Acute toxicity evaluation of biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PEG-PCL-PEG hydrogel

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 91, Issue 1, 2009, Pages 26-36

  Chang, Yang Gong ^a   Qin, Jie Wu ^a   Peng, Wei Dong ^a   Shi, Shuai ^a   Shao, Zhi Fu ^a   Guo, Gang ^a   Huo, Zhen Hu ^a   Zhao, Xia ^a,b   Yu, Quan Wei ^a   Qian, Zhi Yong ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Acute toxicity; Biodegradable; Histopathologic examination; Hydrogel; Thermosensitive

Indexed keywords

ACUTE TOXICITY; ACUTE TOXICITY TEST; AQUEOUS SOLUTIONS; BALB/C MICE; BIODEGRADABLE; BODY TEMPERATURE; BODY WEIGHT; CAPROLACTONE; CELL VIABILITY; CONTROLLED DRUG DELIVERY SYSTEMS; DEGRADATION TEST; GEL FORMATION; HEK293 CELLS; HISTOCHEMICAL ANALYSIS; HISTOPATHOLOGIC EXAMINATION; IN-SITU; IN-VIVO; INTRAPERITONEAL; LOW TEMPERATURES; OBSERVATION PERIOD; PEG HYDROGEL; SOL-GEL-SOL TRANSITIONS; TEMPERATURE INCREASE; THERMOSENSITIVE; TRIBLOCK COPOLYMERS;

CELL MEMBRANES; CONTROLLED DRUG DELIVERY; COPOLYMERIZATION; ETHYLENE; ETHYLENE GLYCOL; GELATION; GELS; HYDROGELS; POLYETHYLENE OXIDES; SOLS; TOXICITY;

POLYETHYLENE GLYCOLS;

COPOLYMER; POLY(ETHYLENE GLYCOL) POLY(EPSILON CAPROLACTONE) POLY(ETHYLENE GLYCOL); UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; BIODEGRADABILITY; BODY TEMPERATURE; CELL STRAIN HEK293; CELL VIABILITY; CHEMICAL STRUCTURE; CYTOTOXICITY; DRUG DELIVERY SYSTEM; GEL; GEL PERMEATION CHROMATOGRAPHY; HEAT SENSITIVITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYDROGEL; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; PHASE TRANSITION; PROTON NUCLEAR MAGNETIC RESONANCE; SOLID; SYNTHESIS; TEMPERATURE; TOXICITY TESTING;

ABSORBABLE IMPLANTS; ANIMALS; BIOCOMPATIBLE MATERIALS; CELL LINE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; HYDROGEL; INFUSIONS, SUBCUTANEOUS; MALE; MATERIALS TESTING; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; PHASE TRANSITION; POLYESTERS; POLYETHYLENE GLYCOLS;

EID: 70049096028     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31370     Document Type: Article

References (26)

1. Jeong B, Bae YH, Lee DS, Kim SW. Biodegradable block copolymers as injectable drug-delivery systems. Nature 1997;388:860-862. (Pubitemid 27377054)
2. Gong CY, Qian ZY, Liu CB, Huang MJ, Gu YC, Wen YJ, Kan B, Wang K, Dai M, Li XY, Gou ML, Tu, MJ, Wei YQ. A thermosensitive hydrogel based on biodegradable amphiphilic PEG-PCL-PEG block copolymers. Smart Mater Struct 2007;16:927-933.
3. Gariépy ER, Leroux JC. In situ-forming hydrogels-review of temperature-sensitive systems. Eur J Pharm Biopharm 2004;58:409-426.
4. Lee JW, Hua FJ, Lee DS. Thermoreversible gelation of biodegradable poly(ε-caprolactone) and poly(ethylene glycol) multiblock copolymers in aqueous solutions. J Control Release 2001; 73:315-327.
5. Li J, Li X, Ni X, Leong KW. Synthesis and characterization of new biodegradable amphiphilic poly(ethylene oxide)-b-poly[(R)-3-hydroxybutyrate]-b- poly(ethylene oxide) triblock copolymers. Macromolecules 2003;36:2661-2667.
6. Kissel T, Li Y, Unger F. ABA-triblock copolymers from biodegradable polyerster A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins. Adv Drug Deliv Rev 2002;54:99-134. (Pubitemid 34075316)
7. Li J, Ni X, Leong KW. Injectable drug-delivery systems based on supramolecular hydrogels formed by poly(ethylene oxide)s and cyclodextrin. J Biomed Mater Res A 2003;65:196-202. (Pubitemid 37521425)
8. Liu CB, Gong CY, Huang MJ, Wang JW, Pan YF, Zhang YD, Li GZ, Gou ML, Wang K, Tu MJ, Wei YQ, Qian ZY. Thermoreversible gel-sol behavior of biodegradable PCL-PEG- PCL triblock copolymer in aqueous solutions. J Biomed Mater Res B 2008;84:165-175.
9. Jeong B, Kim SW, Bae YH. Thermosensitive sol-gel reversible hydrogels. Adv Drug Del Rev 2002;54:37-51.
10. Song MJ, Lee DS, Ahn JH, Kim DJ, Kim SW. Thermosensitive sol-gel transition behaviors of poly(ethylene oxide)/aliphatic polyester/poly(ethylene oxide) aqueous solutions. J Polym Sci Part A: Polym Chem 2004;42:772-784.
11. Liu CB, Gong CY, Pan YF, Zhang YD, Wang JW, Huang MJ, Qian ZY. Synthesis and characterization of a thermosensitive hydrogel based on biodegradable amphiphilic PCL-pluronic(L35)-PCL block copolymers. Colloids Surf A 2007;302:430-438.
12. Gong CY, Shi S, Dong PW, Kan B, Gou ML, Wang XH, Li XY, Luo F, Zhao X, Wei YQ, Qian ZY. Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel. Int J Pharm 2009;365:89-99.
13. Perret R, Skoulios A. Synthese et caracterisation de copolymers sequences polyoxyethylene/poly(ε-caprolactone). Makromol Chem 1972;156:143-156.
14. Martini L, Attwood D, Collett JH, Nicholas CV, Tanodekaew S, Deng NJ, Heatley F, Booth C. Micellisation and gelation of triblock copolymer of ethylene oxide and ε-caprolactone. ClnEmCLn, in aqueous solution. J Chem Soc Faraday Trans 1994;90:1961-1966.
15. Bogdanov B, Vidts A, Bulcke A, Verbeeck R, Schacht E. Synthesis and thermal properties of poly(ethylene glycol)- poly(ε-caprolactone) copolymers. Polymer 1998;39:1631-1636. (Pubitemid 128397891)
16. Li J, Li X, Ni X, Wang X, Li H, Leong KW. Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB- PEO triblock copolymers and ε-cyclodextrin for controlled drug delivery. Biomaterials 2006;27:4132-4140.
17. An JH, Kim HS, Chung DJ, Lee DS. Thermal behaviour of poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) tri-block copolymers. J Mater Sci 2001;36:715-722.
18. Zhou SB, Deng XM, Yang H. Biodegradable poly(ε-caprolactone)- poly(ethylene glycol) block copolymers: Characterization and their use as drug carriers for a controlled delivery system. Biomaterials 2003;24:3563-3570. (Pubitemid 36703130)
19. Huang MH, Li SM, Hutmacher DW, Schantz JT, Vacanti CA, Braud C, Vert M. Degradation and cell culture studies on block copolymers prepared by ring opening polymerization of ε-caprolactone in the presence of poly(ethylene glycol). J Biomed Mater Res A 2004;69:417-427. (Pubitemid 38668167)
20. Bae SJ, Suh JM, Sohn YS, Bae YH, Kim SW, Jeong B. Thermogelling poly(caprolactone-b-ethylene glycol-b-caprolactone) aqueous solutions. Macromolecules 2005;38:5260-5265. (Pubitemid 40925687)
21. Ryu JG, Jeong Y, Kim IS, Lee JH, Nah JW, Kim SH. Clonazepam release from core-shell type nanoparticles of poly(ε-caprolactone)/ poly(ethylene glycol)/poly(ε-caprolactone) triblock copolymers. Int J Pharm 2000;200:231-242. (Pubitemid 30364910)
22. Li J, Ni X, Li X, Tan NK, Lim CT, Ramakrishna S, Leong KW. Micellization phenomena of biodegradable amphiphilic triblock copolymers consisting of poly(ε-hydroxyalkanoic acid) and poly(ethylene oxide). Langmuir 2005;21:8681-8685. (Pubitemid 41396624)
23. Chen X, Qian ZY, Gou ML, Chao GT, Zhang YD, Gu YC, Huang MJ, Wang JW, Pan YF, Wei YQ, Chen JP, Tu MJ. Acute oral toxicity evaluation of biodegradable and pH-sensitive hydrogel based on polycaprolactone. Poly(ethylene glycol) and methylacrylic acid (MAA). J Biomed Mater Res A 2008;84:589-597. (Pubitemid 351237775)
24. Xiong XY, Tam KC, Gan LH. Synthesis and aggregation behavior of pluronic F127/poly(lactic acid) block copolymers in aqueous solutions. Macromolecules 2003;36:9979-9985.
25. Rangelov S, Dimitrov P, Tsvetanov CB. Mixed block copolymer aggregates with tunable temperature behavior. J Phys Chem B 2005;109:1162-1167. (Pubitemid 40206826)
26. Choi SW, Choi SY, Jeong B, Kim SW, Lee DS. Thermoreversible gelation of poly(ethylene oxide) biodegradable polyester block copolymers. II. J Polym Sci Part A: Polym Chem 1999;37:2207-2218.