Reductions in bone mass, structure, and strength in axial and appendicular skeletons associated with increased turnover after ovariectomy in mature cynomolgus monkeys and preventive effects of clodronate

Journal of Bone and Mineral Research

Volumn 17, Issue 3, 2002, Pages 534-543

  Itoh, Fumiaki ^a   Kojima, Masami ^a   Furihata Komatsu, Hanako ^a   Aoyagi, Shigemi ^a   Kusama, Hiroshi ^a   Komatsu, Hidetada ^a   Nakamura, Toshitaka ^b  

^a KISSEI PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Bone mineral density; Deoxypyridinoline; Mechanical testing; Osteocalcin; Peripheral quantitative computed tomography

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCEIN; CLODRONIC ACID; DEOXYPYRIDINOLINE; OSTEOCALCIN;

ANIMAL MODEL; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE MASS; BONE MINERAL; BONE TURNOVER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMUR; LUMBAR SPINE; MONKEY; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; POSTMENOPAUSE OSTEOPOROSIS; SKELETON;

AMINO ACIDS; ANIMALS; BIOLOGICAL MARKERS; BIOMECHANICS; BONE DENSITY; BONE REMODELING; CLODRONIC ACID; FEMALE; FEMUR; LUMBAR VERTEBRAE; MACACA FASCICULARIS; OVARIECTOMY; TIME FACTORS;

EID: 0036177991     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2002.17.3.534     Document Type: Article

References (20)

1. Rates of bone loss in the appendicular and axial skeletons of women
2. Effects of menopause on age-dependent bone loss in the axial and appendicular skeletons in healthy Japanese women
3. Apparent pre- and postmenopausal bone loss evaluated by DXA at different skeletal sites in women: OFELY cohort
4. The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates
5. Bone functional changes in intact, ovariectomized, and ovariectomized, hormone-supplement adult cynomolgus monkeys (Macaca fascicularis) evaluated by serum markers and dynamic histomorphometry
6. Effects of age and sex on bone density in the rhesus monkey
7. Periovulatory progesterone concentration in the peripheral plasma of the rhesus monkey with a methodologic note on the detection of ovulation
8. Patterns of circulating progesterone concentrations during the fertile, menstrual cycle and the remainder of gestation in the rhesus monkey
9. The bisphosphonate, alendronate, prevents bone loss in ovariectomized baboons
10. Zoledronate prevents the development of absolute osteopenia following ovariectomy in adult rhesus monkeys
11. Development of osteopenia in ovariectomized cynomolgus monkey (Macaca fascicularis)
12. Decreased bone mass and strength in ovariectomized cynomolgus monkeys (Macaca fascicularis)
13. Age-related changes in bone mineral density, mean width and area of the lumbar vertebrae in male African green monkey (Cercopithecus aethiops)
14. Responses of trabecular and cortical bone turnover and bone mass and strength to bisphosphonate YH529 in ovariohysterectomized beagles with calcium restriction
15. The androgenic anabolic steroid nandrolone decanoate prevents osteopenia and inhibits bone turnover in ovariectomized cynomolgus monkeys
16. Use of peripheral quantitative computed tomography for densitometry of the neck and spine in cynomolgus monkeys (Macaca fascicularis)
17. Effect of long-term ovariectomy on bone mechanical properties in young female cynomolgus monkeys
18. Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women
19. Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat
20. Clinical trials with bisphosphonates