Promoted transfection efficiency of pDNA polyplexes-loaded biodegradable microparticles containing acid-labile segments and galactose grafts

Pharmaceutical Research

Volumn 29, Issue 2, 2012, Pages 471-482

  Chen, Zhu ^a   Cai, Xiaojun ^a   Yang, Ye ^a   Wu, Guannan ^a   Liu, Yaowen ^a   Chen, Fang ^a   Li, Xiaohong ^b  

^a SOUTHWEST JIAOTONG UNIVERSITY   (China)

^b AFFILIATED HOSPITAL OF NORTH SICHUAN MEDICAL COLLEGE   (China)

Author keywords

Acid labile biodegradable polymers; Endosomal escape; pDNA polyplexes; Targeting effect; Transfection efficiency

Indexed keywords

GALACTOSE; MICROSPHERE; PLASMID DNA; POLY(BENZALDEHYDE POLYETHYLENE GLYCOL); POLYLACTIDE; POLYMER; UNCLASSIFIED DRUG; DNA;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; BIODEGRADABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION; ENCAPSULATION; HEMOLYSIS; MACROPHAGE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SUSTAINED RELEASE PREPARATION; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; HUMAN; LIVER; METABOLISM; PLASMID;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DNA; GALACTOSE; HEMOLYSIS; HUMANS; LIVER; MACROPHAGES; MICROSPHERES; PLASMIDS; RATS; TRANSFECTION;

EID: 84860855314     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0577-4     Document Type: Article

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