Proline-proline-glutamic acid (PPE) protein Rv1168c of Mycobacterium tuberculosis augments transcription from HIV-1 long terminal repeat promoter

Journal of Biological Chemistry

Volumn 287, Issue 20, 2012, Pages 16930-16946

  Bhat, Khalid Hussain ^a   Chaitanya, Chinta Krishna ^a   Parveen, Nazia ^a   Varman, Raja ^a   Ghosh, Sudip ^b   Mukhopadhyay, Sangita ^a  

^a CENTRE FOR DNA FINGERPRINTING AND DIAGNOSTICS   (India)

^b NATIONAL INSTITUTE OF NUTRITION   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CO-INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS; IN-SILICO; LONG TERMINAL REPEATS; M. TUBERCULOSIS; MYCOBACTERIAL; MYCOBACTERIUM TUBERCULOSIS; N-TERMINAL DOMAINS; NUCLEAR FACTORS; SIGNALING EVENTS; SIGNALING PATHWAYS;

PROTEINS; TRANSCRIPTION; TUBES (COMPONENTS); VIRUSES;

AMINO ACIDS;

CHLORAMPHENICOL ACETYLTRANSFERASE; GLUTAMIC ACID; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROLINE; PROLINE PROLINE GLUTAMIC ACID PROTEIN; TOLL LIKE RECEPTOR 2; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIUM CULTURE; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOPRECIPITATION; LONG TERMINAL REPEAT; MACROPHAGE; MOLECULAR DOCKING; MONOCYTE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; TUBERCULOSIS; WESTERN BLOTTING;

AMINO ACID MOTIFS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CELL LINE, TUMOR; HEK293 CELLS; HIV INFECTIONS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TUBERCULOSIS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MYCOBACTERIUM TUBERCULOSIS;

EID: 84860871530     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.327825     Document Type: Article

References (96)

1. UN Joint Programme on HIV/AIDS, Global Report: UNAIDS Report on the Global AIDS Epidemic: 2010, December 2010
2. Kwan, C. K., and Ernst, J. D. (2011) HIV and tuberculosis. A deadly human syndemic. Clin. Microbiol. Rev. 24, 351-376
3. López-Gatell, H., Cole, S. R., Hessol, N. A., French, A. L., Greenblatt, R. M., Landesman, S., Preston-Martin, S., and Anastos, K. (2007) Effect of tuberculosis on the survival of women infected with human immunodeficiency virus. Am. J. Epidemiol. 165, 1134-1142 (Pubitemid 47233709)
4. Diedrich, C. R., and Flynn J. L. (2011) HIV-1/Mycobacterium tuberculosis co-infection immunology. How does HIV-1 exacerbate tuberculosis? Infect. Immun. 79, 1407-1417
5. Lawn S. D., Butera, S. T., and Shinnick, T. M. (2002) Tuberculosis unleashed. The impact of human immunodeficiency virus infection on the host granulomatous response to Mycobacterium tuberculosis. Microbes Infect. 4, 635-646 (Pubitemid 34614552)
6. Williams, B. G., Granich, R., Chauhan, L. S., Dharmshaktu, N. S., and Dye, C. (2005) The impact of HIV/AIDS on the control of tuberculosis in India. Proc. Natl. Acad. Sci. U.S.A. 102, 9619-9624 (Pubitemid 40981730)
7. Coleman, C. M., and Wu, L. (2009) HIV interactions with monocytes and dendritic cells. Viral latency and reservoirs. Retrovirology 6, 51
8. Roy, S., and Wainberg, M. A. (1988) Role of the mononuclear phagocyte system in the development of acquired immunodeficiency syndrome (AIDS). J. Leukocyte Biol. 3, 91-97
9. Brown, A., Zhang, H., Lopez, P., Pardo, C. A., and Gartner, S. (2006) In vitro modeling of the HIV-macrophage reservoir. J. Leukocyte Biol. 80, 1127-1135 (Pubitemid 44646318)
10. Orenstein, J. M., Fox, C., and Wahl, S. M. (1997) Macrophages as a source of HIV during opportunistic infections. Science 276, 1857-1861
11. Garrait, V., Cadranel, J., Esvant, H., Herry, I., Morinet, P., Mayaud, C., and Israël-Biet, D. (1997) Tuberculosis generates a microenvironment enhancing the productive infection of local lymphocytes by HIV. J. Immunol. 159, 2824-2830 (Pubitemid 127681304)
12. Moriuchi, M., Moriuchi, H., Turner, W., and Fauci, A. S. (1998) Exposure to bacterial products renders macrophages highly susceptible to T-tropic HIV-1. J. Clin. Invest. 102, 1540-1550 (Pubitemid 28492221)
13. Zhang, Y., Nakata, K., Weiden, M., and Rom, W. N. (1995) Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication by transcriptional activation at the long terminal repeat. J. Clin. Invest. 95, 2324-2331
14. Kitaura, H., Ohara, N., Kobayashi, K., and Yamada, T. (2001) TNF-α- mediated activation of HIV-1 LTR in monocytoid cells by mycobacteria. FEMS Immunol. Med. Microbiol. 31, 97-103 (Pubitemid 32822873)
15. Toossi, Z., Xia, L., Wu, M., and Salvekar, A. (1999) Transcriptional activation of HIV by Mycobacterium tuberculosis in human monocytes. Clin. Exp. Immunol. 117, 324-330 (Pubitemid 29343605)
16. Toossi, Z., Sierra-Madero, J. G., Blinkhorn, R. A., Mettler, M. A., and Rich, E. A. (1993) Enhanced susceptibility of blood monocytes from patients with pulmonary tuberculosis to productive infection with human immunodeficiency virus type 1. J. Exp. Med. 177, 1511-1516 (Pubitemid 23117144)
17. Bernier, R., Barbeau, B., Olivier, M., and Tremblay, M. J. (1998) Mycobacterium tuberculosis mannose-capped lipoarabinomannan can induce NF-κB-dependent activation of human immunodeficiency virus type 1 long terminal repeat in T cells. J. Gen. Virol. 79, 1353-1361 (Pubitemid 28258443)
18. Kilareski, E. M., Shah, S., Nonnemacher, M. R., and Wigdahl, B. (2009) Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage. Retrovirology 6, 118
19. Mingyan, Y., Xinyong, L., and De Clercq, E. (2009) NF-κB. The inducible factors of HIV-1 transcription and their inhibitors. Mini Rev. Med. Chem. 9, 60-69
20. Molina, J. M., Scadden, D. T., Byrn, R., Dinarello, C. A., and Groopman, J. E. (1989) Production of tumor necrosis factor α and interleukin 1β by monocytic cells infected with human immunodeficiency virus. J. Clin. Invest. 84, 733-737 (Pubitemid 19228341)
21. Pomerantz, R. J., Feinberg, M. B., Trono, D., and Baltimore, D. (1990) Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. J. Exp. Med. 172, 253-261 (Pubitemid 20217267)
22. Koyanagi, Y., O'Brien, W. A., Zhao, J. Q., Golde, D. W., Gasson, J. C., and Chen, I. S. (1988) Cytokines alter production of HIV-1 from primary mononuclear phagocytes. Science 241, 1673-1675
23. Cohen, O. J., Kinter, A., and Fauci, A. S. (1997) Host factors in the pathogenesis of HIV disease. Immunol. Rev. 159, 31-48 (Pubitemid 27499858)
24. Wahl, S. M., Greenwell-Wild, T., Peng, G., Hale-Donze, H., Doherty, T. M., Mizel, D., and Orenstein, J. M. (1998) Mycobacterium avium complex augments macrophage HIV-1 production and increases CCR5 expression. Proc. Natl. Acad. Sci. U.S.A. 95, 12574-12579 (Pubitemid 28483806)
25. Ghassemi, M., Asadi, F. K., Andersen, B. R., and Novak, R. M. (2000) Mycobacterium avium induces HIV up-regulation through mechanisms independent of cytokine induction. AIDS Res. Hum. Retroviruses 16, 435-440 (Pubitemid 30193811)
26. Shattock, R. J., Friedland, J. S., and Griffin, G. E. (1994) Phagocytosis of Mycobacterium tuberculosis modulates human immunodeficiency virus replication in human monocytic cells. J. Gen. Virol. 75, 849-856 (Pubitemid 24118117)
27. Pereira, L. A., Bentley, K., Peeters, A., Churchill, M. J., and Deacon, N. J. (2000) A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter. Nucleic Acids Res. 28, 663-668 (Pubitemid 30068248)
28. Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., 3rd, Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M. A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S., and Barrell, B. G. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544 (Pubitemid 28319235)
29. Delogu, G., Sanguinetti, M., Pusceddu, C., Bua, A., Brennan, M. J., Zanetti, S., and Fadda, G. (2006) PE-PGRS proteins are differentially expressed by Mycobacterium tuberculosis in host tissues. Microbes Infect. 8, 2061-2067 (Pubitemid 44335877)
30. Voskuil, M. I., Schnappinger, D., Rutherford, R., Liu, Y., and Schoolnik, G. K. (2004) Regulation of the Mycobacterium tuberculosis PE/PPE genes. Tuberculosis 84, 256-262 (Pubitemid 38857858)
31. Brennan, M. J., and Delogu, G. (2002) The PE multigene family. A "molecular mantra" for mycobacteria. Trends Microbiol. 10, 246-249 (Pubitemid 34327818)
32. Ramakrishnan, L., Federspiel, N. A., and Falkow, S. (2000) Granuloma-specific expression of Mycobacterium virulence proteins from the glycinerich PE-PGRS family. Science 288, 1436-1439 (Pubitemid 30366332)
33. Choudhary, R. K., Mukhopadhyay, S., Chakhaiyar, P., Sharma, N., Murthy, K. J., Katoch, V. M., and Hasnain, S. E. (2003) PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B-cell response. Infect. Immun. 71, 6338-6343 (Pubitemid 37337691)
34. Li, Y., Miltner, E., Wu, M., Petrofsky, M., and Bermudez, L. E. (2005) A Mycobacterium avium PPE gene is associated with the ability of the bacterium to grow in macrophages and virulence in mice. Cell. Microbiol. 7, 539-548 (Pubitemid 40439453)
35. Abdallah, A. M., Verboom, T., Hannes, F., Safi, M., Strong, M., Eisenberg, D., Musters, R. J., Vandenbroucke-Grauls, C. M., Appelmelk, B. J., Luirink, J., and Bitter, W. (2006) A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol. Microbiol. 62, 667-679 (Pubitemid 44571593)
36. Basu, S., Pathak, S. K., Banerjee, A., Pathak, S., Bhattacharyya, A., Yang, Z., Talarico, S., Kundu, M., and Basu, J. (2007) Execution of macrophage apoptosis by PE-PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-α. J. Biol. Chem. 282, 1039-1050 (Pubitemid 47076567)
37. Nair, S., Ramaswamy, P. A., Ghosh, S., Joshi, D. C., Pathak, N., Siddiqui, I., Sharma, P., Hasnain, S. E., Mande, S. C., and Mukhopadhyay, S. (2009) The PPE18 of Mycobacterium tuberculosis interacts with TLR2 and activates IL-10 induction in macrophage. J. Immunol. 183, 6269-6281
38. Bansal, K., Sinha, A. Y., Ghorpade, D. S., Togarsimalemath, S. K., Patil, S. A., Kaveri, S. V., Balaji, K. N., and Bayry, J. (2010) Src homology 3-interacting domain of Rv1917c of Mycobacterium tuberculosis induces selective maturation of human dendritic cells by regulating PI3K-MAPK-NF- κB signaling and drives Th2 immune responses. J. Biol. Chem. 285, 36511-36522
39. Khan, N., Alam, K., Nair, S., Valluri, V. L., Murthy, K. J., and Mukhopadhyay, S. (2008) Association of strong immune responses to PPE protein Rv1168c with active tuberculosis. Clin. Vaccine Immunol. 15, 974-980 (Pubitemid 351966997)
40. Bacon, J., James, B. W., Wernisch, L., Williams, A., Morley, K. A., Hatch, G. J., Mangan, J. A., Hinds, J., Stoker, N. G., Butcher, P. D., and Marsh, P. D. (2004) The influence of reduced oxygen availability on pathogenicity and gene expression in Mycobacterium tuberculosis. Tuberculosis 84, 205-217 (Pubitemid 38857853)
41. Muttucumaru, D. G., Roberts, G., Hinds, J., Stabler, R. A., and Parish, T. (2004) Gene expression profile of Mycobacterium tuberculosis in a non-replicating state. Tuberculosis 84, 239-246 (Pubitemid 38857856)
42. Betts, J. C., Lukey, P. T., Robb, L. C., McAdam, R. A., and Duncan, K. (2002) Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol. Microbiol. 43, 717-731 (Pubitemid 34597265)
43. Schnappinger, D., Ehrt, S., Voskuil, M. I., Liu, Y., Mangan, J. A., Monahan, I. M., Dolganov, G., Efron, B., Butcher, P. D., Nathan, C., and Schoolnik, G. K. (2003) Transcriptional adaptation of Mycobacterium tuberculosis within macrophages. Insights into the phagosomal environment. J. Exp. Med. 198, 693-704 (Pubitemid 37087769)
44. Homolka, S., Niemann, S., Russell, D. G., and Rohde, K. H. (2010) Functional genetic diversity among Mycobacterium tuberculosis complex clinical isolates. Delineation of conserved core and lineage-specific transcriptomes during intracellular survival. PLoS Pathog. 6, e1000988
45. Sampson, S. L., Lukey, P., Warren, R. M., van Helden, P. D., Richardson, M., and Everett, M. J. (2001) Expression, characterization and subcellular localization of the Mycobacterium tuberculosis PPE gene Rv1917c. Tuberculosis 81, 305-317 (Pubitemid 34087861)
46. Khan, N., Alam, K., Mande, S. C., Valluri, V. L., Hasnain, S. E., and Mukhopadhyay, S. (2008) Mycobacterium tuberculosis heat shock protein 60 modulates immune response to PPD by manipulating the surface expression of TLR2 on macrophages. Cell. Microbiol. 10, 1711-1722 (Pubitemid 352011842)
47. Khan, N., Rahim, S. S., Boddupalli, C. S., Ghousunnissa, S., Padma, S., Pathak, N., Thiagarajan, D., Hasnain, S. E., and Mukhopadhyay, S. (2006) Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein. Blood 107, 1513-1520 (Pubitemid 43242389)
48. Mukhopadhyay, S., Mohanty, M., Mangla, A., George, A., Bal, V., Rath, S., and Ravindran, B. (2002) Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance. J. Immunol. 168, 2914-2921 (Pubitemid 34211671)
49. Khan, N., Ghousunnissa, S., Jegadeeswaran, S. M., Thiagarajan, D., Hasnain, S. E., and Mukhopadhyay, S. (2007) Anti-B7-1/B7-2 antibody elicits innate-effector responses in macrophages through NF-κB-dependent pathway. Int. Immunol. 19, 477-486 (Pubitemid 46523395)
50. Wagner, D. H., Jr., Vaitaitis, G., Sanderson, R., Poulin, M., Dobbs, C., and Haskins, K. (2002) Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes. Proc. Natl. Acad. Sci. U.S.A. 99, 3782-3787 (Pubitemid 34252183)
51. Delogu, G., Bua, A., Pusceddu, C., Parra, M., Fadda, G., Brennan, M. J., and Zanetti, S. (2004) Expression and purification of recombinant methylated HBHA in Mycobacterium smegmatis. FEMS Microbiol. Lett. 239, 33-39 (Pubitemid 39296713)
52. Eswar, N., Webb, B., Marti-Renom, M. A., Madhusudhan, M. S., Eramian, D., Shen, M. Y., Pieper, U., and Sali, A. (2007) UNIT 2.9 comparative protein structure modeling using Modeller. Curr. Protoc. Protein Sci. Chapter 2, Unit 2.9
53. Martí-Renom, M. A., Stuart, A. C., Fiser, A., Sánchez, R., Melo, F., and Sali, A. (2000) Comparative protein structure modeling of genes and genomes. Annu. Rev. Biophys. Biomol. Struct. 29, 291-325 (Pubitemid 30599596)
54. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) PROCHECK. A program to check the stereochemical quality of protein structures. J. Appl. Crystallogr. 26, 283-291
55. Morris, A. L., MacArthur, M. W., Hutchinson, E. G., and Thornton, J. M. (1992) Stereochemical quality of protein structure coordinates. Proteins 12, 345-364
56. Sorgen, P. L., Hu, Y., Guan, L., Kaback, H. R., and Girvin, M. E. (2002) An approach to membrane protein structure without crystals. Proc. Natl. Acad. Sci. U.S.A. 99, 14037-14040 (Pubitemid 35257620)
57. Jin, M. S., Kim, S. E., Heo, J. Y., Lee, M. E., Kim, H. M., Paik, S. G., Lee, H., and Lee, J. O. (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130, 1071-1082 (Pubitemid 47410281)
58. Ritchie, D. W., and Kemp, G. J. (1999) Fast computation, rotation, and comparison of low resolution spherical harmonic molecular surfaces. J. Math. Chem. 20, 383-395 (Pubitemid 129652338)
59. Mizuguchi, K., Deane, C. M., Blundell, T. L., Johnson, M. S., and Overington, J. P. (1998) JOY. Protein sequence-structure representation and analysis. Bioinformatics 14, 617-623 (Pubitemid 28461583)
60. Guex, N. (1996) Swiss-PdbViewer. A new fast and easy to use PDB viewer for the Macintosh. Experientia 52, A26
61. Schwartz, S., Felber, B. K., Fenyö, E. M., and Pavlakis, G. N. (1989) Rapidly and slowly replicating human immunodeficiency virus type 1 isolates can be distinguished according to target-cell tropism in T-cell and monocyte cell lines. Proc. Natl. Acad. Sci. U.S.A. 86, 7200-7203 (Pubitemid 19240893)
62. Nabel, G., and Baltimore, D. (1987) An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326, 711-713 (Pubitemid 17059793)
63. Roulston, A., Lin, R., Beauparlant, P., Wainberg, M. A., and Hiscott, J. (1995) Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-κB/Rel transcription factors. Microbiol. Rev. 59, 481-505
64. Schreck, R., Meier, B., Männel, D. N., Dröge, W., and Baeuerle, P. A. (1992) Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J. Exp. Med. 175, 1181-1194
65. Karin, M., and Lin, A. (2002) NF-κB at the crossroads of life and death. Nat. Immunol. 3, 221-227
66. Asin, S., Bren, G. D., Carmona, E. M., Solan, N. J., and Paya, C. V. (2001) NF-κB cis-acting motifs of the human immunodeficiency virus (HIV) long terminal repeat regulate HIV transcription in human macrophages. J. Virol. 75, 11408-11416 (Pubitemid 33063232)
67. Duh, E. J., Maury, W. J., Folks, T. M., Fauci, A. S., and Rabson, A. B. (1989) Tumor necrosis factor α activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-κB sites in the long terminal repeat. Proc. Natl. Acad. Sci. U.S.A. 86, 5974-5978 (Pubitemid 19217570)
68. He, M. M., Smith, A. S., Oslob, J. D., Flanagan, W. M., Braisted, A. C., Whitty, A., Cancilla, M. T., Wang, J., Lugovskoy, A. A., Yoburn, J. C., Fung, A. D., Farrington, G., Eldredge, J. K., Day, E. S., Cruz, L. A., Cachero, T. G., Miller, S. K., Friedman, J. E., Choong, I. C., and Cunningham, B. C. (2005) Small molecule inhibition of TNF-α. Science 310, 1022-1025
69. Gey van Pittius, N. C., Sampson, S. L., Lee, H., Kim, Y., van Helden, P. D., and Warren, R. M. (2006) Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions.BMCEvol. Biol. 6, 95
70. Newton, V., McKenna, S. L., and De Buck, J. (2009) Presence of PPE proteins in Mycobacterium avium subsp. paratuberculosis isolates and their immunogenicity in cattle. Vet. Microbiol. 135, 394-400
71. Jo, E. K., Yang, C. S., Choi, C. H., and Harding, C. V. (2007) Intracellular signaling cascades regulating innate immune responses to Mycobacteria. Branching out from Toll-like receptors. Cell. Microbiol. 9, 1087-1098 (Pubitemid 46547129)
72. Sánchez, D., Rojas, M., Hernández, I., Radzioch, D., García, L. F., and Barrera, L. F. (2010) Role of TLR2- and TLR4-mediated signaling in Mycobacterium tuberculosis-induced macrophage death. Cell. Immunol. 260, 128-136
73. Pecora, N. D., Gehring, A. J., Canaday, D. H., Boom, W. H., and Harding, C. V. (2006) Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function. J. Immunol. 177, 422-429 (Pubitemid 43939154)
74. Sweet, L., and Schorey, J. S. (2006) Glycopeptidolipids from Mycobacterium avium promote macrophage activation in a TLR2- and MyD88-dependent manner. J. Leukocyte Biol. 80, 415-423 (Pubitemid 44835515)
75. Bafica, A., Scanga, C. A., Schito, M. L., Hieny, S., and Sher, A. (2003) In vivo induction of integrated HIV-1 expression by mycobacteria is critically dependent on Toll-like receptor 2. J. Immunol. 171, 1123-1127 (Pubitemid 36900038)
76. Equils, O., Schito, M. L., Karahashi, H., Madak, Z., Yarali, A., Michelsen, K. S., Sher, A., and Arditi, M. (2003) Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells. Implications of simultaneous activation of TLRs on HIV replication. J. Immunol. 170, 5159-5164 (Pubitemid 36554748)
77. Nair, S., Pandey, A. D., and Mukhopadhyay, S. (2011) The PPE18 protein of Mycobacterium tuberculosis inhibits NF-κB/rel-mediated proinflammatory cytokine production by up-regulating and phosphorylating suppressor of cytokine signaling 3 protein. J. Immunol. 186, 5413-5424
78. Meng, G., Grabiec, A., Vallon, M., Ebe, B., Hampel, S., Bessler, W., Wag- ner, H., and Kirschning, C. J. (2003) Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2. J. Biol. Chem. 278, 39822-39829 (Pubitemid 37248544)
79. Gartner, S., Markovits, P., Markovitz, D. M., Kaplan, M. H., Gallo, R. C., and Popovic, M. (1986) The role of mononuclear phagocytes in HTLV-III/ LAV infection. Science 233, 215-219
80. Coiras, M., López-Huertas, M. R., Pérez-Olmeda, M., and Alcamí, J. (2009) Understanding HIV-1 latency provides clues for the eradication of long term reservoirs. Nat. Rev. Microbiol. 7, 798-812
81. + T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV). Implications for HIV-1 infections of humans. Proc. Natl. Acad. Sci. U.S.A. 98, 658-663
82. Doherty, T. M., Chougnet, C., Schito, M., Patterson, B. K., Fox, C., Shearer, G. M., Englund, G., and Sher, A. (1999) Infection of HIV-1 transgenic mice with Mycobacterium avium induces the expression of infectious virus selectively from a Mac-1-positive host cell population. J. Immunol. 163, 1506-1515 (Pubitemid 29352773)
83. de Noronha, A. L., Báfica, A., Nogueira, L., Barral, A., and Barral-Netto, M. (2008) Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production. Pathol. Res. Pract. 204, 155-161
84. Shen, Y., Shen, L., Sehgal, P., Huang, D., Qiu, L., Du, G., Letvin, N. L., and Chen, Z. W. (2004) Clinical latency and reactivation of AIDS-related mycobacterial infections. J. Virol. 78, 14023-14032 (Pubitemid 39612798)
85. Selwyn, P. A., Hartel, D., Lewis, V. A., Schoenbaum, E. E., Vermund, S. H., Klein, R. S., Walker, A. T., and Friedland, G. H. (1989) A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection. N. Engl. J. Med. 320, 545-550 (Pubitemid 19070537)
86. Thomas, D. J. (2006) Mycobacterial diseases in HIV-positive patients. J. Pharm. Pract. 19, 10-16
87. Singh, K. K., Dong, Y., Patibandla, S. A., McMurray, D. N., Arora, V. K., and Laal, S. (2005) Immunogenicity of the Mycobacterium tuberculosis PPE55 (Rv3347c) protein during incipient and clinical tuberculosis. Infect. Immun. 73, 5004-5014 (Pubitemid 41105658)
88. Zhou, S., Cerny, A. M., Bowen, G., Chan, M., Knipe, D. M., Kurt-Jones, E. A., and Finberg, R. W. (2010) Discovery of a novel TLR2 signaling inhibitor with anti-viral activity. Antiviral Res. 87, 295-306
89. Jacqué, J. M., Fernández, B., Arenzana-Seisdedos, F., Thomas, D., Baleux, F., Virelizier, J. L., and Bachelerie, F. (1996) Permanent occupancy of the human immunodeficiency virus type 1 enhancer by NF-κB is needed for persistent viral replication in monocytes. J. Virol. 70, 2930-2938 (Pubitemid 26121906)
90. Wahl, S. M., Greenwell-Wild, T., Peng, G., Hale-Donze, H., and Orenstein, J. M. (1999) Co-infection with opportunistic pathogens promotes human immunodeficiency virus type 1 infection in macrophages. J. Infect. Dis. 179, S457-S460 (Pubitemid 29198398)
91. Jagodzinski, P. P., and Trzeciak, W. H. (2001) High molecular weight dextran sulfate enhances the activity of NF-κB-regulated promoter in monocytic cell line. Folia Histochem. Cytobiol. 39, 47-48 (Pubitemid 32117850)
92. + monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo. J. Immunol. 178, 6581-6589
93. + blood monocytes. Their role in infection and inflammation. J. Leukocyte Biol. 81, 584-592
94. high. A cytokine-producing monocyte subset which expands during human immunodeficiency virus infection. Eur. J. Immunol. 25, 3418-3424
95. + monocytes in tuberculosis. Efficient APC in pleural effusion but also mark disease severity in blood. J. Leukocyte Biol. 90, 69-75
96. hisubpopulation of monocyte-derived macrophages. J. Immunol. 186, 1638-1645