-
1
-
-
1342343921
-
Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer
-
DOI 10.1038/sj.onc.1207026
-
Attardi, L. D., de Vries, A. and Jacks, T. (2004). Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer. Oncogene 23, 973-980. (Pubitemid 38250943)
-
(2004)
Oncogene
, vol.23
, Issue.4
, pp. 973-980
-
-
Attardi, L.D.1
De Vries, A.2
Jacks, T.3
-
2
-
-
79955795151
-
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression
-
Brady, C. A., Jiang, D., Mello, S. S., Johnson, T. M., Jarvis, L. A., Kozak, M. M., Kenzelmann Broz, D., Basak, S., Park, E. J., McLaughlin, M. E. et al. (2011). Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell 145, 571-583.
-
(2011)
Cell
, vol.145
, pp. 571-583
-
-
Brady, C.A.1
Jiang, D.2
Mello, S.S.3
Johnson, T.M.4
Jarvis, L.A.5
Kozak, M.M.6
Kenzelmann Broz, D.7
Basak, S.8
Park, E.J.9
McLaughlin, M.E.10
-
3
-
-
0346503889
-
Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice
-
DOI 10.1016/S1534-5807(03)00399-X, PII S153458070300399X
-
Branda, C. S. and Dymecki, S. M. (2004). Talking about a revolution: the impact of site-specific recombinases on genetic analyses in mice. Dev. Cell 6, 7-28. (Pubitemid 38089202)
-
(2004)
Developmental Cell
, vol.6
, Issue.1
, pp. 7-28
-
-
Branda, C.S.1
Dymecki, S.M.2
-
4
-
-
70349443284
-
When mutants gain new powers: News from the mutant p53 field
-
Brosh, R. and Rotter, V. (2009). When mutants gain new powers: news from the mutant p53 field. Nat. Rev. Cancer 9, 701-713.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 701-713
-
-
Brosh, R.1
Rotter, V.2
-
5
-
-
70350567735
-
20 Years studying p53 functions in genetically engineered mice
-
Donehower, L. A. and Lozano, G. (2009). 20 years studying p53 functions in genetically engineered mice. Nat. Rev. Cancer 9, 831-841.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 831-841
-
-
Donehower, L.A.1
Lozano, G.2
-
6
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Jr, Butel, J. S. and Bradley, A. (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
McArthur, M.J.4
Montgomery Jr., C.A.5
Butel, J.S.6
Bradley, A.7
-
7
-
-
68149157175
-
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase
-
DuPage, M., Dooley, A. L. and Jacks, T. (2009). Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat. Protoc. 4, 1064-1072.
-
(2009)
Nat. Protoc.
, vol.4
, pp. 1064-1072
-
-
DuPage, M.1
Dooley, A.L.2
Jacks, T.3
-
8
-
-
77957564889
-
Hypoxia in models of lung cancer: Implications for targeted therapeutics
-
Graves, E. E., Vilalta, M., Cecic, I. K., Erler, J. T., Tran, P. T., Felsher, D., Sayles, L., Sweet-Cordero, A., Le, Q. T. and Giaccia, A. J. (2010). Hypoxia in models of lung cancer: implications for targeted therapeutics. Clin. Cancer Res. 16, 4843-4852.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 4843-4852
-
-
Graves, E.E.1
Vilalta, M.2
Cecic, I.K.3
Erler, J.T.4
Tran, P.T.5
Felsher, D.6
Sayles, L.7
Sweet-Cordero, A.8
Le, Q.T.9
Giaccia, A.J.10
-
9
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. and Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
10
-
-
0027179908
-
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
-
Harvey, M., Sands, A. T., Weiss, R. S., Hegi, M. E., Wiseman, R. W., Pantazis, P., Giovanella, B. C., Tainsky, M. A., Bradley, A. and Donehower, L. A. (1993). In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8, 2457-2467. (Pubitemid 23252375)
-
(1993)
Oncogene
, vol.8
, Issue.9
, pp. 2457-2467
-
-
Harvey, M.1
Sands, A.T.2
Weiss, R.S.3
Hegi, M.E.4
Wiseman, R.W.5
Pantazis, P.6
Giovanella, B.C.7
Tainsky, M.A.8
Bradley, A.9
Donehower, L.A.10
-
11
-
-
0028118111
-
Tumor spectrum analysis in p53-mutant mice
-
Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T. and Weinberg, R. A. (1994). Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1-7.
-
(1994)
Curr. Biol.
, vol.4
, pp. 1-7
-
-
Jacks, T.1
Remington, L.2
Williams, B.O.3
Schmitt, E.M.4
Halachmi, S.5
Bronson, R.T.6
Weinberg, R.A.7
-
12
-
-
28544432790
-
The differential effects of mutant p53 alleles on advanced murine lung cancer
-
DOI 10.1158/0008-5472.CAN-05-2193
-
Jackson, E. L., Olive, K. P., Tuveson, D. A., Bronson, R., Crowley, D., Brown, M. and Jacks, T. (2005). The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res. 65, 10280-10288. (Pubitemid 41743720)
-
(2005)
Cancer Research
, vol.65
, Issue.22
, pp. 10280-10288
-
-
Jackson, E.L.1
Olive, K.P.2
Tuveson, D.A.3
Bronson, R.4
Crowley, D.5
Brown, M.6
Jacks, T.7
-
13
-
-
34547660321
-
A spatially and temporally restricted mouse model of soft tissue sarcoma
-
DOI 10.1038/nm1602, PII NM1602
-
Kirsch, D. G., Dinulescu, D. M., Miller, J. B., Grimm, J., Santiago, P. M., Young, N. P., Nielsen, G. P., Quade, B. J., Chaber, C. J., Schultz, C. P. et al. (2007). A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat. Med. 13, 992-997. (Pubitemid 47222037)
-
(2007)
Nature Medicine
, vol.13
, Issue.8
, pp. 992-997
-
-
Kirsch, D.G.1
Dinulescu, D.M.2
Miller, J.B.3
Grimm, J.4
Santiago, P.M.5
Young, N.P.6
Nielsen, G.P.7
Quade, B.J.8
Chaber, C.J.9
Schultz, C.P.10
Takeuchi, O.11
Bronson, R.T.12
Crowley, D.13
Korsmeyer, S.J.14
Yoon, S.S.15
Hornicek, F.J.16
Weissleder, R.17
Jacks, T.18
-
14
-
-
77449155726
-
Imaging primary lung cancers in mice to study radiation biology
-
Kirsch, D. G., Grimm, J., Guimaraes, A. R., Wojtkiewicz, G. R., Perez, B. A., Santiago, P. M., Anthony, N. K., Forbes, T., Doppke, K., Weissleder, R. et al. (2010). Imaging primary lung cancers in mice to study radiation biology. Int. J. Radiat. Oncol. Biol. Phys. 76, 973-977.
-
(2010)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.76
, pp. 973-977
-
-
Kirsch, D.G.1
Grimm, J.2
Guimaraes, A.R.3
Wojtkiewicz, G.R.4
Perez, B.A.5
Santiago, P.M.6
Anthony, N.K.7
Forbes, T.8
Doppke, K.9
Weissleder, R.10
-
15
-
-
2442701845
-
Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis
-
DOI 10.1158/0008-5472.CAN-03-3524
-
Lin, S. C., Lee, K. F., Nikitin, A. Y., Hilsenbeck, S. G., Cardiff, R. D., Li, A., Kang, K. W., Frank, S. A., Lee, W. H. and Lee, E. Y. (2004). Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res. 64, 3525-3532. (Pubitemid 38657927)
-
(2004)
Cancer Research
, vol.64
, Issue.10
, pp. 3525-3532
-
-
Lin, S.-C.J.1
Lee, K.-F.2
Nikitin, A.Yu.3
Hilsenbeck, S.G.4
Cardiff, R.D.5
Li, A.6
Kang, K.-W.7
Frank, S.A.8
Lee, W.-H.9
Lee, E.Y.-H.P.10
-
16
-
-
77957554397
-
Location, location, location-makes all the difference for hypoxia in lung tumors
-
Maity, A. and Koumenis, C. (2010). Location, location, location-makes all the difference for hypoxia in lung tumors. Clin. Cancer Res. 16, 4685-4687.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 4685-4687
-
-
Maity, A.1
Koumenis, C.2
-
17
-
-
0034656212
-
Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
-
Marino, S., Vooijs, M., van Der Gulden, H., Jonkers, J. and Berns, A. (2000). Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 14, 994-1004. (Pubitemid 30253007)
-
(2000)
Genes and Development
, vol.14
, Issue.8
, pp. 994-1004
-
-
Marino, S.1
Vooijs, M.2
Van Der, G.H.3
Jonkers, J.4
Berns, A.5
-
18
-
-
38849167565
-
Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors
-
DOI 10.1158/0008-5472.CAN-07-3049
-
Martinez-Cruz, A. B., Santos, M., Lara, M. F., Segrelles, C., Ruiz, S., Moral, M., Lorz, C., Garcia-Escudero, R. and Paramio, J. M. (2008). Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors. Cancer Res. 68, 683-692. (Pubitemid 351206743)
-
(2008)
Cancer Research
, vol.68
, Issue.3
, pp. 683-692
-
-
Martinez-Cruz, A.B.1
Santos, M.2
Lara, M.F.3
Segrelles, C.4
Ruiz, S.5
Moral, M.6
Lorz, C.7
Garcia-Escudero, R.8
Paramio, J.M.9
-
19
-
-
0031916557
-
An Fgf8 mutant allelic series generated by Cre-and Flp-mediated recombination
-
DOI 10.1038/ng0298-136
-
Meyers, E. N., Lewandoski, M. and Martin, G. R. (1998). An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat. Genet. 18, 136-141. (Pubitemid 28082459)
-
(1998)
Nature Genetics
, vol.18
, Issue.2
, pp. 136-141
-
-
Meyers, E.N.1
Lewandoski, M.2
Martin, G.R.3
-
20
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D. et al. (2009). Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
Madhu, B.7
Goldgraben, M.A.8
Caldwell, M.E.9
Allard, D.10
-
21
-
-
77950923924
-
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer
-
Oliver, T. G., Mercer, K. L., Sayles, L. C., Burke, J. R., Mendus, D., Lovejoy, K. S., Cheng, M. H., Subramanian, A., Mu, D., Powers, S. et al. (2010). Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev. 24, 837-852.
-
(2010)
Genes Dev.
, vol.24
, pp. 837-852
-
-
Oliver, T.G.1
Mercer, K.L.2
Sayles, L.C.3
Burke, J.R.4
Mendus, D.5
Lovejoy, K.S.6
Cheng, M.H.7
Subramanian, A.8
Mu, D.9
Powers, S.10
-
22
-
-
33947647023
-
High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells
-
Raymond, C. S. and Soriano, P. (2007). High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells. PLoS ONE 2, e162.
-
(2007)
PLoS ONE
, vol.2
-
-
Raymond, C.S.1
Soriano, P.2
-
23
-
-
33748331308
-
The mighty mouse: Genetically engineered mouse models in cancer drug development
-
DOI 10.1038/nrd2110, PII NRD2110
-
Sharpless, N. E. and Depinho, R. A. (2006). The mighty mouse: genetically engineered mouse models in cancer drug development. Nat. Rev. Drug Discov. 5, 741-754. (Pubitemid 44323701)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 741-754
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
24
-
-
77953262592
-
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models
-
Singh, M., Lima, A., Molina, R., Hamilton, P., Clermont, A. C., Devasthali, V., Thompson, J. D., Cheng, J. H., Bou Reslan, H., Ho, C. C. et al. (2010). Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models. Nat. Biotechnol. 28, 585-593.
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 585-593
-
-
Singh, M.1
Lima, A.2
Molina, R.3
Hamilton, P.4
Clermont, A.C.5
Devasthali, V.6
Thompson, J.D.7
Cheng, J.H.8
Bou Reslan, H.9
Ho, C.C.10
-
25
-
-
33847230852
-
The p53 family in differentiation and tumorigenesis
-
Stiewe, T. (2007). The p53 family in differentiation and tumorigenesis. Nat. Rev. Cancer 7, 165-168.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 165-168
-
-
Stiewe, T.1
-
26
-
-
0034114458
-
Epiblast-restricted Cre expression in MORE mice: A tool to distinguish embryonic vs. extra-embryonic gene function
-
DOI 10.1002/(SICI)1526-968X(200002)26:2<113::AID-GENE3>3.0.CO;2-2
-
Tallquist, M. D. and Soriano, P. (2000). Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26, 113-115. (Pubitemid 30158091)
-
(2000)
Genesis
, vol.26
, Issue.2
, pp. 113-115
-
-
Tallquist, M.D.1
Soriano, P.2
-
27
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
DOI 10.1038/415045a
-
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C. et al. (2002). p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53. (Pubitemid 34062443)
-
(2002)
Nature
, vol.415
, Issue.6867
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
Brayton, C.10
Sang, H.P.11
Thompson, T.12
Karsenty, G.13
Bradley, A.14
Donehower, L.A.15
-
28
-
-
79957891587
-
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis
-
Young, N. P., Crowley, D. and Jacks, T. (2011). Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis. Cancer Res. 71, 4040-4047.
-
(2011)
Cancer Res.
, vol.71
, pp. 4040-4047
-
-
Young, N.P.1
Crowley, D.2
Jacks, T.3
|