Polymorphic receptors of the innate immune systems (MBL/MASP-2 and TLR2/4) and susceptibility to pneumococcal bacteremia in HIV-infected patients: A case-control study

Current HIV Research

Volumn 7, Issue 2, 2009, Pages 218-223

  Horcajada, Juan P ^a   Lozano, Francisco ^a   Muñoz, Ana ^a   Suarez, Belen ^a   Fariñas Alvarez, Concepción ^b   Almela, Manuel ^a   Smithson, Alex ^a   Martínez, Esteban ^a   Mallolas, Josp ^a   Mensa, Josep ^a   Gatell, Josep M ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b HOSPITAL SIERRALLANA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; COTRIMOXAZOLE; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE 2; MANNOSE BINDING LECTIN; PNEUMOCOCCUS VACCINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR; MASP2 PROTEIN, HUMAN; MBL2 PROTEIN, HUMAN;

ADULT; ALCOHOL CONSUMPTION; BACTEREMIA; CD4 LYMPHOCYTE COUNT; CHEMOPROPHYLAXIS; CHRONIC LIVER DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENOTYPE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; INNATE IMMUNITY; INTRAVENOUS DRUG ABUSE; MAJOR CLINICAL STUDY; MALE; PNEUMOCOCCAL INFECTION; PREVALENCE; REVIEW; RISK ASSESSMENT; RISK FACTOR; ARTICLE; CASE CONTROL STUDY; GENETIC POLYMORPHISM; GENETICS; MICROBIOLOGY; MIDDLE AGED;

ADULT; BACTEREMIA; CASE-CONTROL STUDIES; DISEASE SUSCEPTIBILITY; FEMALE; HIV INFECTIONS; HUMANS; MALE; MANNOSE-BINDING LECTIN; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; MIDDLE AGED; PNEUMOCOCCAL INFECTIONS; POLYMORPHISM, GENETIC; RECEPTORS, IMMUNOLOGIC; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 64749092805     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016209787581382     Document Type: Review

References (34)

1. Kaplan JE, Hanson D, Dworkin MS, et al. Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy. Clin Infect Dis 2000; 30(Suppl 1): S5-14.
2. Tumbarello M, Tacconelli E, Gaetano KD, et al. HIV-associated bacteremia: how it has changed in the highly active antiretroviral therapy (HAART) era. J Acquired Immune Defic Syndr 2000; 23: 145-51.
3. Serraino D, Puro V, Boumis E, et al. Epidemiological aspects of major opportunistic infections of the respiratory tract in persons with AIDS: Europe, 1993-2000. AIDS 2003; 17: 2109-16.
4. Rimland D, Navin TR, Lennox JL, et al. Prospective study of etiologic agents of community-acquired pneumonia in patients with HIV infection. AIDS 2002; 16: 85-95.
5. Hundt M, Heiken H, Schmidt RE. Association of low mannose-binding lectin serum concentrations and bacterial pneumonia in HIV infection. AIDS 2000; 14: 1853-76.
6. Brown JS, Hussell T, Gilliland SM, et al. The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc Natl Acad Sci USA 2002; 99: 16969-74.
7. Neth O, Jack DL, Dodds AW, et al. Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun 2000; 68: 688-93.
8. Roy S, Knox K, Segal S, et al. MBL genotype and risk of invasive pneumococcal disease: a case-control study. Lancet 2002; 359: 1569-73.
9. Kronborg G, Weis N, Madsen HO, et al. Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. J Infect Dis 2002; 185: 1517-20.
10. Thiel SS, Vorup-Jensen T, Stover CM, et al. A second serine protease association with mannan-binding lectin that activates complement. Nature 1997; 386: 506-10.
11. Steffensen R, Thiel S, Varming K, et al. Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. J Immunol Methods 2000; 241: 33-42.
12. Summerfield JA, Ryder S, Sumiya M, et al. Mannose-binding protein gene mutations associated with unusual and severe infections in adults. Lancet 1995; 345: 886-9.
13. Garred P, Madsen HO, Hoffman B, et al. Increased frequency of homozygocity of abnormal mannan-binding protein alleles in patients with suspected immunodeficiency. Lancet 1995; 346: 941-3.
14. Peterslund NA, Koch C, Jensenius JC, Thiel S. Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet 2001; 358: 637-8.
15. McBride MO, Fisher PB, Sumiya M, et al. Mannose-binding protein in HIV-seropositive patients does not contribute to disease progression or bacterial infections. Int J STD AIDS 1998; 9: 683-8.
16. Stengaard-Pedersen K, Thiel S, Gadjeva M, et al. Inherited deficiency of mannan-binding lectin-associated serine protease 2. N Engl J Med 2003: 349: 554-60.
17. Modlin RL, Brightill HD, Godowski PJ. Clinical Implications of Basic Research. The Toll of innate immunity on microbial pathogens. N Engl J Med 1999; 340: 1834-5.
18. Smirnova I, Hamblin MT, McBride C, et al. Excess of rare amino acid polymorphism's in Toll-like receptor 4 in humans. Genetics 2001; 158: 1657-64.
19. Schumann RR, Lorenz E, Latz E, et al. Mutations of TLR 4 are associated with incidence and severity of sepsis in critically ill patients. ICAAC 2001. Presentation 1107.
20. Echchannaoui H, Frei K, Schnell C, Leib SL, Zimmerli W, Landmann R. Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. J Infect Dis 2002; 186: 798-806.
21. Martinez JA, Horcajada JP, Almela M, et al. Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia. Clin Infect Dis 2003; 36: 389-95.
22. Lee LM, Karon JM, Selik R, et al. Survival after AIDS diagnosis in adolescents and adults during the treatment era, United States, 1984-1997. JAMA 2001; 285: 1308-15.
23. DHHS/Henry J. Kaiser Family Foundation Panel on Clinical Practices for the Treatment of HIV infection. Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. October 2006 revision. Available at http://aidsinfo.nih.gov/content files/ AdultandAdolescentGL.pdf
24. Smithson A, Muñoz A, Suarez B, et al. Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. Clin Vaccine Immunol 2007; 14: 256-61.
25. Sutherland AM, Walley KR, Russell JA. Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med 2005; 33: 638-44.
26. Lozano F, Suárez B, Muñoz A, et al. Novel MASP2 variants detected among North African and Sub-Saharan individuals. Tissue Antigens 2005; 66: 131-5.
27. Cervera C, Lozano F, Saval N, et al. The influence of innate immunity gene receptors polymorphisms in renal transplant infections. Transplantation 2007; 83: 1493-500.
28. Garred P, Madsen HO, Halberg P, et al. Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus. Arthritis Rheum 1999; 42: 2145-52.
29. Perez-Castellano M, Peñaranda M, Payeras A, et al. Mannose-binding lectin does not act as an acute-phase reactant in adults with community-acquired pneumococcal pneumonia. Clin Exp Immunol 2006; 145: 228-34.
30. van Emmerik LC, Kuijper EJ, Fijen CA, Dankert J, Thiel S. Binding of mannan-binding protein to various bacterial pathogens of meningitis. Clin Exp Immunol 1994; 97: 411-6.
31. Krarup A, Sorensen UB, Matsushita M, Jensenius JC, Thiel S. Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin. Infect Immun 2005; 73: 1052-60.
32. Skov Sorensen UB, Blom J, Birch-Andersen A, Henrichsen J. Ultrastructural localization of capsules, cell wall polysaccharide, cell wall proteins, and F antigen in pneumococci. Infect Immun 1988; 56:1890-6.
33. Draing C, Pfitzenmaier M, Zummo S, et al. Comparison of lipoteichoic acid from different serotypes of Streptococcus pneumoniae. J Biol Chem 2006; 281: 33849-59.
34. Malley R, Henneke P, Morse SC, et al. Recognition of pneumolysin by Toll-like receptor 4 confers resistence to pneumococcal infection. Proc Natl Acad Sci USA 2003; 100(4): 1966-71.