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Volumn 19, Issue 5, 2012, Pages 588-596

White spotting variant mouse as an experimental model for ovarian aging and menopausal biology

Author keywords

C kit; Germ cells; Menopause; Mouse model; Ovarian follicles; Wv mice

Indexed keywords

CALCIUM; CHOLESTEROL; ESTROGEN; GONADOTROPIN; HORMONE; LIPID; LIPOPROTEIN; PHOSPHOTRANSFERASE; PROGESTERONE; STEM CELL FACTOR;

EID: 84860773378     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/gme.0b013e318239cc53     Document Type: Article
Times cited : (17)

References (66)
  • 1
    • 0035013896 scopus 로고    scopus 로고
    • Reproductive ageing and the menopause
    • Finn CA. Reproductive ageing and the menopause. Int J Dev Biol 2001;45:613-617.
    • (2001) Int J Dev Biol , vol.45 , pp. 613-617
    • Finn, C.A.1
  • 2
    • 34250824919 scopus 로고    scopus 로고
    • Altered ovarian function affects skeletal homeostasis independent of the action of folliclestimulating hormone
    • Gao J, Tiwari-Pandey R, Samadfam R, et al. Altered ovarian function affects skeletal homeostasis independent of the action of folliclestimulating hormone. Endocrinology 2007;148:2613-2621.
    • (2007) Endocrinology , vol.148 , pp. 2613-2621
    • Gao, J.1    Tiwari-Pandey, R.2    Samadfam, R.3
  • 3
    • 0001775693 scopus 로고    scopus 로고
    • Ovarian anatomy and physiology
    • Lobo RA, Kelsey J, Marcus R, eds San Diego, CA: Academic Press
    • Erickson GF. Ovarian anatomy and physiology. In: Lobo RA, Kelsey J, Marcus R, eds. Menopause: Biology and Pathobiology. San Diego, CA: Academic Press, 2000:13-31.
    • (2000) Menopause: Biology and Pathobiology , pp. 13-31
    • Erickson, G.F.1
  • 4
    • 0347057904 scopus 로고    scopus 로고
    • Demographics, environmental influences, and ethnic and international differences in the menopausal experience
    • Lobo RA, Kelsey J, Marcus R, eds San Diego, CA: Academic Press
    • Gold EB. Demographics, environmental influences, and ethnic and international differences in the menopausal experience. In: Lobo RA, Kelsey J, Marcus R, eds. Menopause: Biology and Pathobiology. San Diego, CA: Academic Press, 2000:189-201.
    • (2000) Menopause: Biology and Pathobiology , pp. 189-201
    • Gold, E.B.1
  • 6
    • 0029829917 scopus 로고    scopus 로고
    • A model conforming the decline in follicle numbers to the age of menopause in women
    • Faddy MJ, Gosden RG. A model conforming the decline in follicle numbers to the age of menopause in women. Hum Reprod 1996;7:1484-1486.
    • (1996) Hum Reprod , vol.7 , pp. 1484-1486
    • Faddy, M.J.1    Gosden, R.G.2
  • 7
    • 0032450106 scopus 로고    scopus 로고
    • Perimenopause: The complex endocrinology of the menopausal transition
    • Prior JC. Perimenopause: the complex endocrinology of the menopausal transition. Endocr Rev 1998;19:397-428.
    • (1998) Endocr Rev , vol.19 , pp. 397-428
    • Prior, J.C.1
  • 8
    • 0037397635 scopus 로고    scopus 로고
    • Estrogen and cognitive function in women
    • Sherwin BB. Estrogen and cognitive function in women. Endocr Rev 2003;24:133-151.
    • (2003) Endocr Rev , vol.24 , pp. 133-151
    • Sherwin, B.B.1
  • 9
    • 27644527798 scopus 로고    scopus 로고
    • Women's health: The struggle to restore hormonal balance
    • Stopeck AT. Women's health: the struggle to restore hormonal balance. Am J Med 2005;118:1181-1182.
    • (2005) Am J Med , vol.118 , pp. 1181-1182
    • Stopeck, A.T.1
  • 10
    • 0010402425 scopus 로고    scopus 로고
    • New understanding of the complexity of the menopause and challenges for the future
    • Bellino FL, ed New York NY: Springer- Verlag
    • Wise PM. New understanding of the complexity of the menopause and challenges for the future. In: Bellino FL, ed. Sereno Symposia U.S.A: Biology of Menopause. New York, NY: Springer-Verlag, 2000:1-8.
    • (2000) Sereno Symposia U.S.A: Biology of Menopause , pp. 1-8
    • Wise, P.M.1
  • 11
    • 33750144168 scopus 로고    scopus 로고
    • Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations
    • Cai KQ, Klein-Szanto A, Karthik D, et al. Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations. Gynecol Oncol 2006;103:719-728.
    • (2006) Gynecol Oncol , vol.103 , pp. 719-728
    • Cai, K.Q.1    Klein-Szanto, A.2    Karthik, D.3
  • 13
    • 0032417915 scopus 로고    scopus 로고
    • Hormonal aspects of epithelial ovarian cancer: Review of epidemiological evidence
    • Riman T, Persson I, Nilsson S. Hormonal aspects of epithelial ovarian cancer: review of epidemiological evidence. Clin Endocrinol (Oxf ) 1998; 49:695-707.
    • (1998) Clin Endocrinol (Oxf ) , vol.49 , pp. 695-707
    • Riman, T.1    Persson, I.2    Nilsson, S.3
  • 15
    • 0027459183 scopus 로고
    • Ovarian cancer. Age contrasts in incidence, histology, disease stage at diagnosis, and mortality
    • Yancik R. Ovarian cancer. Age contrasts in incidence, histology, disease stage at diagnosis, and mortality. Cancer 1995;71(2 suppl):517-523.
    • (1995) Cancer , vol.71 , Issue.2 SUPPL. , pp. 517-523
    • Yancik, R.1
  • 16
    • 0141757468 scopus 로고    scopus 로고
    • Etiology of epithelial ovarian cancer: A cellular mechanism for the role of gonadotropins
    • Smith ER, Xu XX. Etiology of epithelial ovarian cancer: a cellular mechanism for the role of gonadotropins. Gynecol Oncol 2003;91:1-2.
    • (2003) Gynecol Oncol , vol.91 , pp. 1-2
    • Smith, E.R.1    Xu, X.X.2
  • 17
    • 1642527925 scopus 로고    scopus 로고
    • A mechanism for COX-2 inhibitor antiinflammatory activity in chemoprevention of epithelial cancers
    • Smith ER, Daly MB, Xu XX. A mechanism for COX-2 inhibitor antiinflammatory activity in chemoprevention of epithelial cancers. Cancer Epidemiol Biomarkers Prev 2004;13:144-145.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 144-145
    • Smith, E.R.1    Daly, M.B.2    Xu, X.X.3
  • 18
    • 31044432767 scopus 로고    scopus 로고
    • Pathogenesis of osteoporosis: Concepts, conflict, and prospects
    • Raisz LG. Pathogenesis of osteoporosis: concepts, conflict, and prospects. J Clin Invest 2005;115:3318-3325.
    • (2005) J Clin Invest , vol.115 , pp. 3318-3325
    • Raisz, L.G.1
  • 19
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • Riggs BL, Khosla S, Melton LJ. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 2002;23:279-302.
    • (2002) Endocr Rev , vol.23 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton, L.J.3
  • 20
    • 0035985888 scopus 로고    scopus 로고
    • Recent developments in the epidemiology of osteoporosis
    • Walker-Bone K, Walter G, Cooper C. Recent developments in the epidemiology of osteoporosis. Curr Opin Rheumatol 2002;14:411-415.
    • (2002) Curr Opin Rheumatol , vol.14 , pp. 411-415
    • Walker-Bone, K.1    Walter, G.2    Cooper, C.3
  • 21
    • 33646153288 scopus 로고    scopus 로고
    • FSH versus estrogen: Who's guilty of breaking bones?
    • Baron R. FSH versus estrogen: who's guilty of breaking bones? Cell Metabol 2006;3:302-305.
    • (2006) Cell Metabol , vol.3 , pp. 302-305
    • Baron, R.1
  • 22
    • 34250887411 scopus 로고    scopus 로고
    • Hypogonadal bone loss: Sex steroids or gonadotropins?
    • Williams GR. Hypogonadal bone loss: sex steroids or gonadotropins? Endocrinology 2007;148:2610-2612.
    • (2007) Endocrinology , vol.148 , pp. 2610-2612
    • Williams, G.R.1
  • 24
    • 33947577656 scopus 로고    scopus 로고
    • Functional analysis of LHA knockout mice
    • Kumar TR. Functional analysis of LHA knockout mice. Mol Cell Endocrinol 2007;269:81-84.
    • (2007) Mol Cell Endocrinol , vol.269 , pp. 81-84
    • Kumar, T.R.1
  • 25
    • 54849426520 scopus 로고    scopus 로고
    • Exogenous and endogenous hormones and breast cancer
    • Chen WY. Exogenous and endogenous hormones and breast cancer. Best Pract Res Clin Endocrinol Metab 2008;22:573-585.
    • (2008) Best Pract Res Clin Endocrinol Metab , vol.22 , pp. 573-585
    • Chen, W.Y.1
  • 26
    • 78651331393 scopus 로고    scopus 로고
    • Bone loss in ovariectomized rats: Dominant role for estrogen but apparently not for FSH
    • Rouach V, Katzburg S, Koch Y, Stern N, Somjen D. Bone loss in ovariectomized rats: dominant role for estrogen but apparently not for FSH. J Cell Biochem 2011;112:128-137.
    • (2011) J Cell Biochem , vol.112 , pp. 128-137
    • Rouach, V.1    Katzburg, S.2    Koch, Y.3    Stern, N.4    Somjen, D.5
  • 27
    • 33646036678 scopus 로고    scopus 로고
    • FSH directly regulates bone mass
    • Sun L, Peng Y, Sharrow AC, et al. FSH directly regulates bone mass. Cell 2006;125:247-260.
    • (2006) Cell , vol.125 , pp. 247-260
    • Sun, L.1    Peng, Y.2    Sharrow, A.C.3
  • 28
    • 34247644813 scopus 로고    scopus 로고
    • Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice
    • Perez GI, Jurisicova A, Wise L, et al. Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice. Proc Natl Acad Sci USA 2007;104:5229-5234.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5229-5234
    • Perez, G.I.1    Jurisicova, A.2    Wise, L.3
  • 31
    • 33745240064 scopus 로고    scopus 로고
    • Effect of duration of dosing on onset of ovarian failure in a chemical-induced mouse model of perimenopause
    • Lohff JC, Christian PJ, Marion SL, Hoyer PB. Effect of duration of dosing on onset of ovarian failure in a chemical-induced mouse model of perimenopause. Menopause 2006;13:482-488.
    • (2006) Menopause , vol.13 , pp. 482-488
    • Lohff, J.C.1    Christian, P.J.2    Marion, S.L.3    Hoyer, P.B.4
  • 32
    • 31544474595 scopus 로고    scopus 로고
    • Recent female mouse models displaying advanced reproductive aging
    • Danilovich N, Ram Sairam M. Recent female mouse models displaying advanced reproductive aging. Exp Gerontol 2006;41:117-122.
    • (2006) Exp Gerontol , vol.41 , pp. 117-122
    • Danilovich, N.1    Ram Sairam, M.2
  • 33
    • 0000212179 scopus 로고
    • The inheritance of black-eyed white spotting in mice
    • Little CC. The inheritance of black-eyed white spotting in mice. Am Nat 1915;49:727-740.
    • (1915) Am Nat , vol.49 , pp. 727-740
    • Little, C.C.1
  • 34
    • 0001047032 scopus 로고
    • Gene-induced embryological modification of primordial germ cells in the mouse
    • Mintz B, Russell ES. Gene-induced embryological modification of primordial germ cells in the mouse. J Exp Zool 1957;134:207-237.
    • (1957) J Exp Zool , vol.134 , pp. 207-237
    • Mintz, B.1    Russell, E.S.2
  • 35
    • 0007349380 scopus 로고
    • Embryological development of primordial germ-cells in the mouse: Influence of a new mutation, Wj
    • Mintz B. Embryological development of primordial germ-cells in the mouse: influence of a new mutation, Wj. J Embryol Exp Morphol 1957; 5:396-403.
    • (1957) J Embryol Exp Morphol , vol.5 , pp. 396-403
    • Mintz, B.1
  • 36
    • 0025042705 scopus 로고
    • The mouse W/c-kit locus A mammalian gene that controls the development of three distinct cell lineages
    • Dubreuil P, Rottapel R, Reith AD, Forrester L, Bernstein A. The mouse W/c-kit locus. A mammalian gene that controls the development of three distinct cell lineages. Ann N Y Acad Sci 1990;599:58-65.
    • (1990) Ann N y Acad Sci , vol.599 , pp. 58-65
    • Dubreuil, P.1    Rottapel, R.2    Reith, A.D.3    Forrester, L.4    Bernstein, A.5
  • 37
    • 0025218634 scopus 로고
    • W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor
    • Reith AD, Rottapel R, Giddens E, Brady C, Forrester L, Bernstein A. W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev 1990;4:390-400.
    • (1990) Genes Dev , vol.4 , pp. 390-400
    • Reith, A.D.1    Rottapel, R.2    Giddens, E.3    Brady, C.4    Forrester, L.5    Bernstein, A.6
  • 38
    • 0025334596 scopus 로고
    • Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W
    • Nocka K, Tan JC, Chiu E, et al. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 1990;9:1805-1813.
    • (1990) EMBO J , vol.9 , pp. 1805-1813
    • Nocka, K.1    Tan, J.C.2    Chiu, E.3
  • 39
    • 34247874637 scopus 로고    scopus 로고
    • A reduction of Cox-2 gene dosage counters the menopausal ovarian morphological aging and tumor phenotype in Wv mice
    • Yang WL, Cai KQ, Smedberg JL, et al. A reduction of Cox-2 gene dosage counters the menopausal ovarian morphological aging and tumor phenotype in Wv mice. Am J Pathol 2007;170:1325-1336.
    • (2007) Am J Pathol , vol.170 , pp. 1325-1336
    • Yang, W.L.1    Cai, K.Q.2    Smedberg, J.L.3
  • 40
    • 0015334745 scopus 로고
    • Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells
    • Murphy ED. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 1972;48: 1283-1295.
    • (1972) J Natl Cancer Inst , vol.48 , pp. 1283-1295
    • Murphy, E.D.1
  • 41
    • 0015610224 scopus 로고
    • Plasma gonadotropin levels during early stages of ovarian tumorigenesis in mice of the Wx-Wv genotype
    • Murphy ED, Beamer WG. Plasma gonadotropin levels during early stages of ovarian tumorigenesis in mice of the Wx-Wv genotype. Cancer Res 1973;33:721-723.
    • (1973) Cancer Res , vol.33 , pp. 721-723
    • Murphy, E.D.1    Beamer, W.G.2
  • 42
    • 0034654307 scopus 로고    scopus 로고
    • Point mutation in Kit receptor tyrosine kinase reveals essential roles for Kit signaling in spermatogenesis and oogenesis without affecting other Kit responses
    • Kissell H, Timokhina I, Hardy MP, et al. Point mutation in Kit receptor tyrosine kinase reveals essential roles for Kit signaling in spermatogenesis and oogenesis without affecting other Kit responses. EMBO J 2000;19:1312-1326.
    • (2000) EMBO J , vol.19 , pp. 1312-1326
    • Kissell, H.1    Timokhina, I.2    Hardy, M.P.3
  • 43
    • 0344306704 scopus 로고    scopus 로고
    • Proliferation and differentiation of spermatogonial stem cells in the W/Wv mutant mouse testis
    • Ohta H, Tohda A, Nishimune Y. Proliferation and differentiation of spermatogonial stem cells in the W/Wv mutant mouse testis. Biol Reprod 2003;69:1815-1821.
    • (2003) Biol Reprod , vol.69 , pp. 1815-1821
    • Ohta, H.1    Tohda, A.2    Nishimune, Y.3
  • 44
    • 68049117307 scopus 로고    scopus 로고
    • Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny following transplantation
    • Kubota H, Avarbock MR, Schmidt JA, Brinster RL. Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny following transplantation. Biol Reprod 2009;81:293-301.
    • (2009) Biol Reprod , vol.81 , pp. 293-301
    • Kubota, H.1    Avarbock, M.R.2    Schmidt, J.A.3    Brinster, R.L.4
  • 45
    • 0034242440 scopus 로고    scopus 로고
    • Precision and accuracy of dual-energy X-ray absorptiometry for determining in vivo body composition of mice
    • Nagy TR, Clair AL. Precision and accuracy of dual-energy X-ray absorptiometry for determining in vivo body composition of mice. Obes Res 2000;8:392-398.
    • (2000) Obes Res , vol.8 , pp. 392-398
    • Nagy, T.R.1    Clair, A.L.2
  • 46
    • 34548538229 scopus 로고    scopus 로고
    • Automated compartmental analysis for high-throughput skeletal phenotyping in femora of genetic mouse models
    • Kohler T, Stauber M, Donahue LR, Mueller R. Automated compartmental analysis for high-throughput skeletal phenotyping in femora of genetic mouse models. Bone 2007;41:659-667.
    • (2007) Bone , vol.41 , pp. 659-667
    • Kohler, T.1    Stauber, M.2    Donahue, L.R.3    Mueller, R.4
  • 47
    • 84860719654 scopus 로고    scopus 로고
    • A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity
    • Reinwald S, Mayer LP, Hoyer PB, Turner CH, Barnes S, Weaver CM. A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity. J Osteoporos 2010;2010:145170.
    • (2010) J Osteoporos 2010 , pp. 145170
    • Reinwald, S.1    Mayer, L.P.2    Hoyer, P.B.3    Turner, C.H.4    Barnes, S.5    Weaver, C.M.6
  • 48
    • 33744750875 scopus 로고    scopus 로고
    • Bone strength: Current concepts
    • Turner CH. Bone strength: current concepts. Ann N Y Acad Sci 2006; 1068:429-446.
    • (2006) Ann N y Acad Sci , vol.1068 , pp. 429-446
    • Turner, C.H.1
  • 49
    • 55449128620 scopus 로고    scopus 로고
    • Sclerzxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo
    • Levay AK, Peacok JD, Lu Y, et al. Sclerzxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo. Circ Res 2008;103:948-956.
    • (2008) Circ Res , vol.103 , pp. 948-956
    • Levay, A.K.1    Peacok, J.D.2    Lu, Y.3
  • 51
    • 33745843261 scopus 로고    scopus 로고
    • Cardioprotective c-kit+ cells are from the bone marrow and regulate myocardial balance of angiogenic cytokines
    • Fazel S, Cimini M, Chen L, et al. Cardioprotective c-kit+ cells are from the bone marrow and regulate myocardial balance of angiogenic cytokines. J Clin Invest 2006;116:1865-1877.
    • (2006) J Clin Invest , vol.116 , pp. 1865-1877
    • Fazel, S.1    Cimini, M.2    Chen, L.3
  • 52
    • 0023424496 scopus 로고
    • Follicular status at menopause
    • Gosden RG. Follicular status at menopause. Hum Reprod 1987;2:617-621.
    • (1987) Hum Reprod , vol.2 , pp. 617-621
    • Gosden, R.G.1
  • 53
    • 0021023416 scopus 로고
    • Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis
    • Cramer DW, Welch WR. Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis. J Natl Cancer Inst 1983;71:717-721.
    • (1983) J Natl Cancer Inst , vol.71 , pp. 717-721
    • Cramer, D.W.1    Welch, W.R.2
  • 56
    • 79952037809 scopus 로고    scopus 로고
    • Estrogen, hormonal replacement therapy and cardiovascular disease
    • Yang XP, Rekelhoff JF. Estrogen, hormonal replacement therapy and cardiovascular disease. Curr Opin Nephrol Hypertens 2011;20:133-138.
    • (2011) Curr Opin Nephrol Hypertens , vol.20 , pp. 133-138
    • Yang, X.P.1    Rekelhoff, J.F.2
  • 59
    • 84860711081 scopus 로고    scopus 로고
    • Echocardiographic evaluation of ventricular function in mice
    • Rottman JN, Ni G, Brown M. Echocardiographic evaluation of ventricular function in mice. Echocardiography 2007;56:1025-1033.
    • (2007) Echocardiography , vol.56 , pp. 1025-1033
    • Rottman, J.N.1    Ni, G.2    Brown, M.3
  • 60
    • 24144475586 scopus 로고    scopus 로고
    • The North American Menopause Society Mayfield Heights, OH: NAMS Accessed September 1, 2011
    • The North American Menopause Society. Menopause Practice: A Clinician's Guide. Mayfield Heights, OH: NAMS, 2004. Available at: http://www.menopause.org. Accessed September 1, 2011.
    • (2004) Menopause Practice: A Clinician's Guide
  • 61
    • 74549196301 scopus 로고    scopus 로고
    • Characterization of an animal model of postmenopausal cardiac hypertrophy and novel mechanism responsible for cardiac decompensation using ovariectomized pressure-overloaded rats
    • Bhuiyan MS, Fukunaga K. Characterization of an animal model of postmenopausal cardiac hypertrophy and novel mechanism responsible for cardiac decompensation using ovariectomized pressure-overloaded rats. Menopause 2010;17:213-221.
    • (2010) Menopause , vol.17 , pp. 213-221
    • Bhuiyan, M.S.1    Fukunaga, K.2
  • 62
    • 4243616684 scopus 로고
    • Reproductive aging and neuroendocrine function
    • Charlton HM, ed New York: Oxford University Press
    • Meites J, Lu JKH. Reproductive aging and neuroendocrine function. In: Charlton HM, ed. Oxford Reviews of Reproductive Biology. New York: Oxford University Press, 1994:215-247.
    • (1994) Oxford Reviews of Reproductive Biology , pp. 215-247
    • Meites, J.1    Lu, J.K.H.2
  • 64
    • 34547893007 scopus 로고    scopus 로고
    • Cardiac and aortic structural alterations due to surgically-induced menopause associated with renovascular hypertension in rats
    • Mendon'a Lde S, Fernandes-Santos C, Mandarim-de-Lacerda CA. Cardiac and aortic structural alterations due to surgically-induced menopause associated with renovascular hypertension in rats. Int J Exp Pathol 2007; 88:301-309.
    • (2007) Int J Exp Pathol , vol.88 , pp. 301-309
    • Mendon'A Lde, S.1    Fernandes-Santos, C.2    Mandarim-De-Lacerda, C.A.3
  • 65
    • 10744228523 scopus 로고    scopus 로고
    • Adult cardiac stem cells are multipotent and support myocardial regeneration
    • Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003;114: 763-776.
    • (2003) Cell , vol.114 , pp. 763-776
    • Beltrami, A.P.1    Barlucchi, L.2    Torella, D.3
  • 66
    • 0032477328 scopus 로고    scopus 로고
    • Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone
    • Risch HA. Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst 1998;90:1774-1786.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1774-1786
    • Risch, H.A.1


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