vol.360 , pp. 1903-1913
    • Lewington, S.1    Clarke, R.2    Qizilbash, N.3    Peto, R.4    Collins, R.5
  • 32
    • 0028788020 scopus 로고
    • Total plasma homocysteine and cardiovascular risk profile. the Hordaland Homocysteine Study
    • Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 1995; 274:1526-1533.
    • (1995) JAMA , vol.274 , pp. 1526-1533
    • Nygard, O.1    Vollset, S.E.2    Refsum, H.3    Stensvold, I.4    Tverdal, A.5    Nordrehaug, J.E.6
  • 33
    • 0030866856 scopus 로고    scopus 로고
    • High homocysteine levels are independently related to isolated systolic hypertension in older adults
    • Sutton-Tyrrell K, Bostom A, Selhub J, Zeigler-Johnson C. High homocysteine levels are independently related to isolated systolic hypertension in older adults. Circulation 1997; 96:1745-1749.
    • (1997) Circulation , vol.96 , pp. 1745-1749
    • Sutton-Tyrrell, K.1    Bostom, A.2    Selhub, J.3    Zeigler-Johnson, C.4
  • 34
    • 0036901255 scopus 로고    scopus 로고
    • Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people
    • Budge MM, de Jager C, Hogervorst E, Smith AD. Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people. J Am Geriatr Soc 2002; 50:2014-2018.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 2014-2018
    • Budge, M.M.1    De Jager, C.2    Hogervorst, E.3    Smith, A.D.4
  • 35
    • 0037114889 scopus 로고    scopus 로고
    • Homocysteine and blood pressure in the Third National Health and Nutrition Examination Survey 1988-1994
    • Limm U, Cassano PA. Homocysteine and blood pressure in the Third National Health and Nutrition Examination Survey, 1988-1994. Am J Epidemiol 2002; 156:1105-1113.
    • (2002) Am J Epidemiol , vol.156 , pp. 1105-1113
    • Limm, U.1    Cassano, P.A.2
  • 36
    • 0347479297 scopus 로고    scopus 로고
    • Plasma homocysteine, hypertension incidence, and blood pressure tracking: The Framingham Heart Study
    • Sundstrom J, Sullivan L, D'Agostino RB, Jacques PF, Selhub J, Rosenberg IH, et al. Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart Study. Hypertension 2003; 42:1100-1105.
    • (2003) Hypertension , vol.42 , pp. 1100-1105
    • Sundstrom, J.1    Sullivan, L.2    D'Agostino, R.B.3    Jacques, P.F.4    Selhub, J.5    Rosenberg, I.H.6
  • 37
    • 27844534033 scopus 로고    scopus 로고
    • Plasma homocysteine concentration and blood pressure in healthy Iranian adults: The Tehran homocysteine survey (2003-2004)
    • DOI 10.1038/sj.jhh.1001911, PII 1001911
    • Fakhrzadeh H, Ghotbi S, Pourebrahim R, Heshmat R, Nouri M, Shafaee A, Larijani B. Plasma homocysteine concentration and blood pressure in healthy Iranian adults: the Tehran Homocysteine Survey (2003-2004). J Hum Hypertens 2005; 19:869-876. (Pubitemid 41637603)
    • (2005) Journal of Human Hypertension , vol.19 , Issue.11 , pp. 869-876
    • Fakhrzadeh, H.1    Ghotbi, S.2    Pourebrahim, R.3    Heshmat, R.4    Nouri, M.5    Shafaee, A.6    Larijani, B.7
  • 38
    • 34247869595 scopus 로고    scopus 로고
    • Lowering homocysteine with B vitamins has no effect on blood pressure in older adults
    • Mc Mahon J, Skeaff M, Williams S, Green T. Lowering homocysteine with B vitamins has no effect on blood pressure in older adults. J Nutr 2007; 137:1183-1187.
    • (2007) J Nutr , vol.137 , pp. 1183-1187
    • Mc Mahon, J.1    Skeaff, M.2    Williams, S.3    Green, T.4
  • 39
    • 0035569991 scopus 로고    scopus 로고
    • Long term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: A 2-year, randomized, placebo-controlled trial
    • Van Dijk RA, Rauwerda JA, Steyn M, Twisk JW, Stehouwer CD. Long term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: a 2-year, randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol 2001; 21:2072-2079.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 2072-2079
    • Van Dijk, R.A.1    Rauwerda, J.A.2    Steyn, M.3    Twisk, J.W.4    Stehouwer, C.D.5
  • 40
    • 0036911080 scopus 로고    scopus 로고
    • Folic acid enhances endothelial function and reduces blood pressure in smokers: A randomised controlled trial
    • Mangoni AA, Sherwood RA, Swift CG, Jackson SH. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomised controlled trial. J Intern Med 2002; 252:497-503.
    • (2002) J Intern Med , vol.252 , pp. 497-503
    • Mangoni, A.A.1    Sherwood, R.A.2    Swift, C.G.3    Jackson, S.H.4
  • 41
    • 23444452249 scopus 로고    scopus 로고
    • Folic acid supplementation for 3 weeks reduces pulse pressure and large artery stiffness independent of MTHFR genotype
    • Williams C, Kingwell BA, Burke K, McPherson J, Dart AM. Folic acid supplementation for 3 weeks reduces pulse pressure and large artery stiffness independent of MTHFR genotype. Am J Clin Nutr 2005; 82:26-31.
    • (2005) Am J Clin Nutr , vol.82 , pp. 26-31
    • Williams, C.1    Kingwell, B.A.2    Burke, K.3    McPherson, J.4    Dart, A.M.5
  • 42
    • 12244311911 scopus 로고    scopus 로고
    • Folate intake and the risk of incident hypertension among US women
    • Forman JP, Rimm EB, Stampfer MJ, Curhan GC. Folate intake and the risk of incident hypertension among US women. JAMA 2005; 293:320-329.
    • (2005) JAMA , vol.293 , pp. 320-329
    • Forman, J.P.1    Rimm, E.B.2    Stampfer, M.J.3    Curhan, G.C.4


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