Tight complex formation between cosmc chaperone and its specific client non-native T-synthase leads to enzyme activity and client-driven dissociation

Journal of Biological Chemistry

Volumn 287, Issue 19, 2012, Pages 15317-15329

  Aryal, Rajindra P ^a   Ju, Tongzhong ^a   Cummings, Richard D ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEX FORMATIONS; COVALENTLY BOUND; ENDOPLASMIC RETICULUM; FREEFORMS; INTERMOLECULAR DISULFIDE BOND; LUMENAL DOMAIN; MOLECULAR CHAPERONES; NON-NATIVE; SOLID SUPPORTS; STABLE COMPLEXES;

CELL MEMBRANES; COVALENT BONDS; ENZYMES;

DISSOCIATION;

CHAPERONE; COSMC PROTEIN; MEMBRANE PROTEIN; T SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVITY; ENZYME RELEASE; IN VITRO STUDY; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY;

ANIMALS; BIOCATALYSIS; BLOTTING, WESTERN; CELL LINE; GALACTOSYLTRANSFERASES; GOLGI APPARATUS; HUMANS; MOLECULAR CHAPERONES; MULTIPROTEIN COMPLEXES; MUTATION; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; SOLUBILITY;

EID: 84860868131     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.312587     Document Type: Article

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