Receptor-mediated, tumor-targeted gene delivery using folate-terminated polyrotaxanes

Molecular Pharmaceutics

Volumn 9, Issue 5, 2012, Pages 1067-1076

  Zhou, Yi ^a   Wang, He ^a   Wang, Chengxi ^a   Li, Yueshan ^b   Lu, Wenfeng ^a   Chen, Shuifang ^a   Luo, Jiandong ^b   Jiang, Yongnan ^a   Chen, Jianhai ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

cyclodextrin; folate receptor targeting; gene carrier; poly(ethylenimine); supramolecule

Indexed keywords

ALPHA CYCLODEXTRIN; DNA; FOLIC ACID; MACROGOL 4000; NANOPARTICLE; PLASMID DNA; POLYETHYLENEIMINE; POLYMER; PROTEIN BAX; PROTEIN P53; ROTAXANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GENE THERAPY; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY; GENE DELIVERY SYSTEM; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR CELL; ZETA POTENTIAL;

ALPHA-CYCLODEXTRINS; ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; FOLATE RECEPTORS, GPI-ANCHORED; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, NUDE; PLASMIDS; POLYETHYLENEIMINE; ROTAXANES; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84860761417     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200315c     Document Type: Article

References (38)

1. Erbacher, P.; Bettinger, T.; Belguise-Valladier, P.; Zou, S.; Coll, J. L.; Behr, J. P.; Remy, J. S. Transfection and physical properties of various saccharide, poly(ethylene glycol), and antibody-derivatized polyethylenimines (PEI) J. Gene Med. 1999, 1 (3) 210-22
2. Glover, D. J.; Lipps, H. J.; Jans, D. A. Towards safe, non-viral therapeutic gene expression in humans Nat. Rev. Genet. 2005, 6 (4) 299-310
3. Lopez, A.; Spracklin, D.; McConkey, S.; Hanna, P. Cutaneous mucinosis and mastocytosis in a shar-pei Can. Vet. J. 1999, 40 (12) 881-3
4. Ogris, M.; Brunner, S.; Schuller, S.; Kircheis, R.; Wagner, E. PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery Gene Ther. 1999, 6 (4) 595-605
5. Putnam, D.; Zelikin, A. N.; Izumrudov, V. A.; Langer, R. Polyhistidine-PEG:DNA nanocomposites for gene delivery Biomaterials 2003, 24 (24) 4425-33
6. Mishra, S.; Heidel, J. D.; Webster, P.; Davis, M. E. Imidazole groups on a linear, cyclodextrin-containing polycation produce enhanced gene delivery via multiple processes J. Controlled Release 2006, 116 (2) 179-91
7. Koshi, Y.; Nakata, E.; Miyagawa, M.; Tsukiji, S.; Ogawa, T.; Hamachi, I. Target-specific chemical acylation of lectins by ligand-tethered DMAP catalysts J. Am. Chem. Soc. 2008, 130 (1) 245-51
8. Pereboev, A.; Pereboeva, L.; Curiel, D. T. Phage display of adenovirus type 5 fiber knob as a tool for specific ligand selection and validation J. Virol. 2001, 75 (15) 7107-13
9. Majumdar, D.; Peng, X. H.; Shin, D. M. The medicinal chemistry of theragnostics, multimodality imaging and applications of nanotechnology in cancer Curr. Top. Med. Chem. 2010, 10 (12) 1211-26
10. Neu, M.; Fischer, D.; Kissel, T. Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives J. Gene Med. 2005, 7 (8) 992-1009
11. Fischer, D.; Li, Y.; Ahlemeyer, B.; Krieglstein, J.; Kissel, T. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis Biomaterials 2003, 24 (7) 1121-31
12. Gong, C. Y.; Wu, Q. J.; Dong, P. W.; Shi, S.; Fu, S. Z.; Guo, G.; Hu, H. Z.; Zhao, X.; Wei, Y. Q.; Qian, Z. Y. Acute toxicity evaluation of biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PEG-PCL-PEG hydrogel J. Biomed. Mater. Res. B, Appl. Biomater. 2009, 91 (1) 26-36
13. Li, J.; Loh, X. J. Cyclodextrin-based supramolecular architectures: syntheses, structures, and applications for drug and gene delivery Adv. Drug Delivery Rev. 2008, 60 (9) 1000-17
14. Cryan, S. A.; Holohan, A.; Donohue, R.; Darcy, R.; O'Driscoll, C. M. Cell transfection with polycationic cyclodextrin vectors Eur. J. Pharm. Sci. 2004, 21 (5) 625-33
15. Yang, C.; Wang, X.; Li, H.; Goh, S. H.; Li, J. Synthesis and characterization of polyrotaxanes consisting of cationic alpha-cyclodextrins threaded on poly[(ethylene oxide)-ran-(propylene oxide)] as gene carriers Biomacromolecules 2007, 8 (11) 3365-74
16. Yang, C.; Wang, X.; Li, H.; Tan, E.; Lim, C. T.; Li, J. Cationic polyrotaxanes as gene carriers: physicochemical properties and real-time observation of DNA complexation, and gene transfection in cancer cells J. Phys. Chem. B 2009, 113 (22) 7903-11
17. Jeong, J. H.; Kim, S. H.; Kim, S. W.; Park, T. G. In vivo tumor targeting of ODN-PEG-folic acid/PEI polyelectrolyte complex micelles J. Biomater. Sci., Polym. Ed. 2005, 16 (11) 1409-19
18. Lai, C. L.; Lai, L.; Zhao, J. B.; Chen, J. H. Synthesis of polyrotaxane-camptothecin conjugates and evaluation of its anti-tumor effect Yao Xue Xue Bao 2010, 45 (7) 920-5
19. Chan, P.; Kurisawa, M.; Chung, J. E.; Yang, Y. Y. Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery Biomaterials 2007, 28 (3) 540-9
20. Moon, C.; Kwon, Y. M.; Lee, W. K.; Park, Y. J.; Chang, L. C.; Yang, V. C. A novel polyrotaxane-based intracellular delivery system for camptothecin: in vitro feasibility evaluation J. Biomed. Mater. Res. A 2008, 84 (1) 238-46
21. Yang, C.; Li, H.; Goh, S. H.; Li, J. Cationic star polymers consisting of alpha-cyclodextrin core and oligoethylenimine arms as nonviral gene delivery vectors Biomaterials 2007, 28 (21) 3245-54
22. Liang, B.; He, M. L.; Xiao, Z. P.; Li, Y.; Chan, C. Y.; Kung, H. F.; Shuai, X. T.; Peng, Y. Synthesis and characterization of folate-PEG-grafted- hyperbranched-PEI for tumor-targeted gene delivery Biochem. Biophys. Res. Commun. 2008, 367 (4) 874-80
23. Mansouri, S.; Cuie, Y.; Winnik, F.; Shi, Q.; Lavigne, P.; Benderdour, M.; Beaumont, E.; Fernandes, J. C. Characterization of folate-chitosan-DNA nanoparticles for gene therapy Biomaterials 2006, 27 (9) 2060-5
24. Yao, H.; Ng, S. S.; Tucker, W. O.; Tsang, Y. K.; Man, K.; Wang, X. M.; Chow, B. K.; Kung, H. F.; Tang, G. P.; Lin, M. C. The gene transfection efficiency of a folate-PEI600-cyclodextrin nanopolymer Biomaterials 2009, 30 (29) 5793-803
25. Ko, J. K.; Sham, N. F.; Guo, X.; Cho, C. H. Beneficial intervention of experimental colitis by passive cigarette smoking through the modulation of cytokines in rats J. Invest. Med. 2001, 49 (1) 21-9
26. Kunath, K.; von Harpe, A.; Fischer, D.; Petersen, H.; Bickel, U.; Voigt, K.; Kissel, T. Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine J. Controlled Release 2003, 89 (1) 113-25
27. Kogel, D.; Fulda, S.; Mittelbronn, M. Therapeutic exploitation of apoptosis and autophagy for glioblastoma Anticancer Agents Med. Chem. 2010, 10 (6) 438-49
28. He, Z.; Ma, W. Y.; Hashimoto, T.; Bode, A. M.; Yang, C. S.; Dong, Z. Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways Cancer Res. 2003, 63 (15) 4396-401
29. Li, J. J.; Zhao, F.; Li, J. Polyrotaxanes for applications in life science and biotechnology Appl. Microbiol. Biotechnol. 2011, 90 (2) 427-43
30. Lu, B.; Wang, C. F.; Wu, D. Q.; Li, C.; Zhang, X. Z.; Zhuo, R. X. Chitosan based oligoamine polymers: synthesis, characterization, and gene delivery J. Controlled Release 2009, 137 (1) 54-62
31. Jiang, H. L.; Kim, Y. K.; Arote, R.; Nah, J. W.; Cho, M. H.; Choi, Y. J.; Akaike, T.; Cho, C. S. Chitosan-graft-polyethylenimine as a gene carrier J. Controlled Release 2007, 117 (2) 273-80
32. Gao, X.; Kim, K. S.; Liu, D. Nonviral gene delivery: what we know and what is next AAPS J. 2007, 9 (1) E92-104
33. Patri, A. K.; Kukowska-Latallo, J. F.; Baker, J. R., Jr. Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex Adv. Drug Delivery Rev. 2005, 57 (15) 2203-14
34. Cho, K. C.; Kim, S. H.; Jeong, J. H.; Park, T. G. Folate receptor-mediated gene delivery using folate-poly(ethylene glycol)-poly(L- lysine) conjugate Macromol. Biosci. 2005, 5 (6) 512-9
35. Mathias, C. J.; Wang, S.; Lee, R. J.; Waters, D. J.; Low, P. S.; Green, M. A. Tumor-selective radiopharmaceutical targeting via receptor-mediated endocytosis of gallium-67-deferoxamine-folate J. Nucl. Med. 1996, 37 (6) 1003-8
36. Quinlan, G. J.; Martin, G. S.; Evans, T. W. Albumin: biochemical properties and therapeutic potential Hepatology 2005, 41 (6) 1211-9
37. Yang, C.; Li, H.; Wang, X.; Li, J. Cationic supramolecules consisting of oligoethylenimine-grafted alpha-cyclodextrins threaded on poly(ethylene oxide) for gene delivery J. Biomed. Mater. Res. A 2009, 89 (1) 13-23
38. Ichihara, H.; Funamoto, K.; Matsushita, T.; Matsumoto, Y.; Ueoka, R. Histological bioanalysis for therapeutic effects of hybrid liposomes on the hepatic metastasis of colon carcinoma in vivo Int. J. Pharm. 2010, 394 (1-2) 174-8