Does innate immune privilege exist?

Journal of Leukocyte Biology

Volumn 67, Issue 4, 2000, Pages 479-487

  Streilein, J W ^a   Stein Streilein, J ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

Adaptive immunity; Eye; Immune regulation; Immunosuppression; Inflammation

Indexed keywords

AQUEOUS HUMOR; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; EYE INFLAMMATION; HUMAN; IMMUNITY; LEUKOCYTE ACTIVATION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0033849032     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.67.4.479     Document Type: Review

References (62)

1. Die entwicklung der in fremden grund versetzten lebenden gewebe
2. A second study of the behavior and fate of skin homografts in rabbits
3. Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye
4. Immunologically privileged sites
5. Immune privilege in the eye: A dangerous compromise
6. Immune privilege as the result of local tissue barriers and immunosuppressive microenvironments
7. Immune privilege and immune regulation in the eye
8. Unraveling immune privilege
9. 1 lymphocyte-induced immune deviation
10. 1 lymphocyte induced immune deviation
11. Deviant immune responses to allogeneic tumors injected intracamerally and subcutaneously in mice
12. Systemic immune unresponsiveness induced in adult mice by anterior chamber presentation of minor histocompatibility antigens
13. Distinctive humoral responses following anterior chamber and intravenous administration of soluble antigen. Evidence for active suppression of IgG2a-secreting B cells
14. Orthotopic corneal transplantation in mice. Evidence that the immunogenetic rules of rejection do not apply
15. T cell mediated responses in a murine model of orthotopic corneal transplantation
16. Immune privilege and suppression of immunogenic inflammation in the anterior chamber of the eye
17. Inhibition of lymphocyte proliferation by aqueous humor
18. Aqueous humor factors and their effects on the immune response in the anterior chamber
19. Isolation and characterization of a unique natural killer cell inhibitory factor present in the anterior chamber of the eye
20. Local inhibition of natural killer cell activity promotes the progressive growth of intraocular tumors
21. Role of macrophage migration inhibitory factor in inhibiting NK cell activity
22. Do immunologically privileged sites require a functioning spleen?
23. Corneal allografts fail to express Ia antigens
24. The expression of HLA antigens by cells in the human cornea
25. The distribution and ontogeny of MHC antigens in murine ocular tissues
26. Aqueous humor contains transforming growth factor-β and a small (<3500 daltons) inhibitor of thymocyte proliferation
27. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor
28. Immunoregulation of the ocular effector responses by soluble factors in aqueous humor
29. Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-beta
30. Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor
31. Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor
32. Suppression of nitric oxide generated by inflammatory macrophages by calcitonin gene-related peptide in aqueous humor
33. Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon
34. Aqueous humor induces transforming growth factor-beta (TGF-beta)-producing regulatory T-cells
35. Specific aqueous humor factors induce activation of regulatory T cells
36. A role of CD95 ligand in preventing graft rejection
37. Fas ligand-induced apoptosis as a mechanism of immune privilege
38. The Fas death factor
39. CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival
40. Role of Fas-Fas ligand interactions in the immunorejection of allogeneic mouse corneal transplants
41. Corneal allografts devoid of epithelium placed beneath the kidney capsule display inherent immune privilege
42. Immunoregulatory properties of bone marrow derived cells in the iris and ciliary body
43. Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 1. Inhibition of T cell activation in vitro by direct cell to cell contact
44. Regional immunity and ocular immune privilege. Immune Responses and the Eye
45. Innate Immunity: The virtues of a nonclonal system of recognition
46. Innate immunity: Impact on the adaptive immune response
47. CD14 expression in rabbit and human corneas
48. Endotoxin-induced uveitis in rats as a model for human disease
49. Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes
50. Mice deficient in tumor necrosis factor receptors p55 and p75, interleukin-4, or inducible nitric oxide synthase are susceptible to endotoxin-induced uveitis
51. Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction
52. Transgenic expression of CD95 ligand on islet B cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts
53. Regulation of the proinflammatory effects of Fas ligand (CD95L)
54. Research into the complementary and anticomplementary power of aqueous humor and vitreous of guinea pigs
55. The complement components and their inhibitors in the intraocular fluids of the guinea pig
56. A small molecular weight factor in aqueous humor acts on Clq to prevent antibody-dependent complement activation
57. Immune privilege microenvironment modulates proinflammatory function of Fas ligand on the cornea
58. Effect of aqueous humor on apoptosis of inflammatory cell types
59. Expression of Qa-2 non-classical class I MHC antigen in the mouse eye
60. CD1 reactive NKT cells are required for development of systemic tolerance through immune privileged site