Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae

Enzyme and Microbial Technology

Volumn 51, Issue 1, 2012, Pages 16-25

  Matsushika, Akinori ^a   Goshima, Tetsuya ^a   Fujii, Tatsuya ^a   Inoue, Hiroyuki ^a   Sawayama, Shigeki ^a,b   Yano, Shinichi ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Ethanol fermentation; Pentose phosphate pathway; Saccharomyces cerevisiae; Transaldolase; Transketolase; Xylose utilization

Indexed keywords

CEREVISIAE; ETHANOL FERMENTATION; ETHANOL PRODUCTION; GENE DISRUPTIONS; KEY ENZYMES; METABOLIC PATHWAYS; NON-OXIDATIVE; OVER-EXPRESSION; PENTOSE PHOSPHATE PATHWAY; RATE LIMITING; SOLE CARBON SOURCE; TRANSALDOLASE; TRANSCRIPTIONAL ANALYSIS; TRANSKETOLASE;

ETHANOL; FERMENTATION; GENES; GLUCOSE;

YEAST;

ALCOHOL; CARBON; GLUCOSE; PENTOSE PHOSPHATE; TRANSALDOLASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NQM1; TRANSCRIPTION FACTOR TAL1; TRANSCRIPTION FACTOR TKL1; TRANSCRIPTION FACTOR TKL2; TRANSKETOLASE; UNCLASSIFIED DRUG; XYLOSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BATCH FERMENTATION; BIOMASS PRODUCTION; CARBON SOURCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME METABOLISM; FUNGAL STRAIN; FUNGUS GROWTH; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE OVEREXPRESSION; GLUCOSE METABOLISM; MUTANT; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PHENOTYPE; PROTEIN FUNCTION; RECEPTOR UPREGULATION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION INITIATION; TRANSCRIPTOMICS;

BASE SEQUENCE; BIOFUELS; DNA, FUNGAL; ETHANOL; FERMENTATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; GENE KNOCKOUT TECHNIQUES; GENES, FUNGAL; MUTATION; PENTOSE PHOSPHATE PATHWAY; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSALDOLASE; TRANSKETOLASE; XYLOSE;

SACCHAROMYCES CEREVISIAE;

EID: 84860836081     PISSN: 01410229     EISSN: 18790909     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2012.03.008     Document Type: Article

References (44)

1. Sims R.E.H., Mabee W., Saddler J.N., Taylor M. An overview of second generation biofuel technologies. Bioresource Technology 2010, 101:1570-1580.
2. Parekh S., Wayman M. Fermentation of cellobiose and wood sugars to ethanol by Candida shehatae and Pichia stipitis. Biotechnology Letters 1986, 8:597-600.
3. Kötter P., Ciriacy M. Xylose fermentation by Saccharomyces cerevisiae. Applied Microbiology and Biotechnology 1993, 38:776-783.
4. Zhang M., Eddy C., Deanda K., Finkelstein M., Picataggio S. Metabolic engineering of a pentose metabolism pathway in ethanologenic Zymomonas mobilis. Science 1995, 267:240-243.
5. Asghari A., Bothast R.J., Doran J.B., Ingram L.O. Ingram Ethanol production from hemicellulose hydrolysates of agricultural residues using genetically engineered Escherichia coli strain KO11. Journal of Industrial Microbiology & Biotechnology 1996, 16:42-47.
6. Hahn-Hägerdal B., Karhumaa K., Jeppsson M., Gorwa-Grauslund M.F. Metabolic engineering for pentose utilization in Saccharomyces cerevisiae. Advances in Biochemical Engineering/Biotechnology 2007, 108:147-177.
7. Matsushika A., Inoue H., Kodaki T., Sawayama S. Ethanol production from xylose in engineered Saccharomyces cerevisiae strains: current state and perspectives. Applied Microbiology and Biotechnology 2009, 84:37-53.
8. Van Vleet J.H., Jeffries T.W. Yeast metabolic engineering for hemicellulosic ethanol production. Current Opinion in Biotechnology 2009, 20:300-306.
9. Lindqvist Y., Schneider G., Ermler U., Sundström M. Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5Å resolution. EMBO Journal 1992, 11:2373-2379.
10. Gancedo J.M., Lagunas R. Contribution of the pentose phosphate pathway to glucose metabolism in Saccharomyces cerevisiae: a critical analysis on the use of labelled glucose. Plant Science Letters 1973, 1:193-200.
11. Fiaux J., Cakar Z.P., Sonderegger M., Wüthrich K., Szyperski T., Sauer U. Metabolic-flux profiling of the yeasts Saccharomyces cerevisiae and Pichia stipitis. Eukaryotic Cell 2003, 2:170-180.
12. Johansson B., Hahn-Hägerdal B. The non-oxidative pentose phosphate pathway controls the fermentation rate of xylulose but not of xylose in Saccharomyces cerevisiae TMB3001. FEMS Yeast Research 2002, 2:277-282.
13. Walfridsson M., Hallborn J., Penttilä M., Keränen S., Hahn-Hägerdal B. Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase. Applied and Environmental Microbiology 1995, 61:4184-4190.
14. Jin Y.S., Alper H., Yang Y.T., Stephanopoulos G. Improvement of xylose uptake and ethanol production in recombinant Saccharomyces cerevisiae through an inverse metabolic engineering approach. Applied and Environmental Microbiology 2005, 71:8249-8256.
15. Metzger M.H., Hollenberg C.P. Isolation and characterization of the Pichia stipitis transketolase gene and expression in a xylose-utilising Saccharomyces cerevisiae transformant. Applied Microbiology and Biotechnology 1994, 42:319-325.
16. Johansson B., Hahn-Hägerdal B. Overproduction of pentose phosphate pathway enzymes using a new CRE-loxP expression vector for repeated genomic integration in Saccharomyces cerevisiae. Yeast 2002, 19:225-231.
17. Karhumaa K., Hahn-Hägerdal B., Gorwa-Grauslund M.F. Investigation of limiting metabolic steps in the utilization of xylose by recombinant Saccharomyces cerevisiae using metabolic engineering. Yeast 2005, 22:359-368.
18. Karhumaa K., Fromanger R., Hahn-Hägerdal B., Gorwa-Grauslund M.F. High activity of xylose reductase and xylitol dehydrogenase improves xylose fermentation by recombinant Saccharomyces cerevisiae. Applied Microbiology and Biotechnology 2007, 73:1039-1046.
19. Karhumaa K., Garcia Sanchez R., Hahn-Hägerdal B., Gorwa-Grauslund M.F. Comparison of the xylose reductase-xylitol dehydrogenase and the xylose isomerase pathways for xylose fermentation by recombinant Saccharomyces cerevisiae. Microbial Cell Factories 2007, 6:5.
20. Kuyper M., Hartog M.M., Toirkens M.J., Almering M.J., Winkler A.A., van Dijken J.P., et al. Metabolic engineering of a xylose-isomerase-expressing Saccharomyces cerevisiae strain for rapid anaerobic xylose fermentation. FEMS Yeast Research 2005, 5:399-409.
21. Tatusov R.L., Galperin M.Y., Natale D.A., Koonin E.V. The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Research 2000, 28:33-36.
22. Huang H., Rong H., Li X., Tong S., Zhu Z., Niu L., et al. The crystal structure and identification of NQM1/YGR043C, a transaldolase from Saccharomyces cerevisiae. Proteins 2008, 73:1076-1081.
23. Schaaff-Gerstenschläger I., Mannhaupt G., Vetter I., Zimmermann F.K., Feldmann H. TKL2, a second transketolase gene of Saccharomyces cerevisiae. Cloning, sequence and deletion analysis of the gene. European Journal of Biochemistry 1993, 217:487-492.
24. Matsushika A., Inoue H., Murakami K., Takimura O., Sawayama S. Bioethanol production performance of five recombinant strains of laboratory and industrial xylose-fermenting Saccharomyces cerevisiae. Bioresource Technology 2009, 100:2392-2398.
25. +-dependent xylitol dehydrogenase gene. Applied and Environmental Microbiology 2009, 75:3818-3822.
26. +-dependent xylitol dehydrogenase increase ethanol production from xylose in recombinant Saccharomyces cerevisiae. Applied Microbiology and Biotechnology 2008, 81:243-255.
27. Matsushika A., Oguri E., Sawayama S. Evolutionary adaptation of recombinant shochu yeast for improved xylose utilization. Journal of Bioscience and Bioengineering 2010, 110:102-105.
28. Schaaff I., Hohmann S., Zimmermann F.K. Molecular analysis of the structural gene for yeast transaldolase. European Journal of Biochemistry 1990, 188:597-603.
29. Kang Y.S., Kane J., Kurjan J., Stadel J.M., Tipper D.J. Effects of expression of mammalian Gα and hybrid mammalian-yeast Gα proteins on the yeast pheromone response signal transduction pathway. Molecular and Cellular Biology 1990, 10:2582-2590.
30. Nikawa J., Sass P., Wigler M. Cloning and characterization of the low affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Molecular and Cellular Biology 1987, 7:3629-3636.
31. Sundström M., Lindqvist Y., Schneider G., Hellman U., Ronne H. Yeast TKL1 gene encodes a transketolase that is required for efficient glycolysis and biosynthesis of aromatic amino acids. Journal of Biological Chemistry 1993, 268:24346-24352.
32. Gietz D., St Jean A., Woods R.A., Schiestl R.H. Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Research 1992, 20:1425.
33. Fujii T., Murakami K., Sawayama S. Cellulase hyperproducing mutants derived from the fungus Trichoderma reesei QM9414 produced large amounts of cellulase at the enzymatic and transcriptional levels. Bioscience Biotechnology and Biochemistry 2010, 74:419-422.
34. Grossman C.E., Niland B., Stancato C., Verhoeven N.M., Van Der Knaap M.S., Jakobs C., et al. Deletion of Ser-171 causes inactivation, proteasome-mediated degradation and complete deficiency of human transaldolase. Biochemical Journal 2004, 382:725-731.
35. Schellenberg G.D., Wilson N.M., Copeland B.R., Furlong C.L. Transketolase from human red blood cells. Methods in Enzymology 1982, 90:223-228.
36. +-dependent xylitol dehydrogenase, and xylulokinase. Journal of Bioscience and Bioengineering 2008, 105:296-299.
37. Bengtsson O., Jeppsson M., Sonderegger M., Parachin N.S., Sauer U., Hahn-Hägerdal B., et al. Identification of common traits in improved xylose-growing Saccharomyces cerevisiae for inverse metabolic engineering. Yeast 2008, 25:835-847.
38. Lu C., Jeffries T. Shuffling of promoters for multiple genes to optimize xylose fermentation in an engineered Saccharomyces cerevisiae strain. Applied and Environmental Microbiology 2007, 73:6072-6077.
39. Lee J., Godon C., Lagniel G., Spector D., Garin J., Labarre J., et al. Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast. Journal of Biological Chemistry 1999, 274:16040-16046.
40. Flores C.L., Rodríguez C., Petit T., Gancedo C. Carbohydrate and energy-yielding metabolism in non-conventional yeasts. FEMS Microbiological Reviews 2000, 24:507-529.
41. Toivari M.H., Salusjarvi L., Ruohonen L., Penttilä M. Endogenous xylose pathway in Saccharomyces cerevisiae. Applied and Environmental Microbiology 2004, 70:3681-3686.
42. Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A., Salamov A., et al. Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis. Nature Biotechnology 2007, 25:319-326.
43. Boer V.M., de Winde J.H., Pronk J.T., Piper M.D. The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. Journal of Biological Chemistry 2003, 278:3265-3274.
44. Wisselink H.W., Cipollina C., Oud B., Crimi B., Heijnen J.J., Pronk J.T., et al. Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae. Metabolic Engineering 2010, 12:537-551.