Evaluation of high-resolution peripheral quantitative computed tomography, finite element analysis and biomechanical testing in a pre-clinical model of osteoporosis: A study with odanacatib treatment in the ovariectomized adult rhesus monkey

Bone

Volumn 50, Issue 6, 2012, Pages 1379-1388

  Jayakar, Richa Y ^a   Cabal, Antonio ^a   Szumiloski, John ^a   Sardesai, Swanand ^a   Phillips, Eual A ^b   Laib, Andres ^c   Scott, Boyd B ^a   Pickarski, Maureen ^a   Duong, Le T ^a   Winkelmann, Christopher T ^a   McCracken, Paul J ^a   Hargreaves, Richard ^a   Hangartner, Thomas N ^d   Williams, Donald S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c SCANCO MEDICAL AG   (Switzerland)

^d Wright State University   (United States)

Author keywords

Bone microstructure; FEA; HR pQCT; Imaging; Odanacatib

Indexed keywords

ODANACATIB;

ACCURACY; ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMECHANICS; BONE STRENGTH; BONE STRESS; COMPRESSION; CONTROLLED STUDY; CORTICAL BONE; DISEASE SEVERITY; EX VIVO STUDY; FINITE ELEMENT ANALYSIS; FRACTURE; HIGH RESOLUTION COMPUTER TOMOGRAPHY; IN VIVO STUDY; MECHANICAL STRESS; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; QUANTITATIVE ANALYSIS; RADIUS; RHESUS MONKEY; TIBIA;

ANIMALS; BIOMECHANICS; BIPHENYL COMPOUNDS; BONE DENSITY; CATHEPSIN K; CYSTEINE PROTEINASE INHIBITORS; DISEASE MODELS, ANIMAL; FEMALE; FINITE ELEMENT ANALYSIS; HUMANS; MACACA MULATTA; OSTEOPOROSIS; OVARIECTOMY; X-RAY MICROTOMOGRAPHY;

EID: 84860835123     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.03.017     Document Type: Article

References (38)

1. Looker A.C., Orwoll E.S., Johnston C.C., Lindsay R.L., Wahner H.W., Dunn W.L., et al. Prevalence of low femoral bone density in older US adults from NHANES III. J Bone Miner Res 1997, 12:1761-1768.
2. Genant H.K., Engelke K., Prevrhal S. Advanced CT bone imaging in osteoporosis. Rheumatology 2008, 47:9-16.
3. Kingsley L.A., Chirgwin J.M., Guise T.A. Breaking new ground to build bone. Proc Natl Acad Sci U S A 2007, 104:10753-10754.
4. Boyle W.J., Simonet W.S., Lacey D.L. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
5. Johnell O., Kanis J.A. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 2006, 17:1726-1733.
6. Pistoia W., Van Rietbergen B., Lochmuller E.M., Lill C.A., Eckstein F., Ruegsegger P. Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 2002, 30:842-848.
7. Seeman E. Is a change in bone mineral density a sensitive and specific surrogate of anti-fracture efficacy?. Bone 2007, 41:308-317.
8. Delmas P.D., Seeman E. Changes in bone mineral density explain little of the reduction in vertebral or nonvertebral fracture risk with anti-resorptive therapy. Bone 2004, 34:599-604.
9. Cummings S.R., Karpf D.B., Harris F., Genant H.K., Ensrud K., LaCroix A.Z., et al. Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs. Am J Med 2002, 112:281-289.
10. Cefalu C.A. Is bone mineral density predictive of fracture risk reduction?. Curr Med Res Opin 2004, 20:341-349.
11. Schuit S.C.E., van der Klift M., Weel A.E.A.M., De Laet C.E.D.H., Burger H., Seeman E., et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 2004, 34:195-202.
12. Homminga J., Van Rietbergen B., Lochmuller E.M., Weinans H., Eckstein F., Huiskes R. The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent "error" loads. Bone 2004, 34:510-516.
13. Homminga J., McCreadie B.R., Ciarelli T.E., Weinans H., Goldstein S.A., Huiskes R. Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level. Bone 2002, 30:759-764.
14. Genant H.K., Jiang Y.B. Advanced imaging assessment of bone quality. Skeletal Dev Remodeling Health Dis Aging 2006, 1068:410-428.
15. Burghardt A.J., Link T.M., Majumdar S. High-resolution computed tomography for clinical imaging of bone microarchitecture. Clin Orthop Relat Res 2011, 469:2179-2193.
16. Laib A., Hauselmann H.J., Ruegsegger P. In vivo high resolution 3D-QCT of the human forearm. Technol Health Care 1998, 6:329-337.
17. Boutroy S., Bouxsein M.L., Munoz F., Delmas P.D. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 2005, 90:6508-6515.
18. Burghardt A.J., Kazakia G.J., Sode M., de Papp A.E., Link T.M., Majumdar S. A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover. J Bone Miner Res 2010, 25:2282-2295.
19. Macdonald H.M., Nishiyama K.K., Kang J.A., Hanley D.A., Boyd S.K. Age-related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: a population-based HR-pQCT study. J Bone Miner Res 2011, 26:50-62.
20. Boutroy S., Van Rietbergen B., Sornay-Rendu E., Munoz F., Bouxsein M.L., Delmas P.D. Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res 2008, 23:392-399.
21. Hargreaves R.J. The role of molecular imaging in drug discovery and development. Clin Pharmacol Ther 2008, 83:349-353.
22. Smith S.Y., Jolette J., Turner C.H. Skeletal health: primate model of postmenopausal osteoporosis. Am J Primatol 2009, 71:752-765.
23. Stroup G., Kumar S., Jerome C. Treatment with a potent cathepsin K inhibitor preserves cortical and trabecular bone mass in ovariectomized monkeys. Calcif Tissue Int 2009, 85:344-355.
24. Itoh F., Kojima M., Furihata-Komatsu H., Aoyagi S., Kusama H., Komatsu H., et al. Reductions in bone mass, structure, and strength in axial and appendicular skeletons associated with increased turnover after ovariectomy in mature cynomolgus monkeys and preventive effects of clodronate. J Bone Miner Res 2002, 17:534-543.
25. Gauthier J.Y., Chauret N., Cromlish W., Desmarais S., Duong L.T., Falgueyret J.P., et al. The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett 2008, 18:923-928.
26. Masarachia P.J., Pennypacker B.L., Pickarshi M., Scott K.R., Wesolowski G.A., Smith S.Y., et al. Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys. J Bone Miner Res 2012, 27:509-523.
27. Burghardt A.J., Buie H.R., Laib A., Majumdar S., Boyd S.K. Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT. Bone 2010, 47:519-528.
28. Burghardt A.J., Kazakia G.J., Ramachandran S., Link T.M., Majumdar S. Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res 2010, 25:983-993.
29. Nishiyama K.K., Macdonald H.M., Buie H.R., Hanley D.A., Boyd S.K. Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study. J Bone Miner Res 2010, 25:882-890.
30. Hildebrand T., Laib A., Muller R., Dequeker J., Ruegsegger P. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res 1999, 14:1167-1174.
31. Hildebrand T., Ruegsegger P. A new method for the model-independent assessment of thickness in three-dimensional images. J Microsc-Oxf 1997, 185:67-75.
32. MacNeil J.A., Boyd S.K. Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method. Bone 2008, 42:1203-1213.
33. MacNeil J.A., Boyd S.K. Improved reproducibility of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys 2008, 30:792-799.
34. Boyd S.K., Moser S., Kuhn M., Klinck R.J., Krauze P.L., Musser R., et al. Evaluation of three-dimensional image registration methodologies for in vivo micro-computed tomography. Ann Biomed Eng 2006, 34:1587-1599.
35. Cusick T., Chen C.M., Pennypacker B.L., Pickarski M., Kimmel D., Scott B.B. Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey. J Bone Miner Res 2012, 27:524-537.
36. Cabal A., Sardesai S., Phillips E.A., Jayakar R.Y., McCracken P.J., Szumiloski J.L., et al. HR-pQCT based finite element analysis estimates of bone strength at ultra-distal radius in ovariectomized rhesus monkeys demonstrates efficacy of odanacatib and differentiation from alendronate. Bone 5-7-2011, 48:S93-S94.
37. Williams D.S., McCracken P.J., Jayakar R.Y., Purcell M.L., Mathers P.D., Savitz A.T., et al. Head-to-head comparison of treatment effects of odanacatib to alendronate in the ovariectomized rhesus monkey: a longitudinal multi-modality imaging study. Bone 5-7-2011, 48:S205-S206.
38. Saparin P., Scherf H., Hublin J.J., Fratzl P., Weinkamer R. Structural adaptation of trabecular bone revealed by position resolved analysis of proximal femora of different primates. Anat Rec 2011, 294:55-67.