CxxS: Fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function

Protein Science

Volumn 11, Issue 10, 2002, Pages 2285-2296

  Fomenko, Dmitri E ^a   Gladyshev, Vadim N ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Computational biology; CxxS motif; Genome; Redox; Thiol disulfide oxidoreductase

Indexed keywords

DISULFIDE; OXIDOREDUCTASE; THIOL; THIOREDOXIN;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; GENOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; SEQUENCE ANALYSIS; SPECIES DIFFERENCE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; ESCHERICHIA COLI; GENOME, ARCHAEAL; GENOME, BACTERIAL; OXIDATION-REDUCTION; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE); SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN;

CAMPYLOBACTER; CAMPYLOBACTER JEJUNI; ESCHERICHIA COLI; METHANOCALDOCOCCUS JANNASCHII; METHANOCOCCUS; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036784622     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.0218302     Document Type: Article

References (42)

1. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
2. ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family
3. Physiological functions of thioredoxin and thioredoxin reductase
4. Bacterial Ohr and OsmC paralogues define two protein families with distinct functions and patterns of expression
5. The SIS domain: A phosphosugar-binding domain
6. Arf proteins: The membrane traffic police?
7. Roles of the glutathione- and thioredoxin-dependent reduction systems in the Escherichia coli and Saccharomyces cerevisiae responses to oxidative stress
8. How G proteins work: A continuing story
9. Recent trends in glutathione biochemistry-glutathione-protein interactions: A molecular link between oxidative stress and cell proliferation?
10. The yeast SCG1 gene: A G α-like protein implicated in the a- and α-factor response pathway
11. The role of iron in the activation of mannonic and altronic acid hydratases, two Fe-requiring hydro-lyases
12. Functional analysis of the Escherichia coli genome using the sequence-to-structure-to-function paradigm: Identification of proteins exhibiting the glutaredoxin/thioredoxin disulfide oxidoreductase activity
13. Genomic-scale comparison of sequence- and structure-based methods of function prediction: Does structure provide additional insight?
14. Reactive oxygen species and signal transduction
15. Thioredoxin and peptide methionine sulfoxide reductase: Convergence of similar structure and function in distinct structural folds
16. The PROSITE database, its status in 1999
17. Antioxidant function of thioredoxin and glutaredoxin systems
18. Redox switch of hsp33 has a novel zinc-binding motif
19. Protein secondary structure prediction based on position-specific scoring matrices
20. Reaction mechanism, evolutionary analysis and role of zinc in Drosophila methionine-R-sulfoxide reductase
21. a values in proteins of the thioredoxin family
22. IscA, an alternate scaffold for Fe-S cluster biosynthesis
23. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements
24. Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase
25. Two conserved domains in regulatory B sub-units mediate binding to the A subunit of protein phosphatase 2A
26. Thioredoxin - A fold for all reasons
27. Identification of a new family of protein phosphatase 2A regulatory subunits
28. Identification and characterization of a new organic hydroperoxide resistance (ohr) gene with a novel pattern of oxidative stress regulation from Xanthomonas campestris pv
29. Comprehensive survey of proteins targeted by chloroplast thioredoxin
30. The phosphatase C(X)5R motif is required for catalytic activity of the Saccharomyces cerevisiae Acr2p arsenate reductase
31. Iron-sulfur cluster assembly: Characterization of IscA and evidence for a specific and functional complex with ferredoxin
32. Characterization of the NifU and NifS Fe-S cluster formation proteins essential for viability in Helicobacter pylori
33. Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur
34. Hydrogen peroxide: A key messenger that modulates protein phosphorylation through cysteine oxidation
35. Roles of thiol-redox pathways in bacteria
36. Activities of mutant Sar1 proteins in guanine nucleotide binding, GTP hydrolysis, and cell-free transport from the endoplasmic reticulum to the Golgi apparatus
37. Incorporation of iron-sulphur clusters in membrane-bound proteins
38. Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction
39. Redox regulation by thioredoxin superfamily; protection against oxidative stress and aging
40. Structure and function of S-adenosylhomocysteine hydrolase
41. Native disulfide bond formation in proteins
42. A strategy for the identification of proteins targeted by thioredoxin