Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: An experimentally supported mathematical model

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Agur, Zvia ^a   Kirnasovsky, Oleg U ^a   Vasserman, Genadiy ^a   Tencer Hershkowicz, Lilach ^a   Kogan, Yuri ^a   Harrison, Hannah ^b   Lamb, Rebecca ^b   Clarke, Robert B ^b  

^a Institute for Medical Biomathematics Isarel   (Israel)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD24 ANTIGEN; DICKKOPF 1 PROTEIN; HERMES ANTIGEN; WNT PROTEIN; DKK1 PROTEIN, HUMAN; NOTCH RECEPTOR; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN; SIGNAL PEPTIDE;

ARTICLE; BREAST CANCER; BREAST CELL; CANCER STEM CELL; CELL COUNT; CELL DIFFERENTIATION; CELL FATE; CELL MATURATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DYNAMICS; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; PREDICTION; PRIMARY TUMOR; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; QUORUM SENSING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; BREAST TUMOR; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; METABOLISM; PATHOLOGY; THEORETICAL MODEL; TUMOR CELL CULTURE; TUMOR CELL LINE;

ANTIGENS, CD24; ANTIGENS, CD44; BREAST NEOPLASMS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, THEORETICAL; NEOPLASTIC STEM CELLS; PROTO-ONCOGENE PROTEINS; RECEPTORS, NOTCH; TUMOR CELLS, CULTURED;

EID: 80052459590     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024225     Document Type: Article

References (32)

1. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF, (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100: 3983-3988.
2. Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, et al. (2008) Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 100: 672-679.
3. Phillips TM, McBride WH, Pajonk F, (2006) The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 98: 1777-1785.
4. Dean M, Fojo T, Bates S, (2005) Tumour stem cells and drug resistance. Nat Rev Cancer 5: 275-284.
5. Brennan KR, Brown AM, (2004) Wnt proteins in mammary development and cancer. J Mammary Gland Biol Neoplasia 9: 119-131.
6. Reya T, Clevers H, (2005) Wnt signalling in stem cells and cancer. Nature 434: 843-850.
7. Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, et al. (2003) In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17: 1253-1270.
8. Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, et al. (2009) Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138: 645-659.
9. Takahashi-Yanaga F, Kahn M, (2010) Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res 16: 3153-3162.
10. Pannuti A, Foreman K, Rizzo P, Osipo C, Golde T, et al. (2010) Targeting Notch to target cancer stem cells. Clin Cancer Res 16: 3141-3152.
11. Takebe N, Ivy SP, (2010) Controversies in cancer stem cells: targeting embryonic signaling pathways. Clin Cancer Res 16: 3106-3112.
12. Kirnasovsky OU, Kogan Y, Agur Z, (2008) Analysis of a Mathematical Model for the Molecular Mechanism of Fate Decision in Mammary Stem Cells. Mathematical Modelling and Natural Phenomena 3: 78-89.
13. Kirnasovsky OU, Kogan Y, Agur Z, (2008) Resilience in Stem Cell renewal: Development of the Agur - Daniel - Ginossar Model. Discrete and Continuous Dynamical Systems 10: 129-148.
14. Agur Z, Kogan Y, Levi L, Harrison H, Lamb R, et al. (2010) Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells. Biol Direct 5: 20.
15. Ribba B, Alarcon T, Marron K, Maini PK, Agur Z, (2004) The use of hybrid cellular automaton models for improving cancer therapy, In Proceedings, Cellular Automata: 6th International Conference on Cellular Automata for Research and Industry, ACRI 2004, Amsterdam, The Netherlands, eds P.M.A. Sloot, B. Chopard, A.G. Hoekstra. Lecture Notes in Computer Science 3305: 444-453.
16. Agur Z, Daniel Y, Ginosar Y, (2002) The universal properties of stem cells as pinpointed by a simple discrete model. J Math Biol 44: 79-86.
17. Zardawi SJ, O'Toole SA, Sutherland RL, Musgrove EA, (2009) Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histol Histopathol 24: 385-398.
18. Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, et al. (2005) Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 65: 5506-5511.
19. Harrison H, Farnie G, Howell SJ, Rock RE, Stylianou S, et al. (2010) Regulation of Breast Cancer Stem Cell Activity by Signalling Through the Notch4 Receptor. Cancer Res.
20. Lee E, Salic A, Kruger R, Heinrich R, Kirschner MW, (2003) The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol 1: E10.
21. Prockop DJ, Gregory CA, Spees JL, (2003) One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues. Proc Natl Acad Sci U S A 100 (Suppl 1): 11917-11923.
22. Verani R, Cappuccio I, Spinsanti P, Gradini R, Caruso A, et al. (2007) Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid. J Neurochem 100: 242-250.
23. Aguilera O, Pena C, Garcia JM, Larriba MJ, Ordonez-Moran P, et al. (2007) The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. Carcinogenesis 28: 1877-1884.
24. Zhou X, Piot BA, Bonin M, Engel LW, Das Sarma S, et al. (2010) Colossal Magnetoresistance in an Ultraclean Weakly Interacting 2D Fermi Liquid. Physical Review Letters 104: 216801.
25. Veeck J, Niederacher D, An H, Klopocki E, Wiesmann F, et al. (2006) Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. Oncogene 25: 3479-3488.
26. Pece S, Serresi M, Santolini E, Capra M, Hulleman E, et al. (2004) Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 167: 215-221.
27. Mahler-Araujo B, Savage K, Parry S, Reis-Filho JS, (2007) Reduction of E-cadherin expression is associated with non-lobular breast carcinomas of basal-like and triple negative phenotype. J Clin Pathol.
28. Voorzanger-Rousselot N, Journe F, Doriath V, Body JJ, Garnero P, (2009) Assessment of circulating Dickkopf-1 with a new two-site immunoassay in healthy subjects and women with breast cancer and bone metastases. Calcif Tissue Int 84: 348-354.
29. Qiao L, Xu ZL, Zhao TJ, Ye LH, Zhang XD, (2008) Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Lett 269: 67-77.
30. Fujita K, Janz S, (2007) Attenuation of WNT signaling by DKK-1 and-2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF. Mol Cancer 6: 71.
31. Sell S, (2004) Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 51: 1-28.
32. Forget MA, Turcotte S, Beauseigle D, Godin-Ethier J, Pelletier S, et al. (2007) The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types. Br J Cancer 96: 646-653.