-
1
-
-
0037111078
-
Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections
-
Agnese D.M., et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J. Infect. Dis. 2002, 186:1522-1525.
-
(2002)
J. Infect. Dis.
, vol.186
, pp. 1522-1525
-
-
Agnese, D.M.1
-
2
-
-
84859707646
-
The presence of functionally relevant toll-like receptor polymorphisms does not significantly correlate with development or outcome of sepsis
-
Ahmad-Nejad P., et al. The presence of functionally relevant toll-like receptor polymorphisms does not significantly correlate with development or outcome of sepsis. Genet. Test. Mol. Biomarkers 2011, 15:645-651.
-
(2011)
Genet. Test. Mol. Biomarkers
, vol.15
, pp. 645-651
-
-
Ahmad-Nejad, P.1
-
3
-
-
1642447860
-
Mutations of genes involved in the innate immune system as predictors of sepsis in very low birth weight infants
-
Ahrens P., et al. Mutations of genes involved in the innate immune system as predictors of sepsis in very low birth weight infants. Pediatr. Res. 2004, 55:652-656.
-
(2004)
Pediatr. Res.
, vol.55
, pp. 652-656
-
-
Ahrens, P.1
-
4
-
-
3142724031
-
Toll-like receptor signalling
-
Akira S., Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4:499-511.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
5
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
-
Angus D.C., Linde-Zwirble W.T., Lidicker J., Clermont G., Carcillo J., Pinsky M.R. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 2001, 29:1303-1310.
-
(2001)
Crit. Care Med.
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
6
-
-
0034084438
-
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
-
Arbour N.C., et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 2000, 25:187-191.
-
(2000)
Nat. Genet.
, vol.25
, pp. 187-191
-
-
Arbour, N.C.1
-
7
-
-
8744301714
-
TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury
-
Barber R.C., Aragaki C.C., Rivera-Chavez F.A., Purdue G.F., Hunt J.L., Horton J.W. TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury. J. Med. Genet. 2004, 41:808-813.
-
(2004)
J. Med. Genet.
, vol.41
, pp. 808-813
-
-
Barber, R.C.1
Aragaki, C.C.2
Rivera-Chavez, F.A.3
Purdue, G.F.4
Hunt, J.L.5
Horton, J.W.6
-
8
-
-
33846531198
-
Innate immunity SNPs are associated with risk for severe sepsis after burn injury
-
Barber R.C., et al. Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clin. Med. Res. 2006, 4:250-255.
-
(2006)
Clin. Med. Res.
, vol.4
, pp. 250-255
-
-
Barber, R.C.1
-
9
-
-
34447557009
-
Innate immunogenetics: a tool for exploring new frontiers of host defence
-
Bochud P.Y., Bochud M., Telenti A., Calandra T. Innate immunogenetics: a tool for exploring new frontiers of host defence. Lancet Infect. Dis. 2007, 7:531-542.
-
(2007)
Lancet Infect. Dis.
, vol.7
, pp. 531-542
-
-
Bochud, P.Y.1
Bochud, M.2
Telenti, A.3
Calandra, T.4
-
10
-
-
54949144335
-
Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation
-
Bochud P.Y., et al. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N. Engl. J. Med. 2008, 359:1766-1777.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 1766-1777
-
-
Bochud, P.Y.1
-
11
-
-
33750009901
-
Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4)
-
Calvano J.E., et al. Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). Clin. Immunol. 2006, 121:186-190.
-
(2006)
Clin. Immunol.
, vol.121
, pp. 186-190
-
-
Calvano, J.E.1
-
12
-
-
0037450804
-
Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
-
Caramalho I., Lopes-Carvalho T., Ostler D., Zelenay S., Haury M., Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 2003, 197:403-411.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 403-411
-
-
Caramalho, I.1
Lopes-Carvalho, T.2
Ostler, D.3
Zelenay, S.4
Haury, M.5
Demengeot, J.6
-
13
-
-
77957222547
-
Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients
-
Carregaro F., Carta A., Cordeiro J.A., Lobo S.M., Silva E.H., Leopoldino A.M. Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients. Mem. Inst. Oswaldo Cruz 2010, 105:649-656.
-
(2010)
Mem. Inst. Oswaldo Cruz
, vol.105
, pp. 649-656
-
-
Carregaro, F.1
Carta, A.2
Cordeiro, J.A.3
Lobo, S.M.4
Silva, E.H.5
Leopoldino, A.M.6
-
14
-
-
39049165161
-
Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China
-
Cheng B., et al. Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China. Crit. Care Med. 2007, 35:2538-2546.
-
(2007)
Crit. Care Med.
, vol.35
, pp. 2538-2546
-
-
Cheng, B.1
-
15
-
-
33745847180
-
TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity
-
Creagh E.M., O'Neill L.A. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol. 2006, 27:352-357.
-
(2006)
Trends Immunol.
, vol.27
, pp. 352-357
-
-
Creagh, E.M.1
O'Neill, L.A.2
-
16
-
-
73149089449
-
Clinical relevance of the TLR4 11367 polymorphism in patients with major trauma
-
Duan Z.X., et al. Clinical relevance of the TLR4 11367 polymorphism in patients with major trauma. Arch. Surg. 2009, 144:1144-1148.
-
(2009)
Arch. Surg.
, vol.144
, pp. 1144-1148
-
-
Duan, Z.X.1
-
17
-
-
36949006088
-
Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever
-
Everett B., et al. Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever. Genes Immun. 2007, 8:699-702.
-
(2007)
Genes Immun.
, vol.8
, pp. 699-702
-
-
Everett, B.1
-
18
-
-
36749054015
-
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans
-
Ferwerda B., et al. TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:16645-16650.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 16645-16650
-
-
Ferwerda, B.1
-
19
-
-
0038466078
-
Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis
-
Feterowski C., et al. Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis. Immunology 2003, 109:426-431.
-
(2003)
Immunology
, vol.109
, pp. 426-431
-
-
Feterowski, C.1
-
20
-
-
77951800129
-
Toll-like receptor 4 D299G polymorphism and the incidence of infections in cirrhotic patients
-
Guarner-Argente C., et al. Toll-like receptor 4 D299G polymorphism and the incidence of infections in cirrhotic patients. Aliment. Pharmacol. Ther. 2010, 31:1192-1199.
-
(2010)
Aliment. Pharmacol. Ther.
, vol.31
, pp. 1192-1199
-
-
Guarner-Argente, C.1
-
21
-
-
59649127441
-
Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit
-
e1-3
-
Henckaerts L., et al. Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit. Care Med. 2009, 37:192-201. e1-3.
-
(2009)
Crit. Care Med.
, vol.37
, pp. 192-201
-
-
Henckaerts, L.1
-
22
-
-
64749092805
-
Polymorphic receptors of the innate immune system (MBL/MASP-2 and TLR2/4) and susceptibility to pneumococcal bacteremia in HIV-infected patients: a case-control study
-
Horcajada J.P., et al. Polymorphic receptors of the innate immune system (MBL/MASP-2 and TLR2/4) and susceptibility to pneumococcal bacteremia in HIV-infected patients: a case-control study. Curr. HIV Res. 2009, 7:218-223.
-
(2009)
Curr. HIV Res.
, vol.7
, pp. 218-223
-
-
Horcajada, J.P.1
-
23
-
-
77955583460
-
Pathway genetic load allows simultaneous evaluation of multiple genetic associations
-
Huebinger R.M., Garner H.R., Barber R.C. Pathway genetic load allows simultaneous evaluation of multiple genetic associations. Burns 2010, 36:787-792.
-
(2010)
Burns
, vol.36
, pp. 787-792
-
-
Huebinger, R.M.1
Garner, H.R.2
Barber, R.C.3
-
24
-
-
19944434085
-
Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia
-
Kajikawa O., et al. Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia. Gene 2005, 344:193-202.
-
(2005)
Gene
, vol.344
, pp. 193-202
-
-
Kajikawa, O.1
-
25
-
-
79959246255
-
Innate immune recognition of Mycobacterium tuberculosis
-
Kleinnijenhuis J., Oosting M., Joosten L.A., Netea M.G., Van Crevel R. Innate immune recognition of Mycobacterium tuberculosis. Clin. Dev. Immunol. 2011, 2011:405310.
-
(2011)
Clin. Dev. Immunol.
, vol.2011
, pp. 405310
-
-
Kleinnijenhuis, J.1
Oosting, M.2
Joosten, L.A.3
Netea, M.G.4
Van Crevel, R.5
-
26
-
-
77952993918
-
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts
-
Kumpf O., et al. Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Crit. Care 2010, 14:R103.
-
(2010)
Crit. Care
, vol.14
-
-
Kumpf, O.1
-
27
-
-
0037071251
-
Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
-
Lorenz E., Mira J.P., Frees K.L., Schwartz D.A. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch. Intern. Med. 2002, 162:1028-1032.
-
(2002)
Arch. Intern. Med.
, vol.162
, pp. 1028-1032
-
-
Lorenz, E.1
Mira, J.P.2
Frees, K.L.3
Schwartz, D.A.4
-
28
-
-
37149013022
-
RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II
-
Maratheftis C.I., Giannouli S., Spachidou M.P., Panayotou G., Voulgarelis M. RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II. Neoplasia 2007, 9:1012-1020.
-
(2007)
Neoplasia
, vol.9
, pp. 1012-1020
-
-
Maratheftis, C.I.1
Giannouli, S.2
Spachidou, M.P.3
Panayotou, G.4
Voulgarelis, M.5
-
29
-
-
70349662172
-
Tumor necrosis factor polymorphisms and alcoholic liver disease: a HuGE review and meta-analysis
-
Marcos M., Gomez-Munuera M., Pastor I., Gonzalez-Sarmiento R., Laso F.J. Tumor necrosis factor polymorphisms and alcoholic liver disease: a HuGE review and meta-analysis. Am. J. Epidemiol. 2009, 170:948-956.
-
(2009)
Am. J. Epidemiol.
, vol.170
, pp. 948-956
-
-
Marcos, M.1
Gomez-Munuera, M.2
Pastor, I.3
Gonzalez-Sarmiento, R.4
Laso, F.J.5
-
30
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov R., Preston-Hurlburt P., Janeway C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388:394-397.
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway, C.A.3
-
31
-
-
67849115979
-
Toll-like receptor 4 polymorphisms and risk of gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study
-
Mensah N.Y., Peterlongo P., Steinherz P., Pamer E.G., Satagopan J., Papanicolaou G.A. Toll-like receptor 4 polymorphisms and risk of gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study. Biol. Blood Marrow Transplant. 2009, 15:1130-1133.
-
(2009)
Biol. Blood Marrow Transplant.
, vol.15
, pp. 1130-1133
-
-
Mensah, N.Y.1
Peterlongo, P.2
Steinherz, P.3
Pamer, E.G.4
Satagopan, J.5
Papanicolaou, G.A.6
-
32
-
-
67649595324
-
Lack of association between TLR4 polymorphism and severe gram-negative bacterial infection in neonates
-
Ozgur T.T., et al. Lack of association between TLR4 polymorphism and severe gram-negative bacterial infection in neonates. Turk. J. Med. Sci. 2009, 39:423-427.
-
(2009)
Turk. J. Med. Sci.
, vol.39
, pp. 423-427
-
-
Ozgur, T.T.1
-
33
-
-
0032170215
-
Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region
-
Poltorak A., et al. Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol. Dis. 1998, 24:340-355.
-
(1998)
Blood Cells Mol. Dis.
, vol.24
, pp. 340-355
-
-
Poltorak, A.1
-
34
-
-
0035450762
-
A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease
-
Read R.C., et al. A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease. J. Infect. Dis. 2001, 184:640-642.
-
(2001)
J. Infect. Dis.
, vol.184
, pp. 640-642
-
-
Read, R.C.1
-
35
-
-
14744275370
-
IL-10 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin
-
Schippers E.F., et al. IL-10 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin. Cytokine 2005, 29:215-228.
-
(2005)
Cytokine
, vol.29
, pp. 215-228
-
-
Schippers, E.F.1
-
36
-
-
67649194968
-
Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study
-
(discussion 122-3)
-
Shalhub S., Junker C.E., Imahara S.D., Mindrinos M.N., Dissanaike S., O'Keefe G.E. Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study. J. Trauma 2009, 66:115-122. (discussion 122-3).
-
(2009)
J. Trauma
, vol.66
, pp. 115-122
-
-
Shalhub, S.1
Junker, C.E.2
Imahara, S.D.3
Mindrinos, M.N.4
Dissanaike, S.5
O'Keefe, G.E.6
-
37
-
-
0037947560
-
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
-
Smirnova I., et al. Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:6075-6080.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 6075-6080
-
-
Smirnova, I.1
-
38
-
-
80052800427
-
Heat shock proteins and high mobility group box 1 protein lack cytokine function
-
Tsan M.F. Heat shock proteins and high mobility group box 1 protein lack cytokine function. J. Leukoc. Biol. 2011, 89:847-853.
-
(2011)
J. Leukoc. Biol.
, vol.89
, pp. 847-853
-
-
Tsan, M.F.1
-
39
-
-
20144383013
-
Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism
-
van der Graaf C., et al. Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism. Cytokine 2005, 30:264-268.
-
(2005)
Cytokine
, vol.30
, pp. 264-268
-
-
van der Graaf, C.1
-
40
-
-
33746042266
-
Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection
-
Van der Graaf C.A., et al. Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection. Eur. Cytokine Netw. 2006, 17:29-34.
-
(2006)
Eur. Cytokine Netw.
, vol.17
, pp. 29-34
-
-
Van der Graaf, C.A.1
-
41
-
-
41149120598
-
Clinical relevance of TLR2, TLR4, CD14 and FcgammaRIIA gene polymorphisms in Streptococcus pneumoniae infection
-
Yuan F.F., et al. Clinical relevance of TLR2, TLR4, CD14 and FcgammaRIIA gene polymorphisms in Streptococcus pneumoniae infection. Immunol. Cell Biol. 2008, 86:268-270.
-
(2008)
Immunol. Cell Biol.
, vol.86
, pp. 268-270
-
-
Yuan, F.F.1
|