A new validated mathematical model of the Wnt signalling pathway predicts effective combinational therapy by sFRP and Dkk

Biochemical Journal

Volumn 444, Issue 1, 2012, Pages 115-125

  Kogan, Yuri ^a   Halevi Tobias, Karin E ^a   Hochman, Gili ^a   Baczmanska, Anna K ^b   Leyns, Luc ^b   Agur, Zvia ^a  

^a Institute for Medical Biomathematics Isarel   (Israel)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Computational modelling; Dickkopf (Dkk); Ordinary differential equation (ODE); Secreted Frizzled related protein (sFRP); Signal transduction; Wnt pathway

Indexed keywords

BETA CATENIN; DICKKOPF 1 PROTEIN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; SECRETED FRIZZLED RELATED PROTEIN 1; WNT PROTEIN; WNT3A PROTEIN;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPUTER MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; LIGAND BINDING; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VALIDATION PROCESS;

ANIMALS; ANTINEOPLASTIC AGENTS; BETA CATENIN; CELL COUNT; COMPUTER SIMULATION; DRUG SYNERGISM; GLYCOPROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; L CELLS (CELL LINE); MICE; SIGNAL TRANSDUCTION; WNT3A PROTEIN;

EID: 84860800881     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111887     Document Type: Article

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