Myelin specific cells infiltrate MCAO lesions and exacerbate stroke severity

Metabolic Brain Disease

Volumn 27, Issue 1, 2012, Pages 7-15

  Ren, Xuefang ^a,b   Akiyoshi, Kozaburo ^a,e   Grafe, Marjorie R ^a   Vandenbark, Arthur A ^a,b,c   Hurn, Patricia D ^d   Herson, Paco S ^a   Offner, Halina ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

^c Sr Research Career Scientist   (United States)

^d UNIVERSITY OF TEXAS   (United States)

^e KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Experimental stroke; Inflammatory responses; Myelin reactive splenocytes; Neurologic deficit

Indexed keywords

MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL INFILTRATION; CELL MIGRATION; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; REPERFUSION; SPLEEN CELL; ALLERGIC ENCEPHALOMYELITIS; ALLOTRANSPLANTATION; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; C57BL MOUSE; CEREBRAL ARTERY DISEASE; CULTURE TECHNIQUE; CYTOLOGY; IMMUNOLOGY; INFLAMMATION; LYMPH NODE; LYMPHOCYTE SUBPOPULATION; METABOLISM; MOUSE MUTANT; MYELIN SHEATH; PATHOLOGY; SPLEEN; STROKE; TRANSGENIC MOUSE; TRANSPLANTATION;

ANIMALIA; MUS;

ADOPTIVE TRANSFER; ANIMALS; AUTOIMMUNITY; BLOOD-BRAIN BARRIER; BRAIN; CELL CULTURE TECHNIQUES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; LYMPH NODES; LYMPHOCYTE SUBSETS; MALE; MICE; MICE, INBRED C57BL; MICE, SCID; MICE, TRANSGENIC; MYELIN PROTEINS; MYELIN SHEATH; SPLEEN; STROKE; TRANSPLANTATION, HOMOLOGOUS;

EID: 84860772146     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-011-9267-5     Document Type: Article

References (44)

1. Akiyoshi K, Dziennis S, Palmateer J, Ren X, Vandenbark AA, Offner H, Herson PS, Hurn PD (2011) Recombinant T Cell Receptor Ligands Improve Outcome After Experimental Cerebral Ischemia. Transl Stroke Res 2:404-410
2. Allan SM, Rothwell NJ (2001) Cytokines and acute neurodegeneration. Nat Rev Neurosci 2(10):734-744 (Pubitemid 33674819)
3. Allan SM, Rothwell NJ (2003) Inflammation in central nervous system injury. Philosophical transactions of the Royal Society of London Series B, Biological sciences 358(1438):1669-1677
4. Becker K, Kindrick D, McCarron R, Hallenbeck J, Winn R (2003) Adoptive transfer of myelin basic protein-tolerized splenocytes to naive animals reduces infarct size: a role for lymphocytes in ischemic brain injury? Stroke 34(7):1809-1815 (Pubitemid 36842650)
5. Becker KJ, McCarron RM, Ruetzler C, Laban O, Sternberg E, Flanders KC, Hallenbeck JM (1997) Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia. Proc Natl Acad Sci U S A 94(20):10873-10878 (Pubitemid 27430828)
6. Campanella M, Sciorati C, Tarozzo G, Beltramo M (2002) Flow cytometric analysis of inflammatory cells in ischemic rat brain. Stroke 22(2):586-592 (Pubitemid 34123411)
7. Cross AH, Raine CS (1990) Serial adoptive transfer of murine experimental allergic encephalomyelitis: successful transfer is dependent on active disease in the donor. J Neuroimmunol 28(1):27-37 (Pubitemid 20148422)
8. Dirnagl U, Klehmet J, Braun JS, Harms H, Meisel C, Ziemssen T, Prass K, Meisel A (2007) Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke 38(2 Suppl):770-773 (Pubitemid 46184257)
9. Downen M, Amaral TD, Hua LL, Zhao ML, Lee SC (1999) Neuronal death in cytokine-activated primary human brain cell culture: role of tumor necrosis factor-alpha. Glia 28(2):114-127 (Pubitemid 29530610)
10. Dziennis S, Mader S, Akiyoshi K, Ren X, Ayala P, Burrows GG, Vandenbark AA, Herson PS, Hurn PD, Offner HA (2011) Therapy with recombinant T-cell receptor ligand reduces infarct size and infiltrating inflammatory cells in brain after middle cerebral artery occlusion in mice. Metab Brain Dis 26(2):123-133
11. Engelhardt B, Sorokin L (2009) The blood-brain and the bloodcerebrospinal fluid barriers: function and dysfunction. Semin Immunopathol 31(4):497-511
12. Fillatreau S, Sweenie CH, McGeachy MJ, Gray D, Anderton SM (2002) B cells regulate autoimmunity by provision of IL-10. Nat Immunol 3(10):944-950 (Pubitemid 35154008)
13. Fletcher JM, Lalor SJ, Sweeney CM, Tubridy N, Mills KH (2010) T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clin Exp Immunol 162(1):1-11
14. Frenkel D, Huang Z, Maron R, Koldzic DN, Moskowitz MA, Weiner HL (2005) Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke. J Neurol Sci 233(1-2):125-132 (Pubitemid 40804828)
15. Gee JM, Kalil A, Thullbery M, Becker KJ (2008) Induction of immunologic tolerance to myelin basic protein prevents central nervous system autoimmunity and improves outcome after stroke. Stroke 39(5):1575-1582
16. Horuk R (2001) Chemokine receptors. Cytokine & Growth Factor Reviews 12(4):313-335 (Pubitemid 32851745)
17. Hurn PD, Subramanian S, Parker SM, Afentoulis ME, Kaler LJ, Vandenbark AA, Offner H (2007) T-and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation. J Cereb Blood Flow Metab 27(11):1798-1805 (Pubitemid 47624547)
18. Iadecola C, Anrather J (2011) The immunology of stroke: from mechanisms to translation. Nat Med 17(7):796-808
19. Khoury SJ, Hancock WW, Weiner HL (1992) Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 176(5):1355-1364
20. Kim JS, Gautam SC, Chopp M, Zaloga C, Jones ML, Ward PA, Welch KM (1995) Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat. J Neuroimmunol 56(2):127-134
21. Kleinschnitz C, Schwab N, Kraft P, Hagedorn I, Dreykluft A, Schwarz T, Austinat M, Nieswandt B, Wiendl H, Stoll G (2010) Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. Blood 115(18):3835-3842
22. Lakhan SE, Kirchgessner A, Hofer M (2009) Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med 7:97
23. Miller A, Lider O, Roberts AB, Sporn MB, Weiner HL (1992) Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigenspecific triggering. Proc Natl Acad Sci U S A 89(1):421-425
24. Miller SD, Karpus WJ, Davidson TS (2010) Experimental autoimmune encephalomyelitis in the mouse. Current protocols in immunology/edited by John E Coligan [et al] Chapter 15:Unit 15 11.
25. Moalem G, Leibowitz-Amit R, Yoles E, Mor F, Cohen IR, Schwartz M (1999) Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 5(1):49-55 (Pubitemid 29050998)
26. Montecucco F, Lenglet S, Gayet-Ageron A, Bertolotto M, Pelli G, Palombo D, Pane B, Spinella G, Steffens S, Raffaghello L, Pistoia V, Ottonello L, Pende A, Dallegri F, Mach F (2010) Systemic and intraplaque mediators of inflammation are increased in patients symptomatic for ischemic stroke. Stroke 41(7):1394-1404
27. Murphy AC, Lalor SJ, Lynch MA, Mills KH (2010) Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis. Brain Behav Immun 24(4):641-651
28. Offner H, Sinha S, Burrows GG, Ferro AJ, Vandenbark AA (2011) RTL therapy for multiple sclerosis: a Phase I clinical study. J Neuroimmunol 231(1-2):7-14
29. Offner H, Sinha S, Wang C, Burrows GG, Vandenbark AA (2008) Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis. Rev Neurosci 19(4-5):327-339
30. Offner H, Subramanian S, Parker SM, Afentoulis ME, Vandenbark AA, Hurn PD (2006a) Experimental stroke induces massive, rapid activation of the peripheral immune system. J Cereb Blood Flow Metab 26(5):654-665
31. Offner H, Subramanian S, Parker SM, Wang C, Afentoulis ME, Lewis A, Vandenbark AA, Hurn PD (2006b) Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages. J Immunol 176(11):6523-6531 (Pubitemid 43787834)
32. Peron JP, Yang K, Chen ML, Brandao WN, Basso AS, Commodaro AG, Weiner HL, Rizzo LV (2010) Oral tolerance reduces Th17 cells as well as the overall inflammation in the central nervous system of EAE mice. J Neuroimmunol 227(1-2):10-17
33. Polanczyk MJ, Jones RE, Subramanian S, Afentoulis M, Rich C, Zakroczymski M, Cooke P, Vandenbark AA, Offner H (2004) T lymphocytes do not directly mediate the protective effect of estrogen on experimental autoimmune encephalomyelitis. Am J Pathol 165(6):2069-2077 (Pubitemid 39578384)
34. Prinz M, Priller J (2010) Tickets to the brain: role of CCR2 and CX3CR1 in myeloid cell entry in the CNS. J Neuroimmunol 224(1-2):80-84
35. Ren X, Akiyoshi K, Dziennis S, Vandenbark AA, Herson PS, Hurn PD, Offner H (2011a) Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke. The Journal of Neuroscience 31(23):8556-8563
36. Ren X, Akiyoshi K, Vandenbark AA, Hurn PD, Offner H (2011b) Programmed Death-1 Pathway Limits Central Nervous System Inflammation and Neurologic Deficits in Murine Experimental Stroke. Stroke 42:2578-2583
37. Streilein JW (1993) Immune privilege as the result of local tissue barriers and immunosuppressive microenvironments. Curr Opin Immunol 5(3):428-432 (Pubitemid 23197457)
38. Streilein JW (1995) Unraveling immune privilege. Science 270(5239):1158-1159
39. Streilein JW, Stein-Streilein J (2000) Does innate immune privilege exist? J Leukoc Biol 67(4):479-487
40. Stromnes IM, Goverman JM (2006) Passive induction of experimental allergic encephalomyelitis. Nat Protoc 1(4):1952-1960 (Pubitemid 46773317)
41. Subramanian S, Zhang B, Kosaka Y, Burrows GG, Grafe MR, Vandenbark AA, Hurn PD, Offner H (2009) Recombinant T cell receptor ligand treats experimental stroke. Stroke 40(7):2539-2545
42. Wang X, Ellison JA, Siren AL, Lysko PG, Yue TL, Barone FC, Shatzman A, Feuerstein GZ (1998) Prolonged expression of interferon-inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat. J Neurochem 71(3):1194-1204 (Pubitemid 28390274)
43. Yamasaki Y, Matsuo Y, Matsuura N, Onodera H, Itoyama Y, Kogure K (1995) Transient increase of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, in ischemic brain areas after focal ischemia in rats. Stroke 26(2):318-322, discussion 322-313
44. Yilmaz G, Granger DN (2010) Leukocyte recruitment and ischemic brain injury. Neuromolecular Med 12(2):193-204